Abstract: Compounds (such as peptides or peptide mimetics) that bind to HIV RRE RNA are provided. In some examples, the compounds inhibit (for example, decrease) binding of Rev to the RRE RNA. In some embodiments, the compounds include two moieties, each of which bind to one of the Rev binding sites in the RRE. In some examples, the moieties include peptides or small molecules. In some examples, the peptides include an arginine-rich motif. The RRE binding compounds may be further linked to a detectable label or cargo moiety. Also provided are methods of treating or inhibiting HIV including administering one or more of the RRE binding compounds to a subject.

Abstract: A fixing bracket for a photographing device includes a rod member, a sliding member, and a plurality of supporting feet. The sliding member is slidably sleeved on an outer surface of the rod member, top ends of the plurality of supporting feet are hinged to the sliding member, and the supporting feet are swingable with respect to the sliding member, at least one limiting protrusion is disposed on the outer surface of the rod member close to a bottom end of the rod member, the at least one limiting protrusion is configured to block the sliding member or the supporting feet from sliding towards the bottom end of the rod member, the at least one limiting protrusion is disposed between the sliding member and the bottom end of the rod member. When the sliding member slides towards the bottom end of the rod member, the supporting feet are gradually unfolded.

Abstract: Embodiments described herein provide various examples of real-time visual object tracking. In another aspect, a process for performing a local re-identification of a target object which was earlier detected in a video but later lost when tracking the target object is disclosed. This process begins by receiving a current video frame of the video and a predicted location of the target object. The process then places a current search window in the current video frame centered on or in the vicinity of the predicted location of the target object. Next, the process extracts a feature map from an image patch within the current search window. The process further retrieves a set of stored feature maps computed at a set of previously-determined locations of the target object from a set of previously-processed video frames in the video. The process next computes a set of correlation maps between the feature map and each of the set of stored feature maps.

Abstract: Computational methods and systems for detecting and troubleshooting anomalous behavior in distributed applications executing in a distributed computing system are described herein. Methods and systems discover nodes comprising the application. Anomaly detection monitors the metrics associated with the nodes for anomalous behavior in order to identify an approximate point in time when anomalous behavior begins to adversely impact performance of the application. Anomaly detection also monitors logs messages associated with the nodes to detect anomalous behavior recorded in the log messages. When anomalous behavior is detected in either the metrics and/or the log messages an alert identifying the anomalous behavior is generated. Troubleshooting guides an administrator and/or application owner to investigate the root cause of the anomalous behavior. Appropriate remedial measures may be determined based on the root cause and automatically or manually executed to correct the problem.

Abstract: A GNSS signal acquisition method based on FPGA step-by-step code phase refinement comprises steps as follows: (1) Coarse acquisition: correlate all received data with the locally generated carrier and the complete pseudo-random code to find the maximum correlation value; obtain the carrier and the rough code phase for fine acquisition if the maximum correlation value conforms to the acquisition threshold; otherwise, repeat Step (1). (2) Fine acquisition: feedback the carrier and the coarse acquisition code phase value from Step (1) to the controller so that the controller can intercept partial of the received signal for mixing with the local carrier from Step (1); then, correlate the result with partial pseudo-random code after eliminating the influence of the carrier to obtain a code phase with higher accuracy.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

Abstract: An apparatus includes a printed circuit board (PCB), and an integrated circuit (IC) package connected with the PCB. The IC package includes a package substrate, a die secured to the package substrate and including an integrated circuit, and a stiffener ring secured to the package substrate and surrounding so as to define a perimeter around the die. The stiffener ring increases a rigidity of the package substrate and delivers electrical power to the integrated circuit, where the stiffener ring includes a first conductive layer forming a power (PWR) plane for the integrated circuit, a second conductive layer forming a ground (GND) plane for the integrated circuit, and an insulating layer disposed between the first conductive layer and the second conductive layer.

Abstract: A method for displaying material includes: displaying an image, a target material, a material selecting frame, and at least one editing control in an image editing area. The at least one editing control is on the material selecting frame. The target material is within the material selecting frame. In addition, the method includes: in response to a dragging operation of the target material, moving the target material and the material selecting frame along a trajectory of the dragging operation. Furthermore, the method includes: in a case where a part of the material selecting frame is within the image editing area in response to the dragging operation, displaying the at least one editing control in the image editing area.

Abstract: An electric toothbrush head and an electric toothbrush are provided. The electric toothbrush head includes a brush head body, bristles and a flexible member. The brush head body includes a brush rod and a brush plate. The brush plate is elastically deformable and has a non-deformed state and an elastically deformed state relative to the brush rod. An included angle between the brush plate and the brush rod is changeable within a range from 0 degrees to X degrees. The X degrees are equal to or greater than 10 degrees. The elastically deformed state includes a first deformed state in which the brush plate is bendable or deformable towards a front surface relative to the brush rod and a second deformed state in which the brush plate is bendable or deformable towards a back surface relative to the brush rod.

Abstract: The disclosure provides a novel design of guide RNA and uses thereof. In one aspect, the guide RNA comprises a spacer sequence flanked by a direct repeat sequence at both the 5? end and the 3? end of the spacer sequence.

Abstract: The present disclosure relates to a pipe holding clip that defines a widthwise direction, a heightwise direction, and a lengthwise direction. The pipe holding clip can include a base portion, a pair of oppositely-arranged lateral portions extending upward from the base portion, a pair of holding arms extending inward from the pair of lateral portions and extending toward the base portion, and a support portion. Two sides of the support portion can be connected to the base portion or the pair of lateral portions. The support portion can include a working surface having an arc shape recessed toward the base portion. The pipe holding clip can provide a suitable holding force to limit the movement of a clamped pipe in an axial direction of the pipe.

Abstract: Placing an event into a particular cluster can allow various inferences about the event. A new payment transaction that looks similar to a previously identified cluster of mostly fraudulent payment transactions, for example, may be higher risk. The present disclosure includes structural data improvements to the way that online clustering of events (which may include web events and not just payment transactions) occurs. A new event can be classified into a particular segment very quickly using feature table searching, which can allow for better decision making when a short timeframe is required (e.g. transaction processing, online advertising, etc.).

Abstract: A use of the combination of IGF1 and IGFEc24 in a preparation of a drug for promoting tissue repair and regeneration is provided. The amino acid sequence of the IGF1 is shown in SEQ ID NO: 1; the amino acid sequence of the IGFEc24 is shown in SEQ ID NO: 2; and the amino acid sequence of the IGF1-24 is shown in SEQ ID NO: 4.

Abstract: The invention provides novel engineered CRISPR/Cas effector enzymes, such as Cas13 (e.g., Cas13e) that substantially maintain guide-sequence-specific endonuclease activity and substantially lack guide-sequence-independent collateral endonuclease activity compared to the corresponding wild-type Cas. Also provided are polynucleotides encoding the same, vectors or host cells comprising the polynucleotides or engineered Cas, and method of use, such as in RNA-based target gene transcript knock down.

Abstract: The present application provides a fastening clip, which comprises a fastening pin and a fastening sleeve. The fastening pin can be inserted into the fastening sleeve, the fastening sleeve comprises a base and two pairs of retaining wings, the two pairs of retaining wings respectively extend downward from a lower surface of the base, and outer sides of at least one of the two pairs of retaining wings have raised ribs extending in a circumferential direction. The fastening clip of the present application can firmly fasten at least two plates.

Abstract: Embodiments described herein relate to a system for positioning indicator lights of a network device. The system may include a circuit board, which may include a circuit board edge positioned behind a front panel of the network device, two surfaces; and a side of the circuit board edge positioned between the two surfaces. The system may also include a hole through the circuit board near the circuit board edge, a cutout extending from a portion of the hole to the side of the circuit board edge, a LED coupled to the surface of the circuit board and adapted to emit light into the hole, and a lightpipe disposed in the hole to receive light emitted from the LED into a first end of the lightpipe. The lightpipe may direct the light from a second end of the lightpipe toward an opening in the front panel of the network device.

Abstract: Embodiments described herein relate to a system for positioning indicator lights of a network device. The system may include a circuit board, which may include a circuit board edge positioned behind a front panel of the network device, two surfaces; and a side of the circuit board edge positioned between the two surfaces. The system may also include a hole through the circuit board near the circuit board edge, a cutout extending from a portion of the hole to the side of the circuit board edge, a LED coupled to the surface of the circuit board and adapted to emit light into the hole, and a lightpipe disposed in the hole to receive light emitted from the LED into a first end of the lightpipe. The lightpipe may direct the light from a second end of the lightpipe toward an opening in the front panel of the network device.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.