Abstract: An HP spherical deformation diagnosis model and a construction method thereof are provided. The HP spherical deformation diagnosis model is used for identifying whether HP spherical deformation exists in an IHC dyeing image of an HP positive gastric mucosal sample, and includes: an image processing module and an identification module; the image processing module comprises a contrast enhancement module, an image filtering module, and an HP dyeing extraction module; the contrast enhancement module comprises: an HIS color model transformation module, which is used for transforming an original image from an RGB color model to an HIS color model in which hue, saturation, and intensity are separated; and a piecewise linear transformation module, which is used for enhancing a grayscale region of interest in the image by using a piecewise linear transformation method for a brightness component in the HIS color module, so as to improve the image.

Abstract: An antigen and kit for the detection of a Helicobacter pylori antibody, and a preparation method thereof are provided. The kit includes an antigen for the detection of the Helicobacter pylori antibody, the antigen is Helicobacter pylori HpC-025 with the deposit registration number of CCTCC No: M20221024, and the detection object of the kit is oral exudate. The antigen is a natural antigen and has a sensitivity superior to the sensitivities of the natural antigen of Hp international standard strain 11637, the natural antigen of Hp-Ag from the Japanese Institute of Immunology and the recombinant antigen of Hp-Ag. The kit has no significant requirements for usage scenarios, can be used in medical institutions at all levels or at home, and can be used for household screening of Helicobacter pylori.

Abstract: A furnace tube for thin film deposition, includes: a process tube; a wafer boat, arranged inside the process tube and provided with multi-layered supporting members along the length direction of the process tube; a gas supply tube, arranged inside the process tube and provided with multi-layered gas supply holes along the length direction of the process tube. Multi-layered exhaust holes are arranged on the sidewall of the process tube along the length direction, wherein the distribution area of the gas supply holes is gradually reduced from top to bottom along the length direction of the sidewall of the process tube, and the distribution area of the exhaust holes is gradually reduced from top to bottom along the length direction of the sidewall of the process tube.

Abstract: An HP spherical deformation diagnosis model and a construction method thereof are provided. The HP spherical deformation diagnosis model is used for identifying whether HP spherical deformation exists in an IHC dyeing image of an HP positive gastric mucosal sample, and includes: an image processing module and an identification module; the image processing module comprises a contrast enhancement module, an image filtering module, and an HP dyeing extraction module; the contrast enhancement module comprises: an HIS color model transformation module, which is used for transforming an original image from an RGB color model to an HIS color model in which hue, saturation, and intensity are separated; and a piecewise linear transformation module, which is used for enhancing a grayscale region of interest in the image by using a piecewise linear transformation method for a brightness component in the HIS color module, so as to improve the image.

Abstract: The present disclosure relates to a novel influenza immunogen with broad-spectrum anti-influenza virus effect and the immunization method thereof. The present disclosure provides a novel anti-influenza immunogen whose sequence comprises the amino acid sequence shown in SEQ ID No: 1 and SEQ ID No: 2, or an immunogenic fragment thereof, or a combination thereof. In addition, the present disclosure also provides use of the recombinant vector vaccine using said immunogen in the anti-influenza vaccine, and the immunization method of the recombinant vector vaccine using said immunogen. Through the sequential administration of multiple vector vaccines expressing the novel influenza immunogen, and the combined use of systemic administration and local administration, a high-level T cell immune response is induced in the local respiratory tract, which can produce broad-spectrum protection against multiple influenza virus infections.

Abstract: The invention relates to the technical field of false eyelash processing, and is particularly an improved false eyelash manufacturing process and processing device. The process comprises the following steps of: S1: obtaining an auxiliary film by a laser forming machine or a 3D printing film forming process; and S2: bending and shaping a tip part of an eyelash filament by a vacuum negative-pressure shaping method to obtain an eyelash filament with a curved tip part. According to the invention, a thread in an existing manufacturing process is replaced with the auxiliary film, so that compared with the thread, the auxiliary film has no greater elasticity, thus lowering operation requirements, making the manufacturing of false eyelashes more stable, and improving the production efficiency of false eyelashes.

Abstract: Disclosed is a wafer backside cleaning method, comprising: using a wafer clamping part to hold a wafer, a gap being formed between the wafer clamping part and the wafer; injecting a protective gas into the gap at a first flow rate; adjusting the flow rate of the protective gas from the first flow rate to a second flow rate, and rotating the wafer under the drive of the first rotational speed of the wafer clamping part to clean the backside of the wafer; adjusting the rotational speed of the wafer clamping part from the first rotational speed to a second rotational speed, so that the wafer is driven by the wafer clamping part to rotate for the drying process; stopping rotating the wafer, adjusting the flow rate of the protective gas to the first flow rate again from the second flow rate, and then taking out the wafer; and stopping injecting the protective gas after the wafer is taken out.

Abstract: A polyurethane composition with stable matt surface and good chalking resistance, which is suitable for use as a sealant and/or an adhesive for sealing and/or bonding, preferably for gap-filling, particularly in construction and manufacturing industries. The polyurethane composition includes:—a polyurethane prepolymer containing an isocyanate group, including a MDI-based prepolymer synthesized from a polyether diol and a polyether triol with MDI, and a TDI-based prepolymer synthesized from a polyether diol and a polyether triol with TDI; and —a phenyl alkyl sulfonate in an amount of 12-25 wt %, preferably 18-25 wt %, based on the total weight of the composition.

Abstract: A high-temperature tube furnace comprises: a process tube (1) with a top cover (101) arranged on the top end thereof, the top cover (101) being provided with through holes (1011); a gas supply pipe (2) communicating with the through holes (1011) of the top cover (101) of the process tube (1), process gas being introduced into the process tube (1) through the gas supply pipe (2) and the through holes (1011) of the top cover (101) of the process tube (1); a wafer boat (3) arranged in the process tube (1), and comprising a supporting frame (301) and supporting plates (302), the supporting plates (302) being distributed in multiple layers along the length direction of the supporting frame (301) and used for supporting multiple substrates (w), each substrate (w) being placed on one supporting plate and each supporting plate supporting the entire bottom of the substrate (w).

Abstract: The semiconductor device includes a substrate, a first nitride semiconductor layer disposed on the substrate, a second nitride semiconductor layer disposed on the first nitride semiconductor layer and having a bandgap greater than that of the first nitride semiconductor layer. The semiconductor device further includes a first gate conductor disposed on a first region of the second nitride semiconductor layer, a first source electrode disposed on a first side of the first gate conductor, a first field plate disposed on a second side of the first gate conductor, a first conductive terminal and a second conductive terminal disposed on a second region of the second nitride semiconductor layer, and a resistor formed in the first nitride semiconductor layer and electrically connected between the first conductive terminal and the second conductive terminal, wherein the resistor comprises at least one conductive region.

Abstract: The present invention provides an antibody targeting an AXL protein or an antigen binding fragment thereof, and a preparation method therefor and use thereof. Further provided are an isolated polynucleotide encoding the antibody targeting the AXL protein or the antigen binding fragment thereof, and a vector comprising the isolated polynucleotide. The antibody targeting the AXL provided by the present invention can specifically bind to the AXL protein, can mediate ADCC to kill tumors, or have an anti-tumor effect as a target recognition domain of CART cells, and can be used for preventing or treating tumors, and hence it has a wide application prospect.

Abstract: The present invention provides a recombinant viral vector, an immunogenic composition containing the same, and the use thereof. The recombinant viral vector comprises a polynucleotide encoding a fusion peptide of CD4 helper T cell epitopes, the epitope fusion peptide comprising a cytomegalovirus epitope and/or an influenza virus epitope. The epitope fusion peptide and the recombinant viral vector provided by the present invention can improve the level of cellular immune response to a target immunogen, particularly to a weak immunogen, and overcome the immune tolerance of immune system to an antigen, particularly to a tumor antigen or an infection-related antigen. The products of the present invention are suitable for enhancing the efficacy of vaccines.

Abstract: A semiconductor device includes a nitride-based transistor, a first metal layer, a second metal layer, a third metal layer, a source pad, and a drain pad. The first metal layer is disposed over the nitride-based transistor. The second metal layer is disposed over the first metal layer. The third metal layer is disposed over the second metal layer and includes a first pattern and a second pattern which are spaced apart from each other. The source pad is immediately above the first metal layer, the second metal layer, and the first pattern of the third metal layer and is electrically coupled with the nitride-based transistor. The drain pad is immediately above the first metal layer, the second metal layer, and the second pattern of the third metal layer and is electrically coupled with the nitride-based transistor.

Abstract: A substrate processing apparatus includes a clamp mechanism, a spray head mechanism, a rotary drive mechanism, a heating mechanism, and a control mechanism. The heating mechanism includes a heating plate arranged below a substrate, wherein the heating plate is provided with at least two cavities in a radial direction, and the cavities are distributed at different radii. During the process of the liquid nozzle moving from the center of the substrate to the edge of the substrate along the radial direction of the substrate, when the liquid nozzle moves to a certain area above the substrate, the control mechanism controls the thermal energy of fluid in the cavity located at the corresponding radius of the area.

Abstract: Disclosed in an embodiment of the present invention is a substrate processing apparatus, comprising a processing chamber, a liquid supply tank and a recovery tank. A first pipeline connects a first liquid inlet and a liquid outlet of the liquid supply tank, so as to circulate the chemical liquid inside the liquid supply tank. A second pipeline connects the first pipeline and a liquid inlet of the processing chamber, so as to transfer the chemical liquid in the liquid supply tank to the processing chamber. A third pipeline connects the first pipeline and a first liquid inlet of the recovery tank, so as to transfer the chemical liquid in the liquid supply tank to the recovery tank. A fourth pipeline connects a liquid outlet of the processing chamber and a second liquid inlet of the recovery tank, so as to return the used chemical liquid in the processing chamber to the recovery tank.

Abstract: The present description relates to methods of treating neurodegenerative diseases characterized by the accumulation of aberrant forms of the microtubule associated protein Tau (MAPT) using substituted thieno[3,2-b]pyridine compounds, forms, and pharmaceutical compositions thereof.

Abstract: The present description relates to methods of treating neurodegenerative diseases characterized by the accumulation of aberrant forms of the microtubule associated protein Tau (MAPT) using substituted pyrrolo[2,3-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.

Abstract: The present description relates to methods of treating neurodegenerative diseases characterized by the accumulation of aberrant forms of the microtubule associated protein Tau (MAPT) using substituted thieno[3,2-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.

Abstract: The present invention discloses the use of SNAT2 competitive inhibitors or gene expression inhibition in the preparation of drugs for the prevention and/or treatment of hypertensive disorders. The SNAT2 competitive inhibitor is ?-aminoisobutyric acid (MeAIB). The present invention demonstrates that MeAIB, a competitive inhibitor of SNAT2, and knockout of the SNAT2 gene can prevent and treat hypertension, and is of significant value in the prevention and treatment of primary hypertension. The present invention provides evidence showing that SNAT2 serves as a potential target for drug discovery and an intervention tool in primary hypertension.

Abstract: Provided is an antibody capable of specifically binding to CD47or an antigen binding fragment thereof. Also provided is a recombinant oncolytic virus, which is operably inserted with or comprises a gene coding sequence of an anti-CD47antibody or a CD47ligand, wherein the anti-CD47antibody comprises an Fc mutant having A330L/I332E mutations (ALIE antibody), i.e., the anti-CD47antibody is ?CD47-Fc(ALIE). Also provided are a preparation method for the recombinant oncolytic virus, a use of the recombinant oncolytic virus in preparation of anti-tumor drugs, and a vaccinia virus Tiantan strain capable of efficiently expressing an ?CD47-Fc(ALIE) gene.