Abstract: The present invention relates to the field of pharmaceutical and chemical engineering, and specifically relates to a weakly acidic microenvironment-sensitive aptamer for tumors, a triptolide conjugate. The conjugate is formed by conjugation between the 14-position hydroxyl group of triptolide and the aptamer via an acetal ester linking bond, which is an acid-sensitive linking bond with a cleavage condition of (pH=3.5-6.5), which is much less pH-sensitive and is more likely to cleave under the tumor microenvironment. Based on the characteristics of the aptamer targeting the highly expressed proteins on the membrane surface of tumor cells, the conjugate delivered triptolide targeted to tumor cells and mediated endocytosis to reach the lysosome; based on the characteristics of the acidic environment of lysosomes, the acetal ester linking bond released intact triptolide in the lysosomal acidic environment, targeting and killing of tumor cells.

Abstract: Provided is a fully decoupled MEMS gyroscope, including an anchor point unit, a sensing unit elastically connected to the anchor point unit, and a driving unit configured to drive the sensing unit to move. The anchor point unit includes a center anchor point subunit located at a center of a rectangle and four side anchor points. The driving unit includes four driving members located on four sides of the rectangle. The sensing unit includes two X mass blocks symmetrically arranged in two avoiding intervals, two Y mass blocks symmetrically arranged in the other two avoiding intervals, four Z mass blocks respectively located at an outer side of each driving member, and four Z detection decoupling members respectively located at an outer side of each Z mass block. The X mass blocks and the Y mass blocks are respectively connected to each side anchor point.

Abstract: A magnetic member includes a bobbin, a coil and a magnetic core. The bobbin includes a first portion and a second portion. The second portion is connected to the first portion and includes a thermoplastic material. The first portion includes an insulating material that is different from the thermoplastic material. The coil is wound on the first portion of the bobbin and includes a terminal end fixed at the second portion of the bobbin. The magnetic core is disposed on the bobbin and extends through the bobbin.

Abstract: At least one computer processor can replace visual words of an unsupervised machine learning classification model with visual objects of an image. At least two co-occurring single visual objects adjacent to each other in pixels of the image can be combined to obtain a compound visual object. The unsupervised machine learning classification model can be augmented to model the image as a mixture of subjects, where each subject is represented through placements of the visual objects in a mixture of concentric spheres centering on a mixture of intersections on a mixture of horizontal layers. At least one processor can learn latent relationships between the placements of the visual objects in a three-dimensional space depicted in the image and image semantics. Learning the latent relationships trains the unsupervised machine learning classification model to perform image subject classification through the placements of the visual objects in a new image.

Abstract: An adaptive control method and system for an upper limb rehabilitation robot based on a game theory and surface Electromyography (sEMG) is disclosed. A movement trajectory that a robot is controlled to run within a training time is designed during subject operation. An sEMG-based Back Propagation Neural Network (BPNN) muscle force estimation model establishes a nonlinear dynamic relationship between an sEMG signal and end force by constructing a three-layer neural network. A human-computer interaction system is analyzed by the game theory principle, and a role of the robot is deduced. The control rate between the robot and a subject is updated by Nash equilibrium, and adaptive weight factors of the robot and the subject are determined. The robot adaptively adjusts the training mode thereof according to a movement intention of the subject during operation and a weight coefficient obtained by the game theory principle.

Abstract: An embodiment includes identifying, during a video conference attended by a first attendee, other attendees of the video conference. The embodiment renders a virtual meeting environment including virtual representations of the other attendees, where the rendering includes accessing relationship characteristic data indicative of relationships between the first attendee and other attendees. The embodiment calculates positions for virtual representations of the other attendees in the first attendee's virtual field of view based on the relationship characteristic data. The embodiment also detects simultaneous speech from two of the other attendees and, in response, directs the individual speech from each of the other attendees to respective audio channels.

Abstract: A system for testing an assist function of electric vehicle wireless power transfer includes: a pit, a vehicle-assembly support platform, and an electromagnetic field strength measurement instrument. A ground-assembly support platform is arranged inside the pit, the vehicle-assembly support platform is arranged on an upper side of the ground-assembly support platform, and a to-be-tested member is arranged on an upper side of the ground-assembly support platform. A ground-assembly device coil is arranged on an upper surface of the ground-assembly support platform, a vehicle-assembly device coil is arranged inside the vehicle-assembly support platform, the ground-assembly device coil charges an entire vehicle, and the ground-assembly device coil further cooperates with the vehicle-assembly device coil to charge a vehicle component. A mechanical arm is arranged on ground of a test site, an interference member is arranged on a front end of the mechanical arm.

Abstract: Aspects are provided for dynamic resource sharing between V2V and I2V communications. A wireless device selects resources from a shared resource pool in frequency and time. The shared resource pool is shared for I2V communication and communication over a PC5 interface originating from a User Equipment (UE). The wireless device identifies a first priority level for communication from a set of priority levels for I2V communication and UE originated communication. The set of priority levels may comprise at least one priority level unique to the I2V communication.

Abstract: An energy Internet system, an energy routing conversion device, and an energy control method, relating to a field of energy information. An alternating-current (AC) side energy routing conversion device of the energy Internet system includes a plurality of first route ports, and a direct-current (DC) side energy routing conversion device includes a plurality of second route ports, where each second route port is connected to a corresponding first route port by means of a corresponding DC busbar. A plurality of energy devices are connected to a DC busbar by means of corresponding first AC/DC converters or first DC converters. The AC side energy routing conversion device and the DC side energy routing conversion device collect energy information of the energy devices and adjust energy of the energy devices on a basis of energy balance constraint conditions.

Abstract: A method includes accessing a digital pathology image that depicts tumor cells sampled from a subject. A plurality of patches may be selected from the digital pathology image, wherein each of the patches depicts tumor cells. A mutation prediction may be generated for each of the patches, wherein the mutation prediction represents a prediction of a likelihood that an actionable mutation appears in the patch. Based on the plurality of mutation predictions, a prognostic prediction related to one or more treatment regimens for the subject may be generated. The prognostic prediction may be based on determining one or more mutational contexts of the digital pathology image as an unknown driver or a tumor suppressor, an oncogene driver mutation, or a gene fusion.

Abstract: The present disclosure provides a blending method of high-quality and dual-purpose flour for bread and noodles, belonging to the technical field of flour processing. The method includes: selecting flour of a high-quality and dual-purpose wheat variety for bread and noodles as a high-quality basic flour for blending; according to a large gradient experimental design, selecting a gradient range ratio with a sedimentation value ?46.0 mL and a dough development time ?9.6 min, followed by subdividing for small gradient experiments; selecting a ratio with flour sedimentation value and dough development time that reach an ideal value to blend a large amount of flour; and making bread and noodles for scoring, followed by determining a blending ratio if a scoring result reaches an ideal value.

Abstract: An assembled subway station and a construction method thereof are provided. The assembled subway station includes a plurality of components combined in a ring shape, comprising a bottom plate component, two bottom corner components, two side wall components, a middle plate component, two top corner components, and a top plate component. Connection surfaces of each component are each provided with a concave-convex structure being matched with another concave-convex structure on a relevant connection surface of an adjacent component. Butt joint positions of two adjacent components are filled with sealing structures. The embedded grooves of two adjacent components are oppositely arranged, and connecting members for exerting opposite fastening forces on the two adjacent components are installed in the oppositely arranged embedded grooves.

Abstract: An inflatable folding tunnel reinforcement structure and a construction method thereof are provided. The inflatable folding tunnel reinforcement structure includes an inflation port, an airbag, a water blocking net, a steel plate, a scissor folding mechanism, a vertical support plate, an arc-shaped support plate, drainage channels, an upper support rod, a lower support rod, a locking pin, a threaded steel rod, a rolling connection pin, and an induction motor, where the upper support rod and the lower support rod are unfolded in opposite directions to a preset position through the steel rod; and the drainage channels are configured to perform water guidance and resistance for a leakage-proofing purpose. The construction method includes: preparation before construction, device fixation, on-site construction, structural inspection, and site cleaning. The present disclosure can treat various tunnel defects efficiently and conveniently and achieve a desired leakage-proofing effect.

Abstract: Container data sharing is provided. A second container of a cluster of containers is started to process a service request in response to detecting a failure of a first container processing the service request. The service request and data generated by the first container that failed stored on a physical external memory device is accessed. The service request and the data generated by the first container that failed is loaded on the second container from the physical external memory device via a dedicated hardware link for high-speed container failure recovery.

Abstract: Systems and methods relate to predicting disease progression by processing digital pathology images using neural networks. A digital pathology image that depicts a specimen stained with one or more stains is accessed. The specimen may have been collected from a subject. A set of patches are defined for the digital pathology image. Each patch of the set of patches depicts a portion of the digital pathology image. For each patch of the set of patches and using an attention-score neural network, an attention score is generated. The attention-score neural network may have been trained using a loss function that penalized attention-score variability across patches in training digital pathology images labeled to indicate no or low subsequent disease progression. Using a result-prediction neural network and the attention scores, a result is generated that represents a prediction of whether or an extent to which a disease of the subject will progress.

Abstract: The present disclosure relates to a control method of a virtual object, a control apparatus, a device and a medium. The method displays a target virtual scene in a target interactive interface, under the condition that there is a target virtual object in the plurality of virtual objects, displays a target control, the target virtual object being a virtual object controllable by the virtual subject in a non-contact manner; in response to receiving a trigger operation on the target control, causes the virtual subject to perform non-contact control on the target virtual object according to a control mode corresponding to the target control, wherein the target virtual scene includes a plurality of virtual objects and a virtual subject controlled by a user.

Abstract: Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.

Abstract: This application provides a data transmission method and apparatus. The method includes: obtaining, by a terminal, information used to indicate a first condition; obtaining to-be-transmitted data; and when the first condition is met, sending, by the terminal over a sidelink, the to-be-transmitted data that is on a first logical channel by using a first carrier frequency and the to-be-transmitted data that is on a second logical channel by using a second carrier frequency. In this method, the same data is sent, over the sidelink, on different carrier frequencies by using two logical channels, and a receiving device can receive the same duplicate data, thereby improving data transmission reliability.

Abstract: The present disclosure provides a high-temperature negative-pressure air exchange sterilizer and a sterilization method thereof. An air inlet is disposed at a bottom of a waterproof shell of the sterilizer, and an inlet filter is installed at the air inlet. Air entering from the air inlet is divided into two paths at a check valve. One path is connected with a negative-pressure fan through a pipeline B, and the other path is communicated with an air outlet through a pipeline A. A plurality of heating rods and temperature sensors are disposed in the pipeline A. The pipeline A is zigzag disposed at an upper part of the waterproof shell, and a thermal insulation material is disposed outside a zigzag part. A butterfly valve and an outlet filter screen are sequentially disposed at the air outlet in an air exhaust direction. The problem that viruses exhaled by breathing of an infected person are mixed in aerosol, so that a person in close contact with the infected person is likely to be infected is solved.

Abstract: A curing agent for disposal of municipal solid waste incineration (MSWI) fly ash and a preparation method and use method thereof are provided. In the present disclosure, a loofah nanofiber crystal, a rice husk ash (RHA), sodium hydroxide, and water are adopted as raw materials to prepare the curing agent, and the curing agent can effectively realize the safe disposal and curing of heavy metals in an MSWI fly ash. The highest curing rates of the curing agent for heavy metals Pb2+, Zn2+, Cd2+, Cr3+, and Cu2+ can reach 99.7%, 99.4%, 99.5%, 98.7%, and 99.5%, respectively. The special three-dimensional (3D) cross-linked network structure of the loofah nanofiber crystal and the excellent physical and chemical adsorption properties and ion exchange capacity of the RHA are fully used in the curing agent of the present disclosure.