Abstract: The invention provides anti-VISTA antibody drug conjugates which may be used for targeted delivery of anti-inflammatory agents such as steroids to immune cells, e.g., myeloid cells. The invention also provides methods of using anti-VISTA antibody drug conjugates in the treatment of inflammatory and/or autoimmune conditions and/or for alleviating the toxicity of anti-inflammatory agents such as steroids.

Abstract: A compound represented by the following general formula, a preparation method thereof, a pharmaceutical composition containing the compound, and a use of the compound in preparation of drugs for preventing and/or treating EGFR kinase-mediated cancers and other diseases.

Abstract: A double-layer coiled tubing double-gradient drilling system, on the basis of conventional drilling equipment, includes a double-layer coiled tubing system, separating fluid, a downhole lifting pump system, throttling control systems and a data monitoring system. Power fluid enters an annular space of the tubing through an adapter, passes through a downhole lifting pump, enters an inner pipe through a bridge channel, and enters the bottom hole through the drill bit. Return fluid enters an annular channel of the tubing through a recovery hole, then enters the inner pipe through the bridge channel and enters the lifting pump, and then enters a solid control system through the adapter and the control systems in sequence. Gradient control of the bottom hole pressure is realized through monitoring of the separating fluid and control of the drilling pump unit and throttling control systems. The problem of narrow safe drilling density window is solved.

Abstract: A wireless charging system for a planar wireless accessory includes a receiving coil positioned within the planar wireless accessory and a transmitting coil positioned within a planar electronic device. The transmitting coil generates a magnetic flux that is received by the receiving coil to charge a battery of the planar wireless accessory when the planar wireless accessory is positioned relative to the planar electronic device according to a select charging configuration of multiple user-selectable charging configurations. The transmitting coil and the receiving coil are shaped and positioned to charge the battery at a substantially uniform rate at each different one of the multiple user-selectable charging configurations.

Abstract: A tanning agent-free leather making method is provided. A raw hide is subjected to controllable dehydration with a molecular sieve-polar organic solvent composite dehydration media to achieve a dehydrated hide, and then a tanning agent-free leather is prepared by increasing the surface roughness of the dehydrated hide and reducing the surface energy of the dehydrated hide. The present disclosure does not use any metal or non-metal tanning agent, which is eco-friendly. The present disclosure breaks the balance of water distribution between the raw hide and the polar organic solvent, which realizes a multi-medium self-driven directional controllable dehydration of the raw hide, effectively solving the problems during dehydration of the raw hide only using polar organic solvent. The molecular sieve-polar organic solvent dehydration system is easy to recover and can be recycled for the controllable dehydration of the raw hide multiple times. Therefore, a brand-new clean leather making technology is provided.

Abstract: Provided are meltblown nonwovens, and articles thereof. The meltblown nonwovens can be formed form a composition comprising an ethylene/alpha-olefin interpolymer and specific additive. The meltblown nonwovens according to embodiments disclosed herein exhibit a high volume resistivity and can be used in filtration applications.

Abstract: A file reading method includes following operations: determining, by a processor, whether a file in a SIM card is stored in a non-volatile memory; performing, by the processor, a reading process to read the file from the SIM card if the file is not stored in the non-volatile memory; and storing, by the processor, the file into the non-volatile memory.

Abstract: The invention discloses a method, system, and computer program product for service update management. The method, during a first update procedure for a first service in a computing system, in response to a detection that the first update procedure fails, a state of a second service on which the first service depends in the computing system is checked. In response to the second service being in a first state, the first update procedure is suspended. Resources allocated to the first update procedure by the computing system are released. The released resources are allocated to the second update procedure of the second service. The second update procedure is implemented based on the allocated released resources. With these embodiments, failures during the update procedures for the services may be automatically detected and removed based on a dependency relationship between the services. Therefore, the performance of the update procedures may be increased.

Abstract: Various embodiments of an apparatus, method(s), system(s) and computer program product(s) described herein are directed to a Reminder Engine. The Reminder Engine detects a selection, by a first user account, of one or more reminder attributes for a message received in an online chat session. The Reminder Engine generates a reminder object for the message according to the one or more selected reminder attributes. The Reminder Engine receives a reminder notification based on expiration of a duration attribute associated with the reminder object.

Abstract: The present invention relates to an alkenyl pyrimidine compound, a preparation method therefor, and an application thereof. Particularly, the present invention relates to a compound having EGFR inhibitory activity and a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, a preparation method thereof, a pharmaceutical composition containing the compound, and a use of the compound in the preparation of drugs for preventing and/or treating cancer and other diseases mediated by EGFR kinase.

Abstract: An approach is provided in which the approach constructs a detection packet that includes a time to live indicator. The approach sends the detection packet from a virtual machine to one of multiple virtual network devices, wherein the virtual network device recognizes the detection packet based on the time to live indicator. The approach determines a network fault point based on receiving a notification packet from one of the multiple virtual network devices, and reports one of the multiple network interface devices that causes the network fault point.

Abstract: A system and method for generating a predicted vehicle trajectory includes a generative adversarial network configured to receive a trajectory vector of a target vehicle and generate a set of latent state vectors using the received trajectory vector and an artificial neural network. The latent state vectors each comprise a high-level sub-vector, ZH. The GAN enforces ZH to be correlated to an annotation coding representing semantic categories of vehicle trajectories. The GAN selects a subset, from the set of latent state vectors, using farthest point sampling and generates a predicted vehicle trajectory based on the selected subset of latent state vectors.

Abstract: The present invention relates to the field of alkylation catalysts, and disclosed are a composite ZSM-5 molecular sieve, a preparation method therefor, a catalyst and an application thereof. A single crystal of the composite ZSM-5 molecular sieve comprises a main crystal and a twin crystal; the main crystal and the twin crystal are both ZSM-5 crystals; a crystal plane [010] of the main crystal is covered by a crystal plane [100] of the twin crystal; and the ratio of the number of sinusoidal pore openings to the number of straight pore openings on the outer surface of the single crystal of the composite ZSM-5 molecular sieve is (0.7-10:1), and the molar ratio Y1 of an Si element to an Al element within 10 nm of the surface is (300-2000):1. The single crystal of the composite ZSM-5 molecular sieve of the present invention has a large ratio of the number of sinusoidal pore openings to the number of straight pore openings, and is aluminum-poor on the surface and aluminum-rich on the inside.

Abstract: A rotor is provided, and is used in a permanent-magnet motor. The rotor includes a rotating shaft (111) and a rotor iron core (112) sleeved on the rotating shaft (111). The rotor further includes several first permanent-magnet structures (14), the several first permanent-magnet structures (14) are distributed on the rotor iron core (112) in a circumferential direction of the rotor iron core (112), each first permanent-magnet structure (14) includes a first permanent magnet (141) and a second permanent magnet (142) that are disposed in a radial direction of the rotor iron core (112), and coercive force of the first permanent magnet (141) is less than coercive force of the second permanent magnet (142).

Abstract: Various embodiments of an apparatus, method(s), system(s) and computer program product(s) described herein are directed to a Reminder Engine. The Reminder Engine detects a selection, by a first user account, of one or more reminder attributes for a message received in an online chat session. The Reminder Engine generates a reminder object for the message according to the one or more selected reminder attributes. The Reminder Engine receives a reminder notification based on expiration of a duration attribute associated with the reminder object.

Abstract: A modified T cell comprising a functional exogenous receptor is provided. The functional exogenous receptor comprises: (a) an extracellular ligand binding domain, (b) a transmembrane domain, and (c) an intracellular signaling domain (ISD) comprising a chimeric signaling domain (CMSD), wherein the CMSD comprises a plurality of Immune-receptor Tyrosine-based Activation Motifs (ITAMs) optionally connected by one or more linkers. Further provided are vectors, methods of producing, pharmaceutical compositions, kits, and methods of treatment thereof.

Abstract: A method for task-informed planning by a behavior planning system of a vehicle includes observing a previous trajectory of an agent within a distance from the vehicle. The method also includes predicting, by the behavior planning system, a set of potential trajectories for the agent and/or the vehicle based on observing the previous trajectory. The method further includes selecting, by the behavior planning system, a potential action from a set of potential actions associated with a task to be performed by the vehicle, each potential action being associated with a utility value based on the respective potential action and the set of potential trajectories, the selected potential action being associated with a highest utility value of respective utility values associated with the set of potential actions. The method still further includes controlling the vehicle to perform an action associated with the potential action selected by the behavior planning system.

Abstract: A double-layer coiled tubing double-gradient drilling system, on the basis of conventional drilling equipment, includes a double-layer coiled tubing system, spacer fluid, a downhole lifting pump system, throttling control systems and a data monitoring system. Power fluid enters an annular space of the tubing through an adapter, passes through a downhole lifting pump, enters an inner pipe through a bridge channel, and enters the bottom hole through the drill bit. Return fluid enters an annular channel of the tubing through a recovery hole, then enters the inner pipe through the bridge channel and enters the lifting pump, and then enters a solid control system through the adapter and the control systems in sequence. Gradient control of the bottom hole pressure is realized through monitoring of the spacer fluid and control of the drilling pump unit and throttling control systems. The problem of narrow safe drilling density window is solved.

Abstract: The present application discloses a human T-lymphoblastic leukemia/lymphoma cell strain named as ZYXY-T1, and its construction method and use thereof. It was conserved in China Center for Type Culture Collection (Wuhan, China) on Jan. 20, 2021, and the preservation number was CCTCC NO: C202143. The present application is obtained by separating mononuclear cells from peripheral blood of one ETP-ALL patient, and culturing the cells in vitro for continuous natural passage. The strain has the typical surface antigen expression characteristics of ETP-ALL, that is, it does not express CD1?, CD5 or CD8, and highly expresses a stem cell marker CD34, and has good proliferation ability in vitro and tumorigenesis ability in vivo; it can be used as a cell material to study the occurrence and development mechanism of ETP-ALL, and can also be used to screen and evaluate ETP-ALL drugs to guide clinical medication.

Abstract: The present invention discloses a communication method having data transmission sorting mechanism. Whether an object under process is a mobile terminated object is determined. When the object under process is the mobile terminated object, a processing priority is set to be the highest priority, a receiving process is performed and response content is generated when required. When the object under process is a mobile originated object, a transmission process is performed, the processing priority is set according to a processing priority setting of a related transmission entity and the mobile originated object is added to a transmission list. When an object transmission is not able to be performed, the response content is added to a response list. When the object transmission is able to be performed, the response content in the response list is transmitted first and the mobile originated object in the transmission list is transmitted subsequently.