Patents by Inventor Xin Cheng

Xin Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240255419
    Abstract: A system and method for characterizing biological activity in a live cell using a mid-infrared photothermal system and at least one molecular probe. A mid-infrared optical source generates a mid-infrared beam, the mid-infrared beam being directed at the sample to induce a thermal effect. A visible light source generates a light, the light illuminating the sample on the substrate. An optical detector collects the light after interaction with the sample. Biological activity in the sample is characterized based on a spectral shift. Each molecular probe includes an substrate and a chemical functional group.
    Type: Application
    Filed: January 26, 2024
    Publication date: August 1, 2024
    Applicant: Trustees of Boston University
    Inventors: Ji-Xin Cheng, Hongjian He
  • Publication number: 20240255429
    Abstract: A stimulated Raman photothermal (SRP) microscope for imaging a sample. A first optical source omits an intensity-modulated pump beam. A second optical source omits an intensity-modulated Stokes beam. The Stokes beam is combined with the pump beam to form a combined beam. The combined beam is directed to the sample to induce a thermal effect caused by the stimulated Raman process. A third optical source emits a probe beam, the probe beam is directed to the sample. An optical detector detects modulation of the probe beam after modulation by the sample to measure an SRP signal.
    Type: Application
    Filed: January 26, 2024
    Publication date: August 1, 2024
    Applicant: Trustees of Boston University
    Inventor: Ji-Xin Cheng
  • Publication number: 20240248030
    Abstract: Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sensitivity and sub-micron lateral spatial resolution. Such performance exceeds the diffraction limit of infrared microscopy and allows label-free three-dimensional chemical imaging of live cells and organisms. Distributions of endogenous lipid and exogenous drug inside single cells can be visualized. MIP imaging technology may enable applications from monitoring metabolic activities to high-resolution mapping of drug molecules in living systems, which are beyond the reach of current infrared microscopy.
    Type: Application
    Filed: January 30, 2024
    Publication date: July 25, 2024
    Inventors: Delong Zhang, Ji-Xin Cheng
  • Patent number: 12019596
    Abstract: An integrated platform system that employ a series of machine learning techniques and prediction and detection units that can process input data and extract and generate meaningful insights and predictions therefrom. The system integrates together multiple different data storage types and applications that generates data of different types, and an associated processing system for processing the different data types, store the data in a common data model to normalize the data, determine the data lineage of the data, and then process the data using different types of techniques. The data can also be processed by a prediction unit for generating meaningful insights and predictions or by an anomaly detection unit for detecting one or more anomalies in the data.
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: June 25, 2024
    Assignee: KPMG LLP
    Inventors: Niels Hanson, James Johnson Gardner, Punit S. Orpe, Wendy Du, Laurence Anthony Brown, Ranjan Vivek Mannige, David Green, Michael Ahn, Yang Zhou, Andrew Yuan, Adam Helio Rosa, Kyle B. Chen, Alex Perusse, Christian Alexander Manaog, Yeshwanth Somu, Xin Cheng, Torey C. Bearly, Raghav Saboo, Sphoorthy Pamaraju, Erik Ernst, Can Ozuretmen, Yuan Zhang
  • Publication number: 20240184831
    Abstract: A client device is provided with access to an electronic document using a user interface (UI) for a first application. The electronic document includes a reference to data associated with a second application. Upon detection of a first user interaction with a UI element associated with the reference to the data, the UI for the first application is updated to include, in the electronic document, at least a portion of the data associated with the second application. A request is received to modify data associated with the second application based on a second user interaction with the at least the portion of the data included in the electronic document. An instruction is transmitted to a computing system associated with the second application to modify the at least the portion of the data in accordance with the request.
    Type: Application
    Filed: November 30, 2023
    Publication date: June 6, 2024
    Inventors: Behnoosh Hariri, Yu Xin Cheng, Sebastian Marcin Kozlowski, Miles Henrichs, Juntae Park, Gregory George Galante, Donald Howard, Dennis Jing Jing Liang, Bikin Chiu
  • Patent number: 11994687
    Abstract: A display system includes an optical device configured according to constructive interference for a plurality of wavelengths at a focal length. The display system includes a fiber. The display system includes a controller configured to scan the fiber using a Lissajous scanning method to generate a display. The display can be disposed within a focal plane of the optical device. The controller is configured to modulate light intensity from the fiber. The controller can be configured to form a display image that passes through the optical device. The display system can include an optical combiner configured to reflect the display image from the optical device and form a virtual image. The optical device can be configured to magnify a display image from the display and form a virtual image.
    Type: Grant
    Filed: May 5, 2021
    Date of Patent: May 28, 2024
    Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Zhaoyi Li, Yao-Wei Huang, Peng Lin, Ji-Xin Cheng, Federico Capasso
  • Publication number: 20240159667
    Abstract: Systems and methods for detecting photothermal effect in a sample are described herein. In these systems and methods, a pump source is configured to generate a pump pulse train, a probe source is configured to generate a probe pulse train and is synchronized with the pump pulse train, and a camera collects the resulting data. The camera is configured to collect a first signal corresponding to a hot frame, wherein the hot frame includes visible probe beam as modified by a pump beam and a second signal corresponding to a cold frame, wherein the cold frame includes visible probe beam that has not been modified by a pump beam. A processor can subtract the second signal from the first signal to detect the photothermal effect.
    Type: Application
    Filed: November 16, 2023
    Publication date: May 16, 2024
    Inventors: Ji-Xin CHENG, Yeran BAI, Delong ZHANG, Ali SHAKOURI, D. Kerry MAIZE
  • Patent number: 11982615
    Abstract: Systems and methods are provided for performing photothermal dynamic imaging. An exemplary method includes: scanning a sample to produce a plurality of raw photothermal dynamic signals; receiving the raw photothermal dynamic signals of the sample; generating a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise; and performing an inverse operation on the second signals to retrieve at least one thermodynamic signal in a temporal domain.
    Type: Grant
    Filed: March 28, 2023
    Date of Patent: May 14, 2024
    Assignee: Trustees of Boston University
    Inventors: Ji-Xin Cheng, Lu Lan, Jiaze Yin
  • Publication number: 20240150374
    Abstract: Described herein are KAT6A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with KAT6A.
    Type: Application
    Filed: November 13, 2023
    Publication date: May 9, 2024
    Inventors: Xin CHENG, Luoheng QIN, Feng REN
  • Patent number: 11976646
    Abstract: A microfluidic chip pump is provided. The microfluidic chip pump may include: a pump housing comprising a pump cavity, a moveable member arranged in the pump cavity, separating the pump cavity into a first chamber and a second chamber; and an actuator assembly configured to drive the moveable member between a first stable position and a second stable position, changing a volume of the first chamber and a volume of the second chamber. When the moveable member is at the first stable position, the first chamber may reach a minimum volume. When the moveable member is at the second stable position, the first chamber may reach a maximum volume. The microfluidic chip pump may be configured to expel a fixed volume of fluid from the second chamber each time the moveable member is driven from the first stable position to the second stable position.
    Type: Grant
    Filed: April 14, 2022
    Date of Patent: May 7, 2024
    Assignee: HEALTELL (GUANGZHOU) MEDICAL TECHNOLOGY CO., LTD
    Inventors: Xin Cheng, Hanguang Zhao, Youwei Jiang, Bob Xu, Yu Liu, Rifei Chen
  • Patent number: 11959982
    Abstract: A low-cost modular liquid nitrogen low-temperature multi-nuclear magnetic resonance probe includes a Dewar, a pluggable coil and a front-end gain amplifier. The Dewar includes a cylindrical sandwich chamber, the center of the cylindrical sandwich chamber constitutes a room-temperature chamber, a sandwich of the cylindrical sandwich chamber is divided into a vacuum chamber and a liquid nitrogen chamber by a liquid nitrogen vessel wall, the vacuum chamber is located between the room-temperature chamber and the liquid nitrogen chamber, the pluggable coil and the front-end gain amplifier are provided in the vacuum chamber, the pluggable coil comprises a coil portion and a pluggable base, the coil portion is in pluggable connection with the pluggable base, and the pluggable coil is connected with the front-end gain amplifier. The probe realizes the transmission of radio frequency pulses and the reception of magnetic resonance signals, and is applicable to whole-body imaging of a small animal.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: April 16, 2024
    Assignee: INNOVATION ACADEMY FOR PRECISION MEASUREMENT SCIENCE AND TECHNOLOGY, CAS
    Inventors: Zhi Zhang, Qingjia Bao, Chaoyang Liu, Xinjie Liu, Fang Chen, Jiaxin Wang, Xin Cheng, Maili Liu
  • Publication number: 20240116899
    Abstract: The disclosure provides for compounds and methods for modulating or inhibiting glutaminyl-peptide cyclotransferase-like protein (QPCTL). In one aspect, described herein are compounds of Formulas (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), and (IIbb), stereoisomer thereof, or salts or solvates thereof. Further provided herein are methods of treating a disease or a condition comprising administering a compound of Formula (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), or (IIbb), a stereoisomer thereof, or a salt or solvate thereof.
    Type: Application
    Filed: August 23, 2023
    Publication date: April 11, 2024
    Inventors: Xin CHENG, Yingtao LIU, Luoheng QIN
  • Publication number: 20240109880
    Abstract: Described herein are KAT6A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with KAT6A.
    Type: Application
    Filed: October 13, 2023
    Publication date: April 4, 2024
    Inventors: Xin CHENG, Luoheng QIN, Feng REN
  • Patent number: 11940380
    Abstract: Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sensitivity and sub-micron lateral spatial resolution. Such performance exceeds the diffraction limit of infrared microscopy and allows label-free three-dimensional chemical imaging of live cells and organisms. Distributions of endogenous lipid and exogenous drug inside single cells can be visualized. MIP imaging technology may enable applications from monitoring metabolic activities to high-resolution mapping of drug molecules in living systems, which are beyond the reach of current infrared microscopy.
    Type: Grant
    Filed: February 21, 2023
    Date of Patent: March 26, 2024
    Assignee: Purdue Research Foundation
    Inventors: Delong Zhang, Ji-Xin Cheng
  • Publication number: 20240085502
    Abstract: A low-cost modular liquid nitrogen low-temperature multi-nuclear magnetic resonance probe includes a Dewar, a pluggable coil and a front-end gain amplifier. The Dewar includes a cylindrical sandwich chamber, the center of the cylindrical sandwich chamber constitutes a room-temperature chamber, a sandwich of the cylindrical sandwich chamber is divided into a vacuum chamber and a liquid nitrogen chamber by a liquid nitrogen vessel wall, the vacuum chamber is located between the room-temperature chamber and the liquid nitrogen chamber, the pluggable coil and the front-end gain amplifier are provided in the vacuum chamber, the pluggable coil comprises a coil portion and a pluggable base, the coil portion is in pluggable connection with the pluggable base, and the pluggable coil is connected with the front-end gain amplifier. The probe realizes the transmission of radio frequency pulses and the reception of magnetic resonance signals, and is applicable to whole-body imaging of a small animal.
    Type: Application
    Filed: November 10, 2021
    Publication date: March 14, 2024
    Applicant: INNOVATION ACADEMY FOR PRECISION MEASUREMENT SCIENCE AND TECHNOLOGY, CAS
    Inventors: Zhi ZHANG, Qingjia BAO, Chaoyang LIU, Xinjie LIU, Fang CHEN, Jiaxin WANG, Xin CHENG, Maili LIU
  • Patent number: 11926101
    Abstract: According to examples, an apparatus may include a processor and a memory on which are stored machine-readable instructions that when executed by the processor, may cause the processor to identify a property of a portion of a three-dimensional (3D) part to be fabricated and determine, based on the identified property, a thermal value associated with the portion. The instructions may also cause the processor to, based on the determined thermal value, determine a first agent composition to be used to fabricate the portion and determine a second agent composition to be used to fabricate a section external and adjacent to the portion, in which the first agent composition and the second agent composition may be determined to cause the portion and the external section to be fabricated to have the identified property while maintaining the external section separate from the portion.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: March 12, 2024
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Jacob Wright, Matthew A. Shepherd, Vanessa Verzwyvelt, Xin Cheng
  • Patent number: 11913881
    Abstract: An example microscope includes a pump laser for providing a first illumination to a sample. A laser array provides a second illumination to the sample. The laser array may include a plurality of laser elements, each providing oblique illuminations to the sample. An illumination collecting source collects the first illumination and the second illumination from the sample. The illumination collecting source may capture transient 3D refractive index (RI) variations in the sample due to the first illumination and second illumination.
    Type: Grant
    Filed: January 23, 2023
    Date of Patent: February 27, 2024
    Assignee: Trustees of Boston University
    Inventors: Ji-Xin Cheng, JIan Zhao, Lei Tian, Alex Matlock
  • Publication number: 20240053264
    Abstract: A mid-infrared photothermal microscopy system images a sample. A mid-infrared optical source generates a mid-infrared beam which is directed along a first optical path to reach the substrate on a first side and heat the sample. A probe light source generates a probe light which is directed along a second optical path to reach the substrate on a second side and illuminate the sample. A first laser scanner is positioned along the first optical path and configured to rotate to redirect light and scan the sample with the mid-infrared beam. A second laser scanner is positioned along the second optical path and configured to rotate to redirect light and scan the sample with the probe light. The laser scanners each include at least one mirror driven to rotate such that the mid-infrared beam and the probe light scan the sample synchronously.
    Type: Application
    Filed: August 15, 2023
    Publication date: February 15, 2024
    Applicant: Trustees of Boston University
    Inventors: Ji-Xin Cheng, Lu Lan, Jiaze Yin
  • Publication number: 20240035979
    Abstract: Systems and methods implement of high-speed delay scanning for spectroscopic SRS imaging characterized by scanning a first pulsed beam across a stepwise reflective surface (such as a stepwise mirror or a reflective blazed grating) in a Littrow configuration to generate near continuous temporal delays relative to a second pulsed beam. Systems and methods also implement deep learning techniques for image restoration of spectroscopic SRS images using a trained encoder-decoder convolution neural network (CNN) which in some embodiments may be designed as a spatial-spectral residual net (SS-ResNet) characterized by two parallel filters including a first convolution filter on the spatial domain and a second convolution filter on the spectral domain.
    Type: Application
    Filed: August 17, 2023
    Publication date: February 1, 2024
    Applicant: Trustees of Boston University
    Inventors: Ji-Xin Cheng, Haonan Lin
  • Patent number: 11883344
    Abstract: An example photoacoustic system for neurostimulation includes a light producing device for producing light of a specific wavelength. At least one nanotransducer is binded on a surface of a neuron. The nanotransducer converts the light with the specific wavelength into at least one acoustic wave at or near the neuron.
    Type: Grant
    Filed: January 30, 2023
    Date of Patent: January 30, 2024
    Assignee: Trustees of Boston University
    Inventors: Chen Yang, Ji-Xin Cheng