Abstract: Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefore, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.

Abstract: Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.

Abstract: The present application relates to the field of pharmaceutical chemistry, relates to a fused bicyclic compound containing pyrrolinone, and in particular relates to a compound represented by formula (II), a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and the use thereof in the treatment of diseases (such as cancer).

Abstract: A temperature fuse assembly for a high-power DC circuit is provided. The temperature fuse assembly includes a case extending from a first case end to a second case end and an isolated lead projecting from the second case end. A bushing electrically isolates the isolated lead from the case. A high-gauge wire is electrically connected to the case at a first wire end and electrically connected to the isolated lead at a second wire end. A portion of the high-gauge wire is helically wound about an exterior of the bushing. When a temperature of the temperature fuse assembly exceeds a threshold temperature, the temperature fuse assembly is configured to conduct a DC current of the high-power DC circuit through the high-gauge wire. The high-gauge wire is configured to melt under a load of the DC current and interrupt the high-power DC circuit.

Abstract: A drug combination containing a TLR7 agonist. Specifically, a drug combination jointly using the compound of formula I acting as a TLR7 agonist and entecavir for the treatment of hepatitis B virus infection and a use thereof, the drug combination having a good anti-hepatitis B virus infection effect.

Abstract: A control method for controlling retraction of a boom is applied to a hydraulic system which combines retraction of the boom by self-weight with retraction of the boom by pressure. The control method includes: when the boom is retracted, controlling the self-weight retraction proportional valve to be at a maximum opening; obtaining an actual speed at which the boom is retracted; controlling a rotation speed of the pressure retraction motor to rise or an opening degree of the pressure retraction proportional valve to increase when the actual speed is less than a preset speed; and controlling the rotation speed of the pressure retraction motor to reduce or the opening degree of the pressure retraction proportional valve to decrease when the actual speed is greater than the preset speed.

Abstract: A remote switch-off mechanism and a rotary switch relates to the field of electrical technologies. A housing, an energy storage component, and a tripping component are provided. The energy storage component includes a latch, an energy storage spring, a rotating shaft, and an energy storage panel connected to the rotating shaft, an abutting portion is disposed on the energy storage panel, a first end of the energy storage spring is clamped to the housing, and a second end of the energy storage spring abuts against the abutting portion. The latch includes a hinged portion hinged to the housing, a limiting portion for limiting the second end of the energy storage spring, and a tripping portion that cooperates with the tripping component, and an elastic member is disposed between the latch and the housing, so that the tripping portion has a trend of moving toward the tripping component.

Abstract: A package assembly includes a circuit substrate, a top-emitting (TE) vertical cavity surface emitting laser (VCSEL) die having a two-dimensional (2D) matrix addressable emitter array, and a driver integrated circuit (IC) having a flip-chip interconnect configuration. The TE-VCSEL die and the driver IC are coupled together to form a die stack that is mounted to the circuit substrate, with the TE-VCSEL die arranged between the driver IC and the circuit substrate. TE-VCSEL die comprises an optical output arranged at a main surface coupled to the driver IC. The optical output is configured to output light generated by one or more emitters of the emitter array. Thus, the TE-VCSEL die is configured to emit light away from the circuit substrate.

Abstract: Disclosed are a drug delivery carrier complex targeting a central nervous system and a preparation method and an application thereof, relating to the technical field of biomedicine. The preparation method includes following steps: carrying out azide modification on carrier cells to obtain azide-modified carrier cells; modifying sulfhydryl group and cholesterol to two ends of therapeutic miRNA respectively, and then performing ligation reaction to modified therapeutic miRNA and an acryl complex to form a miRNA complex; and co-incubating the azide-modified carrier cells with the miRNA complex, and forming the drug delivery carrier complex through click chemistry reaction.

Abstract: A four-dimensional (4D) light-detection-and-ranging sensor using frequency modulated continuous wave is provided with an ultra-high velocity resolution. At a transmitting terminal, the hybrid waveform of a driving laser is used to minimize the phase noise generated by a distributed-feedback laser during wavelength scanning. The hybrid waveform is obtained by combining direct-current signal (not modulated) and alternating-current (AC) signal. The AC signal is a predistorted triangle or AC waveform for extracting location. The continuous wave (CW) extracts velocity. At a receiving terminal, a radar radio-frequency receiver is combined with an avalanche photodiode (APD) with multiple layers accumulated in series to obtain excellent responsivity and saturated current. The mixed waveform coordinated with the APD prevents Doppler shift frequency from being contaminated by low-frequency flicker noise.

Abstract: The present invention provides a bluetooth headset-based voice translation system including: a first translation bluetooth headset, a second translation bluetooth headset, an audio signal processing center and a translation module. The audio signal processing center includes a Fourier-transform module, a signal cross-correlation processing module, a judgment module and a gain module. Time-frequency signal processing and signal cross-correlation processing are respectively performed on first and second audio signals respectively collected by the first and second translation Bluetooth headsets, thereby determining a sound source position and performing gain processing on the first and second audio signals. Finally, the translation module performs recognition and translation. The present invention further provides a bluetooth headset-based voice translation method.

Abstract: Provided is a compound of formula I or II, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and the medical uses thereof in treating diseases benefiting from the capsid protein assembly inhibitor, particularly diseases caused by hepatitis B virus infection.

Abstract: A system may include a plurality of subsystems, such as an identity management system configured to store information associated with digital identities, a resource management system configured to store information associated with resources of a community, a financial system configured to manage financial transactions, an infrastructure system configured to manage a digital representation of the community, a transportation system configured to manage a plurality of transportation devices of the community, an education system configured to manage the education of the community, a security system configured to secure information of the plurality of subsystems, an energy system configured to manage an electrical transmission system and an electrical generation system of the community, and a central hub system configured to manage other subsystems.

Abstract: An optical device may include a substrate including a conductive core, a first layer stack on a first surface of the conductive core, a conductor-filled trench extending through the first layer stack to the conductive core such that the conductor-filled trench is on the first surface of the conductive core, and a second layer stack on a second surface of the conductive core. The optical device may include a vertical-cavity surface-emitting laser (VCSEL) chip above the conductor-filled trench. The VCSEL chip may include an array of VCSELs. A size of the conductor-filled trench may match a size of the VCSEL chip, match a size of an emission region of the array of VCSELs, or be greater than the size of the emission region of the array of VCSELs and less than the size of the VCSEL chip.

Abstract: A micro-flow throttling device, comprising: a casing used for assembling; a throttling structure mounted inside the casing to form resistance to control a fluid flow, wherein the throttling structure comprises a first axial hole formed inside a fine threaded rod, a first radial hole is formed on one side of the first axial hole, a fine thread flow channel is mounted on one side of the first radial hole, and a second cavity is formed between the fine thread flow channel and a coarse thread flow channel; a regulating structure mounted on the casing and used for regulating the flow rate of the fluid; and a butt-joint structure mounted on the inner wall of the casing and used for performing disassembly and assembly limiting on the throttling structure.

Abstract: The present invention provides a model for high-throughput screening of endocrine disruptors and a method for screening the same. In the present invention, primary structural alerts, secondary structural alerts and tertiary structural alerts of compounds are extracted according to a nuclear receptor, and then the primary structural alerts, the secondary structural alerts and the tertiary structural alerts form a nuclear receptor high-throughput screening model; hierarchical structural alert matching is carried out on target compounds through the nuclear receptor high-throughput screening model, and ligand-receptor binding mode analysis and semi-quantitative prediction of binding activity and disrupting activity are performed.

Abstract: Photonics has become a dominant or evolving technological solution for communications to meet the increasing demand for bandwidth. Accordingly, photonic communications is moving towards coherent modulation formats to further increase capacity by encoding information in both phase and amplitude of the optical signal. Whilst coherent optical transmitters and coherent optical receivers are more complex than their on-off counterparts leveraging monolithic photonic elements and photonic integrated circuits employing said photonic elements offers a lower cost route for coherent optical components. Further, external modulation, using phase modulators or amplitude modulators or a combination thereof, can increase modulation bandwidth relative to directly modulated lasers for increased data transmission. Novel optical hybrid circuits and external modulators are present which are compatible photonic integrated circuit manufacturing techniques and monolithic integration.

Abstract: The present disclosure relates to a compound containing cycloalkyl or haloalkyl, and specifically discloses a compound represented by formula I?, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and a use thereof in treating tumors.

Abstract: A sulfoximine-containing ATR inhibitor compound as represented by formula (I), a preparation method therefor, a pharmaceutical composition containing same, and the use thereof in the treatment of ATR-related or ATR-mediated diseases and/or conditions.