Patents by Inventor William R. Wagner

William R. Wagner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11298452
    Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.
    Type: Grant
    Filed: September 22, 2018
    Date of Patent: April 12, 2022
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner, Sang-Ho Ye
  • Publication number: 20220049098
    Abstract: A zwitterionic polysiloxane polymer (e.g., a polyurethane elastomer) composition having poly(dialkylsiloxane) blocks and a zwitterionic moiety is prepared by the copolymerization of a poly(dialkylsiloxane) diol, a diisocyanate, a tertiary amine alkyl diol, and a poly(dialkylsiloxane) diamine to form a poly(urethane urea) copolymer. A substituted saturated heterocylic compound is reacted with the tertiary amine of the poly(urethane urea) copolymer to introduce a zwitterionic group into the poly(urethane urea) copolymer backbone. A polysiloxane polymer having a zwitterionic moiety is prepared by reacting a diallyl tertiary amine compound and a substituted saturated heterocylic compound to form a diallyl zwitterionic macromer and cross-linking a vinyl terminated poly(dialkylsiloxane) and the diallyl zwitterionic macromer with a curing agent to introduce a zwitterionic group into the poly(dialkylsiloxane) polymer.
    Type: Application
    Filed: August 10, 2021
    Publication date: February 17, 2022
    Inventors: William R. Wagner, Sang Ho Ye, Seungil Kim, Sung Kwon Cho
  • Publication number: 20220039946
    Abstract: A method of making a valve structure includes a step of rotating a mandrel and an electrodeposition target attached to the mandrel about a rotational axis of the mandrel. The target includes an exterior surface having at least one conductive surface portion and at least one non-conductive surface portion. The method also includes a step of electrodepositing a polymer matrix of a biodegradable, biocompatible polymer composition onto the at least one conductive surface portion and the at least one non-conductive surface portion of the exterior surface of the rotating electrodeposition target to form the valve structure.
    Type: Application
    Filed: August 16, 2021
    Publication date: February 10, 2022
    Inventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, William R. Wagner
  • Publication number: 20210361826
    Abstract: Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodible in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.
    Type: Application
    Filed: August 5, 2021
    Publication date: November 25, 2021
    Inventors: Hongbin Jiang, William R. Wagner, Tomo Yoshizumi, Yang Zhu
  • Patent number: 11129711
    Abstract: Provided herein is a mandrel for use in electrospinning prosthetic valve devices. Also provided are prosthetic valve devices for implantation in an animal or a human. Methods of making and using the valve devices are also provided herein.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: September 28, 2021
    Inventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, William R. Wagner
  • Patent number: 11123454
    Abstract: Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: September 21, 2021
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Hongbin Jiang, William R. Wagner, Tomo Yoshizumi, Yang Zhu
  • Publication number: 20210236700
    Abstract: The present invention relates to substrates and composites having dynamic, reversible micron-level luminal surface deformation including texture or geometric instabilities, e.g., surface wrinkling and folding. The surface deformation and its reversal to the original surface form or to another, different surface form, is effective to reduce or prevent surface fouling and, more particularly, in certain applications, to reduce or prevent unwanted platelet adhesion and thrombus formation. The substrates and composites include a wide variety of designs and, more particularly, biomedical-related designs, such as, synthetic vascular graft or patch designs.
    Type: Application
    Filed: October 18, 2017
    Publication date: August 5, 2021
    Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UPMC, UNIVERSIDAD DE SANTIAGO DE CHILE
    Inventors: WILLIAM R. WAGNER, SACHIN SHANKAR VELANKAR, SANG HO YE, EDITH TZENG, LUKA POCIVAVSEK, ENRIQUE CERDA
  • Publication number: 20210236688
    Abstract: Provided herein is a prosthetic heart valve device including a biocompatible and biodegradable metal frame comprising a proximal end, a distal end, and a sidewall therebetween, the sidewall having a plurality of openings therethrough. The device further includes a biocompatible and biodegradable polymeric heart valve having an annular portion attached at least one contact point to the proximal end of the frame and at least one leaflet attached to and extending distally from the annular portion.
    Type: Application
    Filed: April 25, 2019
    Publication date: August 5, 2021
    Inventors: William R. Wagner, Antonio D'Amore, Vesselin N. Shanov
  • Patent number: 11045218
    Abstract: Disclosed herein are devices and methods for accessing the interior of the heart through a wall thereof. The device includes a main body, a flange at an end thereof, and a passage therethrough to allow for access to the interior of the heart when the device is placed on an outer surface thereof. The device can be formed of any suitable biocompatible and/or biodegradable material, and can have a passage sized to allow for transmittance of tools/devices normally used for interventions in the interior of the heart therethrough.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: June 29, 2021
    Assignees: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Vinay Badhwar, Antonio D'Amore, William R. Wagner
  • Publication number: 20210187158
    Abstract: The invention relates to biomimetic, biodegradable composites including a magnesium (Mg) alloy mesh and a polymer/extracellular matrix (ECM). These hybrid composites, more particularly, are useful for the fabrication of medical implant devices, e.g., scaffolds, and are effective for bone regeneration. The fabrication process includes creating the Mg alloy mesh, and concurrently electrospinning the polymer and electrospraying the ECM onto the mesh.
    Type: Application
    Filed: April 4, 2018
    Publication date: June 24, 2021
    Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UNIVERSITY OF CINCINNATI
    Inventors: WILLIAM R. WAGNER, SANG-HO YE, YINGQI CHEN
  • Publication number: 20210085834
    Abstract: A multi-layer device is provided that is useful in tissue regeneration, for example, for vascular regeneration, e.g., for use in treatment of a coronary vascular disease, such as for treatment of myocardial infarction. A method of making the device also is provided.
    Type: Application
    Filed: July 26, 2018
    Publication date: March 25, 2021
    Inventors: Antonio D'Amore, Matteo Solazzo, William R. Wagner
  • Patent number: 10940239
    Abstract: Provided herein is a method of making an aligned ECM scaffold useful in refractive correction of the eye and repair of the cornea. Methods of use of the scaffold as well as a scaffold construct are provided.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: March 9, 2021
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Yiqin Du, James L. Funderburgh, William R. Wagner, Jian Wu
  • Patent number: 10888442
    Abstract: The invention relates to endovascular medical implant devices and materials of composition for forming these devices to provide improved mechanical properties and biodegradability. The devices include a combination or integration of superelastic material, biodegradable metal and, thin film nitinol and/or biodegradable polymer. A structural frame is formed of individual elongated pieces composed of biodegradable metal. These pieces are joined together by connector pieces composed of superelastic material. At least a portion of the structural frame has deposited thereon the thin film nitinol and/or biodegradable polymer. The structural frame of the device is collapsible for insertion in a delivery tube and, recoverable for deployment and placement in a vascular location of a patient body.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: January 12, 2021
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Youngjae Chun, William R. Wagner, Xinzhu Gu, Peter Drew Wearden, Tomo Yoshizumi
  • Publication number: 20200237494
    Abstract: A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
    Type: Application
    Filed: September 20, 2019
    Publication date: July 30, 2020
    Inventors: Mohammed S. El-Kurdi, William R. Wagner, David A. Vorp, John J. Stankus, Lorenzo Soletti, Jonathan McGrath, Yi Hong, J. Christopher Flaherty
  • Publication number: 20200222583
    Abstract: Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.
    Type: Application
    Filed: February 19, 2020
    Publication date: July 16, 2020
    Inventors: Hongbin Jiang, William R. Wagner, Tomo Yoshizumi, Yang Zhu
  • Publication number: 20200170791
    Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.
    Type: Application
    Filed: January 30, 2020
    Publication date: June 4, 2020
    Inventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, David S. Schwartzman, William R. Wagner
  • Patent number: 10589002
    Abstract: Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: March 17, 2020
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Hongbin Jiang, William R. Wagner, Tomo Yoshizumi, Yang Zhu
  • Patent number: 10583004
    Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: March 10, 2020
    Assignee: University of Pittsburgh — Of the Commonwealth System of Higher Education
    Inventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, David S. Schwartzman, William R. Wagner
  • Publication number: 20200054448
    Abstract: A template for a valve construct for replacement of at least one of a mitral valve and a tricuspid valve includes at least an anterior leaflet portion and at least a posterior leaflet portion, each leaflet portion having a proximal edge, a distal edge, and side edges extending between the proximal edge and the distal edge. The template further includes a plurality of substantially straight elongated chordae portions each having a proximal end connected to the distal edge of one of the at least two leaflet portions and a distal end extending therefrom and one or more papillary muscle head portions formed at a commissure between distal ends of at least two of the plurality of chordae portions. A total width of the leaflet portions of the template is substantially equal to a circumference of a native annulus of a heart valve.
    Type: Application
    Filed: February 23, 2018
    Publication date: February 20, 2020
    Inventors: Vinay Badhwar, Antonio D'Amore, Yasumoto Matsumura, William R. Wagner
  • Publication number: 20200030495
    Abstract: An injectable hydrogel composition that forms a porous gel rapidly after injection fro tissue engineering. The composition comprises a biodegradable, biocompatible, gelling polymer, that is optionally reverse-gelling; an Extra cellular matrix (ECM) material and a biocompatible porogen. Methods of making and using the composition are provided. A kit also is provided comprising the ingredients for making the hydrogel.
    Type: Application
    Filed: April 3, 2018
    Publication date: January 30, 2020
    Inventors: Stephen F. Badylak, Hong Jiang, Hideyoshi Sato, William R. Wagner, Yang Zhu