Abstract: In an embodiment, a device includes: a first fin extending from a substrate; a gate stack disposed on the first fin; a source/drain region disposed in the first fin; a contact etch stop layer (CESL) disposed over the source/drain region; a gate spacer extending along a side of the gate stack; and a dielectric plug disposed between the CESL and the gate spacer, where the dielectric plug, the CESL, the gate spacer, and the source/drain region collectively define a void physically separating the gate stack from the source/drain region.

Abstract: In an embodiment, a device includes: a first fin extending from a substrate; a gate stack disposed on the first fin; a source/drain region disposed in the first fin; a contact etch stop layer (CESL) disposed over the source/drain region; a gate spacer extending along a side of the gate stack; and a dielectric plug disposed between the CESL and the gate spacer, where the dielectric plug, the CESL, the gate spacer, and the source/drain region collectively define a void physically separating the gate stack from the source/drain region.

Abstract: Provided are small molecule inhibitors of the KRAS(G12D) mutant oncoprotein having the structural formula: R00F2C—L—R0 and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: A calibration method for fringe projection systems based on plane mirrors. Firstly, two mirrors are placed behind the tested object. Through the reflection of mirrors, the camera can image the measured object from the front and other two perspectives, so as to obtain 360-degree two-dimensional information of the measured object. The projector projects three sets of phase-shifting fringe patterns with frequencies of 1, 8, and 64. The camera captures the fringe image to obtain an absolute phase map with a frequency of 64 by using the phase-shifting method and the temporal phase unwrapping algorithm. By using the calibration parameters between the projector and the camera, the absolute phase map can be converted into three-dimensional information of the measured object. Then, the mirror calibration is realized by capturing a set of 3D feature point pairs, so that the 3D information from different perspectives is transformed into a unified world coordinate system.

Abstract: The present application provides a compound of Formula (I): A-L-B (I), or a pharmaceutically acceptable salt thereof, wherein A, L, and B are as described herein. Compositions comprising the compounds of Formula (I) (and optionally a fluorescent probe) are also provided, as well as the methods of (i) using the compound of formula (I) for identifying a misfolding-prone or an aggregating-prone protein in a sample, (ii) determining concentration of a misfolding-prone or an aggregating-prone protein in a sample, (iii) imaging an organ or tissue comprising a misfolding-prone or an aggregating-prone protein in a subject, (iv) diagnosing or monitoring treatment of a disease or condition associated with a misfolding-prone or an aggregating-prone protein in a subject, and (v) diagnosing a disease or condition characterized by accumulation of misfolding-prone or aggregation-prone peptides or proteins in a blood of a subject.

Abstract: This disclosure describes one or more implementations of a depth prediction system that generates accurate depth images from single input digital images. In one or more implementations, the depth prediction system enforces different sets of loss functions across mix-data sources to generate a multi-branch architecture depth prediction model. For instance, in one or more implementations, the depth prediction model utilizes different data sources having different granularities of ground truth depth data to robustly train a depth prediction model. Further, given the different ground truth depth data granularities from the different data sources, the depth prediction model enforces different combinations of loss functions including an image-level normalized regression loss function and/or a pair-wise normal loss among other loss functions.

Abstract: Methods of treating schizophrenia comprising administering at least one compound chosen from Compound (I): and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising at least one compound chosen from Compound (I) and pharmaceutically acceptable salts thereof are also disclosed.

Abstract: Disclosed are an ATX inhibitor, a preparation method therefor, and the use thereof, which belong to the technical field of pharmaceutical chemistry. In particular, the ATX inhibitor is a compound having the structure of formula I?, or a pharmaceutically acceptable salt, an ester, an isomer, a solvate, a prodrug or an isotope marker thereof. Compared with the existing ATX inhibitor GLPG-1690, the ATX inhibitor has higher inhibitory activity, also has excellent efficacy, in vitro/in vivo pharmacokinetic properties and safety, and has broad clinical application prospects.

Abstract: A wake-up desk lamp, comprises a main control unit which is respectively connected with and send control signals to a desk lamp control unit and a wake-up light control unit respectively; the desk lamp control unit is connected to the desk lamp drive unit, and the desk lamp control unit control the desk lamp drive unit according to the control signal to drive a desk lamp emitting module to turn on and off; the wake-up light control unit is connected to the wake-up light drive unit, the wake-up light control unit control the wake-up light drive unit according to the control signal to drive a wake-up light emitting module to turn on and off. The lamp has both lighting function and wake-up function, which saves the area occupied by the lamp and the power consumption, and the user purchases one product to have the effect of two products.

Abstract: The present disclosure includes a system, method, and article of manufacture for generating an entity graph. The method may comprise determining a relationship between a first entity and a second entity based upon internal data, external data, and/or online data associated with the first entity, and generating the entity graph comprising at least two nodes and an edge connecting the at least two nodes. The method may further comprise, in various embodiments, tailoring marketing to the first entity based upon the entity graph, detecting fraud against the first entity based upon the entity graph, periodically updating the entity graph based upon new internal data and new online data, and/or adjusting the edge based upon a change in the relationship between the first entity and the second entity.

Abstract: A magnetic field measuring method includes: applying a magnetic field to a first particle and a second particle; generating a first output light by the first particle according to the magnetic field and a first coupling strength between the first particle and the second particle; and calculating a strength of the magnetic field according to a strength of the first output light. A magnetic field measuring system and a magnetic field measuring apparatus are also disclosed herein.

Abstract: Embodiments of the disclosed technology provide an apparatus for controlling a standing wave linear accelerator. An example standing wave linear accelerator includes an accelerating tube, a motor, and a microwave power source connected between the accelerating tube and the motor. An example apparatus includes a main processor configured to receive an envelope signal of a reflected wave signal output by the accelerating tube, determine whether an amplitude of the envelope signal is greater than an envelope threshold, and if it is determined that the amplitude of the envelope signal is less than the envelope threshold, determine whether to change a rotation direction of the motor by comparing the amplitude of the envelope signal with an envelope reference signal stored in a memory. The memory is connected to the main processor and is configured to store the envelope threshold and the envelope reference signal.

Abstract: The present invention generally relates to an isoxazole derivative, a preparation therefor, and a use thereof. In particular, the present invention provides a farnesoid X receptor (FXR) agonist compound, and a stereoisomer, a tautomer, a polymorph, a solvate (e.g., a hydrate), a pharmaceutically acceptable salt, an ester, a metabolite, and an N-oxide, and the chemically protected forms and prodrugs thereof. The present invention further provides a preparation method for the compound, an intermediate thereof, and a pharmaceutical composition and kit containing the same and used thereof for treating FXR-mediated diseases or conditions.

Abstract: Provided are applications of a hexokinase 2-specific inhibitor in preparing a medicament for preventing and treating acute central nervous system injury.

Abstract: An adaptive measurement and calculation method for luminescence values of a chemiluminescence analyzer is provided. A fixed step length is adopted for continuous multi-point reading to obtain a complete correspondence diagram of detection positions and luminescence values. Two nearest luminescence values on the left and right sides of a maximum value are selected, the nearest luminescence values on both sides are connected to form a straight line, and an intersection of two straight lines is taken as an approximate maximum luminescence value. The measurement and calculation method can adapt to random positions of the detected object, and stably obtain the approximate maximum luminescence value, thus reducing increased complex hardware design and cost to confirm accuracy of the measurement position.

Abstract: The invention discloses a single-frame fringe pattern analysis method based on multi-scale generative adversarial network. A multi-scale generative adversarial neural network model is constructed and a comprehensive loss function is applied. Next, training data are collected to train the multi-scale generative adversarial network. During the prediction, a fringe pattern is fed into the trained multi-scale network where the generator outputs the sine term, cosine term, and the modulation image of the input pattern. Finally, the arctangent function is applied to compute the phase. When the network is trained, the parameters of the network do not need to manually tune during the calculation. Since the input of the neural network is only a single fringe pattern, the invention provides an efficient and high-precision phase calculation method for moving objects.

Abstract: The present disclosure provides the synthesis and application of respiratory syncytial virus inhibitor, being a compound of formula I or a pharmaceutically acceptable salt, ester, isomer, solvate, prodrug or isotope label thereof. Compared with the existing inhibitors, the compounds of formula I have the advantages of superior activity and higher exposure in vivo.

Abstract: Provided are applications of a hexokinase 2-specific inhibitor in preparing a medicament for preventing and treating acute central nervous system injury.

Abstract: Provided are a load transfer method and system in thunder and lightning weather. The method includes: detecting lightning and predicting a position and time of a lightning strike to obtain a lightning prediction result; determining a transmission line possibly struck by lightning in a power grid according to the lightning prediction result; determining a load transfer scheme; and before the lightning occurs, transferring at least part of loads on the transmission line possibly struck by lightning according to the load transfer scheme.

Abstract: The present disclosure provides circulation system and method for detecting immune adherence of porcine erythrocytes. The system includes: a flow chamber, a gasket, a mobile-phase liquid storage bottle, a peristaltic pump, silicone hoses, and a cell culture dish provided with a glass slide, where the gasket is placed on an edge of the glass slide, and the flow chamber is covered on the gasket; the flow chamber, the mobile-phase liquid storage bottle, and the peristaltic pump are connected in sequence with the silicone hoses to form the circulation system; and a porcine erythrocyte suspension of immune adherence-sensitized GFP-E. coli is injected into the mobile-phase liquid storage bottle. In the present disclosure, the circulation system and method for detecting immune adherence of porcine erythrocytes can be used for detection and analysis of working parameters such as a mobile phase flow velocity, a shear force, and a maximum retention time.