Abstract: The present invention provides a novel vaccine for preventing and treating Merkel cell carcinoma. The present invention constructs a therapeutic vaccine based on a Merkel cell polyomavirus capsid protein VP1 by taking the Merkel cell polyomavirus capsid protein VP1 as an antigen, in combination with a TLR agonist. The present invention effectively solves the problem of prevention and treatment of the Merkel cell carcinoma and has great application value and application prospects.

Abstract: A multi-sector data correction method for gamma imaging while drilling includes the steps of: (a) dividing each gamma imaging sector into a plurality of counting zones; (b) counting a number of valid counting pulses for each counting zone at a predetermined time interval during MWD; (c) constructing a plurality of measurement vectors based on a value of recording times of each counting zone; (d) establishing a correction matrix with a conditional number less than a set value through an optimization algorithm; and (e) calculating a gamma intensity of each measured sector with the plurality of measurement vectors and the correction matrix as constructed, so as to complete the correction on the measurement data of each measured sector for each predetermined time interval. This method eliminate problems such as rotational measurement distortion of the gamma imaging while drilling tool and improve the accuracy of calculating the formation dip angle.

Abstract: The disclosed subject matter provides a coupling-in structure, a diffractive optical structure, and an optical display device. The coupling-in structure includes a substrate, and a coupling-in portion disposed on the substrate, wherein the coupling-in portion is configured to couple light into the substrate so that the light propagates within the substrate via total internal reflection. The coupling-in portion includes a coupling-in grating, a first film layer, and a second film layer that are stacked. The difference between the refractive index n1 of the coupling-in grating and the refractive index n2 of the first film layer satisfies: n1?n2?0.3. The average coupling-in efficiency R1 of the coupling-in grating for light is greater than 60%. After light is coupled into the interior of the substrate by the coupling-in grating, its average transmittance T0 through the second film layer is less than 0.1%.

Abstract: A method can include generating synthetic seismic data using a velocity model of a subsurface geologic environment; perturbing the velocity model of the subsurface geologic environment to generate a perturbed velocity model of the subsurface geologic environment; performing an iteration of a full-waveform inversion using the synthetic seismic data and the perturbed velocity model to generate seismic survey source and receiver illumination weights; and generating an image of the subsurface geologic environment using the seismic survey source and receiver illumination weights, where the seismic source and receiver illumination weights act to balance seismic illumination.

Abstract: A method, system, apparatus, and medium for generating critical scenarios in autonomous driving tests are provided. The method includes: generating an initial scenario based on a lane-coordinate system; constructing a one-way single-lane car-following scenario, specifically including: creating a road and vehicles based on the initial scenario, the vehicles including an autonomous vehicle controlled by an intelligent driving model (IDM) and an agent vehicle; constructing a one-way dual-lane cut-in scenario, specifically including: creating a dual-lane road and vehicles based on the initial scenario, the vehicles including an autonomous vehicle controlled by the IDM model and an intelligent-agent vehicle; and generating, based on the constructed one-way single-lane car-following scenario and the constructed one-way dual-lane cut-in scenario, critical scenarios for autonomous-vehicle testing.

Abstract: Antibodies, antigen-binding fragments, and conjugates (e.g., antibody-drug conjugates) thereof that bind CD73 are disclosed. The disclosure further relates to methods and compositions for use in the treatment of, e.g., cancer by administering the compositions provided herein.

Abstract: An apparatus for preparing polyalpha-olefins includes a mixing unit, a microchannel reaction unit, a high-pressure separation unit, a low-pressure separation unit, a gas circulation unit, a post-treatment unit and a pressure control unit, the mixing unit, the microchannel reaction unit, the high-pressure separation unit, the low-pressure separation unit that are successively connected. The gas circulation unit, the microchannel reaction unit is provided with the BF3 gas inlet, the mixing unit is provided with the auxiliary feed inlet, and the olefin raw material inlet, the gas circulation unit is connected with the BF3 gas inlet, the low-pressure separation unit is further connected with the post-treatment unit, and the high-pressure separation unit, the pressure control unit, and the gas circulation unit are further successively connected.

Abstract: The present disclosure provides a 3D vehicle target detection method for fusing image texture features and prior information. Through pixel-level fusion of point clouds and images, the method achieves high-precision and real-time three-dimensional vehicle detection in combination with decision-level fusion of a feature distance and channel attention, improves the detection stability in a complex environment, and is suitable for autonomous driving and intelligent transportation systems.

Abstract: A method may include ocean bottom sensor (OBS) acquisition designed for complex earth model building and imaging with full waveform inversion (FWI) technology. Various combinations of OBS source and receiver patterns, as well as source design may be validated with FWI sensitivity kernel analysis technique. Usually, OBS design is done using conventional methods based on wavelength, frequency requirements, ray tracing and rules of thumps. The method of the disclosed embodiments utilizes OBS design and acquisition combined with FWI sensitivity kernel analysis.

Abstract: A method may include ocean bottom sensor (OBS) acquisition designed for complex earth model building and imaging with full waveform inversion (FWI) technology. Various combinations of OBS source and receiver patterns, as well as source design may be validated with FWI sensitivity kernel analysis technique. Usually, OBS design is done using conventional methods based on wavelength, frequency requirements, ray tracing and rules of thumps. The method of the disclosed embodiments utilizes OBS design and acquisition combined with FWI sensitivity kernel analysis.

Abstract: The present invention provides a class of compounds containing tricyclic heteroaryl groups. Specifically, the present invention provides compounds of the structure represented by the following formula (I) (the definition of each group is described in the specification), pharmaceutical compositions containing the compounds of formula (I), as well as optical isomers, pharmaceutical acceptable salts, prodrugs, deuterated derivatives, hydrates, solvates, etc. The compounds of formula (I) can effectively inhibit protein kinases including CDK and/or TRK, thereby playing a role in the treatment of various tumors and related disease.

Abstract: An integrated platform system that employ a series of machine learning techniques and prediction and detection units that can process input data and extract and generate meaningful insights and predictions therefrom. The system integrates together multiple different data storage types and applications that generates data of different types, and an associated processing system for processing the different data types, store the data in a common data model to normalize the data, determine the data lineage of the data, and then process the data using different types of techniques. The data can also be processed by a prediction unit for generating meaningful insights and predictions or by an anomaly detection unit for detecting one or more anomalies in the data.

Abstract: A method, system, apparatus, and medium for generating critical scenarios in autonomous driving tests are provided. The method includes: generating an initial scenario based on a lane-coordinate system; constructing a one-way single-lane car-following scenario, specifically including: creating a road and vehicles based on the initial scenario, the vehicles including an autonomous vehicle controlled by an intelligent driving model (IDM) and an agent vehicle; constructing a one-way dual-lane cut-in scenario, specifically including: creating a dual-lane road and vehicles based on the initial scenario, the vehicles including an autonomous vehicle controlled by the IDM model and an intelligent-agent vehicle; and generating, based on the constructed one-way single-lane car-following scenario and the constructed one-way dual-lane cut-in scenario, critical scenarios for autonomous-vehicle testing.

Abstract: A method for performing seismic imaging of a subsurface formation includes receiving input data. The method also includes generating a simulated source-side wavefield and a simulated receiver-side wavefield based upon the input data. The method also includes producing an angle gather based upon the simulated source-side wavefield and the simulated receiver-side wavefield. The method also includes utilizing the angle gather in a virtual source term in Born modeling to improve an image quality of the angle gather.

Abstract: The present invention is based, in part, on cancer vaccine compositions that comprise PTEN- and p53-deficient cancer cells with activated TGF?-Smad/p63 signaling pathway, and methods for using same to prevent and/or treat cancer.

Abstract: Disclosed are a light guide device, an optical display system, and a display device. The light guide device includes a substrate and a first diffraction structure provided at the substrate. The first diffraction structure includes a first grating. The first grating includes a plurality of first grating units provided at intervals of a first period P1 along a first vector direction u1 and at intervals of a second period P2 along a second vector direction u2. The first vector direction u1 is intersected with the second vector direction u2, the first period P1 is longer than the second period P2, forming unequal periods in two vector directions, and the first period P1 is at least 1.5 times the second period P2.

Abstract: Embodiments of the present disclosure provide an optical waveguide structure, an optical module and a head-mounted display device; wherein the optical waveguide structure comprises an optical waveguide, and a coupling-out zone and at least two coupling-in zones provided on the optical waveguide; the at least two coupling-in zones are configured for coupling in light of different colors; the coupling-out zone is configured for coupling the light, which has been coupled in through the at least two coupling-in zones, out of the optical waveguide at different field angles, respectively.

Abstract: The invention discloses a point cloud feature recognition and annotation algorithm based on improved PointNet ++. The algorithm includes a supervoxel growth method suitable for deep learning networks and a deep learning network suitable for dense scanning data. This method improves PointNet ++ and constructs a deep learning network suitable for large-scale point cloud recognition. While processing point clouds in each region, it considers the relationship between point clouds in each area, it solves the technical problem that the traditional PointNet series network cannot handle large-scale point clouds. A super-voxel growth method for voxelized point cloud calibration is proposed, which is suitable for determining the characteristic parameters in voxels with a strong resolution, easy calculation, and strong robustness, and realizes fast, efficient, and meaningful voxelized point cloud calibration.