Patents by Inventor Yi-Hsing Chen

Yi-Hsing Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190381118
    Abstract: Use of Lactobacillus paracasei for preparing for a combination for alleviating axillary osmidrosis is provided in the present invention, wherein Lactobacillus paracasei refers in particular to Lactobacillus paracasei GMNL-653, featuring abilities of aggregating and inhibiting pathogens of axillary osmidrosis for alleviation of armpit odors and presented as a topical medication or a combination of cosmetics in which fragrance is added.
    Type: Application
    Filed: October 4, 2018
    Publication date: December 19, 2019
    Inventors: Yi-Hsing Chen, Wan-Hua Tsai, Chia-Hsuan Chou, Tsuei-Yin Huang
  • Patent number: 10456428
    Abstract: A method and a composition having the Lactobacillus paracasei strain GMNL-653 for treating psoriasis is provided. The Lactobacillus paracasei strain GMNL-653 has anti-inflammation properties, and inhibits the secretion of cytokine IL-6 and IL-17, so that the psoriasis symptoms caused by over-inflammation are improved/relieved.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: October 29, 2019
    Assignee: GENMONT BIOTECH INC.
    Inventors: Yi-Hsing Chen, Wan-Hua Tsai, Chia-Hsuan Chou, Pei-Jane Tsai, Tsuei Yin Huang
  • Patent number: 10456430
    Abstract: A composition is used for prevention or treatment of bacterial vaginosis (BV) and regulation of vaginal immunity and said composition with effective amount is selected from the groups comprising Lactobacillus rhamnosus GMNL-680 and Lactobacillus plantarum GMNL-682; the composition of the present invention is used to prevent and treat bacterial vaginosis by inhibition of the growth of pathogens and regulation of the expression of immunoregulators and is prepared in the forms of pharmaceutical compositions, food or other combinations thereof.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: October 29, 2019
    Assignee: Genmont Biotech Incorporation
    Inventors: Yi-Hsing Chen, Wan-Hua Tsai, Wen-Ling Yeh
  • Publication number: 20190320659
    Abstract: The present invention relates to a plant growth regulator of elevating anti-stress ability and use thereof. The plant growth regulator, which is consisted of Lactobacillus fermenting culture solution, has excellent thermostability and safety without any side effect, significantly elevating ability against biotic and abiotic stresses. Therefore, the Lactobacillus fermenting culture solution can be applied as the plant growth regulator or a use in preparation of a composition for elevating anti-stress ability of a plant.
    Type: Application
    Filed: March 25, 2019
    Publication date: October 24, 2019
    Inventors: Yi-Hsing Chen, Wan-Hua Tsai, Tsuei-Yin Huang, Hsiang-En Huang, Yu-Jen Hsu
  • Publication number: 20190290707
    Abstract: The present invention relates to a probiotic composition for preventing, improving or alleviating pancreatic cancer and a method for preventing, improving or alleviating the pancreatic cancer and its complications using the probiotic composition. The probiotic composition, which is consisted of specific strains and specific ratio of Lactobacillus paracasei to Lactobacillus reuteri, can significantly improve or alleviate various symptomatic indicators and severity of pancreatic cancer, thereby being applied on a method for preventing, improving or alleviating the pancreatic cancer and its complications using an oral composition including the Lactobacillus strains.
    Type: Application
    Filed: March 22, 2019
    Publication date: September 26, 2019
    Inventors: Yi-Hsing Chen, Wan-Hua Tsai, Wen-Ling Yeh, Ming-Shiou Jan, Yen-Wan Hsiao, Li-Jin Hsu, Junko Sugawara
  • Publication number: 20190247295
    Abstract: The present invention provides a use for probiotic preparing skin care composition, wherein the probiotic comprises Lactobacillus plantarum (GMNL-6) with preservation number of BCRC 910777 or CCTCC M 2017765. The composition may be externally-coating drug, pharmaceuticals for external use, care products for external use or cosmetics, and may achieve the effects of improving the skin conditions or aesthetic appearance by promoting secretion of collagen or expression of ceramide synthase.
    Type: Application
    Filed: February 12, 2018
    Publication date: August 15, 2019
    Inventors: Yi-Hsing Chen, Wan-Hua Tsai, Chia-Hsuan Chou, Ying-Ju Chiang
  • Patent number: 10300094
    Abstract: A method for inhibiting bacterial adhesion of oral pathogens, comprising administering a heat-inactivated Lactobacillus strain to a subject in need to inhibit bacterial adhesion of oral pathogens is disclosed. The Lactobacillus strain is selected from Lactobacillus paracasei GMNL-143, Lactobacillus helveticus GMNL-164 or Lactobacillus rhamnosus GMNL-464. A composition for inhibiting bacterial adhesion of oral pathogens is also disclosed.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: May 28, 2019
    Assignee: GENMONT BIOTECH INC.
    Inventors: Yi-Hsing Chen, Ya-Hui Chen, Chien-Chen Wu
  • Patent number: 10159701
    Abstract: A use of a Lactobacillus paracasei strain to prepare a composition for resisting bone loss is provided. The Lactobacillus paracasei strain GMNL-653 is capable of promoting the expression of TGF-? and IL-10, while inhibiting the expression of osteoclast related genes and reducing the content of IL-17A in serum, so that the bone loss is slowed down.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: December 25, 2018
    Assignee: GENMONT BIOTECH INC.
    Inventors: Yi-Hsing Chen, Wan-Hua Tsai, Chia-Hsuan Chou, Pei-Jane Tsai, Tsuei Yin Huang
  • Patent number: 10159700
    Abstract: A composition of Lactobacillus fermentum GMNL-296 and a use of Lactobacillus fermentum GMNL-296 for producing a composition to improve the infection symptoms of Clostridium difficile are provided. The Lactobacillus fermentum GMNL-296 is to promote the expression of anti-inflammatory cytokine IL-10 and Treg cell related transcription factors, so that the infection symptoms of weight loss and intestinal abnormalities are improved.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: December 25, 2018
    Assignee: GENMONT BIOTECH INC.
    Inventors: Yi-Hsing Chen, Wan-Hua Tsai
  • Publication number: 20180256651
    Abstract: A composition having the Lactobacillus paracasei strain GMNL-653 for treating psoriasis is provided. The Lactobacillus paracasei strain GMNL-653 has anti-inflammation properties, and inhibits the secretion of cytokine IL-6 and IL-17, so that the psoriasis symptoms caused by over-inflammation are improved/relieved.
    Type: Application
    Filed: August 14, 2017
    Publication date: September 13, 2018
    Inventors: Yi-Hsing Chen, Wan-Hua Tsai, Chia-Hsuan Chou, Pei-Jane Tsai, Tsuei Yin Huang
  • Publication number: 20180256654
    Abstract: A use of a Lactobacillus paracasei strain to prepare a composition for resisting bone loss is provided. The Lactobacillus paracasei strain GMNL-653 is capable of promoting the expression of TGF-? and IL-10, while inhibiting the expression of osteoclast related genes and reducing the content of IL-17A in serum, so that the bone loss is slowed down.
    Type: Application
    Filed: November 29, 2017
    Publication date: September 13, 2018
    Inventors: Yi-Hsing CHEN, Wan-Hua Tsai, Chia-Hsuan Chou, Pei-Jane Tsai, Tsuei Yin Huang
  • Publication number: 20180236015
    Abstract: A composition having Lactobacillus Plantarum strain GMNL-662 for promoting bone regrowth is provided. The Lactobacillus Plantarum strain GMNL-662 has an ability to promote the expression of osteogenic genes, inhibit the expression of osteoclast related genes, and promote the expression of osteogenesis-related cytokine TGF-?, so that the bone loss is improved.
    Type: Application
    Filed: May 24, 2017
    Publication date: August 23, 2018
    Inventors: Yi-Hsing Chen, Wan-Hua Tsai, Chia-Hsuan Chou, Chi Chien Lin
  • Publication number: 20180228851
    Abstract: The present invention is related to a Lactobacillus strain, composition and use thereof for treating autoimmune disease and related complications. The composition comprises at least one isolate of Lactobacillus paracasei strain GMNL-32, L. reuteri strain GMNL-89 or L. reuteri strain GMNL-263, and a pharmaceutical carrier, for treating syndromes and related complications of the autoimmune diseases.
    Type: Application
    Filed: April 16, 2018
    Publication date: August 16, 2018
    Inventors: Chih-Yang HUANG, Wei-Wen KUO, Bor-Show TZANG, Yi-Hsing CHEN
  • Patent number: 9980990
    Abstract: The present invention is related to a Lactobacillus strain, composition and use thereof for treating autoimmune disease and related complications. The composition comprises at least one isolate of Lactobacillus paracasei strain GMNL-32, L. reuteri strain GMNL-89 or L. reuteri strain GMNL-263, and a pharmaceutical carrier, for treating syndromes and related complications of the autoimmune diseases.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: May 29, 2018
    Assignee: GenMont Biotech Incorporation
    Inventors: Chih-Yang Huang, Wei-Wen Kuo, Bor-Show Tzang, Yi-Hsing Chen
  • Publication number: 20180050072
    Abstract: A composition of Lactobacillus fermentum GMNL-296 and a use of Lactobacillus fermentum GMNL-296 for producing a composition to improve the infection symptoms of Clostridium difficile are provided. The Lactobacillus fermentum GMNL-296 is to promote the expression of anti-inflammatory cytokine IL-10 and Treg cell related transcription factors, so that the infection symptoms of weight loss and intestinal abnormalities are improved.
    Type: Application
    Filed: December 1, 2016
    Publication date: February 22, 2018
    Inventors: Yi-Hsing CHEN, Wan-Hua TSAI
  • Patent number: 9895400
    Abstract: A use of a Lactobacillus reuteri GMNL-263 in decreasing blood lipid levels is disclosed. Lactobacillus reuteri GMNL-263 (accession No.: CCTCC M 209263) specifically inhibits gene expression related to pro-inflammatory factor and lipid synthesis and promotes gene expression related to cholesterol metabolism. Lactobacillus reuteri GMNL-263 is utilized to produce a composition for decreasing blood lipid levels, thereby achieving the aim of hyperlipidemia treatment.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: February 20, 2018
    Assignee: Genmont Biotech Inc.
    Inventors: Yi-Hsing Chen, Ya-Hui Chen, Tzu-Chi Lou, Ting-Yun Shen
  • Publication number: 20170281698
    Abstract: A method for inhibiting bacterial adhesion of oral pathogens, comprising administering a heat-inactivated Lactobacillus strain to a subject in need to inhibit bacterial adhesion of oral pathogens is disclosed. The Lactobacillus strain is selected from Lactobacillus paracasei GMNL-143, Lactobacillus helveticus GMNL-164 or Lactobacillus rhamnosus GMNL-464. A composition for inhibiting bacterial adhesion of oral pathogens is also disclosed.
    Type: Application
    Filed: June 8, 2016
    Publication date: October 5, 2017
    Inventors: Yi-Hsing Chen, Ya-Hui CHEN, Chien-Chen WU
  • Patent number: 9601388
    Abstract: A method of fabricating a semiconductor device includes providing a semiconductor substrate having a first region and a second region, forming a first dielectric layer over the semiconductor substrate, forming a first metal layer over the first dielectric layer, the first metal layer having a first work function, removing at least a portion of the first metal layer in the second region, and thereafter, forming a semiconductor layer over the first metal layer in the first region and over the at least partially removed first metal layer in the second region. The method further includes removing the semiconductor layer and forming a second metal layer on the first metal layer in the first region and on the at least partially removed first metal layer in the second region, the second metal layer having a second work function that is different than the first work function.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: March 21, 2017
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Ryan Chia-Jen Chen, Jr-Jung Lin, Chien-Hao Chen, Yi-Hsing Chen, Kuo-Tai Huang, Yih-Ann Lin, Yi-Shien Mor
  • Publication number: 20160293490
    Abstract: A method of fabricating a semiconductor device includes providing a semiconductor substrate having a first region and a second region, forming a first dielectric layer over the semiconductor substrate, forming a first metal layer over the first dielectric layer, the first metal layer having a first work function, removing at least a portion of the first metal layer in the second region, and thereafter, forming a semiconductor layer over the first metal layer in the first region and over the at least partially removed first metal layer in the second region. The method further includes removing the semiconductor layer and forming a second metal layer on the first metal layer in the first region and on the at least partially removed first metal layer in the second region, the second metal layer having a second work function that is different than the first work function.
    Type: Application
    Filed: January 29, 2016
    Publication date: October 6, 2016
    Inventors: Ryan Chia-Jen Chen, Jr-Jung Lin, Chien-Hao Chen, Yi-Hsing Chen, Kuo-Tai Huang, Yih-Ann Lin, Yi-Shien Mor
  • Patent number: 9362124
    Abstract: Provided are methods of patterning metal gate structures including a high-k gate dielectric. In an embodiment, a soluble hard mask layer may be used to provide a masking element to pattern a metal gate. The soluble hard mask layer may be removed from the substrate by water or a photoresist developer. In an embodiment, a hard mask including a high-k dielectric is formed. In a further embodiment, a protection layer is formed underlying a photoresist pattern. The protection layer may protect one or more layers formed on the substrate from a photoresist stripping process.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: June 7, 2016
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Chien-Hao Chen, Shun Wu Lin, Chi-Chun Chen, Ryan Chia-Jen Chen, Yi-Hsing Chen, Matt Yeh, Donald Y. Chao, Kuo-Bin Huang