Abstract: A modified T cell comprising a functional exogenous receptor is provided. The functional exogenous receptor comprises: (a) an extracellular ligand binding domain, (b) a transmembrane domain, and (c) an intracellular signaling domain (ISD) comprising a chimeric signaling domain (CMSD), wherein the CMSD comprises a plurality of Immune-receptor Tyrosine-based Activation Motifs (ITAMs) optionally connected by one or more linkers. Further provided are vectors, methods of producing, pharmaceutical compositions, kits, and methods of treatment thereof.

Abstract: A method for task-informed planning by a behavior planning system of a vehicle includes observing a previous trajectory of an agent within a distance from the vehicle. The method also includes predicting, by the behavior planning system, a set of potential trajectories for the agent and/or the vehicle based on observing the previous trajectory. The method further includes selecting, by the behavior planning system, a potential action from a set of potential actions associated with a task to be performed by the vehicle, each potential action being associated with a utility value based on the respective potential action and the set of potential trajectories, the selected potential action being associated with a highest utility value of respective utility values associated with the set of potential actions. The method still further includes controlling the vehicle to perform an action associated with the potential action selected by the behavior planning system.

Abstract: A double-layer coiled tubing double-gradient drilling system, on the basis of conventional drilling equipment, includes a double-layer coiled tubing system, spacer fluid, a downhole lifting pump system, throttling control systems and a data monitoring system. Power fluid enters an annular space of the tubing through an adapter, passes through a downhole lifting pump, enters an inner pipe through a bridge channel, and enters the bottom hole through the drill bit. Return fluid enters an annular channel of the tubing through a recovery hole, then enters the inner pipe through the bridge channel and enters the lifting pump, and then enters a solid control system through the adapter and the control systems in sequence. Gradient control of the bottom hole pressure is realized through monitoring of the spacer fluid and control of the drilling pump unit and throttling control systems. The problem of narrow safe drilling density window is solved.

Abstract: The present application discloses a human T-lymphoblastic leukemia/lymphoma cell strain named as ZYXY-T1, and its construction method and use thereof. It was conserved in China Center for Type Culture Collection (Wuhan, China) on Jan. 20, 2021, and the preservation number was CCTCC NO: C202143. The present application is obtained by separating mononuclear cells from peripheral blood of one ETP-ALL patient, and culturing the cells in vitro for continuous natural passage. The strain has the typical surface antigen expression characteristics of ETP-ALL, that is, it does not express CD1?, CD5 or CD8, and highly expresses a stem cell marker CD34, and has good proliferation ability in vitro and tumorigenesis ability in vivo; it can be used as a cell material to study the occurrence and development mechanism of ETP-ALL, and can also be used to screen and evaluate ETP-ALL drugs to guide clinical medication.

Abstract: The present invention discloses a communication method having data transmission sorting mechanism. Whether an object under process is a mobile terminated object is determined. When the object under process is the mobile terminated object, a processing priority is set to be the highest priority, a receiving process is performed and response content is generated when required. When the object under process is a mobile originated object, a transmission process is performed, the processing priority is set according to a processing priority setting of a related transmission entity and the mobile originated object is added to a transmission list. When an object transmission is not able to be performed, the response content is added to a response list. When the object transmission is able to be performed, the response content in the response list is transmitted first and the mobile originated object in the transmission list is transmitted subsequently.

Abstract: The invention provides a plant EPSPS mutant (i.e. 5-enolpyruvylshikimate-3-phosphate synthase mutant), which is derived from plant, and has glyphosate resistance after mutation. Also provided is an encoding gene, which can encode the above plant EPSPS mutant; and a vector containing the above encoding gene; and a cell containing the above vector. Further provided are uses of the above plant EPSPS mutant.

Abstract: Compositions and kits for diagnosing and prognosing Alzheimer's Disease (AD) in a human patient include a binding agent such as a monoclonal antibody for a biomarker conjugated to a detectable moiety such as a fluorophore, wherein the biomarker is chosen from CD163, CD91, CD59, MerTK and other phagocytosis-related molecules. Further compositions and kits employ panels of fluorophore-conjugated monoclonal antibodies for biomarkers including scavenger receptors. Methods for determining the relative expression of biomarkers, diagnosing AD, and determining the efficacy of AD therapeutic candidates such as phagocytosis-promoting agents and scavenger receptor agonists also appear.

Abstract: Provided are a plant EPSPS mutant containing mutations L195P and S247G and an encoding gene and the use thereof, related to the field of genetic engineering technology. Comparing the plant EPSPS mutant with E. coli EPSPS, the amino acid sequence of the plant EPSPS mutant has the mutation L195P at position 195 corresponding to E. coli EPSPS and/or the mutation S247G at position 247 corresponding to E. coli EPSPS. The mutation of either of the two sites or the simultaneous mutation of the two sites can confer or improve the resistance of the plant EPSPS mutant to glyphosate. Plants or recombinant bacteria for transforming the plant EPSPS mutant can grow normally in the presence of glyphosate.

Abstract: Described herein are techniques for improving disaster recovery, in particular disaster recovery pertaining to data transfer requests. The data transfer request can be received by each of multiple deployments; however, only a primary deployment can process the request. The data transferred by the primary deployment may be replicated in the secondary deployments. In response to a failover event, one of the secondary deployments can be designated as the new primary development and continue the data transfer based on the data transfer request and the replication information received from the old primary deployment prior to the failover.

Abstract: The invention provides a plant EPSPS mutant (i.e., 5-enolpyruvylshikimate-3-phosphate synthase mutant), which is derived from a plant and is mutated to have glyphosate resistance. Also provided is an encoding gene, which can encode the plant EPSPS mutant. In addition, a vector containing the encoding gene and a cell containing the vector is provided by the invention. Further, a use of the plant EPSPS mutant is provided.

Abstract: The embodiments of the present application disclose a contact structure forming method, a contact structure, and a semiconductor device. The method includes: providing a substrate, the substrate having a plurality of isolation regions therein, the isolation regions isolating an active region on the substrate into several portions; etching the active regions and the isolation regions simultaneously by the first etching processing, to form a first contact hole, a protruding active region being formed at the active region in the bottom of the first contact hole; depositing a first dielectric layer to cover the sidewall and bottom of the first contact hole; and etching the bottom of the first contact hole by the second etching processing, to form a contact structure having a target depth.

Abstract: A measurement device and method for a semiconductor structure are provided. The measurement device for the semiconductor structure includes a bearing platform, a clamping mechanism, and an image acquisition system. The clamping mechanism is installed on the bearing platform and includes a clamp disposed along a vertical direction. The clamp is configured to clamp the semiconductor structure such that the semiconductor structure is clamped with a to-be-measured surface facing a side. The image acquisition system is disposed by a side of the clamping mechanism, and is configured to acquire a three-dimensional morphology of the semiconductor structure from the side.

Abstract: An electric power steering apparatus and a control method thereof are disclosed. One example electric power steering apparatus includes: a first motor, configured to provide steering assistance corresponding to rotation of a steering wheel, wherein the first motor is powered by two power supplies, and each of the two power supplies drives the first motor to generate part of the steering assistance; and a second motor, configured to provide additional steering assistance corresponding to the rotation of the steering wheel when the first motor loses part or all of the steering assistance, wherein the additional steering assistance comprises at least part of the steering assistance lost by the first motor, and the second motor is driven by one power supply coupled from the two power supplies, to generate the additional steering assistance.

Abstract: A cleansing wipe may be formed from a nonwoven and includes a first ethylene/alpha-olefin interpolymer and a second ethylene/alpha-olefin interpolymer. The cleansing wipe may also have a SaMbSc configuration, wherein the M, meltblown layer, is formed from the first ethylene/alpha-olefin interpolymer and the second ethylene/alpha-olefin interpolymer. The cleansing wipe may be formed a nonwoven comprising bicomponent fibers that incorporate the first ethylene/alpha-olefin interpolymer and the second ethylene/alpha-olefin interpolymer.

Abstract: Systems and methods for predicting a trajectory of a moving object are disclosed herein. One embodiment downloads, to a robot, a probabilistic hybrid discrete-continuous automaton (PHA) model learned as a deep neural network; uses the deep neural network to infer a sequence of high-level discrete modes and a set of associated low-level samples, wherein the high-level discrete modes correspond to candidate maneuvers for the moving object and the low-level samples are candidate trajectories; uses the sequence of high-level discrete modes and the set of associated low-level samples, via a learned proposal distribution in the deep neural network, to adaptively sample the sequence of high-level discrete modes to produce a reduced set of low-level samples; applies a sample selection technique to the reduced set of low-level samples to select a predicted trajectory for the moving object; and controls operation of the robot based, at least in part, on the predicted trajectory.

Abstract: A TBM-mounted system and method for quickly predicting compressive strength of rocks based on rock mineral composition and fabric characteristics. The system is mounted on gripper shoe's side surface of an open-type TBM, and includes a protective device, hydraulic device, servo motor, detection device, control system and a data comprehensive analysis platform. The hydraulic device is mounted on the protective device's side wall, for controlling movement of detection device horizontally. The servo motor controls rotation of detection device. The detection device collects a variety of geological parameters of target surrounding rock affecting compressive strength of rock and providing basic data for compressive strength prediction of rock. The control system controls work of hydraulic device, servo motor and each detection device.

Abstract: A tanning agent-free leather making method is provided. A raw hide is subjected to controllable dehydration with a molecular sieve-polar organic solvent composite dehydration media to achieve a dehydrated hide, and then a tanning agent-free leather is prepared by increasing the surface roughness of the dehydrated hide and reducing the surface energy of the dehydrated hide. The present disclosure does not use any metal or non-metal tanning agent, which is eco-friendly. The present disclosure breaks the balance of water distribution between the raw hide and the polar organic solvent, which realizes a multi-medium self-driven directional controllable dehydration of the raw hide, effectively solving the problems during dehydration of the raw hide only using polar organic solvent. The molecular sieve-polar organic solvent dehydration system is easy to recover and can be recycled for the controllable dehydration of the raw hide multiple times. Therefore, a brand-new clean leather making technology is provided.

Abstract: An intelligent lithology identification system and method based on images and spectrum technology. The intelligent lithology identification system includes a rock shape analysis system, an image identification system, a sample processing system, a spectrum analysis system, and a central analysis and control system; wherein the central analysis and control system determines the final lithology of a sample according to the rock identification results from the image identification system and the analysis results from the spectrum analysis system. The technical solution further identifies the content and type of minerals by using spectrum technology, integrates and analyzes the results of spectrum analysis and image identification, and finally gives the lithology of the rock, which greatly improves the accuracy of lithology identification.

Abstract: One or more implementations of the present specification provide risk control of transactions based on a graphical structure model. A graphical structure model trained by using labeled samples is obtained. The graphical structure model is defined based on a transaction data network that includes nodes representing entities in a transaction and edges representing relationships between the entities. Each labeled sample includes a label indicating whether a node corresponding to the labeled sample is a risky transaction node. The graphical structure model is configured to iteratively calculate an embedding vector of the node in a latent feature space based on an original feature of the node or a feature of an edge associated with the node. An embedding vector of an input sample is calculated by using the graphical structure model. Transaction risk control is performed on the input sample based on the embedding vector.

Abstract: A graphical structure model trained by using labeled samples is obtained. The graphical structure model is defined based on an enterprise relationship network that includes nodes and edges. Each labeled sample includes a label indicating whether a corresponding node is a risky credit node. The graphical structure model is configured to iteratively calculate an embedding vector of at least one node in a hidden feature space based on an original feature of the at least one node and/or a feature of an edge associated with the at least one node. An embedding vector corresponding to a test-sample is calculated by using the graphical structure model. Credit risk analysis is performed on the test-sample. The credit risk analysis is performed based on a feature of the test-sample represented in the embedding vector. A node corresponding to the test-sample is labeled as a credit risk node.