Patents by Inventor Xin Gao

Xin Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11213591
    Abstract: The present disclosure belongs to the field of pharmaceutical preparations and relates to the design of a series of lipophilic derivatives by using wild-type penetrating peptide penetratin. These penetratin derivatives have a strong ability to penetrate the ocular tissues and do not cause ocular tissue toxicity. As ocular absorption enhancers, non-invasive routes could be used to achieve intraocular drug delivery and increase the ocular bioavailability of drugs. These penetratin derivatives and the ophthalmic drug delivery system constructed by them are used for eye drop administration, which could replace the intraocular injection with poor patients compliance, which greatly enhances the convenience and safety of the treatment of intraocular and fundus diseases.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: January 4, 2022
    Assignee: FUDAN UNIVERSITY
    Inventors: Gang Wei, Kuan Jiang, Weiyue Lu, Chang Liu, Lingyu Tai, Xin Gao
  • Publication number: 20210398605
    Abstract: A method for training a deep neural network model based on a known genome sequence includes receiving the known genome sequence; training the deep neural network model with a current negative set obtained from the known genome sequence; applying the deep neural network model to the known genome sequence and recording false positive sets; selecting a subset of the new false positive sets; updating the current negative set with the new false positive sets; and repeating the steps of training, applying, selecting and updating until a number of the new false positive sets is smaller than a given threshold.
    Type: Application
    Filed: October 24, 2019
    Publication date: December 23, 2021
    Inventors: Xin GAO, Ramzan UMAROV
  • Publication number: 20210394662
    Abstract: An intelligent transfer vehicle for shared bicycles includes: a cockpit, a vehicle body platform, shared bicycle parking racks, a wheeled device, a power source unit, and a vehicle-mounted unit. The intelligent transfer vehicle combines the function of a parking platform and a transfer platform into one, and can have three transfer modes to reduce reliance on a dispatch center, save costs and improve transfer efficiency.
    Type: Application
    Filed: May 28, 2021
    Publication date: December 23, 2021
    Inventors: Fang DENG, Xiang SHI, Wenjie CHEN, Xiaobo WU, Xinyu FAN, Lele ZHANG, Li LIANG, Xin GAO, Xianghu YUE, Ziman YE, Feng GAO
  • Publication number: 20210388077
    Abstract: The present application provides a multispecific antibody and preparation method and use thereof. The multispecific antibody comprises: a) a Fab fragment specifically binding to a first antigen, wherein the Fab fragment consists of a light chain and CH1 and a variable region of a heavy chain; b) a first peptide linker with the N-terminal end fused to the heavy chain; c) a second peptide linker with the N-terminal end fused to the light chain, wherein only one disulfide bond can be formed between the first and the second peptide linkers, and each of the first and the second peptide linkers is independently selected from the group consisting of a peptide linker comprising any of the sequences as set forth in SEQ ID NO. 1-2, wherein X represents any amino acid other than Cys, or is absent. The antibody can be readily produced by recombinant expression and can simultaneously target two different antigens or different epitopes of the same antigen, or multiple epitopes of more different antigens.
    Type: Application
    Filed: July 8, 2020
    Publication date: December 16, 2021
    Inventor: Xin GAO
  • Publication number: 20210350876
    Abstract: A method for similarity searching directly on nanopore raw current signals, the method including receiving a reference genome sequence; receiving a query genome sequence; transforming the reference genome sequence, with a nanopore sequencing device, into a raw current signal X; transforming the query genome sequence, based on a pore model, into a query current signal Y; and mapping the query current signal Y to the raw current signal X based on a subsequence extension of dynamic time warping distance Dist, which calculates a distance between the raw current signal X and a padded signal query Y?. The padded signal query Y? is the query current signal Y to which an element y0 has been added, the raw current signal X and the query current signal Y are electrical currents, and the raw current signal X corresponds to a genome of an organism.
    Type: Application
    Filed: October 16, 2019
    Publication date: November 11, 2021
    Inventors: Xin GAO, Sheng WANG, Renmin HAN
  • Publication number: 20210317523
    Abstract: A method for sequencing biopolymers. The method includes selecting with a sequence generator module an input nucleotide sequence having plural k-mers; simulating with a deep learning simulator, actual electrical current signals corresponding to the input nucleotide sequence; identifying reads that correspond to the actual electrical current signals; and displaying the reads. The deep learning simulator includes a context-dependent deep learning model that takes into consideration a position of a k-mer of the plural k-mers on the input nucleotide sequence when calculating a corresponding actual electrical current.
    Type: Application
    Filed: June 23, 2021
    Publication date: October 14, 2021
    Inventors: Xin GAO, Yu LI, Sheng WANG, Renmin HAN
  • Patent number: 11142753
    Abstract: The present invention discloses a ?-galactosidase mutant, and a preparation method and application thereof, belonging to the fields of gene engineering and enzyme engineering. Amino acids of specific sites in the ?-galactosidase are mutated, the ?-galactosidase is transferred into a recombinant bacterium, and enzymatic transformation is performed under optimized conditions, so that the yield of galactooligosaccharide produced by the mutant reaches 59.8%, which is increased by about 70% as compared with that of wild enzyme, thereby implementing the increase of the galactooligosaccharide yield. The present invention has very high industrialized application value.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: October 12, 2021
    Assignee: JIANGNAN UNIVERSITY
    Inventors: Jing Wu, Dan Wu, Xin Gao
  • Patent number: 11127285
    Abstract: A method for improved traffic congestion estimation is provided using signal phase and timing data from traffic signals at intersections and probe data from vehicles traversing said intersections. An example method may include: identifying each of a plurality of paths through an intersection; identifying signal phase and timing data for each traffic light associated with each path through the intersection; receiving probe data for vehicles approaching or traversing the intersection; estimating a number of vehicles failing to traverse the intersection along a path through the intersection; estimating a congestion status of the path through the intersection based on the number of vehicles failing to traverse the intersection; and causing the congestion status to be provided to permit updating of a map to reflect the congestion status.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: September 21, 2021
    Assignee: HERE GLOBAL B.V.
    Inventors: Jingwei Xu, Xin Gao, Weimin Huang, Bruce Bernhardt
  • Patent number: 11093854
    Abstract: The present disclosure provides an emoji recommendation method and device.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: August 17, 2021
    Assignee: BEIJING XINMEI HUTONG TECHNOLOGY CO., LTD.
    Inventors: Xin Gao, Li Zhou, Xinyong Hu
  • Patent number: 11078531
    Abstract: A method for sequencing biopolymers. The method includes selecting with a sequence generator module an input nucleotide sequence having plural k-mers; simulating with a deep learning simulator, actual electrical current signals corresponding to the input nucleotide sequence; identifying reads that correspond to the actual electrical current signals; and displaying the reads. The deep learning simulator includes a context-dependent deep learning model that takes into consideration a position of a k-mer of the plural k-mers on the input nucleotide sequence when calculating a corresponding actual electrical current.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: August 3, 2021
    Assignee: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Xin Gao, Yu Li, Sheng Wang, Renmin Han
  • Patent number: 11053475
    Abstract: Described herein are methods of expanding a population of hematopoietic stem cells by contacting the population of hematopoietic stem cells with an effective amount of an inhibitor of G-protein coupled receptor 65 (GPR65) and providing a population of expanded, substantially undifferentiated hematopoietic stem cells. Exemplary GPR65 inhibitors include siRNAs and certain sphingolipids. Also described are populations of expanded hematopoietic stem cells produced by the methods, media and kits containing GPR65 inhibitors, and methods for administering an expanded population of hematopoietic stem cells to patients.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: July 6, 2021
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Emery H. Bresnick, Xin Gao, Kirby D. Johnson
  • Publication number: 20210151666
    Abstract: A semiconductor device includes a first magnetic tunneling junction (MTJ) and a second MTJ on a substrate, a passivation layer on the first MTJ and the second MTJ, and an ultra low-k (ULK) dielectric layer on the passivation layer. Preferably, a top surface of the passivation layer between the first MTJ and the second MTJ is lower than a top surface of the passivation layer directly on top of the first MTJ.
    Type: Application
    Filed: January 4, 2021
    Publication date: May 20, 2021
    Inventors: Hui-Lin Wang, Tai-Cheng Hou, Wei-Xin Gao, Fu-Yu Tsai, Chin-Yang Hsieh, Chen-Yi Weng, Jing-Yin Jhang, Bin-Siang Tsai, Kun-Ju Li, Chih-Yueh Li, Chia-Lin Lu, Chun-Lung Chen, Kun-Yuan Liao, Yu-Tsung Lai, Wei-Hao Huang
  • Publication number: 20210135625
    Abstract: A photovoltaic array fault diagnosis method based on composite information is provided. The method includes: collecting and preprocessing composite information data of photovoltaic array working state, including image data and text data; using the image data of photovoltaic array working state to train a pre-established fault classification model of deep convolutional neural network, to thereby obtain an image fault classification model; using the text data of photovoltaic array working state to train a pre-established fault classification model based on a support vector machine, to thereby obtain a text fault classification model; fusing the image fault classification model and the text fault classification model by logistic regression algorithm to obtain a fusion model, and training the fusion model using the composite information data of photovoltaic array working state to thereby obtain the photovoltaic array fault diagnosis model.
    Type: Application
    Filed: November 9, 2020
    Publication date: May 6, 2021
    Inventors: Fang DENG, Zelang LIANG, Ning DING, Xinyu FAN, Xin GAO, Yuyun CAI, Jie CHEN
  • Publication number: 20210125579
    Abstract: Disclosed is a calibration device and calibration method for display panel brightness-uniformity.
    Type: Application
    Filed: October 23, 2020
    Publication date: April 29, 2021
    Inventors: ZHEN-XIN GAO, HONG-YANG GE
  • Publication number: 20210119115
    Abstract: A method for fabricating semiconductor device includes the steps of: forming a first magnetic tunneling junction (MTJ) on a substrate; forming a first ultra low-k (ULK) dielectric layer on the first MTJ; performing a first etching process to remove part of the first ULK dielectric layer and forming a damaged layer on the first ULK dielectric layer; and forming a second ULK dielectric layer on the damaged layer.
    Type: Application
    Filed: December 27, 2020
    Publication date: April 22, 2021
    Inventors: Hui-Lin Wang, Tai-Cheng Hou, Wei-Xin Gao, Fu-Yu Tsai, Chin-Yang Hsieh, Chen-Yi Weng, Jing-Yin Jhang, Bin-Siang Tsai, Kun-Ju Li, Chih-Yueh Li, Chia-Lin Lu, Chun-Lung Chen, Kun-Yuan Liao, Yu-Tsung Lai, Wei-Hao Huang
  • Publication number: 20210090689
    Abstract: Embodiments of the present disclosure describe a fingerprint contribution method for predicting a Gibbs free energy of biochemical reactions, methods of training a fingerprint contribution model for predicting a Gibbs free energy of biochemical reactions, methods of predicting a Gibbs free energy of biochemical reactions, a non-transitory computer readable medium comprising instructions which, when read by a computing device, cause a processor to execute a method for predicting a Gibbs free energy of biochemical reactions, and the like.
    Type: Application
    Filed: January 8, 2019
    Publication date: March 25, 2021
    Inventors: Xin GAO, Meshari Saud ALAZMI, Hiroyuki KUWAHARA
  • Publication number: 20210082162
    Abstract: A method for image reconstruction from plural copies, the method including receiving a series of measured projections pi of a target object h and associated background; iteratively reconstructing images hi(k) of the target object and images gi(k) of the background of the target object for each member i of the series of the measured projections pi over plural iterations k; and generating a final image of the target object h, based on the reconstructed images hi, when a set condition is met. The index i describes how many elements are in the series of projections pi, and iteration k indicates how many times the reconstruction of the image target is performed.
    Type: Application
    Filed: March 19, 2019
    Publication date: March 18, 2021
    Inventors: Xin GAO, Renmin HAN
  • Patent number: 10916694
    Abstract: A method for fabricating semiconductor device includes the steps of: forming a first magnetic tunneling junction (MTJ) on a substrate; forming a first ultra low-k (ULK) dielectric layer on the first MTJ; performing a first etching process to remove part of the first ULK dielectric layer and forming a damaged layer on the first ULK dielectric layer; and forming a second ULK dielectric layer on the damaged layer.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: February 9, 2021
    Assignee: UNITED MICROELECTRONICS CORP.
    Inventors: Hui-Lin Wang, Tai-Cheng Hou, Wei-Xin Gao, Fu-Yu Tsai, Chin-Yang Hsieh, Chen-Yi Weng, Jing-Yin Jhang, Bin-Siang Tsai, Kun-Ju Li, Chih-Yueh Li, Chia-Lin Lu, Chun-Lung Chen, Kun-Yuan Liao, Yu-Tsung Lai, Wei-Hao Huang
  • Publication number: 20210012908
    Abstract: A computer-implemented method and system for modeling the pathophysiology of a human intervertebral disc may comprise an anatomic dataset and a biophysical model disposed in connection with a simulation program. The biophysical model may comprise a plurality of subsystems, including, without limitation, governing equations, constitutive equations, boundary conditions, initial conditions, and parameter values. By altering certain subsystems of the biophysical model, a user may selectively solve for certain pathophysiological metrics using at least one of a plurality of algorithms disposed within the simulation program.
    Type: Application
    Filed: June 3, 2020
    Publication date: January 14, 2021
    Inventors: WEIYONG GU, XIN GAO
  • Publication number: 20200410299
    Abstract: A method for classifying data into classes includes receiving new data; receiving support data, wherein the support data is a subset of previously classified data; processing with a first set of layers of a deep learning classifier the new data and the support data to obtain a learned representation of the new data and the support data; and applying a second set of layers of the deep learning classifier to the learned representation to associate the new data with a corresponding class.
    Type: Application
    Filed: March 27, 2019
    Publication date: December 31, 2020
    Inventors: Xin GAO, Yu LI