Abstract: Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sensitivity and sub-micron lateral spatial resolution. Such performance exceeds the diffraction limit of infrared microscopy and allows label-free three-dimensional chemical imaging of live cells and organisms. Distributions of endogenous lipid and exogenous drug inside single cells can be visualized. MIP imaging technology may enable applications from monitoring metabolic activities to high-resolution mapping of drug molecules in living systems, which are beyond the reach of current infrared microscopy.

Abstract: According to examples, an apparatus may include a processor and a memory on which are stored machine-readable instructions that when executed by the processor, may cause the processor to identify a first orientation of a first surface portion of a three-dimensional (3D) model. The instructions may also cause the processor to, based on the identified first orientation of the first surface portion, determine a first thickness of a first section of a first geological region of the 3D model, the first section being adjacent to the first surface portion, in which a plurality of different orientations of 3D model surface portions are correlated to a plurality of different thicknesses. The instructions may further cause the processor to define the first section of the first geological region to have the determined first thickness.

Abstract: Microscopic analysis of a sample includes a fluorescent dye disposed within the sample. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. An optical source generates a probe beam directed to impinge on the sample. A detector detects fluorescent emissions from the sample when the probe beam impinges on the sample. A data acquisition and processing system acquires and processes the detected fluorescent emissions from the sample to: (i) generate a signal indicative of infrared absorption by the sample, (ii) generate a signal indicative of temperature in the sample based on the signal indicative of infrared absorption by the sample, (iii) generate an image of the sample using the signal indicative of temperature in the sample.

Abstract: The invention provides compounds of formula (I) as shown below, including their possible enantiomers and diastereomers, as well as pharmaceutically acceptable salts, hydrates or solvates thereof. The invention also provides pharmaceutical compositions of these compounds, methods for their preparation, and their use in the treatment of diseases and disorders (including cancers).

Abstract: Systems and methods implement of high-speed delay scanning for spectroscopic SRS imaging characterized by scanning a first pulsed beam across a stepwise reflective surface (such as a stepwise mirror or a reflective blazed grating) in a Littrow configuration to generate near continuous temporal delays relative to a second pulsed beam. Systems and methods also implement deep learning techniques for image restoration of spectroscopic SRS images using a trained encoder-decoder convolution neural network (CNN) which in some embodiments may be designed as a spatial-spectral residual net (SS-ResNet) characterized by two parallel filters including a first convolution filter on the spatial domain and a second convolution filter on the spectral domain.

Abstract: The invention provides compounds of formula (I) as shown below, as well as pharmaceutically acceptable salts, hydrates or solvates thereof. The invention also provides pharmaceutical compositions of these compounds, methods for their preparation, and their use in the treatment of diseases and disorders (including cancers).

Abstract: The utility model relates to a noise reduction device for an outlet side of a fan, and a heat exchange system including the noise reduction device. The noise reduction device includes: a connecting portion configured to be connected with at least a part of the air duct cover, and form an accommodation space communicating with an airflow on the outlet side via at least one of the through holes; and at least one first chamber and/or at least one second chamber, the first chamber being located in the accommodation space and filled with a sound-absorbing material, and the second chamber being located in the accommodation space and configured as a resonant noise-reduction cavity. The utility model is easy to manufacture, install and maintain, the noise reduction effect is obvious, and therefore the utility model has significant practicability.

Abstract: A method for the determination of antibiotic susceptibility through stimulated Raman scattering microscopy is disclosed. The method utilizes a imaging apparatus adapted to collect a laser signal through a sample having a bacteria for imaging the metabolism of the sample. The sample can be manipulated with an antibiotic for imaging to determine the susceptibility of a bacteria to the provided antibiotic.

Abstract: In example implementations, an apparatus is provided. The apparatus includes a dispense element, a memory, and a processor. The dispense element dispense a fusing agent onto a build material. The memory stores an absorption level decay data of the fusing agent and at least one adjustment recipe. The processor is communicatively coupled to the dispense element, and the memory. The processor controls the dispense element to dispense the fusing agent based on an adjustment recipe of the at least one adjustment recipe that is selected. The adjustment recipe is selected based on an absorption level determined from the absorption level decay data and an age of the fusing agent.

Abstract: A method includes directing a first plurality of probe laser pulses through a sample, dividing each of the first plurality of probe laser pulses to generate a first interferogram, and generating first image data reproducible as a first phase image of the sample. A plurality of pump laser bursts are directed onto the sample to heat the sample. A second plurality of probe laser pulses are directed through the sample at a predetermined time delay. Each of the second plurality of probe laser pulses are divided to generate a second interferogram. Second image data is generated that is reproducible as a second phase image of the sample. A transient phase shift is determined in the second phase image relative to the first phase image. A vibrational spectroscopy property is determined of the sample based on the transient phase shift, thereby allowing an identification of chemical bond information of within the sample.

Abstract: An oil separator and an air conditioning system provided with the oil separator are disclosed by the present disclosure. The oil separator comprises: an inlet (20) configured to receive a refrigerant; a duct (10) through which the refrigerant flows, the duct having a circumferential wall and comprising: a first section comprising a first muffler adjacent to the inlet, the first muffler (60) comprising a chamber (11) defined by a first wall (13) of the first section and designed to have a length dimension (L) in a length direction of the duct and a depth dimension (H) intersecting the length dimension; and a second section downstream of the first section, a second wall (23) of the second section being provided with a second muffler (70); and an oil separation assembly (80,90) through which the refrigerant passing through the duct passes. The present disclosure has a simple and reliable structure and is easy to implement.

Abstract: Methods of the present invention comprise photoinactivation of catalase in combination with low-concentration peroxide solutions and/or ROS generating agents to provide antibacterial effects.

Abstract: A display system includes an optical device configured according to constructive interference for a plurality of wavelengths at a focal length. The display system includes a fiber. The display system includes a controller configured to scan the fiber using a Lissajous scanning method to generate a display. The display can be disposed within a focal plane of the optical device. The controller is configured to modulate light intensity from the fiber. The controller can be configured to form a display image that passes through the optical device. The display system can include an optical combiner configured to reflect the display image from the optical device and form a virtual image. The optical device can be configured to magnify a display image from the display and form a virtual image.

Abstract: In one example, a control process for an additive manufacturing machine includes displacing a platform, measuring the actual displacement of the platform, determining that the actual displacement varies from a nominal displacement, and determining an amount of an agent to be applied to build material layered on the displaced platform based on the determined variation.

Abstract: A system determines an object part density relative to a build region in a layer of build material used in an additive manufacturing machine, the object part density based on a relative portion of the build region where an energy absorbing agent is applied. The system controls a thermal characteristic of the build region in the layer of build material based on the determined object part density.

Abstract: A photoacoustic catheter includes an elongated catheter body and a housing positioned near a distal end of the elongated catheter body. A length of multimode fiber extends through the elongated catheter body and has a distal end that is beveled at about 45° relative to a longitudinal axis of the multimode fiber and is positioned in the housing. An ultrasonic transducer, electrically connected to an electrical wire extending along the elongated catheter body, is positioned within the housing. A mirror element is also positioned within the housing and includes a mirror surface beveled at about 45° relative to the longitudinal axis of the multimode fiber. The catheter is operable to deliver an optical wave through the multimode fiber and to deliver an ultrasonic wave collinearly from the housing and out of an aperture of the housing to obtain optical data and ultrasonic data within a mammalian luminal organ.

Abstract: Methods of the present invention comprise photoinactivation of catalase in combination with low-concentration peroxide solutions and/or ROS generating agents to provide antibacterial effects.

Abstract: A multimodal ultrasound/photoacoustic tumor margin detection system. The system can be comprised of an imaging and system control console, which can include an ultrasound and data acquisition subsystem including an ultrasound transmitter and receiver configured to transmit and receive ultrasonic energy. A host-control computer configured to provide a function generator function and a delay generation function can also be a part of the imaging and system control console.

Abstract: Systems and methods implement of high-speed delay scanning for spectroscopic SRS imaging characterized by scanning a first pulsed beam across a stepwise reflective surface (such as a stepwise mirror or a reflective blazed grating) in a Littrow configuration to generate near continuous temporal delays relative to a second pulsed beam. Systems and methods also implement deep learning techniques for image restoration of spectroscopic SRS images using a trained encoder-decoder convolution neural network (CNN) which in some embodiments may be designed as a spatial-spectral residual net (SS-ResNet) characterized by two parallel filters including a first convolution filter on the spatial domain and a second convolution filter on the spectral domain.

Abstract: In an example, a method includes receiving, at a processor, a data model of an object to be generated in additive manufacturing. A virtual build volume comprising a representation of at least a portion of the object may be segmented into a plurality of nested segments comprising a core segment and a peripheral segment. Segmenting the virtual build volume may comprise determining a dimension of the peripheral segment based on at least one of a geometry of the object and an intended object property.