Abstract: Disclosed are monoclonal antibodies, antigen binding fragments, and bi-specific antibodies that specifically bind a coronavirus spike protein, such as SARS-CoV-2. Also disclosed is the use of these antibodies for inhibiting a coronavirus infection, such as a SARS-CoV-2 infection. In addition, disclosed are methods for detecting a coronavirus, such as SARS-CoV-2, in a biological sample, using the disclosed antibodies.

Abstract: The embodiments of the disclosure provide an intelligent glass and an intelligent window system, and relates to the technical field of window display. The intelligent glass of the disclosure includes a touch display assembly and a glass assembly. The touch display assembly is communicatively coupled to the glass assembly, and is configured to send a corresponding dimming instruction to the glass assembly based on a received touch instruction, such that the glass assembly adjusts its light transmittance based on the dimming instruction.

Abstract: The present disclosure relates to a liquid flow charging device for a flow cell and a flow cell comprising the liquid flow charging device. The liquid flow charging device comprises a first electrode and a second electrode. The first electrode is electrically connected to a liquid flow flowing through a flow channel assembly of the flow cell. The second electrode is located at a predetermined position on a radially outer side of the liquid flow and has a cylindrical inner peripheral surface surrounding the liquid flow. The liquid flow charging device has improved charging efficiency, stable charging performance, and enhanced safety.

Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural and/or functional features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.

Abstract: The invention relates to a cuvette assembly for a sample processor, a flow cell for a sample processor comprising the cuvette assembly, and a sample processor comprising the cuvette assembly or the flow cell. The cuvette assembly comprises a cuvette body and a reflector. The cuvette body is in the shape of a rectangular parallelepiped and comprises a sample detection channel vertically penetrating the cuvette body. The cuvette body has long sides and short sides in a horizontal section. The reflector has a flat surface attached to a first side surface extending along one of the long sides of the cuvette body and a spherical surface that is opposite to the flat surface and has a truncated lower half. The reflector is positioned so that it is flush with a lower surface of the cuvette body and a center of sphere of the spherical surface falls into the sample detection channel, and the reflector extends along the long side and exceeds the short side.

Abstract: A temperature fuse assembly for a high-power DC circuit is provided. The temperature fuse assembly includes a case extending from a first case end to a second case end and an isolated lead projecting from the second case end. A bushing electrically isolates the isolated lead from the case. A high-gauge wire is electrically connected to the case at a first wire end and electrically connected to the isolated lead at a second wire end. A portion of the high-gauge wire is helically wound about an exterior of the bushing. When a temperature of the temperature fuse assembly exceeds a threshold temperature, the temperature fuse assembly is configured to conduct a DC current of the high-power DC circuit through the high-gauge wire. The high-gauge wire is configured to melt under a load of the DC current and interrupt the high-power DC circuit.

Abstract: The present disclosure relates to a nozzle for a sample processor, a carrier of a nozzle for a sample processor, a nozzle assembly for a sample processor, and a sample processor. The nozzle includes a body and an orifice. The body is adapted to be loaded and held in the carrier. The carrier can be slidably inserted into the sample processor in a detachable manner. The orifice is provided in the body and is configured to inject a sample from an injector body in a predetermined mode. An end surface of the body is adapted to abut against an end surface of the injector body along a sample injection direction. The nozzle assembly and the sample processor according to the present disclosure include the above-described nozzle and carrier. With the aid of the carrier, it is not necessary to install the nozzle to the injector body upstream of the nozzle, so that various adjustment operations when reinstalling the nozzle can be omitted, thereby simplifying the process of reinstalling the nozzle.

Abstract: An automatic fire-extinguishing system and method for a cable tunnel. The system includes an inspection robot, a positioning robot, and guide rails fixed on an inner top of the tunnel, where the inspection robot and the positioning robot are connected to the guide rails respectively, and the positioning robot is arranged in a groove of the inspection robot and able to be moved by the inspection robot along the guide rails; and the positioning robot is able to independently enter and exit an inner space of the inspection robot along the guide rails, and the positioning robot is configured to control a built-in fire-extinguishing mechanism to extinguish fire at a position with a preset distance from a fire source. Both fire-fighting medium docking and fire extinguishing are realized; a quick access to a battery is realized and fire-extinguishing inspection efficiency of a cable tunnel is improved.

Abstract: The present application belongs to the field of pharmaceutical chemistry, and relates to a furo[3,4-b]pyrrole-containing BTK inhibitor, and in particular, to a compound of formula (I), a stereisomer or pharmacologically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and use thereof in treating BTK-related diseases.

Abstract: The present disclosure provides a deuterium-modified thienopyridone compound, a preparation method therefor, a pharmaceutical composition thereof, and a medical use thereof. The deuterium-modified thienopyridone compound is shown in formula I, and has been shown to inhibit HPK1 kinase activity, being capable of achieving an anti-tumour effect.

Abstract: A low-dropout voltage regulator is provided. The low-dropout voltage regulator includes a differential amplifier pair, a secondary amplification circuit that is self-stabilized, an output circuit, and a frequency compensation circuit. The secondary amplification circuit includes a first amplification transistor and a second amplification transistor. The first amplification transistor includes a first terminal, a second terminal, and a third terminal. The second amplification transistor includes a first terminal, a second terminal, and a third terminal. The second terminal of the first amplification transistor is electrically connected to the second terminal of the second amplification transistor to form an input terminal of the secondary amplification circuit to be connected to an output terminal of the differential amplifier pair.

Abstract: New benzodiazepine compounds, and a preparation method therefor and the use thereof are provided. Short-acting benzodiazepine derivatives have the characteristics of a fast onset, short acting time, deep strength, being quickly metabolized, fast wake-up, etc. In anesthesia experiments on mice and rats, short-acting benzodiazepine derivatives have a comparable onset time to remazolam, but have a significantly shortened acting time and wake-up time. Moreover, some of the compounds have a significantly enhanced depth of action. Thus, the compounds have the characteristics of a faster onset, shorter acting time, greater strength of action, being metabolized faster, faster wake-up, etc. In long-term infusion anesthesia experiments on rats, compared with remazolam, the short-acting benzodiazepine derivatives have a significantly shortened wake-up time and recovery time, and have the characteristics of faster wake-up, a faster recovery, etc.

Abstract: The present disclosure relates to thermal cutoff device pellet composition. Provided is a pellet composition having enhanced aging performance, electrical performance, pellet output, pellet density and pellet crush strength for use in a thermally-actuated, current cutoff device. The solid thermal pellet composition comprises an organic compound having a low vapor pressure at room temperature, such as tetraphenylsilane. The thermal pellet composition comprising tetraphenylsilane can significantly improve interruption performance, pellet output, pellet density, pellet crush strength and aging performance of the thermal cutoff device.

Abstract: In an aspect, a method of forming a coating on a busbar comprises cold spraying a powder comprising a plurality of metal particles onto the busbar at a velocity sufficiently high to cause the plurality of metal particles to deform upon contact with the busbar thereby forming the coating on the busbar; wherein the plurality of metal particles comprises greater than or equal to 50 weight percent of at least one of nickel, tin, silver, zinc, or copper based on the total weight of the metal particles; and wherein the coating has an average thickness of greater than or equal to 10 micrometers. In another aspect, a coated busbar is formed by cold spraying.

Abstract: This application provides a system and a method for accessing a remote resource. The system includes a local node and a remote node. The local node is configured to: determine a resource access request, where the resource access request includes a resource access operation and an address that is of the local node and that is pointed to by the resource access operation; determine an address of a corresponding remote node; send an operation packet to the remote node, where the operation packet includes the resource access operation and the address of the remote node; and receive an operation result packet sent by the remote node, and determine an operation result based on the operation result packet.

Abstract: An acousto-optic leakage monitoring system for main steam pipeline in nuclear power plant. The system includes an acoustic emission leakage monitoring loop and a spectrum leakage monitoring loop, wherein the signal input ends of the acoustic emission leakage monitoring loop and the signal input ends of the spectrum leakage monitoring loop are respectively arranged at detection points of the main steam pipeline. The signal output ends of the acoustic emission leakage monitoring loop and the signal output ends of the spectrum leakage monitoring loop are communicatively connected to each other through a network switch, and the network switch is sequentially connected with a control unit and a display unit.

Abstract: An optical package may include a fan-out-wafer-level-packaging (FOWLP) sub-package including a redistribution layer (RDL) on a molded component including an electrical chip. The optical package may include an optical chip over the FOWLP sub-package. The optical chip may be electrically connected to the RDL. An area of a surface of the RDL may be larger than an area of a surface of the optical chip. The optical package may include a package housing over the optical chip such that light to be received or transmitted by the optical chip may is to pass through the package housing.

Abstract: Provided is a compound as an Akt kinase inhibitor. The present invention specifically relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and the use thereof in the preparation of a drug for treating Akt kinase-related diseases.

Abstract: In some implementations, a substrate comprises a ceramic core, multiple metal-filled vias through the ceramic core, and a first metal layer, on a top side of the ceramic core, including metal traces, over respective metal-filled vias. The substrate comprises a second metal layer, including a first electrical contact over a first metal trace, a second electrical contact over a second metal trace, and a third electrical contact over a third metal trace, where the second metal trace is electrically isolated from the first and third metal traces. The substrate comprises a thin dielectric layer separating the first metal layer and the second metal layer. The dielectric layer between the first metal layer and the second layer provides the substrate with a low parasitic inductance and a low thermal resistance based on a thickness of the dielectric layer and/or a material used for the dielectric layer.

Abstract: A cascaded avalanche photodiode (APD) is provided with high responsivity and high saturation current. Single multiplication layer (M-layer) is inserted with multiple field control layers to be cut into several M-layers in different regions. Thus, with the breakdown voltage decreased, the critical field lowered, the saturation power enhanced, and the gain increased, avalanche breakdown effect is achieved.