Abstract: Microscopic analysis of a sample includes a fluorescent dye disposed within the sample. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. An optical source generates a probe beam directed to impinge on the sample. A detector detects fluorescent emissions from the sample when the probe beam impinges on the sample. A data acquisition and processing system acquires and processes the detected fluorescent emissions from the sample to: (i) generate a signal indicative of infrared absorption by the sample, (ii) generate a signal indicative of temperature in the sample based on the signal indicative of infrared absorption by the sample, (iii) generate an image of the sample using the signal indicative of temperature in the sample.

Abstract: A lesion detection system for use with a patient, comprising an optoacoustic guide wire assembly configured to be insertable into a patient's tissue. The optical acoustic guide wire assembly can be comprised of an optical waveguide have a first end and a second end, a light source coupled to the second end of the optical waveguide, wherein said light source configured to emit energy to the patient's tissue, at least one transducer configured to detect an ultrasound signal emitted from the patient's tissue in response to energy emitted from the light source, and a computer system.

Abstract: The utility model relates to a noise reduction device for an outlet side of a fan, and a heat exchange system including the noise reduction device. The noise reduction device includes: a connecting portion configured to be connected with at least a part of the air duct cover, and form an accommodation space communicating with an airflow on the outlet side via at least one of the through holes; and at least one first chamber and/or at least one second chamber, the first chamber being located in the accommodation space and filled with a sound-absorbing material, and the second chamber being located in the accommodation space and configured as a resonant noise-reduction cavity. The utility model is easy to manufacture, install and maintain, the noise reduction effect is obvious, and therefore the utility model has significant practicability.

Abstract: An apparatus for preparing polyalpha-olefins has an input unit (1), a microchannel reactor (2), and a post-treatment unit (3) that are successively connected. The input unit has a mixer and/or pipeline(s) for delivering an olefin raw material, an auxiliary feed and a BF3 catalyst to the microchannel reactor (2). The apparatus and process that utilizes the apparatus allow flexible and rapid mixing of the catalyst, the auxiliary feed and the olefin raw material, and have the advantages of high polymerization reaction speed, good mass and heat transfer effects, high reaction conversion, good product selectivity and excellent performance, thereby being suitable for large-scale industrial production.

Abstract: A system for neuromodulation includes a split-ring resonator (SRR) comprising a resonance circuit, the SRR being implantable in a cranial target site and a source of microwave signals, wherein the microwave signals are deliverable wirelessly to couple with the SRR to produce a localized electrical field, wherein the localized electrical field inhibits one or more neurons at the cranial target site with submillimeter spatial precision.

Abstract: Methods of the present invention comprise photoinactivation of catalase in combination with low-concentration peroxide solutions and/or ROS generating agents to provide antibacterial effects.

Abstract: A method for seismic processing includes receiving measured seismic data collected by recording seismic waves that propagate through a subterranean domain, simulating synthetic seismic data using a model of the subterranean domain, generating a first time-space panel including the measured seismic data and a second time-space panel including the synthetic seismic data, applying a first moving window to the first time-space panel and a second moving window to the second time-space panel, determining a misfit by comparing the measured seismic data in the first moving window with the synthetic seismic data in the second moving window, and adjusting the model based on the misfit.

Abstract: The present invention provides a class of compounds containing tricyclic heteroaryl groups. Specifically, the present invention provides compounds of the structure represented by the following formula (I) (the definition of each group is described in the specification), pharmaceutical compositions containing the compounds of formula (I), as well as optical isomers, pharmaceutical acceptable salts, prodrugs, deuterated derivatives, hydrates, solvates, etc. The compounds of formula (I) can effectively inhibit protein kinases including CDK and/or TRK, thereby playing a role in the treatment of various tumors and related disease.

Abstract: A furniture assembly system (10), comprising: a plurality of cross panels (100,100a), wherein each cross panel comprises a plurality of engaging apertures (102) of a right-angle cross shape arranged in one or more rows and one or more columns, with each engaging aperture being separated from an adjacent engaging aperture at a predetermined distance, at least one top panel (300) comprising a plurality of lock-down apertures, at least one support member (200,200a,200b), wherein the or each support member comprises a first interaction edge (201) and a second interaction edge (202) connectable to the cross panel, and a third interaction edge (203) connectable to the top panel, the first interaction edge and the second interaction edge being substantially perpendicular to the third interaction edge, and wherein each of the first interaction edge and the second interaction edge comprises at least one hook joint (210) shaped and sized to be insertable into the engaging aperture of the cross panel and to extend b

Abstract: Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.

Abstract: Systems and methods are provided for performing photothermal dynamic imaging. An exemplary method includes: scanning a sample to produce a plurality of raw photothermal dynamic signals; receiving the raw photothermal dynamic signals of the sample; generating a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise; and performing an inverse operation on the second signals to retrieve at least one thermodynamic signal in a temporal domain.

Abstract: The present invention provides an application of CST1 in prevention and/or treatment of liver immune dysregulation diseases. Specifically, the present invention provides an application of a CST1 gene, or a protein thereof, or a promoter thereof for preparing a composition or a preparation. The composition or the preparation is used for prevention and/or treatment of liver immune dysregulation diseases.

Abstract: A system for neuromodulation includes a split-ring resonator (SRR) comprising a resonance circuit, the SRR being implantable in a cranial target site and a source of microwave signals, wherein the microwave signals are deliverable wirelessly to couple with the SRR to produce a localized electrical field, wherein the localized electrical field inhibits one or more neurons at the cranial target site with submillimeter spatial precision.

Abstract: Microscopic analysis of a sample includes a fluorescent dye disposed within the sample. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. An optical source generates a probe beam directed to impinge on the sample. A detector detects fluorescent emissions from the sample when the probe beam impinges on the sample. A data acquisition and processing system acquires and processes the detected fluorescent emissions from the sample to: (i) generate a signal indicative of infrared absorption by the sample, (ii) generate a signal indicative of temperature in the sample based on the signal indicative of infrared absorption by the sample, (iii) generate an image of the sample using the signal indicative of temperature in the sample.

Abstract: An integrated platform system that employ a series of machine learning techniques and prediction and detection units that can process input data and extract and generate meaningful insights and predictions therefrom. The system integrates together multiple different data storage types and applications that generates data of different types, and an associated processing system for processing the different data types, store the data in a common data model to normalize the data, determine the data lineage of the data, and then process the data using different types of techniques. The data can also be processed by a prediction unit for generating meaningful insights and predictions or by an anomaly detection unit for detecting one or more anomalies in the data.

Abstract: An oil separator and an air conditioning system provided with the oil separator are disclosed by the present disclosure. The oil separator comprises: an inlet (20) configured to receive a refrigerant; a duct (10) through which the refrigerant flows, the duct having a circumferential wall and comprising: a first section comprising a first muffler adjacent to the inlet, the first muffler (60) comprising a chamber (11) defined by a first wall (13) of the first section and designed to have a length dimension (L) in a length direction of the duct and a depth dimension (H) intersecting the length dimension; and a second section downstream of the first section, a second wall (23) of the second section being provided with a second muffler (70); and an oil separation assembly (80,90) through which the refrigerant passing through the duct passes. The present disclosure has a simple and reliable structure and is easy to implement.

Abstract: Systems and methods for detecting photothermal effect in a sample are described herein. In these systems and methods, a pump source is configured to generate a pump pulse train, a probe source is configured to generate a probe pulse train and is synchronized with the pump pulse train, and a camera collects the resulting data. The camera is configured to collect a first signal corresponding to a hot frame, wherein the hot frame includes visible probe beam as modified by a pump beam and a second signal corresponding to a cold frame, wherein the cold frame includes visible probe beam that has not been modified by a pump beam. A processor can subtract the second signal from the first signal to detect the photothermal effect.

Abstract: A system determines an object part density relative to a build region in a layer of build material used in an additive manufacturing machine, the object part density based on a relative portion of the build region where an energy absorbing agent is applied. The system controls a thermal characteristic of the build region in the layer of build material based on the determined object part density.

Abstract: A system for neuromodulation includes a split-ring resonator (SRR) comprising a resonance circuit, the SRR being implantable in a cranial target site and a source of microwave signals, wherein the microwave signals are deliverable wirelessly to couple with the SRR to produce a localized electrical field, wherein the localized electrical field inhibits one or more neurons at the cranial target site with submillimeter spatial precision.

Abstract: Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sensitivity and sub-micron lateral spatial resolution. Such performance exceeds the diffraction limit of infrared microscopy and allows label-free three-dimensional chemical imaging of live cells and organisms. Distributions of endogenous lipid and exogenous drug inside single cells can be visualized. MIP imaging technology may enable applications from monitoring metabolic activities to high-resolution mapping of drug molecules in living systems, which are beyond the reach of current infrared microscopy.