Patents by Inventor Xiao Xu

Xiao Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240010697
    Abstract: This disclosure relates, inter alia to: modified interleukin 2 (IL-2) polypeptides; RNA polynucleotides, DNA polynucleotides, non-viral vectors, and viral vectors encoding such modified IL-2 polypeptides; methods of making such modified IL-2 polypeptides and RNA polynucleotides, DNA polynucleotides, non-viral vectors, and viral vectors encoding same; and methods of using such modified IL-2 polypeptides and RNA polynucleotides, DNA polynucleotides, non-viral vectors, and viral vectors encoding same.
    Type: Application
    Filed: October 13, 2021
    Publication date: January 11, 2024
    Applicant: CYTIMM THERAPEUTICS, INC.
    Inventors: HAINING HUANG, XIAO XU, YU FENG, GUILIANA MOGNOL, CAN JIN, DIANA GUIMET
  • Patent number: 11866703
    Abstract: The present disclosure provides a method for knocking out an N-myristoyltransferase (NMT) gene from Eimeria tenella, and belongs to the technical field of microorganisms. The method includes: mixing sporozoites of Eimeria tenella with a pCRISPR::EtNMT plasmid and a pEtNMT::DHFR plasmid, and subjecting a resulting mixture to electrotransformation to obtain NMT gene-knockout Eimeria tenella. The method provided by the present disclosure can successfully knock out the NMT gene from Eimeria tenella, which lays a foundation for studying the function of the Eimeria tenella gene and developing a vaccine therefor.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: January 9, 2024
    Assignee: LANZHOU VETERINARY RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Jianping Cai, Zigang Qu, Xiao Xu, Jing Wang, Zhenxing Gong, Heng Wang, Xueyang He, Wenqing Wang
  • Patent number: 11865196
    Abstract: An engineered radioactive polymeric microsphere, and a preparation and application thereof. The preparation method includes: adding a styrene monomer and a disperser and/or a crosslinker into a medium, followed by feeding of nitrogen or helium and stirring to obtain a first reaction mixture; heating the first reaction mixture, and adding an initiator, followed by reaction under stirring at a constant temperature to obtain a second reaction mixture; subjecting the second reaction mixture to washing with ethanol and water, and vacuum drying to obtain a crude polymeric microsphere; subjecting the crude polymeric microsphere to radiation-induced graft polymerization with a functional monomer to obtain the functionalized polymeric microsphere; and exposing the functionalized polymeric microsphere to a radionuclide to prepare the engineered radioactive polymeric microsphere.
    Type: Grant
    Filed: June 21, 2023
    Date of Patent: January 9, 2024
    Assignees: Xiamen University, Shanghai University
    Inventors: Gang Liu, Xiao Xu, Hongjuan Ma, Zhenwen Zhao, Hu Chen, Pan He, Chao Liu, Chengchao Chu, Dong Li
  • Publication number: 20230350702
    Abstract: A plurality of constraint relationships in a UI are identified and grouped into two types, a constraint relationship of a first type is solved in an integrated development environment (IDE), and a constraint relationship of a second type is a constraint relationship solved in a terminal or the IDE. The plurality of constraint relationships are used to determine a layout of one or more components in the UI. The IDE calculates a first intermediate solution set based on the constraint relationship of the first type in the plurality of constraint relationships. The first intermediate solution set is used to determine the layout of the one or more components in the UI together with the constraint relationship of the second type.
    Type: Application
    Filed: July 13, 2023
    Publication date: November 2, 2023
    Inventors: Tao Wen, Xiao Xu, Jun Liu, Tengfei Cui
  • Publication number: 20230346992
    Abstract: An engineered radioactive polymeric microsphere, and a preparation and application thereof. The preparation method includes: adding a styrene monomer and a disperser and/or a crosslinker into a medium, followed by feeding of nitrogen or helium and stirring to obtain a first reaction mixture; heating the first reaction mixture, and adding an initiator, followed by reaction under stirring at a constant temperature to obtain a second reaction mixture; subjecting the second reaction mixture to washing with ethanol and water, and vacuum drying to obtain a crude polymeric microsphere; subjecting the crude polymeric microsphere to radiation-induced graft polymerization with a functional monomer to obtain the functionalized polymeric microsphere; and exposing the functionalized polymeric microsphere to a radionuclide to prepare the engineered radioactive polymeric microsphere.
    Type: Application
    Filed: June 21, 2023
    Publication date: November 2, 2023
    Inventors: Gang LIU, Xiao XU, Hongjuan MA, Zhenwen ZHAO, Hu CHEN, Pan HE, Chao LIU, Chengchao CHU, Dong LI
  • Publication number: 20230322668
    Abstract: Provided herein, inter alia, are compounds, pharmaceutical compositions and methods related to the treatment of viral infections caused by coronavirus or enterovirus. Provided herein are compounds of Formula (I), (II) and (III) and methods of using the compounds for therapy. These compounds are peptidomimetics that inhibit protease 3CL of a coronavirus, and are useful for treating conditions caused by viral infections, including COVID-19.
    Type: Application
    Filed: June 15, 2023
    Publication date: October 12, 2023
    Applicant: ACEA Therapeutics, Inc.
    Inventors: Long Mao, Xiao Xu, Namir Shaabani, Can Jin
  • Publication number: 20230316535
    Abstract: An image detection method includes processing a to-be-processed image based on a first segmentation model to obtain a to-be-detected image corresponding to a to-be-detected object. The to-be-processed image is obtained when the to-be-detected object is located in a scene. The method further includes detecting the to-be-detected image to obtain a detection result corresponding to the to-be-detected object. The first segmentation model is trained using a first label that is determined based on a second segmentation model. The second segmentation model is obtained by training using at least a fused image carrying a second label. The fused image is generated by fusing a sub-image corresponding to a detection object and a sub-image corresponding to another scene. The sub-image corresponding to the detection object is determined based on the second label.
    Type: Application
    Filed: March 8, 2023
    Publication date: October 5, 2023
    Inventors: Dizhi MA, Xiao XU
  • Publication number: 20230288429
    Abstract: Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.
    Type: Application
    Filed: March 8, 2023
    Publication date: September 14, 2023
    Inventors: Xiao Xu, Yama A. Abassi, Xiaobo Wang, Jiangbo Gan
  • Publication number: 20230287551
    Abstract: The present disclosure provides a heat treatment method for realizing grain boundary serration in a nickel-based superalloy forging, including introducing a serrated grain boundary into a microstructure of a nickel-based superalloy forging by using a heat treatment method for controlling a cooling rate; the heat treatment method for controlling cooling speed includes the following steps: step S1: holding the nickel-based superalloy forging for 0.5-4 h at 1,050-1,200° C.; step S2: cooling the nickel-based superalloy forging to 650-800° C. at a preset cooling rate, and holding for 1-8 h, where the preset cooling rate is 1-20° C./min; and step S3, taking out and cooling the nickel-based superalloy forging to room temperature with water. The heat treatment method for realizing grain boundary serration in a nickel-based superalloy forging provided by the present disclosure can realize the grain boundary serration in the nickel-based superalloy forging.
    Type: Application
    Filed: February 20, 2023
    Publication date: September 14, 2023
    Inventors: Honglei HU, Fenghua CAO, Zhisong LI, Xiao XU, Yifei GUI
  • Patent number: 11753373
    Abstract: Provided herein, inter alia, are compounds, pharmaceutical compositions and methods related to the treatment of viral infections caused by coronavirus or enterovirus. Provided herein are compounds of Formula (I), (II) and (III) and methods of using the compounds for therapy. These compounds are peptidomimetics that inhibit protease 3CL of a coronavirus, and are useful for treating conditions caused by viral infections, including COVID-19.
    Type: Grant
    Filed: June 1, 2022
    Date of Patent: September 12, 2023
    Assignee: ACEA Therapeutics, Inc.
    Inventors: Long Mao, Xiao Xu, Namir Shaabani, Can Jin
  • Patent number: 11756772
    Abstract: An ion source assembly and method has a source gas supply to provide a molecular carbon source gas to an ion source chamber. A source gas flow controller controls flow of the molecular carbon source gas to the ion source chamber. An excitation source excites the molecular carbon source gas to form carbon ions and radicals. An extraction electrode extracts the carbon ions from the ion source chamber, forming an ion beam. An oxidizing co-gas supply provides oxidizing co-gas to chamber. An oxidizing co-gas flow controller controls flow of the oxidizing co-gas to the chamber. The oxidizing co-gas decomposes and reacts with carbonaceous residues and atomic carbon forming carbon monoxide and carbon dioxide within the ion source chamber. A vacuum pump system removes the carbon monoxide and carbon dioxide, where deposition of atomic carbon within the ion source chamber is reduced and a lifetime of the ion source is increased.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: September 12, 2023
    Assignee: Axcelis Technologies, Inc.
    Inventors: David Sporleder, Neil Bassom, Neil K. Colvin, Mike Ameen, Xiao Xu
  • Patent number: 11739408
    Abstract: The present disclosure provides a heat treatment method for realizing grain boundary serration in a nickel-based superalloy forging, including introducing a serrated grain boundary into a microstructure of a nickel-based superalloy forging by using a heat treatment method for controlling a cooling rate; the heat treatment method for controlling cooling speed includes the following steps: step S1: holding the nickel-based superalloy forging for 0.5-4 h at 1,050-1,200° C.; step S2: cooling the nickel-based superalloy forging to 650-800° C. at a preset cooling rate, and holding for 1-8 h, where the preset cooling rate is 1-20° C/min; and step S3, taking out and cooling the nickel-based superalloy forging to room temperature with water. The heat treatment method for realizing grain boundary serration in a nickel-based superalloy forging provided by the present disclosure can realize the grain boundary serration in the nickel-based superalloy forging.
    Type: Grant
    Filed: February 20, 2023
    Date of Patent: August 29, 2023
    Assignee: SHANGHAI DIANJI UNIVERSITY
    Inventors: Honglei Hu, Fenghua Cao, Zhisong Li, Xiao Xu, Yifei Gui
  • Patent number: 11699563
    Abstract: An ion implantation system, ion source, and method are provided, where an ion source is configured to ionize an aluminum-based ion source material and to form an ion beam and a by-product including a non-conducting material. An etchant gas mixture has a predetermined concentration of fluorine and a noble gas that is in fluid communication with the ion source. The predetermined concentration of fluorine is associated with a predetermined health safety level, such as approximately a 20% maximum concentration of fluorine. The etchant gas mixture can have a co-gas with a concentration less than approximately 5% of argon. The aluminum-based ion source material can be a ceramic member, such as a repeller shaft, a shield, or other member within the ion source.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: July 11, 2023
    Assignee: Axcelis Technologies, Inc.
    Inventors: Neil K. Colvin, Neil Bassom, Xiao Xu
  • Patent number: 11660743
    Abstract: A ball screw spline assembly includes a ball screw spline including a first nut including a first mounting surface adapted to receive a first fastening element; a second nut including a second mounting surface adapted to receive a second fastening element; and a shaft passing through the first nut and the second nut; the housing including a first portion and a second portion, the first portion extends in a direction substantially parallel to the shaft, and the second portion extends in a direction substantially perpendicular to the shaft; a connecting plate coupling the second nut to the first portion, the first nut is installed to the second portion; the first mounting surface and the second mounting surface are located within a space defined by the first portion, the second portion and the connecting plate, such that the ball screw spline is integrally installable to the housing.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: May 30, 2023
    Assignee: ABB SCHWEIZ AG
    Inventors: Xiao Xu, Tao Feng
  • Publication number: 20230145666
    Abstract: Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.
    Type: Application
    Filed: January 10, 2023
    Publication date: May 11, 2023
    Inventors: Xiao Xu, Yama A. Abassi, Xiaobo Wang, Jiangbo Gan
  • Publication number: 20230130050
    Abstract: A system for monitoring cells, which includes a device for monitoring cell-substrate impedance, the device having a plurality of wells on a nonconductive substrate, where each of the plurality of wells has an electrode array fabricated on the substrate for measurement of cell-substrate impedance; an impedance analyzer that measures cell-substrate impedance from the plurality of wells; electronic circuitry with multiple analogue-to-digital conversion channels, where the electronic circuitry electrically connects the electrode arrays to the impedance analyzer such that the electrode arrays are electrically monitored at millisecond time resolution; and a software program that analyzes the measured cell-substrate impedance.
    Type: Application
    Filed: November 23, 2022
    Publication date: April 27, 2023
    Inventors: Xiaobo Wang, Yama A. Abassi, Biao Xi, Wen Fu Zhang, Xiao Xu
  • Publication number: 20230111730
    Abstract: An electric power converter for a photovoltaic energy source, including: an inverter to receive a dynamically changing DC signal generated by the photovoltaic energy source and to generate a corresponding dynamically changing AC signal having a frequency substantially equal to a mains supply frequency; and an electromagnetic apparatus, including: a magnetic core and a plurality of windings around the magnetic core. The windings include: one or more input windings to receive the dynamically changing AC signal as an AC input; one or more output windings to provide an AC output signal; and control windings configured to control electromagnetic coupling between the input and output windings; and a control component configured to dynamically control electrical currents through the control windings so that the electrical characteristics of the AC output signal are relatively constant despite the dynamically changing AC signal and include a fundamental frequency equal to the mains supply frequency.
    Type: Application
    Filed: July 8, 2020
    Publication date: April 13, 2023
    Inventors: Andrew John SCOBIE, Kamel BOUALLAGA, Patryk Wladyslaw POCIASK, Leong Kit GAN, Xiao XU
  • Patent number: 11612602
    Abstract: The present disclosure provides pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: March 28, 2023
    Assignee: ACEA Therapeutics, Inc.
    Inventors: Xiao Xu, Xiaobo Wang, Long Mao, Li Zhao, Biao Xi
  • Publication number: 20230089208
    Abstract: A battery includes a battery cell and a box. A surface of the battery cell is provided with an electrode terminal. A portion of the box forms an accommodating chamber having an opening. The battery cell is accommodated in the accommodating chamber. The surface of the battery cell is configured to be fixedly connected to a cover covering the opening to fixedly connect the battery cell to the cover.
    Type: Application
    Filed: August 29, 2022
    Publication date: March 23, 2023
    Inventors: Xiao XU, Xiping LIAO
  • Patent number: 11604197
    Abstract: Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: March 14, 2023
    Assignee: Agilent Technologies, Inc.
    Inventors: Xiao Xu, Yama A. Abassi, Xiaobo Wang, Jiangbo Gan