Patents by Inventor Wei Hung

Wei Hung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic compounds and methods of use thereof
    Patent number: 11548866
    Abstract: There are provided new inhibitors of MDM2. Also provided are methods of synthesizing the agents, pharmaceutical formulations including the agents, and methods of using the agents to treat, ameliorate or cure diseases characterized by MDM2 over-expression or malfunction.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: January 10, 2023
    Assignee: LIGATURE THERAPEUTICS PTE. LTD.
    Inventors: Rajavel Srinivasan, Wei Hung
  • Therapeutic compounds and methods of use thereof
    Patent number: 11542274
    Abstract: There are provided new heterobifunctional agents designed to mediated formation of protein-protein dimers and promote ubiquitination of a protein of the dimer. Also provided are methods of synthesizing the agents, pharmaceutical formulations including the agents, and methods of using the agents to treat, ameliorate or cure diseases characterized by protein over-expression or malfunction.
    Type: Grant
    Filed: September 23, 2021
    Date of Patent: January 3, 2023
    Assignee: Agency for Science, Technology and Research (A*STAR)
    Inventors: Wei Hung, Thomas Hugo Keller, Wei Ling Wang, Gang Wang, Congbao Kang
  • Therapeutic compounds and methods of use thereof
    Patent number: 11504381
    Abstract: There are provided new heterobifunctional agents designed to mediate formation of protein-protein dimers and promote ubiquitination of a protein of interest component of the dimer. Also provided are methods of synthesizing the agents, pharmaceutical formulations including the agents, and methods of using the agents to treat, ameliorate or cure diseases characterized by protein over-expression or malfunction.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: November 22, 2022
    Assignee: LIGATURE THERAPEUTICS PTE. LTD.
    Inventors: Rajavel Srinivasan, Wei Hung
  • THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20210147441
    Abstract: There are provided new heterobifuctional agents designed to mediated formation of protein-protein dimers and promote ubiqutination of a protein of the dimer. Also provided are methods of synthesizing the agents, pharmaceutical formulations including the agents, and methods of using the agents to treat, ameliorate or cure diseases characterized by protein over-expression or malfunction.
    Type: Application
    Filed: September 22, 2020
    Publication date: May 20, 2021
    Inventors: Wei Hung, Thomas Hugo Keller, Wei Ling Wang, Gang Wang, Congbao Kang
  • Macrolide compound with bis-oxazoly
    Publication number: 20100041896
    Abstract: This patent mainly provides a new macrolide compound named FW-04-806, which contains bis-oxazoly in molecule. FW-04-806, a bis-oxazolyl macrolide compound extracted and separated from the ferment liquid of streptomyces FIM-04-806, has anti-tumor activities and provides a chemical research basis for natural drugs and the lead compound for the research and development of new anti-tumor drugs. Anti-tumor in vitro experiment shows that minimal median inhibitory concentration IC50 is 12.36 ug/ml to K562 cell (human chronic mydogenous leukemia leap clone).
    Type: Application
    Filed: August 12, 2008
    Publication date: February 18, 2010
    Inventors: Zheng WEI, Zhentai Cheng, Tian-en Wei, Yuanrong Cheng, Yunyang Lian, Wei Hung