Abstract: A package assembly includes a circuit substrate, a top-emitting (TE) vertical cavity surface emitting laser (VCSEL) die having a two-dimensional (2D) matrix addressable emitter array, and a driver integrated circuit (IC) having a flip-chip interconnect configuration. The TE-VCSEL die and the driver IC are coupled together to form a die stack that is mounted to the circuit substrate, with the TE-VCSEL die arranged between the driver IC and the circuit substrate. TE-VCSEL die comprises an optical output arranged at a main surface coupled to the driver IC. The optical output is configured to output light generated by one or more emitters of the emitter array. Thus, the TE-VCSEL die is configured to emit light away from the circuit substrate.

Abstract: A four-dimensional (4D) light-detection-and-ranging sensor using frequency modulated continuous wave is provided with an ultra-high velocity resolution. At a transmitting terminal, the hybrid waveform of a driving laser is used to minimize the phase noise generated by a distributed-feedback laser during wavelength scanning. The hybrid waveform is obtained by combining direct-current signal (not modulated) and alternating-current (AC) signal. The AC signal is a predistorted triangle or AC waveform for extracting location. The continuous wave (CW) extracts velocity. At a receiving terminal, a radar radio-frequency receiver is combined with an avalanche photodiode (APD) with multiple layers accumulated in series to obtain excellent responsivity and saturated current. The mixed waveform coordinated with the APD prevents Doppler shift frequency from being contaminated by low-frequency flicker noise.

Abstract: Disclosed are a drug delivery carrier complex targeting a central nervous system and a preparation method and an application thereof, relating to the technical field of biomedicine. The preparation method includes following steps: carrying out azide modification on carrier cells to obtain azide-modified carrier cells; modifying sulfhydryl group and cholesterol to two ends of therapeutic miRNA respectively, and then performing ligation reaction to modified therapeutic miRNA and an acryl complex to form a miRNA complex; and co-incubating the azide-modified carrier cells with the miRNA complex, and forming the drug delivery carrier complex through click chemistry reaction.

Abstract: The present invention provides a bluetooth headset-based voice translation system including: a first translation bluetooth headset, a second translation bluetooth headset, an audio signal processing center and a translation module. The audio signal processing center includes a Fourier-transform module, a signal cross-correlation processing module, a judgment module and a gain module. Time-frequency signal processing and signal cross-correlation processing are respectively performed on first and second audio signals respectively collected by the first and second translation Bluetooth headsets, thereby determining a sound source position and performing gain processing on the first and second audio signals. Finally, the translation module performs recognition and translation. The present invention further provides a bluetooth headset-based voice translation method.

Abstract: Provided is a compound of formula I or II, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and the medical uses thereof in treating diseases benefiting from the capsid protein assembly inhibitor, particularly diseases caused by hepatitis B virus infection.

Abstract: An optical device may include a substrate including a conductive core, a first layer stack on a first surface of the conductive core, a conductor-filled trench extending through the first layer stack to the conductive core such that the conductor-filled trench is on the first surface of the conductive core, and a second layer stack on a second surface of the conductive core. The optical device may include a vertical-cavity surface-emitting laser (VCSEL) chip above the conductor-filled trench. The VCSEL chip may include an array of VCSELs. A size of the conductor-filled trench may match a size of the VCSEL chip, match a size of an emission region of the array of VCSELs, or be greater than the size of the emission region of the array of VCSELs and less than the size of the VCSEL chip.

Abstract: A micro-flow throttling device, comprising: a casing used for assembling; a throttling structure mounted inside the casing to form resistance to control a fluid flow, wherein the throttling structure comprises a first axial hole formed inside a fine threaded rod, a first radial hole is formed on one side of the first axial hole, a fine thread flow channel is mounted on one side of the first radial hole, and a second cavity is formed between the fine thread flow channel and a coarse thread flow channel; a regulating structure mounted on the casing and used for regulating the flow rate of the fluid; and a butt-joint structure mounted on the inner wall of the casing and used for performing disassembly and assembly limiting on the throttling structure.

Abstract: A system may include a plurality of subsystems, such as an identity management system configured to store information associated with digital identities, a resource management system configured to store information associated with resources of a community, a financial system configured to manage financial transactions, an infrastructure system configured to manage a digital representation of the community, a transportation system configured to manage a plurality of transportation devices of the community, an education system configured to manage the education of the community, a security system configured to secure information of the plurality of subsystems, an energy system configured to manage an electrical transmission system and an electrical generation system of the community, and a central hub system configured to manage other subsystems.

Abstract: The present invention provides a model for high-throughput screening of endocrine disruptors and a method for screening the same. In the present invention, primary structural alerts, secondary structural alerts and tertiary structural alerts of compounds are extracted according to a nuclear receptor, and then the primary structural alerts, the secondary structural alerts and the tertiary structural alerts form a nuclear receptor high-throughput screening model; hierarchical structural alert matching is carried out on target compounds through the nuclear receptor high-throughput screening model, and ligand-receptor binding mode analysis and semi-quantitative prediction of binding activity and disrupting activity are performed.

Abstract: Photonics has become a dominant or evolving technological solution for communications to meet the increasing demand for bandwidth. Accordingly, photonic communications is moving towards coherent modulation formats to further increase capacity by encoding information in both phase and amplitude of the optical signal. Whilst coherent optical transmitters and coherent optical receivers are more complex than their on-off counterparts leveraging monolithic photonic elements and photonic integrated circuits employing said photonic elements offers a lower cost route for coherent optical components. Further, external modulation, using phase modulators or amplitude modulators or a combination thereof, can increase modulation bandwidth relative to directly modulated lasers for increased data transmission. Novel optical hybrid circuits and external modulators are present which are compatible photonic integrated circuit manufacturing techniques and monolithic integration.

Abstract: The present disclosure relates to a compound containing cycloalkyl or haloalkyl, and specifically discloses a compound represented by formula I?, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and a use thereof in treating tumors.

Abstract: A sulfoximine-containing ATR inhibitor compound as represented by formula (I), a preparation method therefor, a pharmaceutical composition containing same, and the use thereof in the treatment of ATR-related or ATR-mediated diseases and/or conditions.

Abstract: The present disclosure relates to a layered bimetallic hydroxide-based hydrogel bipolar membrane and a method for preparing the same. The method includes: blade-coating a quaternized polyethersulfone solution on a substrate, and carrying out drying to obtain an anion exchange layer; immersing the layer sequentially and cyclically in a sodium alginate solution and a first metal ion mixed solution to obtain a hydrogel anion exchange membrane; immersing the hydrogel membrane sequentially in a second metal ion mixed solution and an alkaline solution; and blade-coating a sulfonated polyethersulfone solution on the obtained membrane, and carrying out drying to obtain the layered bimetallic hydroxide-based hydrogel bipolar membrane. The anion and cation exchange membrane layers on two sides of the bipolar membrane prepared in the present disclosure are closely bound by way of hydrogel cross-linking.

Abstract: An emergency descent system for an aerial work platform includes a telescopic hydraulic cylinder provided a piston rod inside, a counterbalance valve, an oil return pipe and a proportional valve. An interior of the telescopic hydraulic cylinder is divided into a cavity with rod and a cavity with non-rod. An inlet of the counterbalance valve is connected to the cavity with non-rod, and an outlet of the counterbalance valve is connected to an oil supply pipe. The oil return pipe is connected to the cavity with rod and a control port of the counterbalance valve, the oil return pipe is connected to an emergency oil source which is used for providing hydraulic oil to the oil return pipe. An inlet of the proportional valve is connected to the cavity with non-rod, and an outlet of the proportional valve is connected to the oil return pipe.

Abstract: A pyridyl-containing compound represented by formula I and a preparation method therefor, and the use thereof in the preparation for a drug for treating tumors.

Abstract: Provided herein are nucleic acid molecules encoding a SARS-CoV-2 S ectodomain—HBsAg fusion protein. When expressed in mammalian cells (for example, by administration to a mammalian subject), the fusion protein self-assembles to form a HBsAg protein nanoparticle with SARS-CoV-2 S ectodomain trimers extending radially outward from an outer surface of the HBsAg protein nanoparticle. Thus, in several aspects, the disclosed nucleic acid molecule can be used to generate an immune response to SARS-CoV-2 in a subject.

Abstract: Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2.

Abstract: An optical device may include a substrate including a conductive core, a first layer stack on a first surface of the conductive core, a conductor-filled trench extending through the first layer stack to the conductive core such that the conductor-filled trench is on the first surface of the conductive core, and a second layer stack on a second surface of the conductive core. The optical device may include a vertical-cavity surface-emitting laser (VCSEL) chip above the conductor-filled trench. The VCSEL chip may include an array of VCSELs. A size of the conductor-filled trench may match a size of the VCSEL chip, match a size of an emission region of the array of VCSELs, or be greater than the size of the emission region of the array of VCSELs and less than the size of the VCSEL chip.

Abstract: In some implementations, an emitter assembly includes a vertical cavity surface emitting laser (VCSEL) device. The VCSEL device may include a substrate. The VCSEL device may include a plurality of VCSELs on the substrate. The VCSEL device may include at least one anode layer on the substrate and electrically connected to the plurality of VCSELs. The VCSEL device may include a cathode electrode over at least a portion of multiple VCSELs, of the plurality of VCSELs, and electrically connected to the multiple VCSELs. The cathode electrode may include multiple cathode electrode fingers. The emitter assembly may include a bridge element that electrically connects a first finger of the multiple cathode electrode fingers and a second finger of the multiple cathode electrode fingers.

Abstract: A variable valve actuation device for an engine includes a rocker arm mechanism, a camshaft, an actuation mechanism and a blocking mechanism. The rocker arm roller can slide on a roller shaft so as to have two operating positions, a first cam and a second cam which are adjacent are provided on the camshaft, the rocker arm mechanism is actuated, based on the different operating positions of the rocker arm roller, by the first cam or the second cam, respectively, to enable the engine to have two valve lifts, a control cam is further provided on one side of the first cam or the second cam, the control cam can actuate the blocking mechanism, and the rocker arm roller is blocked from switching in a switching prohibited portion of the first cam and the second cam, and is allowed to switching in a non-switching prohibited portion.