Patents by Inventor William R. Wagner

William R. Wagner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200054448
    Abstract: A template for a valve construct for replacement of at least one of a mitral valve and a tricuspid valve includes at least an anterior leaflet portion and at least a posterior leaflet portion, each leaflet portion having a proximal edge, a distal edge, and side edges extending between the proximal edge and the distal edge. The template further includes a plurality of substantially straight elongated chordae portions each having a proximal end connected to the distal edge of one of the at least two leaflet portions and a distal end extending therefrom and one or more papillary muscle head portions formed at a commissure between distal ends of at least two of the plurality of chordae portions. A total width of the leaflet portions of the template is substantially equal to a circumference of a native annulus of a heart valve.
    Type: Application
    Filed: February 23, 2018
    Publication date: February 20, 2020
    Inventors: Vinay Badhwar, Antonio D'Amore, Yasumoto Matsumura, William R. Wagner
  • Publication number: 20200030495
    Abstract: An injectable hydrogel composition that forms a porous gel rapidly after injection fro tissue engineering. The composition comprises a biodegradable, biocompatible, gelling polymer, that is optionally reverse-gelling; an Extra cellular matrix (ECM) material and a biocompatible porogen. Methods of making and using the composition are provided. A kit also is provided comprising the ingredients for making the hydrogel.
    Type: Application
    Filed: April 3, 2018
    Publication date: January 30, 2020
    Inventors: Stephen F. Badylak, Hong Jiang, Hideyoshi Sato, William R. Wagner, Yang Zhu
  • Publication number: 20200010979
    Abstract: A system and method are provided for manufacturing filamentous polymer matrices, comprising electrospinning a polymer fiber into a gap between two or more spaced-apart electrodes.
    Type: Application
    Filed: March 16, 2018
    Publication date: January 9, 2020
    Inventors: Antonio D'Amore, William R. Wagner
  • Publication number: 20190365981
    Abstract: Provided herein is a percutaneous expandable venous cannula device, and related methods. The device is easily inserted, for example, using standard Seldinger technique via the right internal jugular. The device includes multiple, multi-holed limbs that softly fill, e.g., the right atrium to facilitate complete drainage, enable retraction of the chamber in surgery, and mitigate suction occlusion, filling the entire atrium and allowing for efficient and rapid emptying of the chamber. In aspects, the device facilitates minimally-invasive aortic or mitral valve surgery with single placement via the right internal jugular as the sole cannula needed for full support.
    Type: Application
    Filed: February 12, 2018
    Publication date: December 5, 2019
    Inventors: Vinay Badhwar, Antonio D'Amore, Daniel McKeel, William R. Wagner
  • Publication number: 20190216847
    Abstract: Provided herein are antioxidant, thermally-responsive copolymer-based compositions and methods of making and using the compositions, e.g., for treatment of ischemia reperfusion injury in a patient. The copolymer comprises a hydrocarbyl backbone, and a plurality of pendant pyrrolidone, antioxidant radical, polyester oligomer, and N-alkyl amide groups.
    Type: Application
    Filed: October 6, 2017
    Publication date: July 18, 2019
    Inventors: William R. Wagner, Yasumoto Matsumura, Murugesan Velayutham, Yang Zhu
  • Publication number: 20190183524
    Abstract: Disclosed herein are devices and methods for accessing the interior of the heart through a wall thereof. The device includes a main body, a flange at an end thereof, and a passage therethrough to allow for access to the interior of the heart when the device is placed on an outer surface thereof. The device can be formed of any suitable biocompatible and/or biodegradable material, and can have a passage sized to allow for transmittance of tools/devices normally used for interventions in the interior of the heart therethrough.
    Type: Application
    Filed: January 20, 2017
    Publication date: June 20, 2019
    Inventors: Vinay Badhwar, Antonio D'Amore, William R. Wagner
  • Patent number: 10239071
    Abstract: A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a polymer delivery assembly. The housing defines a chamber which surrounds the tubular member holder. The rotational drive rotates the tubular member during the fiber application process.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: March 26, 2019
    Assignees: Neograft Technologies, Inc., University Of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Lorenzo Soletti, Mohammed S. El-Kurdi, Jon McGrath, Andrew Ziegler, J. Christopher Flaherty, William R. Wagner, David Vorp
  • Publication number: 20190046689
    Abstract: A cell growth matrix is provided that comprises a biodegradable elastomeric polymer electrodeposited concurrently with a sprayed or electrosprayed liquid that is a physiological solution or which comprises a mammalian blood product such as serum, plasma or platelet rich plasma. The matrix is useful as a cell-growth matrix and for repair of a tissue in a mammal, for instance by implantation in a mammal at a site in need of repair, such as in an abdominal wall.
    Type: Application
    Filed: February 9, 2018
    Publication date: February 14, 2019
    Inventors: Yi Hong, Nicholas J. Amoroso, Kazuro Lee Fujimoto, Ryotaro Hashizume, William R. Wagner
  • Publication number: 20190022300
    Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.
    Type: Application
    Filed: September 22, 2018
    Publication date: January 24, 2019
    Inventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner, Sang-Ho Ye
  • Publication number: 20180369160
    Abstract: Devices for local delivery of tacrolimus or a derivative thereof are provided, wherein the devices comprise a polymeric matrix containing tacrolimus or a derivative thereof that provides for delayed and extended release of tacrolimus or a derivative thereof. The devices can locally deliver tacrolimus or a derivative thereof to injured nervous system tissue upon implantation in a subject. Thus, techniques for local delivery of tacrolimus or a derivative thereof and methods of treatment using such devices are also provided.
    Type: Application
    Filed: June 18, 2018
    Publication date: December 27, 2018
    Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Kia M. Washington, William R. Wagner, Michael Brandt Steketee, Yolandi Van der Merwe, Xinzhu Gu
  • Patent number: 10092676
    Abstract: A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs. Methods of making and using the biohybrid scaffold are provided.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: October 9, 2018
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Nicholas J. Amoroso, Stephen Francis Badylak, Yi Hong, Alexander Huber, Keisuke Takanari, William R. Wagner
  • Patent number: 10080834
    Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: September 25, 2018
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, CARNEGIE MELLON UNIVERSITY
    Inventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner, Sang-Ho Ye
  • Patent number: 10065352
    Abstract: A system for electrospinning a fiber matrix on a tubular member includes at least one nozzle, a tubular member in a spaced relationship to the at least one nozzle, and a fluid source for pressurizing a lumen of the tubular member. An electrical potential is applied between the at least one nozzle and either the tubular member or fluid from the fluid source. The electrical potential draws at least one fiber from the at least one nozzle to the tubular member.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: September 4, 2018
    Assignees: Neograft Technologies, Inc., University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Jon McGrath, Lorenzo Soletti, Mohammed S. El-Kurdi, William R. Wagner, J. Christopher Flaherty
  • Publication number: 20180243473
    Abstract: Provided herein is a bilayer medical device (e.g., “patch”) for use in treating ischemic cardiomyopathy as well as for treatment of other conditions. The medical device comprises a first, support layer and a second, ECM-containing layer over the first layer. Methods of making and using the device also are provided herein.
    Type: Application
    Filed: September 9, 2016
    Publication date: August 30, 2018
    Inventors: Stephen F. Badylak, Antonio D'Amore, Matthew T. Wolf, William R. Wagner
  • Patent number: 9968714
    Abstract: Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: May 15, 2018
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Kazuro Lee Fujimoto, Jianjun Guan, Bradley B. Keller, Kimimasa Tobita, William R. Wagner
  • Publication number: 20180071087
    Abstract: Provided herein is a mandrel for use in electrospinning prosthetic valve devices. Also provided are prosthetic valve devices for implantation in an animal or a human. Methods of making and using the valve devices are also provided herein.
    Type: Application
    Filed: February 26, 2016
    Publication date: March 15, 2018
    Inventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, William R. Wagner
  • Publication number: 20180071088
    Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.
    Type: Application
    Filed: February 26, 2016
    Publication date: March 15, 2018
    Inventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, David S. Schwartzman, William R. Wagner
  • Patent number: 9901659
    Abstract: A cell growth matrix is provided that comprises a biodegradable elastomeric polymer electrodeposited concurrently with a sprayed or electrosprayed liquid that is a physiological solution or which comprises a mammalian blood product such as serum, plasma or platelet rich plasma. The matrix is useful as a cell-growth matrix and for repair of a tissue in a mammal, for instance by implantation in a mammal at a site in need of repair, such as in an abdominal wall.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: February 27, 2018
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Yi Hong, Nicholas J. Amoroso, Kazuro Lee Fujimoto, Ryotaro Hashizume, William R. Wagner
  • Publication number: 20170368204
    Abstract: The present invention discloses compositions and methods for clinical imaging. In particular, these compositions and methods provide improvements to cardiovascular imaging. Such improvements are drawn to the creation and use of polymer-based microbubbles comprising metal nanoparticle additives that provide contrast images of highly improve resolution when compared to conventional lipid based microbubbles. For example, the compositions and methods may be used for dark field X-ray scattering contrast images for angiography.
    Type: Application
    Filed: January 12, 2016
    Publication date: December 28, 2017
    Inventors: Flordeliza S. Villanueva, Bin Qin, Bruce Raymond Whiting, William R. Wagner, Charles F. McTiernan
  • Publication number: 20170340463
    Abstract: The invention relates to endovascular medical implant devices and materials of composition for forming these devices to provide improved mechanical properties and biodegradability. The devices include a combination or integration of superelastic material, biodegradable metal and, thin film nitinol and/or biodegradable polymer. A structural frame is formed of individual elongated pieces composed of biodegradable metal. These pieces are joined together by connector pieces composed of superelastic material. At least a portion of the structural frame has deposited thereon the thin film nitinol and/or biodegradable polymer. The structural frame of the device is collapsible for insertion in a delivery tube and, recoverable for deployment and placement in a vascular location of a patient body.
    Type: Application
    Filed: November 11, 2015
    Publication date: November 30, 2017
    Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: YOUNGJAE CHUN, WILLIAM R. WAGNER, XINZHU GU, PETER DREW WEARDEN, TOMO YOSHIZUMI