Abstract: Provided is a site-specific PEG-modified interleukin 2 (IL-2) mutant. Compared with a parent IL-2, the mutant has an improved preference for a Treg cell and a prolonged half-life period. Also provided are a composition comprising the IL-2 mutant, a nucleic acid encoding the IL-2 mutant, a vector comprising the nucleic acid, and a host cell. Further provided are the IL-2 mutant and therapeutic use of a pharmaceutical composition comprising same.

Abstract: A wide-area monitoring system for wide-band oscillation and a method for locating a source of wide-band oscillation are provided. The system includes: a plurality of signal sensing modules configured to acquire electrical signals of measured points; a plurality of wide-band measurement devices configured to perform spectrum analysis based on the electrical signals and generate oscillation alarm information based on spectrum analysis results, and to start wave recording in response to wave recording instructions, to generate wave recording files for a same time section, and upload the wave recording files and spectrum analysis results; a wide-band measurement master station configured to determine whether there is a wide-band oscillation risk in a power system according to the oscillation alarm information, send the wave recording instructions to all of the wide-band measurement devices when there is the wide-band oscillation risk, and locate an oscillation source based on the spectrum analysis results.

Abstract: A method, a device and a storage medium for controlling an output phase of a wide-band synchronous signal source is provided.

Abstract: Provided are a reactor charging and refueling system and a reactor charging and refueling method, which performs charging and refueling operations on a reactor pressure vessel having a cover capable of being opened downwards. The system comprises: a component of bolt operating device and pallet, a lifting device, an attitude adjusting device and a transfer device, wherein the component of bolt operating device and pallet, the lifting device, the attitude adjusting device and the transfer device are located underwater in a reactor core pool; the attitude adjusting device is arranged on top of the lifting device; the component of bolt operating device and pallet is connected to the attitude adjusting device; the lifting device is fixedly connected to the transfer device; and the transfer device can carry the lifting device, and the attitude adjusting device and the component of bolt operating device and pallet that are installed on the lifting device so as to be movable in a horizontal direction.

Abstract: An approach is provided for managing library dependencies. Requests to publish multiple libraries to a public library repository are received. The requests include specifications of respective sets of one or more dependencies of the libraries and respective validation scripts. A dependency version tree that includes the specifications of the respective sets of one or more dependencies is built. A request to upload a new version of a library to the public library repository is received. A validation component using the dependency version tree and the validation scripts validates a compatibility between the library and one or more libraries dependent upon the library.

Abstract: Enhanced distributed tracing is provided. A set of microservices in a sequence of microservices preceding a preselected microservice in the sequence of microservices are identified. Each tracing data sample received from the set of microservices preceding the preselected microservice in the sequence of microservices is identified. Each tracing data sample corresponding to a set of selected transactions received from the set of microservices preceding the preselected microservice in the sequence of microservices that was dropped during rate-limiting sampling performed by the preselected microservice is deleted based on analysis of a result of the rate-limiting sampling of the set of selected transactions received from the preselected microservice thereby retaining a subset of tracing data samples corresponding to the set of selected transactions collected during head-based sampling.

Abstract: A gas turbine engine, comprising a fan section, compressor section, combustor section, and turbine section in serial flow arrangement, at least one of the fan section, the compressor section, or the turbine section comprising: a rotor comprising a plurality of blades and rotatable about a rotational axis; and a casing assembly disposed at least partially around the rotor, the casing assembly comprising: a forward casing section; an aft casing section; an outer ring coupled to the forward casing section and the aft casing section, the outer ring coupled to the forward casing section at a joint; and an inner containment ring radially inward of the outer ring, and at least partially axially aligned with the plurality of blades.

Abstract: A light-emitting panel includes a substrate including a first surface and a second surface opposite to each other, light-emitting elements disposed on the first surface, driver chips, at least one of the driver chips disposed on the second surface, and first connection vias penetrating through the substrate. At least one of the driver chips is electrically connected to a respective one of the light-emitting elements through a respective one of the first connection vias. In the technical solutions, at least part of the driver chips are disposed on the second surface of the substrate, that is, at least part of the driver chips are disposed on a different substrate surface from the light-emitting elements. Thus, the driver chips are effectively prevented from interfering with the light-emitting effect of the light-emitting elements, and more space can be provided for disposing light-emitting elements, thereby ensuring the light-emitting effect of the light-emitting panel.

Abstract: A method includes sintering a lithium-rich metal oxide (LRMO) material at a sintering temperature to form a sintered LRMO material and quenching the sintered LRMO material from the sintering temperature to room temperature in less than 500 milliseconds to form a quenched LRMO material represented by a chemical formula Lix(MnyNi1-y)2-xO2, where x is greater than 1.05 and less than 1.25, and y ranges from 0.95 to 0.1.

Abstract: The disclosed computer-implemented method may include detecting, by a computing device, a login attempt from a client device to an online service. The method may include determining, based on a unique identifier of the client device, that the client device is associated with the online service. Additionally, the method may include determining that an attribute of the client device is associated with a primary location of a user account of the online service. The method may also include performing a security action for the login attempt based on the association with the user account. Furthermore, the method may include eliminating a requirement of one or more user credentials of the user account for the login attempt based on the security action. Finally, the method may include completing the login attempt to the online service for the client device. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A semiconductor device and a lead frame. The semiconductor device comprises at least one semiconductor chip that is attached to a surface of a base island in a first plane, wherein a connecting rib is connected to the base island, and has a first part which is obliquely connected to the base island; the connecting rib has a second part, and the second part has a surface in a second plane; the second plane is parallel to the first plane and is a plane different from the first plane; the connecting rib has a branch part divided from the second part and the branch part has, in the second plane, a surface used for receiving a lead connected to the semiconductor chip; and the branch part has an edge which is distant from a first edge of the base island by a first distance.

Abstract: A turbine engine for an aircraft includes an integral frame. The integral frame includes an inner hub, a frame case having an outer band portion and a containment portion integrally formed with the outer band portion, and a plurality of struts connecting the inner hub with the outer band portion. The outer band is opposite the inner hub to form an air flow path therebetween, and the containment portion extends in an axial direction of the turbine engine away from the outer band. The containment portion is positioned radially outward of a plurality of rotating airfoils and extends axially over the plurality of rotating airfoils. The outer band portion and the containment portion of the frame case can be an integral composite having a plurality of reinforcing fibers embedded in a matrix or an integral metallic part.

Abstract: Provided are an array substrate, a display substrate and a display device. The array substrate includes: a substrate, a driving circuit layer on a side of the substrate and including: gate driving circuits in a first frame region extending in a first direction, a first signal line and a second signal line extending in the first direction, and a third signal line extending in a second direction. The first signal line is on a side of the second signal line away from a driving region. The gate driving circuits include a dummy gate driving circuit and a starting row gate driving circuit; an end of the first signal line is electrically connected to the third signal line, the other end is electrically connected to a driving chip. The third signal line is electrically connected to the dummy gate driving circuit and the starting row gate driving circuit.

Abstract: The present invention provides an adaptive flame-retardant cooling interface comprising a thermal conductive film, a porous membrane, an array of evaporative pads accommodated compartments of a supporting frame positioned between the thermal conductive film and the porous membrane. The adaptive flame-retardant cooling interface is operable at a cooling state and a restoration state. At the cooling state, the thermal conductive film is configurable to transfer heat from a heat source to the array of evaporative pads to increase water vapor pressure in the evaporation pads, and the array of evaporative pads is configurable to desorb water vapor out to ambient environment through the porous membrane. When the adaptive flame-retardant cooling interface is attached to a cooler object, the array of evaporative pads is configurable to adsorb water vapor from ambient environment through the porous membrane such that a cooling capacity of the adaptive flame-retardant cooling interface is restored.

Abstract: A gene regulating chlorophyll degradation and coloration in okra and its applications, in the field of fruit and vegetable preservation. Through transcriptome data analysis of okra with gibberellic acid (GA) treatment, an ERF (Ethylene Response Factors) transcription factor, AeABR1 was identified. Subsequently, by constructing transiently expressed okra and transgenic Arabidopsis thaliana lines, it was confirmed that the AeABR1 gene positively regulates chlorophyll degradation in okra. Real-time quantitative fluorescence PCR (RT-qPCR) and dual luciferase assays demonstrated that AeABR1 protein reduces chlorophyll content of okra by down-regulating the expression of chlorophyll degradation gene AeCLH1, thereby participating in post-harvest color regulation. This provides preliminary insights into the molecular mechanism of AeABR1, offering a novel target gene and theoretical foundation for post-harvest preservation of okra.

Abstract: The disclosure is related to methods of cancer early detection. In some embodiments, a panel of selected protein tumor markers are used for effective and affordable multi-cancer early detection.

Abstract: A computer-implemented process is disclosed. An application is loaded into a local address space. A request by the application to load a target shared library is intercepted by an interceptor. Using the interceptor and based upon the request being intercepted, a shared library correlation table is searched for a loading count and a loading policy associated with the target shared library. Based upon the loading count and the loading policy, a selection is made between loading the target shared library as a shared library container, and loading the target shared library into the local address space. The target shared library is loaded based upon the selecting. The loading count represents a number of times the target shared library was loaded, and the loading policy indicates how the target shared library is to be loaded.

Abstract: A method for configuring reactive power capacity of a power grid to which offshore wind power is connected on a large scale includes the following steps. Static voltage stability index of substations in a regional power grid to which the offshore wind power is connected on the large scale and at multiple points and relative dynamic voltage drop area index for an N-2 fault are calculated. Thus, weak nodes in voltage stability are located, thereby implementing a prediction of a risk to the voltage stability of the regional power grid. These nodes are used as candidate reactive power compensation configuration nodes. An objective function is established as the minimum total cost of reactive power compensation devices at the candidate reactive power compensation configuration nodes. A multi-type reactive power optimization configuration model including static voltage stability constraints, voltage stability constraints under faulty state, and other constraints is solved.

Abstract: The invention discloses a method, system, and computer program product for service update management. The method, during a first update procedure for a first service in a computing system, in response to a detection that the first update procedure fails, a state of a second service on which the first service depends in the computing system is checked. In response to the second service being in a first state, the first update procedure is suspended. Resources allocated to the first update procedure by the computing system are released. The released resources are allocated to the second update procedure of the second service. The second update procedure is implemented based on the allocated released resources. With these embodiments, failures during the update procedures for the services may be automatically detected and removed based on a dependency relationship between the services. Therefore, the performance of the update procedures may be increased.

Abstract: Examples of circuits, multiplier-adders, and circuit optimization methods are described. One example circuit includes a digital addition circuit and an analog addition circuit. The digital addition circuit is configured to perform bitwise digital accumulation on bits that belong to a first bit position range and that are in a plurality of groups of partial products. The plurality of groups of partial products are obtained by multiplying a plurality of first values by a plurality of second values. The first bit position range refers to S bit positions of a product value of one of the first values and one of the second values. S is a positive integer. The product value is obtained by performing bitwise accumulation after a group of partial products are shifted.