Patents by Inventor Xuan Zhang

Xuan Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11427864
    Abstract: The present invention relates generally to methods and kits for detecting one or more biomarkers, such as an Epidermal Growth Factor Receptor (EGFR) mutation, e.g., T790M mutation, L858R mutation, one or more exon19 insertions and/or one or more exon19 deletions in the EGFR gene, in a biological sample to aid in diagnosis, prognosis, monitoring, or therapy selection for a disease such as, for example, cancer. The methods and kits are useful in aiding in diagnosis, prognosis, monitoring, or therapy selection for lung cancer, e.g., non-small cell lung cancer (NSCLC).
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: August 30, 2022
    Assignee: Exosome Diagnostics, Inc.
    Inventors: Johan Karl Olov Skog, Elena Castellanos-Rizaldos, Vasisht Tadigotla, Dominik Grimm, Xuan Zhang, Wei Yu
  • Patent number: 11414600
    Abstract: The present invention relates to a liquid crystal display device. The liquid crystal display device of the present invention comprises a first substrate, a second substrate, and a liquid crystal composition disposed between said first substrate and said second substrate, wherein said first substrate and said second substrate are disposed in parallel and opposite to each other; alignment layers are disposed on the sides of said first and second substrates that are close to said liquid crystal composition; and said alignment layers are provided with vertical alignment films that allow liquid crystal molecules in said liquid crystal composition to be arranged roughly perpendicular to said first and second substrates, with said liquid crystal molecules having a pretilt angle of 88.5° to 89.5°.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: August 16, 2022
    Assignee: SHIJIAZHUANG CHENGZHIYONGHUA DISPLAY MATERIAL CO., LTD.
    Inventors: Jiaming Li, Zhian Liang, Guoliang Yun, Sumin Kang, Xuan Zhang, Ruixiang Liang
  • Publication number: 20220234994
    Abstract: The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.
    Type: Application
    Filed: February 16, 2022
    Publication date: July 28, 2022
    Inventors: JIA-NING XIANG, HAO-WEI SHIH, XIAOMING WU, XUAN ZHANG, JAMES TIEN
  • Publication number: 20220194047
    Abstract: A roof laminate (10) includes a roof membrane (12, 100, 200, 300) and a protective sheet (14, 114, 214, 314) removably affixed thereto. The surface (20) of the roof membrane (12, 100, 200, 300) can be protected from dirt, scratches and scrapes by a protective sheet (14, 114, 214, 314) which also provides other beneficial attributes that aid an installer. The membrane (12, 100, 200) and the sheet (14, 114, 214) are heat laminated together in the absence of adhesive and tackifiers. Alternatively, the membrane (12, 300) and the sheet (14, 314) are surface treated and then brought into contact with one another in the absence of adhesive and tackifiers. The sheet (14, 114, 214, 314)) may be single layer or include at least a first layer (30) directly secured to a second layer (32). The first layer (30) provides at least one of UV protection, anti-slip, and anti-glare to the roof laminate (10) and so aids the installer in at least one of those respects.
    Type: Application
    Filed: April 22, 2020
    Publication date: June 23, 2022
    Inventors: Xuan Zhang, Brittany Walls, Brock Walker, Anil Shenoy, David French
  • Publication number: 20220169628
    Abstract: The invention is directed towards compounds (e.g., Formula (I)), their mechanism of action, and methods of modulating proliferation activity, and methods of treating diseases and disorders using the compounds described herein (e.g., Formula (I)).
    Type: Application
    Filed: February 7, 2020
    Publication date: June 2, 2022
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Guangrong Zheng, Daohong Zhou, Pratik Pal, Xingui Liu, Dinesh Thummuri, Wanyi HU, Peiyi Zhang, Dongwen Lyu, Yaxia Yuan, Xuan Zhang
  • Publication number: 20220162244
    Abstract: Provided are an organic electroluminescent material and a device thereof. The organic electroluminescent material is a metal complex containing a ligand La having a structure of Formula 1A and a ligand Lb, having a structure of Formula 1B. Such metal complexes are applicable to electroluminescent devices and can obtain a higher sublimation yield during sublimation and have a lower evaporation temperature and can provide better device performance such as an increased device lifetime and a narrower full width at half maximum. Further provided are an electroluminescent device containing the metal complex and a compound composition containing the metal complex.
    Type: Application
    Filed: November 15, 2021
    Publication date: May 26, 2022
    Applicant: BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD.
    Inventors: Ming Sang, Zhen Wang, Hongbo Li, Wei Cai, Yanhua Liu, Bin Tang, Xuan Zhang, Chi Yuen Raymond Kwong, Chuanjun Xia
  • Patent number: 11319316
    Abstract: The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises a compound of Formula (I) or a compound of Formula (II). The selective killing of senescent cells may delay aging and/or treat age-related disorders.
    Type: Grant
    Filed: July 3, 2020
    Date of Patent: May 3, 2022
    Assignee: BioVentures, LLC
    Inventors: Guangrong Zheng, Daohong Zhou, Xuan Zhang, Yingying Wang, Jianhui Chang
  • Patent number: 11319708
    Abstract: A roof assembly, having: a roof deck; an insulation board assembly mounted onto the roof deck; and a roofing membrane adhered onto the insulation board assembly, wherein the insulation board assembly comprises: a foam insulation board, a woven top facer on a top side of the foam insulation board, and a woven bottom facer on a bottom side of the foam insulation board.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: May 3, 2022
    Assignee: CARLISLE CONSTRUCTION MATERIALS, LLC
    Inventors: Matthew Leatherman, Xuan Zhang, Cody Turnow
  • Publication number: 20220106261
    Abstract: Compositions that include cationic surfactants and methods of synthesizing compositions that include cationic surfactants. The surfactants include a quaternary amine and a saturated or unsaturated alkyl chain with 4 to 28 carbons. The surfactants can be generated by reacting a fatty acid modified with an amino alkyl group and an epihalohydrin in the presence of a base. The cationic surfactants can be generated by reacting a fatty acid modified with an amino alkyl group, an epihalohydrin, and a carboxylic acid. The cationic surfactants can be generated by reacting a carboxylic acid, an epihalohydrin, and a catalyst to afford a halo-substituted alkyl ester, followed by reacting the halo-substituted alky ester with a fatty acid modified with an amino alkyl group.
    Type: Application
    Filed: December 15, 2021
    Publication date: April 7, 2022
    Applicant: Saudi Arabian Oil Company
    Inventors: Xuan Zhang, Ming Han, Jinxun Wang
  • Publication number: 20220106260
    Abstract: Compositions that include cationic surfactants and methods of synthesizing compositions that include cationic surfactants. The surfactants include a quaternary amine and a saturated or unsaturated alkyl chain with 4 to 28 carbons. The surfactants can be generated by reacting a fatty acid modified with an amino alkyl group and an epihalohydrin in the presence of a base. The cationic surfactants can be generated by reacting a fatty acid modified with an amino alkyl group, an epihalohydrin, and a carboxylic acid. The cationic surfactants can be generated by reacting a carboxylic acid, an epihalohydrin, and a catalyst to afford a halo-substituted alkyl ester, followed by reacting the halo-substituted alky ester with a fatty acid modified with an amino alkyl group.
    Type: Application
    Filed: December 15, 2021
    Publication date: April 7, 2022
    Applicant: Saudi Arabian Oil Company
    Inventors: Xuan Zhang, Ming Han, Jinxun Wang
  • Publication number: 20220106262
    Abstract: Compositions that include cationic surfactants and methods of synthesizing compositions that include cationic surfactants. The surfactants include a quaternary amine and a saturated or unsaturated alkyl chain with 4 to 28 carbons. The surfactants can be generated by reacting a fatty acid modified with an amino alkyl group and an epihalohydrin in the presence of a base. The cationic surfactants can be generated by reacting a fatty acid modified with an amino alkyl group, an epihalohydrin, and a carboxylic acid. The cationic surfactants can be generated by reacting a carboxylic acid, an epihalohydrin, and a catalyst to afford a halo-substituted alkyl ester, followed by reacting the halo-substituted alky ester with a fatty acid modified with an amino alkyl group.
    Type: Application
    Filed: December 15, 2021
    Publication date: April 7, 2022
    Applicant: Saudi Arabian Oil Company
    Inventors: Xuan Zhang, Ming Han, Jinxun Wang
  • Patent number: 11286232
    Abstract: Compositions that include cationic surfactants and methods of synthesizing compositions that include cationic surfactants. The surfactants include a quaternary amine and a saturated or unsaturated alkyl chain with 4 to 28 carbons. The surfactants can be generated by reacting a fatty acid modified with an amino alkyl group and an epihalohydrin in the presence of a base. The cationic surfactants can be generated by reacting a fatty acid modified with an amino alkyl group, an epihalohydrin, and a carboxylic acid. The cationic surfactants can be generated by reacting a carboxylic acid, an epihalohydrin, and a catalyst to afford a halo-substituted alkyl ester, followed by reacting the halo-substituted alky ester with a fatty acid modified with an amino alkyl group.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: March 29, 2022
    Assignee: Saudi Arabian Oil Company
    Inventors: Xuan Zhang, Ming Han, Jinxun Wang
  • Patent number: 11279669
    Abstract: The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.
    Type: Grant
    Filed: June 18, 2021
    Date of Patent: March 22, 2022
    Assignee: XWPHARMA LTD.
    Inventors: Jia-Ning Xiang, Hao-Wei Shih, Xiaoming Wu, Xuan Zhang, James Tien
  • Publication number: 20220073662
    Abstract: Copolymer compositions and methods of making copolymer compositions with enhanced stability in high temperature and high salinity environments. The copolymers include hydrophobic monomers and sulfonated monomers. The sulfonated monomers can include 2-acrylamido-2-methylpropane sulfonic acid and allyl sulfonate. The sulfonated monomers increase the stability of the polymers in harsh conditions, and in high temperature, high salinity environments. The sulfonated monomers also reduce or prevent the hydrolysis of acrylamide groups, and therefore enhance the stability of the copolymer. The copolymer compositions can be made with free radical polymerization and an initiation complex.
    Type: Application
    Filed: September 9, 2020
    Publication date: March 10, 2022
    Inventors: Xuan Zhang, Ming Han, Jian Hou, Jinxun Wang
  • Patent number: 11268027
    Abstract: A liquid crystal composition, and a liquid crystal display element or liquid crystal display comprising the liquid crystal composition, and belongs to the field of liquid crystal display, wherein the liquid crystal composition comprises a compound represented by formula I, one or more compounds represented by formula II, one or more compounds represented by formula III, one or more compounds represented by formula IV, and at least one polymerizable compound, and has a large dielectric anisotropy (??) and a large optical anisotropy (?n), and has an obvious advantage in the development of a liquid crystal display having a high transmittance and a low cell thickness.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: March 8, 2022
    Assignee: SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIAL CO., LTD.
    Inventors: Sumin Kang, Zhian Liang, Guoliang Yun, Ruixiang Liang, Jiaming Li, Xuan Zhang
  • Publication number: 20220055982
    Abstract: The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.
    Type: Application
    Filed: June 18, 2021
    Publication date: February 24, 2022
    Inventors: JIA-NING XIANG, HAO-WEI SHIH, XIAOMING WU, XUAN ZHANG, JAMES TIEN
  • Patent number: 11254873
    Abstract: A liquid crystal composition, and a liquid crystal display element or liquid crystal display including the liquid crystal composition and belonging to the field of liquid crystal display. The liquid crystal composition includes a compound represented by formula I, a compound represented by formula II, one or more compounds represented by formula III, and at least one polymerizable compound. The liquid crystal composition simultaneously has a low rotary viscosity, a large refractive index, and a fast response speed.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: February 22, 2022
    Assignee: SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIAL, CO., LTD.
    Inventors: Sumin Kang, Zhian Liang, Ruixiang Liang, Jiaming Li, Guoliang Yun, Xuan Zhang
  • Patent number: 11242486
    Abstract: A liquid crystal composition, and a liquid crystal display element or liquid crystal display comprising the liquid crystal composition, and belongs to the field of liquid crystal display. The liquid crystal composition comprises a compound represented by formula I, a compound represented by formula II, one or more compounds represented by formula III, and at least one polymerizable compound. The liquid crystal composition has a higher clearing point (CP), a large K value, a suitable optical anisotropy (?n), and a fast response speed.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: February 8, 2022
    Assignee: SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIAL CO., LTD.
    Inventors: Sumin Kang, Zhian Liang, Ruixiang Liang, Guoliang Yun, Jiaming Li, Xuan Zhang
  • Patent number: 11242487
    Abstract: A liquid crystal composition, and a liquid crystal display element or liquid crystal display comprising the liquid crystal composition, and belongs to the field of liquid crystal display, the liquid crystal composition of the present disclosure comprising a compound represented by formula I, one or more compounds represented by formula II, one or more compounds represented by formula III, and at least one polymerizable compound. The liquid crystal composition simultaneously has a low rotary viscosity (?1), a larger dielectric anisotropy (??), and a fast response speed.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: February 8, 2022
    Assignee: SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIAL CO., LTD.
    Inventors: Sumin Kang, Zhian Liang, Guoliang Yun, Xuan Zhang, Jiaming Li, Ruixiang Liang
  • Publication number: 20220033348
    Abstract: Compositions that include cationic surfactants and methods of synthesizing compositions that include cationic surfactants. The surfactants include a quaternary amine and a saturated or unsaturated alkyl chain with 4 to 28 carbons. The surfactants can be generated by reacting a fatty acid modified with an amino alkyl group and an epihalohydrin in the presence of a base. The cationic surfactants can be generated by reacting a fatty acid modified with an amino alkyl group, an epihalohydrin, and a carboxylic acid. The cationic surfactants can be generated by reacting a carboxylic acid, an epihalohydrin, and a catalyst to afford a halo-substituted alkyl ester, followed by reacting the halo-substituted alky ester with a fatty acid modified with an amino alkyl group.
    Type: Application
    Filed: July 29, 2020
    Publication date: February 3, 2022
    Inventors: Xuan Zhang, Ming Han, Jinxun Wang