Abstract: Compositions of the present disclosure include a first dCas9-FokI-sgRNA complex and a second dCas9-FokI-sgRNA complex. The first sgRNA is configured to target a first side of a genomic fusion site and the second sgRNA is configured to target a second side of the genomic fusion site. The first and second complexes only cut DNA upon dimerization. Thus, upon binding of both first dCas9-FokI-sgRNA complex and second dCas9-FokI-sgRNA complex, the dimer is produced and DNA cleavage proceeds at the genomic fusion site. The dCas9-FokI-sgRNA complexes are loaded on a folded-DNA shell for transport across the cellular membrane. The shell has a viral-mimic structure that maximizes cell entry, is non-cytotoxic, has low-to-nonimmunogenicity, and provides excellent capacity to enclose and protect the complexes. These systems exhibit both cellular (via the shell) and molecular (via the complexes) specificity, significantly reducing off-target activity and the associated harmful side-effects.

Abstract: The present disclosure relates to a field of display technologies and provides a light diffusing component, a backlight component having the same, and a display device. The light diffusing component may include a main body, a protruding portion, and a reflecting portion. The protruding portion is disposed on a side of the main body and protruded from the main body; the reflecting portion is disposed on the protruding portion and an edge region of the main body portion connected to the protruding portion, so as to reflect light incident from a lower portion of the light diffusing component. Light transmittance of the reflecting portion gradually increases in a direction away from a center of the diffusing component.

Abstract: A fastener includes a fastening pin and a sleeve component disposed around the fastening pin and movable up and down relative to the fastening pin. The sleeve component includes fixing claws that are able to stretch outward and retract inward. A pin of the fastening pin comprises a small-diameter rod section and an upper large-diameter rod section. When the fixing claws move relative to the pin to abut against an outer surface of the upper large-diameter rod section, the fixing claws stretch outward, and the fastener is in a locked state. When the fixing claws move to the outside of the small-diameter rod section relative to the pin, the fixing claws retract inward, and the fastener is in a release state.

Abstract: The present application provides a fastening clip, which comprises a fastening pin and a fastening sleeve. The fastening pin can be inserted into the fastening sleeve, the fastening sleeve comprises a base and two pairs of retaining wings, the two pairs of retaining wings respectively extend downward from a lower surface of the base, and outer sides of at least one of the two pairs of retaining wings have raised ribs extending in a circumferential direction. The fastening clip of the present application can firmly fasten at least two plates.

Abstract: Placing an event into a particular cluster can allow various inferences about the event. A new payment transaction that looks similar to a previously identified cluster of mostly fraudulent payment transactions, for example, may be higher risk. The present disclosure includes structural data improvements to the way that online clustering of events (which may include web events and not just payment transactions) occurs. A new event can be classified into a particular segment very quickly using feature table searching, which can allow for better decision making when a short timeframe is required (e.g. transaction processing, online advertising, etc.).

Abstract: Disclosed is a fastener, comprising: a fastener main body having a side wall; a pair of blocking bosses, a pair of blocking boss gaps being formed between the pair of blocking bosses; a pair of clamping steps; and a pair of resilient holding arms, each resilient holding arm having a connecting end and a free end, wherein the connecting end is connected to the side wall of the fastener main body; wherein a panel gap is formed between the blocking boss and the clamping step in an axial direction of the fastener main body; and wherein the connecting end of the resilient holding arm is arranged in the corresponding blocking boss gap between the blocking bosses and is staggered from the clamping steps.

Abstract: Various examples are disclosed for forecasting resource usage and computing capacity utilizing an exponential decay. In some examples, a computing environment can obtain usage measurements from a data stream over a time interval, where the usage measurements describe utilization of computing resource. The computing environment can generate a weight function for individual ones of the usage measurements, where the weight function exponentially decays the usage measurements based on a respective time period at which the usage measurements were obtained. The computing environment can forecast a future capacity of the computing resources based on the usage measurements and the weight function assigned to the individual ones of the usage measurements. The computing environment can further upgrade a forecast engine to use the exponential decay without resetting the forecast engine or its memory.

Abstract: A device to sense degree of twist in a screwdriver and the magnitude of force applied includes a contacting portion, a deformation portion, a sensing portion, and a processor. The contacting portion receives a grip and twist pressure through the deformation portion which is tiltedly fixed to the contacting portion. The deformation portion carries the sensing portion and elastically deforms under the force and/or the torsion. The sensing portion detects a deformation of the deformation portion and generates a corresponding electrical signal. The processor receives the signal and determines the values of the twist caused and the force applied.

Abstract: Computational methods and systems that proactively manage usage of computational resources of a distributed computing system are described. A sequence of metric data representing usage of a resource is detrended to obtain a sequence of non-trendy metric data. Stochastic process models, a pulse wave model and a seasonal model of the sequence of non-trendy metric data are computed. When a forecast request is received, a sequence of forecasted metric data is computed over a forecast interval based on the estimated trend and one of the pulse wave or seasonal model that matches the periodicity of the sequence of non-trendy metric data. Alternatively, the sequence of forecasted metric data is computed based on the estimated trend and the stochastic process model with a smallest accumulated residual error. Usage of the resource by virtual objects of the distributed computing system may be adjusted based on the sequence of forecasted metric data.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

Abstract: Embodiments described herein provide various examples of a face-detection system. In one aspect, a process for performing image detections on grayscale images is disclosed. This process can begin by receiving a training image dataset, wherein the training image dataset includes a first subset of color images. The process then converts each image in the first subset of color images in the training image dataset into a grayscale image to obtain a first subset of converted grayscale images. Next, the process trains an image-detection statistical model using the training image dataset including the first subset of converted grayscale images. The process next receives a set of grayscale input images. The process subsequently performs image detections on the set of grayscale input images using the trained image-detection statistical model.

Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

Abstract: Computational methods and systems that proactively manage usage of computational resources of a distributed computing system are described. A sequence of metric data representing usage of a resource is detrended to obtain a sequence of non-trendy metric data. Stochastic process models, a pulse wave model and a seasonal model of the sequence of non-trendy metric data are computed. When a forecast request is received, a sequence of forecasted metric data is computed over a forecast interval based on the estimated trend and one of the pulse wave or seasonal model that matches the periodicity of the sequence of non-trendy metric data. Alternatively, the sequence of forecasted metric data is computed based on the estimated trend and the stochastic process model with a smallest accumulated residual error. Usage of the resource by virtual objects of the distributed computing system may be adjusted based on the sequence of forecasted metric data.

Abstract: A speed reducer includes an input shaft, an output shaft, and a gear assembly coupled to the input shaft. The gear assembly includes a housing, an external gear, and at least two internal gears. The external gear is located within the housing and inscribes the at least two internal gears. One side of the at least two internal gears is rotatably coupled to the input shaft, and another side of the at least two internal gears is coupled to a connecting column of the output shaft. The at least two internal gears are offset on the input shaft, and the input shaft drives the at least two internal gears to maintain engagement with the external gear. The connecting column maintains transmission of the output shaft and the at least two internal gears.

Abstract: A data line used in a mobile phone is disclosed. The data line used in a mobile phone includes a body, a first connection terminal, a second connection terminal, and connection lines connecting said first and second connection terminals are disposed inside said body; wherein said connection lines include two core data communication lines and two core voltage lines; said data line further includes a display screen disposed outside said body, and a DSP chip, a voltage detecting circuit, and/or a current detecting circuit disposed inside said body. Performing the data line used in a mobile phone of the present invention can monitor the voltage and/or current flowing through the data line in real time, and detect hidden dangers in time and eliminate the probability of damage during charging of the mobile phone.

Abstract: A production method for comb honey is provided, which comprises the following steps of: Step 1, making a comb frame comprising a comb honey mold and a rectangularly disposed rim, wherein several steel wires are disposed through the comb honey mold; Step 2, making a comb honey production box; Step 3, pressing a comb foundation on the steel wires in the comb honey mold; Step 4, placing several comb frames in the comb honey production box of Step 2 during the honey-secreting period; Step 5, opening a cover plate to check the comb foundation in 3-4 days after the completion of Step 4, removing a comb frame of which comb foundation has been deformed, and conducting covering with the cover plate; Step 6, opening the cover plate to check the covering situation of combs in 8-20 days after the completion of Step 5, and taking out comb frames if the covering is completed; Step 7, scraping beewax and propolis on the periphery of the comb honey mold to obtain a comb honey having the same shape as the comb honey mold.

Abstract: A method of manufacturing a substrate of a display device is provided. The method includes: providing a substrate body; coating a photoresist layer on the substrate body; exposing the photoresist layer by using a plurality lenses of an exposure machine through a mask, wherein the mask includes a light incident region and a light overlap region, the light overlap region includes a transparent zone and a non-transparent zone, and the light incident region includes a transparent zone and a non-transparent zone, and wherein an area of each transparent zone of the light overlap region is larger or smaller than an area of each transparent zone of the light incident region; and developing the photoresist layer after exposing to obtain a photoresist pattern. The embodiment of the disclosure also provides a mask applied to the method.

Abstract: A device to sense degree of twist in a screwdriver and the magnitude of force applied includes a contacting portion, a deformation portion, a sensing portion, and a processor. The contacting portion receives a grip and twist pressure through the deformation portion which is tiltedly fixed to the contacting portion. The deformation portion carries the sensing portion and elastically deforms under the force and/or the torsion. The sensing portion detects a deformation of the deformation portion and generates a corresponding electrical signal. The processor receives the signal and determines the values of the twist caused and the force applied.

Abstract: The present disclosure provides a battery module. The battery module includes a plurality of secondary batteries stacked along a thickness direction, a top of each secondary battery being provided with an electrode terminal; and a connecting component provided at the top of the secondary battery, the connecting component being connected to at least two electrode terminals for electrically connecting at least two secondary batteries. The connecting component includes a first fixed connecting piece and a second fixed connecting piece, and along an extending direction of the connecting component, the first fixed connecting piece matches and is engaged with the second fixed connecting piece. The present disclosure solves the problem of the unreliable connection between the connecting component and the electrode terminal.

Abstract: Various embodiments of a vision-based privacy-preserving embedded fall-detection system are disclosed. This embedded fall-detection system can include one or more cameras for capturing video images of one or more persons. Moreover, this embedded fall-detection system can include various fall-detection modules for processing the captured video images including: a pose-estimation module, an action-recognition module, and a fall-detection module, all of which can perform the intended fall-detection functionalities within the embedded system environment in real-time in order to detect falls of the one or more persons. When a fall is detected, instead of sending the original captured images, the embedded fall-detection system can transmit sanitized video images to the server, wherein each detected person is represented by a skeleton figure in place of the actual person images, thereby preserving the privacy of the detected person.