Abstract: The present application belongs to the field of pharmaceutical chemistry, and relates to a furo[3,4-b]pyrrole-containing BTK inhibitor, and in particular, to a compound of formula (I), a stereisomer or pharmacologically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and use thereof in treating BTK-related diseases.

Abstract: A method for manufacturing a busbar (1), in particular a laminated busbar (1), configured for mounting an electronic component, in particular a passive electronic component such as a capacitor, on the busbar (1), comprising: providing a first conductive layer (11) made from aluminum, providing a first connector element (15) for connecting the first conductive layer (11) and the electronic component, wherein the first connector element (15) is at least partially covered with nickel and/or tin, and creating an bond between the first conductive layer (11) and the first connector element (15) by laser welding.

Abstract: Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.

Abstract: Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2.

Abstract: A crane extension and installation device includes an extension device, a winch, a pulley and a cable. A main arm includes a vertical slide rail, the main arm is inclined relative to vertical, and three second pulleys at different heights of the slide rail are installed in the vertical direction of the slide rail, and the second pulley can slide vertically along the slide rail and can be fixed at a certain position of the slide rail. The extension device includes a number of cantilever beams connected end to end. The front end of the extension device is a cantilever beam, and a fixed pulley is installed on the lower peripheral surface of the extension device. The end face of the cantilever beam is equipped with a vertical lower arm through a joint, and the bottom end of the lower arm has a first pulley fixed by the joint.

Abstract: The wind-wave complementary energy integrated system based on fixed foundation and generation and transmission method thereof pertains to the field of ocean renewable energy utilization, solving the problem of combining the wind and wave energy in a support structure, including a wind turbine, a tower, a wave energy device and a single pile foundation, the wind turbine is connected to the tower, and the single pile foundation is at the bottom of the tower, the single pile foundation is connected to the seabed, and the wave energy device is mounted on the tower near the sea surface. The effect is the renewable energy utilization rate and the energy conversion rate are effectively improved, thus reducing the cost to a certain extent and having high utility.

Abstract: An acousto-optic leakage monitoring system for main steam pipeline in nuclear power plant. The system includes an acoustic emission leakage monitoring loop and a spectrum leakage monitoring loop, wherein the signal input ends of the acoustic emission leakage monitoring loop and the signal input ends of the spectrum leakage monitoring loop are respectively arranged at detection points of the main steam pipeline. The signal output ends of the acoustic emission leakage monitoring loop and the signal output ends of the spectrum leakage monitoring loop are communicatively connected to each other through a network switch, and the network switch is sequentially connected with a control unit and a display unit.

Abstract: An array of surface-emitting lasers is provided. The array outputs high brightness in a unipolar way. The array comprises a stress-adjustment unit and a plurality of epitaxial device units. The stress-adjustment unit is used to adjust stress. The stress from a substrate is used to select a laser mode for an aperture unit. The selection of the laser mode is enhanced for the aperture unit without sacrificing driving current. Low current operation is achieved in a single mode for effectively reducing volume and further minimizing the size of the whole array to achieve high-quality laser output. An object can be scanned by the outputted laser to obtain a clear image with a high resolution. Hence, the present invention is applicable for face recognition with high recognition and high security.

Abstract: Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2.

Abstract: An active tuned mass damper applied to the offshore monopile wind turbine belongs to the field of marine technology. A mass block is connected to the inner wall of the tower through a spring. The two ends of the damper and the force actuator are connected to the mass block and the inner wall of the tower, respectively. When the installation of tower is finished, the spring and the damper begin to work. The movement of mass block will partly offset the movement of the tower caused by the wave force. The force actuator starts to work before the mating. The exact position of the nacelle can be obtained from the Global Positioning System (DGPS). The position of tower can be adjusted in the horizontal plane through the force actuator. So, the offshore installation time for nacelle will be saved. The whole installation time and cost will also be reduced.

Abstract: A single-photon detector is provided. The detector has multiple avalanche layers. It has an avalanche photodiode (APD) structure using single photon. The APD is made of indium aluminum arsenide (InAlAs). At least two avalanche layers are designed. When the layer for avalanche is numbered only one and the gain is very big, the speed will be deteriorated very quickly. With the design of two avalanche layers in the present invention for the very big gain, the speed deterioration can be suppressed. After measuring, the present invention shows a faster speed as compared to prior arts. It proves that, by using more than two avalanche layers, the present invention effectively improves the feature of single-photon detector. Hence, the present invention is especially suitable for single-photon detection.

Abstract: An efficient wide bandgap GaN-based LED chip based on a surface plasmon effect and a manufacturing method therefor. The efficient wide bandgap GaN-based LED chip is of a flip-chip structure, and comprises, from bottom to top in sequence, a substrate, a buffer layer, an unintentionally doped GaN layer, an n-GaN layer, a quantum well layer, an electron blocking layer, a p-GaN layer, a metallic reflecting mirror layer, a passivation layer, a p-electrode layer, an n-electrode layer; and a position of a bottom surface of the metallic reflecting mirror layer connected to a surface of the p-GaN layer is provided with a micro-nano composite metal structure. A micro metal structure comprises alternating protrusion portions and recess portions; and a nano metal structure is distributed on an interface of the micro metal structure and the p-GaN layer.

Abstract: A method for inhibiting the formation, deposition and adherence of scale to metallic and other surfaces in the equipment, vessels and/or piping of facilities for the handling of oil and gas produced fluid is disclosed. An effective scale inhibiting amount of alginate is added to a produced fluid containing a scale-forming divalent cation. The alginate effectively cross-links with a scale-forming divalent cation, e.g., calcium, forming an alginate gel for subsequent separation and removal from the produced fluid.

Abstract: Methods and a system are provided. A method includes automatically detecting, by an attribute structural variation detector, attribute structural variations in record schemas of a database lacking schema enforcement. The automatically detecting step includes encoding, by an encoder, nodes in the record schemas based on respective updated node labels to obtain a plurality of codes. The encoding step comprises, for each of the plurality of codes: recording, by a label frequency counter, a frequency f1 of the record schemas that include a given label; and recording, by a label frequency counter, a frequency fc of the record schemas that use a given one of the plurality of codes to update a label of a next level. An attribute variation is detected and retrieved responsive to the frequency fc?0, and the frequency f1>(two times the frequency fc).

Abstract: Disclosed are a flexible circuit board component and a display device. The flexible circuit board component includes a flexible circuit board and a foam structure. The flexible circuit board includes a first area and a second area which are arranged in a first direction and connected to each other. The foam structure is located on a side of the first area in the flexible circuit board, and includes a first foam and a second foam, and in the first direction, the second foam is located between the first foam and the second area. After the flexible circuit board component is affixed to a non-light-emitting display side of a display panel, in a direction perpendicular to an interface of the foam structure and the flexible circuit board, a height of the second foam on a side adjacent to the second area is less than a height of the first foam.

Abstract: An avalanche photodiode (APD) is provided with a mixed composite charge layer. A novel structure of InAlAs is designed with the mixed layer. A single P-type field control layer is divided into three layers of different materials with each two forming a heterojunction structure. By controlling the relative concentration distributions and thicknesses of the first, second, and third P-type field control layers along with a mesa shape formed through chemical selective etching, a part of the second P-type field control layer is exposed to the air with a part of the first one etched out at the same time through this single structure having the mesa shape. Thus, the field of a multiplication layer is further confined at center to concentrate electric-field so that fringe field is low but not collapsed. Hence, the overall speed is increased, the intensity high, and sensitivity good while response is fast and efficiency high.

Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.

Abstract: A resource sharing method is performed at a mobile terminal, the method including the following steps: obtaining configured user identifier; obtaining multimedia data; obtaining a resource sharing request, and associating the user identifier with the multimedia data according to the resource sharing request; generating a resource sharing instruction according to an association relationship between the user identifier and the multimedia data; and executing the resource sharing instruction.

Abstract: A semiconductor structure and a method for forming same are provided.

Abstract: Technical solutions are described to implement a scalable write ahead log using a distributed file system. A general aspect includes a method for providing consistency among metadata replicas and content in an enterprise content management cluster. The method includes recording a transaction log entry in response to receiving a content modification request, the transaction log entry including a version identifier set to a first version value. The method also includes updating the transaction log entry to a second version value in response to successfully modifying content and one of a plurality of metadata replicas containing metadata corresponding to the request. The method also includes updating the transaction log entry to a third version value in response to successfully modifying each of the metadata replicas. The present document further describes examples of other aspects such as methods, computer products.