Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.

Abstract: Provided is a pharmaceutical composition for preventing or treating inflammatory bowel disease (IBD) comprising a mixed extract of at least two of Aucklandia lappa Decne, Terminalia chebula Retzius, and Zingiber officinale Rosc. as an active ingredient and a method thereof, and more specifically, to a pharmaceutical composition having an inhibitory effect on monocyte adhesion in intestinal epithelial cells, an effect of inhibiting the production of inflammatory cytokines, an effect of ameliorating colitis in an animal model of dextran sodium sulfate (DSS)-induced colitis, and an effect of ameliorating Crohn's disease in an animal model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced Crohn's disease.

Abstract: Provided is a composition for preventing, improving or treating obesity, which includes a Platycodon grandiflorum extract as an active ingredient and a method for preparing the extract with an improved anti-obesity effect. The extract shows an effect of inhibiting increases in body weight and fat mass caused by a high-fat diet for normalization, an increase in fasting blood glucose and a decrease in energy expenditure in a diet-induced obesity mouse model. Further, compared to an extract prepared by a conventional extraction method, the Platycodon grandiflorum extract shows a more excellent effect of inhibiting increases in body weight and fat mass, fasting blood glucose, and blood lipid and adipokine contents in experiments, resulting in an excellent anti-obesity effect. Therefore, the Platycodon grandiflorum extract prepared is expected to be useful for preventing obesity and treating obesity-related complications that can be caused by an increase in fat mass as well as obesity.

Abstract: The present invention relates to a heterodimeric Fc-fused protein comprising a first Fc region and a second Fc region of an immunoglobulin Fc pair and a physiologically active protein composed of two or more different subunits, wherein one or more subunits of the physiologically active protein are linked separately to one or more ends of the N-terminus or C-terminus of the first Fc region and/or the second Fc region, and CH3 domains of the first Fc region and the second Fc region are mutated so as to promote the heterodimeric Fc formation. Moreover, the present invention relates to a pharmaceutical composition comprising the heterodimeric Fc-fused protein.

Abstract: A catalyst composition and a method for preparing an olefin polymer by using the same are provided herein. In some embodiments, a catalyst composition includes a transition metal compound having a compound (A) represented by Chemical Formula 1 and a compound (B) represented by Chemical Formula 2 present in a molar ratio of 1.6:1 to 18. The catalyst composition has high activity in an olefin polymerization reaction and can contribute to a reduction of catalyst cost. The catalyst composition aides in high copolymerizability of olefin monomers, and the produced olefin polymers can exhibit excellent processability and long-term physical properties, suitable for a pipe.

Abstract: A display device according to an embodiment includes a display panel and a protection layer that is disposed on the display panel, wherein the protection layer includes: a first protection layer; a metal layer that overlaps the first protection layer and includes a hole; and an adhesive layer disposed between the first protection layer and the metal layer. The adhesive layer includes a first area disposed between the first protection layer and the metal layer, and a second area and a third area that are disposed in the hole, wherein a peeling strength of the second area and a peeling strength of the third area are different from each other.

Abstract: A peptide that binds specifically to neuropilin-1 (NRP1) without binding to neuropilin-2 (NRP2) is provided. A fusion protein, a fusion antibody, small-molecule drug, a nanoparticle, or a liposome, which comprises the peptide, and a pharmaceutical composition for treating or preventing cancer or angiogenesis-related diseases, and a composition for diagnosing cancer or angiogenesis-related diseases are provided. A polynucleotide encoding the peptide that binds specifically to NRP1 and a method for screening the peptide that binds specifically to NRP1 are provided. An antibody heavy-chain constant region Fc-fused peptide binding specifically to NRP1 has the property of binding specifically to NRP1, and thus when it is administered in vivo, it accumulates selectively in tumor tissue, and widens the intercellular space between tumor-associated endothelial cells to promote its extravasation and increases its tumor tissue penetration.

Abstract: A luminaire a small number of carefully designed extrusions is easily manufactured. The housing is formed by joining four pieces having a first extrusion profile. A second extrusion profile is used for the side and end covers. A third profile is used for access covers. The housing frames a lens, such as an acrylic sheet, and long lines of LEDs are positioned to shine directly into the side of the lens. A reflective layer on the lens directs all or some of the LED light out the luminaire's front, perhaps directing some light out the back. Strategically positioned diffusors ensure a pleasing lighting effect. The result is a very thin and light weight luminaire having a large surface area. The luminaire can be suspended by threaded nipples, by cables threaded through holes in the back, or by brackets screwed to threaded inserts.

Abstract: A storage device including: a bridge board to receive a first command; an authenticator to receive user information; and a memory device to receive the first command from the bridge board, the memory device includes a memory controller which determines a status of the memory device, provides status information including the determined status of the memory device to the bridge board, determines the status of the memory device as an unlocked status or a locked status, the bridge board includes a transceiver which communicates with the host through an interface, a register which stores interface information, and a bridge board controller which generates a first response to the first command in a format corresponding to the interface using the interface information, and provides the first response to a host, the first response includes a status bit which inhibits or allows a write operation with respect to the memory device.

Abstract: Luminaire housings for architectural, industrial and warehouse applications have extrusions with parallel flat sides connected by a cross member. The wireway can be enclosed by the extrusion's roof or by cover segments clamped over an open top extrusion. Wireway openings provide access to the wireway. Nuts slid into T-channels in the roof or cover segments provide for mounting or suspension via wall brackets, cables, and housing brackets. Threaded nipples accessible through the roof or cover segments provide for pendant stem mounting. Continuous run brackets can join housings end to end. Optical elements slid into slots and channels in the housing can be retained by end caps. A housing cover over the wireway can be clamped in place by screws threaded into fixture brackets retained within the housing. The housing grooves in the cover segments can slidably engage the extrusion until the cover segments are clamped in place.

Abstract: Disclosed is an apparatus for collecting a by-product in a semiconductor manufacturing process. An objective of the present invention is to provide an apparatus for collecting a by-product such that exhaust gas having great amount of light gas is coagulated while having sufficient residence time in a long flow path, whereby the exhaust gas is collected as a high-density by-product. For this purpose, the apparatus includes: a housing receiving and discharging introduced exhaust gas and configured with a horizontal vortex plate; an upper plate covering an upper portion of the housing; an internal collecting tower provided with a collecting tower cover and a seed eliminating fin to extend a flow path and residence time of the exhaust gas; a heater having a heat conduction plate; and an extended discharging pipe configured to extend the flow path and residence time of the exhaust gas and discharge the exhaust gas.

Abstract: Disclosed are a speech processing method and a speech processing apparatus in a 5G communication environment through speech processing by executing embedded artificial intelligence (AI) algorithms and/or machine learning algorithms. The speech processing method includes determining a temporary pause of reception of a first spoken utterance, outputting a first spoken response utterance as a result of speech recognition processing of a second spoken utterance received after the temporary pause, determining, as an extension of the first spoken utterance, a third spoken utterance that is received after outputting the first spoken response utterance, deleting, using a deep neural network model, a duplicate utterance part from a fourth spoken utterance that is obtained by combining the first and the third spoken utterance, and outputting a second spoken response utterance as a result of speech recognition processing of the fourth spoken utterance from which the duplicate utterance part has been deleted.

Abstract: The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By comprising the organic electroluminescent compound according to the present disclosure, an organic electroluminescent device having low driving voltage and/or high luminous efficiency and/or long lifespan can be provided.

Abstract: Disclosed is a support unit for supporting a substrate. The support unit includes a support plate having an inner space defined therein, a heating member disposed in the inner space and emitting light for heating the substrate supported on the support unit, and a reflective member disposed along an edge region of the support plate and reflecting thermal energy of the light to an edge region of the substrate supported on the support unit.

Abstract: Disclosed are a speech processing method and apparatus therefor which execute an installed artificial intelligence algorithm and/or machine learning algorithm to perform speech processing in a 5G communication environment.

Abstract: The present invention relates to a method for predicting the physical properties of polymers. More specifically, the present invention relates to a method for predicting the processability of polymers using a molecular weight distribution curve.

Abstract: Provided is a nucleic acid system introduced into a bacterial strain to generate a genetically engineered bacterial strain that grows in solid tumors but does not grow in non-tumor tissues, the nucleic acid system comprising: a first DNA fragment that encodes a toxin gene that expresses a toxin that kills the genetically engineered bacterial strain; a second DNA fragment that encodes an antidote gene that expresses an antidote that negates the toxin; a first promotor that controls transcription of the antidote gene, such that glucose represses the transcription of the antidote gene; and a first constitutive promoter that causes constitutive expression of the toxin gene; wherein the second DNA fragment is transcribed in the solid tumors but not transcribed in the non-tumor tissues.

Abstract: A catalyst composition, a method from preparing an olefin polymer using the same, and an olefin polymer prepared from the same are disclosed herein. In some embodiments, a catalyst composition includes a first metallocene compound represented by the Chemical Formula 1, a second metallocene compound represented by the Chemical Formula 2, and a support. The catalyst composition can exhibit high activity in an olefin polymerization reaction and thus contribute to reducing catalyst costs, and can also exhibit high copolymerizability which can secure excellent processability and long-term physical properties, and thus, is suitable for providing polymers for pipes.

Abstract: The inventive concept provides a support unit for supporting a substrate. The support unit includes a support plate that has an interior space and on which the substrate is placed, a heating member that is provided in the interior space and that heats the substrate placed on the support plate, a heat insulating plate provided in the interior space and disposed under the heating member, a reflective plate provided in the interior space and disposed under the heat insulating plate, and a heat dissipation plate provided in the interior space and disposed under the a reflective plate.