Abstract: A heterodimeric Fc-fused protein and a pharmaceutical composition comprising the heterodimeric Fc-fused protein are disclosed. The heterodimeric Fc-fused protein comprises first and second Fc regions of an immunoglobulin heavy chain constant region (Fc) pair and in which IL-21 is bound to at least one of the N-terminus or the C-terminus of the first Fc region and/or the second Fc region, wherein CH3 domains of the first Fc region and the second Fc region are mutated such that the formation of a heterodimer is promoted. When the heterodimeric Fc-fused protein according to the present invention is used, an in vivo half-life of IL-21 included in the heterodimeric Fc-fused protein may be significantly increased.

Abstract: The present invention relates to a supported hybrid catalyst system for ethylene slurry polymerization and a method for preparing ethylene polymer therewith. The supported hybrid catalyst system according to the present invention may exhibit high activity during ethylene slurry polymerization, and enables preparation of an ethylene polymer having a narrow molecular weight distribution but excellent processability.

Abstract: The present invention relates to a composition for inhibiting regulatory T cell immunosuppression, containing a fusion protein comprising a peptide that binds specifically to neuropilin 1 (NRP1). The fusion protein comprising the peptide that binds specifically to neuropilin 1 according to the present invention can reduce the proportion of regulatory T cells among CD4+ T cells in tumor tissue and inhibit the activity of regulatory T cells that infiltrated into tumor tissue, thereby down-regulating immunosuppression in the tumor tissue without causing systemic toxicity. Thus, the fusion protein can exhibit a high effect on tumor treatment.

Abstract: The present disclosure relates to a foot-and-mouth disease virus vaccine composition, especially a recombinant bivalent vaccine composition against type O and type A foot-and-mouth disease viruses. The present disclosure further relates to a method for preparing the foot-and-mouth disease virus vaccine composition, and a use of the foot-and-mouth disease virus vaccine composition in preparing medicines for preventing and/or controlling foot-and-mouth disease in animals.

Abstract: The present disclosure proposes a server for customer management. The server according to the present disclosure may include a processor and/or a memory. The processor may process a payment by a first user based on payment information, generate evaluation tag information including an evaluation tag to be displayed at a first terminal, deliver the evaluation tag information to the first terminal, acquire information indicating a third evaluation tag selected by the first user from the first terminal, deliver statistical information including the number of users who have selected the evaluation tag to a shop terminal, acquire information indicating a customer management message and a coupon to be sent to a user who has selected a predetermined evaluation tag from the shop terminal, and deliver the information indicating the customer management message and the coupon to the corresponding terminal.

Abstract: The present invention relates to a heterodimeric Fc-fused protein comprising a first Fc region and a second Fc region of an immunoglobulin Fc pair and a physiologically active protein composed of two or more different subunits, wherein one or more subunits of the physiologically active protein are linked separately to one or more ends of the N-terminus or C-terminus of the first Fc region and/or the second Fc region, and CH3 domains of the first Fc region and the second Fc region are mutated so as to promote the heterodimeric Fc formation. Moreover, the present invention relates to a pharmaceutical composition comprising the heterodimeric Fc-fused protein.

Abstract: Described herein is a framework for optimal demand-based allocation. In accordance with one aspect of the framework, trip data is extracted from vehicle operation data received from one or more vehicle data devices servicing a region of interest. Vehicle demands for multiple tiles of the region of interest and mutual travel times between neighboring tiles are estimated based at least in part on the trip data. A set of candidate tiles for allocating vehicle stations may then be determined by minimizing total travel time based on the mutual travel times and vehicle demands.

Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.

Abstract: Disclosed is an apparatus for collecting a by-product in a semiconductor manufacturing process. An objective of the present invention is to provide an apparatus for collecting a by-product such that exhaust gas having great amount of light gas is coagulated while having sufficient residence time in a long flow path, whereby the exhaust gas is collected as a high-density by-product. For this purpose, the apparatus includes: a housing receiving and discharging introduced exhaust gas and configured with a horizontal vortex plate; an upper plate covering an upper portion of the housing; an internal collecting tower provided with a collecting tower cover and a seed eliminating fin to extend a flow path and residence time of the exhaust gas; a heater having a heat conduction plate; and an extended discharging pipe configured to extend the flow path and residence time of the exhaust gas and discharge the exhaust gas.

Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.

Abstract: The present invention relates to a method for predicting the physical properties of polymers. More specifically, the present invention relates to a method for predicting the processability of polymers using a molecular weight distribution curve.

Abstract: The present invention relates to a method for predicting the physical properties of polymers. More specifically, the present invention relates to a method for predicting long-term stability of polymers using a molecular weight distribution curve.

Abstract: A composition for solar cell electrodes includes a conductive powder, a glass frit, and an organic vehicle. The glass frit contains about 20 mol % to about 40 mol % of an alkali metal, about 20 mol % to about 30 mol % of zinc (Zn), and about 7 mol % to about 20 mol % of magnesium (Mg) in terms of oxide content.

Abstract: A luminaire for architectural, industrial and warehouse applications can be assembled using an extruded housing having curved sides connected by a cross member. Window openings in the curved sides can allow light to exit toward the sides of the luminaire while most of the light exits through a lens on the bottom. The extrusion can have channels and slots such that optical elements and an LED array can be slid into the housing and retained by endcaps. A housing cover can overlie a wireway while being held in place by screws creating a clamping force between the housing cover and fixture brackets retained within the housing. The luminaire can be suspended by the fixture brackets or by elements attached to the fixture brackets.

Abstract: Described herein is a framework to facilitate vehicle position planning. In accordance with one aspect of the framework, transition information is determined based on the vehicle data, wherein the transition information includes pairs of starting and ending road segments and corresponding passenger states. Short-term demand for vehicles may be calculated based on the transition information and the historical transactional records. The short-term demand may then be used to generate a cruising recommendation.

Abstract: A method for activating a battery cell. The battery cell includes a positive electrode coated with a nickel cobalt manganese (NCM) positive electrode material, into which lithium nickel oxide (LNO) has been added or mixed. The method includes a step of charging the battery cell; and a step of discharging the battery cell, when, in the step of charging the battery cell, the battery cell is charged under a charging condition of C-rate of 0.1 C to 0.5 C in a state of being heated at a temperature of 45° C. to 60° C. When the activation process is performed according to the present invention having the above-described configuration, the pressing/heating conditions for suppressing generation of a gas may be provided to prevent swelling, battery deformation, and performance deterioration due to the generation of the gas from occurring.

Abstract: Disclosed are a speech recognition apparatus for speech recognition, and a method therefor. A speech recognition method for speech recognition includes detecting an event during a first spoken utterance, transmitting a suspension request signal requesting suspension of signal processing for the first spoken utterance at the point in time when the event is detected, and waiting for recognition of a second spoken utterance. According to the present disclosure, by canceling an erroneously spoken utterance through 5G network service and AI algorithm, a speech recognition process can proceed rapidly.

Abstract: A peptide that binds specifically to neuropilin-1 (NRP1) without binding to neuropilin-2 (NRP2) is provided. A fusion protein, a fusion antibody, small-molecule drug, a nanoparticle, or a liposome, which comprises the peptide, and a pharmaceutical composition for treating or preventing cancer or angiogenesis-related diseases, and a composition for diagnosing cancer or angiogenesis-related diseases are provided. A polynucleotide encoding the peptide that binds specifically to NRP1 and a method for screening the peptide that binds specifically to NRP1 are provided. An antibody heavy-chain constant region Fc-fused peptide binding specifically to NRP1 has the property of binding specifically to NRP1, and thus when it is administered in vivo, it accumulates selectively in tumor tissue, and widens the intercellular space between tumor-associated endothelial cells to promote its extravasation and increases its tumor tissue penetration.

Abstract: A multi-channel surround audio signal providing method is performed by one or more of an audio device and a mobile terminal in electronic devices including speakers capable of receiving an audio signal in a 5G environment connected for Internet of Things. The method includes searching for electronic devices capable of receiving a multi-channel surround audio signal, designating two or more of the electronic devices as a surround speaker sound channel, transmitting a test audio signal generated to synchronize a level of the sound of the surround speaker sound channel to the electronic devices, receiving a signal of the output feedback audio from a microphone, and adjusting a level of an audio output by the electronic devices, based on the feedback audio signal to synchronize the level of the sound of the surround speaker sound channel. The method operates between an audio device and a wireless speaker by 5G communication.

Abstract: The present disclosure provides a folding device for manufacturing an electrode assembly having a structure in which plate type unit cells are wound with a separator film, including: a mandrel configured to rotate and wind a web in which plate type unit cells are arranged on an upper surface of the separator film at predetermined intervals so that the unit cells are sequentially stacked with the separator film interposed therebetween; and a pair of rollers configured to horizontally bend a surplus winding end portion of the separator film, which is formed by arranging a first unit cell at a winding start portion of the web in a state of being spaced apart from a winding end portion of the separator film, in a direction covering an upper surface of the first unit cell, wherein the mandrel includes one or more grippers composed of one or more upper legs configured to fix an upper surface portion of the first unit cell and one or more lower legs configured to fix a lower surface portion of the separator film