Abstract: The present disclosure provides a class of Pyridopyrimidine compounds having a structure shown in Formula (I) or their pharmaceutically acceptable salts, or stereoisomers or prodrug molecules and applications thereof. The compounds in the present disclosure can efficiently and selectively degrade AKT3 protein in cells without affecting AKT1/2, thereby significantly inhibiting tumor cell proliferation mediated by high expression of AKT3 protein. It can be used to prepare therapeutic drugs for cancer and other diseases related to abnormal expression of AKT3 protein.

Abstract: A deep learning-based method for fusing multi-source urban energy data and a storage medium are provided to perform data fusion on multi-source urban energy data found in big data and perform multi-scale and multimodal information fusion by using a cross-modal transformer, thereby implementing cross-modal mutual fusion of multi-source heterogeneous types of data to obtain a fused feature for prediction of a quantity of energy that will be used in the future and a quantity of energy that needs to be produced. The present disclosure proposes a multi-scale cooperative multimodal transformer architecture to enhance an effect of representation learned from an unaligned multimodal sequence. Not only there is a higher degree of correlation in multi-source urban energy data fusion, but also a system becomes more lightweight.

Abstract: This application provides a bullet-screen comment display method, where the bullet-screen comment display method includes: determining bullet-screen comment area basic information corresponding to a target bullet-screen comment from a target picture; identifying an invalid pixel set of the target picture; determining a bullet-screen comment filling area corresponding to the target bullet-screen comment based on the bullet-screen comment area basic information and the invalid pixel set; and filling the bullet-screen comment filling area with the target bullet-screen comment.

Abstract: Disclosed herein are, inter alia, inhibitors of protein arginine methyltransferase 9 and pharmaceutical compositions thereof, and methods comprising the use of protein arginine methyltransferase 9 inhibitors for the treatment of a protein arginine methyltransferase 9-modulated disease or disorder, such as a hematological cancer.

Abstract: A driving model training method, a driver identification method, an apparatus, a device and a medium are provided. The training method comprises: acquiring training behavior data of a user wherein the training behavior data are associated with a user identifier; acquiring training driving data associated with the user identifier based on the training behavior data; acquiring positive and negative samples from the training driving data based on the user identifier, and dividing the positive and negative samples into a training set and a test set; training the training set using a bagging algorithm, and acquiring an original driving model; testing the original driving model using the test set, and acquiring a target driving model. The training method effectively enhances generalization of the driving model, solves the problem of poor identification results of the existing driving identification model, and improves the accuracy rate of identifying driving of drivers.

Abstract: A microfluidic chip for analyte detection, which is provided with a liquid storage tank (121), the liquid storage tank (121) is internally provided with a through hole I (141), one opening of the through hole I is located in the liquid storage tank, and the liquid in the liquid storage tank passes through the through hole I to bypass the outer boundary (12511) of the portion where the inner surface of the liquid storage tank contacts the sealing member, thereby avoiding leakage due to a possible gap in a sealed position when the liquid flows through the sealed position. At the same time, the design can reduce the processing precision requirement, save cost, etc.

Abstract: A reusable protective clothing includes a one-piece protective suit which includes integrated top and trousers attached with gloves and shoe covers, and a protective headpiece having a face shield. A front side of the protective headpiece is provided with a full-vision goggle with 180-degree field of view, the full-vision goggle is integrated with the face shield, a back side of the protective headpiece is provided with a protective hood made of a material of the one-piece protective suit, the protective hood is integrated with the top, the front side of the protective headpiece is provided with an air vent for a mouth and a nose configured according to facial features of a wearer, and an outer side of the protective headpiece is provided with ear-shaped hooks. The protective clothing is designed according to application environment and medical requirements to prevent exposure to pathogenic microorganisms.

Abstract: According to implementations of the subject matter described herein, a solution is proposed for three-dimensional (3D) object detection. In this solution, feature representations of a plurality of points are extracted from point cloud data related to a 3D object. Initial feature representations of a set of candidate 3D objects are determined based on the feature representations of the plurality of points. Based on the feature representations of the plurality of points and the initial feature representations of the set of candidate 3D objects, a detection result for the 3D object is generated by determining self-correlations between the set of candidate 3D objects and cross-correlations between the plurality of points and the set of candidate 3D objects. In this way, without grouping points into candidate 3D objects, the 3D object in a 3D scene can be localized and recognized based on the self-correlations and cross-correlations.

Abstract: The present disclosure relates to an earphone, comprising: a sound production component, at least a portion of the sound production component extending into a concha cavity; ear hook disposed between an auricle and a head of the user, extending toward a side of the auricle away from the head, and connecting the sound production component; in a non-wearing state, the ear hook and the sound production component form a first projection on a first plane comprising an outer contour, a first end contour, an inner contour, and a second end contour, the outer contour, the first end contour, the second end contour, and a tangent segment connecting the first end contour and the second end contour define a first closed curve, a ratio of a projection area of the sound production component on the first plane to a first area of the first closed curve is between 0.25 and 0.4.

Abstract: Embodiments of the present disclosure provide a speaker. The speaker may include a diaphragm; a magnetic circuit component; and a coil connected to the diaphragm, at least part of the coil being arranged in a magnetic gap formed by the magnetic circuit component, and the coil driving the diaphragm to vibrate to generate sound after the coil being energized. The diaphragm may include a main-body region and a folded-ring region surrounding the main-body region, the main-body region may include a first inclined section and a first connecting section connected to the coil, the first inclined section may be attached to a portion of the folded-ring region, and the first inclined section may be tilted in a direction away from the coil with respect to the first connecting section.

Abstract: Provided is an anti-HER3 humanized monoclonal antibody. The antibody binds HER3 antigen, has high affinity and biological activity and low immunogenicity, and is stable in structure. The antibody can be used for preparing drugs for preventing or treating HER3-related diseases.

Abstract: Embodiments of this disclosure provide sidelink resource multiplexing and indication methods and apparatuses thereof. The method includes: receiving by a second device length information indicating a length of a first part in a slot transmitted by a terminal equipment or a network device; and performing transmission and/or reception of sidelink information by the second device with a first device according to the length information. Hence, the second device is able to process the first part according to the length information, thereby improving performance of sidelink transmission.

Abstract: The present invention discloses a multi-energy complementary system for a co-associated abandoned mine and a use method. The multi-energy complementary system for a co-associated abandoned mine includes a mining mechanism, a grouting mechanism and an energy mechanism. In the present invention, the mining of coal and uranium resources is realized through the mining mechanism, the subsidence and seepage reduction of the stratum is realized through the grouting mechanism, and the effective utilization of waste resources is realized through the energy mechanism. Finally, with the efficient cooperation of the three mechanisms, safe and efficient development and utilization of co-associated resources in the full life cycle are realized, and the purposes of green and efficient mining of coal and uranium resources and secondary development of a coal seam goaf are achieved, thereby facilitating the realization of dual-carbon goals and the development of low-carbon green energy.

Abstract: A system is disclosed, in accordance with one or more embodiments of the present disclosure. The system includes a metrology tool configured to acquire one or more measurements of a portion of a sample. The system includes a controller including one or more processors configured to execute program instructions causing the one or more processors to: generate a surface kinetics model output based on a surface kinetics model; determine an expected response of the surface kinetics model output to excitation by polarized light; compare the determined expected response to the one or more measurements; generate one or more metrics based on the comparison between the determined expected response and the one or more measurements of the sample; adjust one or more parameters of the surface kinetics model to generate an adjusted surface kinetics model; and apply the adjusted surface kinetics model to simulate on-sample performance during plasma processing.

Abstract: A method for constructing an efficient product surface defect detection model based on network collaborative pruning is provided. According to an initial product surface defect detection model, the method provides a network-based collaborative pruning method and constructs the efficient product surface defect detection model. On a premise of ensuring an accuracy of a product defect detection method, a product surface defect detection time is reduced to satisfy manufacturer's requirements on the product surface defect detection time and accuracy of product surface defects.

Abstract: Provided is a display substrate. The display substrate includes: a display region and a bonding region on a side of the display region, wherein the display region includes a plurality of pixel columns; and a wiring structure, disposed between the display region and the bonding region and including a plurality of traces, wherein one of the plurality of traces corresponds to one of the plurality of pixel columns, the plurality of traces are electrically connected to the plurality of pixel columns to supply an electric signal to pixels, and each of the plurality of traces includes a plurality of sub-traces, wherein at least one of line lengths and line widths of sub-traces corresponding to at least a part of the plurality of traces are different, such that total resistances of the at least the part of the plurality of traces are basically equal.

Abstract: An immobilized enzymolysis equipment for reconstituted rice milk powder includes a bottom box, a heating device is arranged on an upper surface of the bottom box, and a splash-proof device is arranged on an upper surface of the heating device. Support legs are fixedly connected to corners of a lower surface of the bottom box. A rotating motor is arranged on a bottom surface of an inner cavity of the bottom box. The rotating motor is provided to achieve the effect of rotating a centrifugal device. The centrifugal device is rotationally connected to one side, extending to the upper surface of the bottom box, of the rotating motor, so as to achieve water-milk separation of reconstituted milk powder.

Abstract: An obstacle avoidance method for a robot, an obstacle avoidance apparatus for a robot, a robot, a computer-readable storage medium, and an electronic device are disclosed. The obstacle avoidance method for a robot includes: determining a target traveling position of the robot determining an avoidance mode of the robot and controlling the robot to travel along an outer edge of a first obstacle so as to bypass the first obstacle, in response to detecting that the first obstacle exists between a current position of the robot and the target traveling position during traveling of the robot, where the height of the first obstacle is less than a measurement height range of the robot. The operational efficiency of the robot can be improved, and the operational continuity of the robot can be enhanced.

Abstract: A laser device includes a shell, an upper cover assembly, a plurality of light-emitting assemblies, and a plurality of conductive pins. The shell includes a base plate, a frame body, and a first flange. The first flange is bent relative to the frame body and is fixedly connected to the base plate. The upper cover assembly is fixed to the shell. The plurality of light-emitting assemblies are disposed on the base plate. Any one of the plurality of conductive pins is electrically connected to a light-emitting assembly. The frame body includes a plurality of flanging holes. A depth of any one of the plurality of flanging holes is greater than a thickness of the frame body. A portion of the any one of the plurality of conductive pins is located at an outside of the accommodating space through a corresponding flanging hole.

Abstract: The present application discloses a sound-output device, including a signal processing circuit, configured to generate a bone-conducted control signal and an air-conducted control signal based on an initial sound signal; a vibration speaker, configured to generate a bone-conducted sound wave based on the bone-conducted control signal; and an air-conduction speaker, configured to generate an air-conducted sound wave based on the air-conducted control signal, wherein a signal component of at least partial frequency band in the air-conducted control signal has an amplitude and a phase canceling at least partial leakage of sound generated by the vibration speaker, such that at least partial component in the air-conducted sound wave cancels the at least partial leakage of sound.