Abstract: A ramp generator includes an operational amplifier having an output to generate a ramp signal. An integration current source is coupled to a first input and a reference voltage is coupled to a second input of the operational amplifier. A feedback capacitor is coupled between the first input and the output of the operational amplifier. A monitor circuit is coupled to the first and second inputs of the operational amplifier to generate an output flag in response to a comparison of the first and second inputs. A trimming control circuit is configured to generate a trimming signal in response to the output flag. An assist current source is configured to conduct an assist current from the output of the operational amplifier to ground in response the trimming signal generated by the trimming control circuit.

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

Abstract: Embodiments of the present disclosure relate to a method and an optical communication device implemented in an optical network and a computer-readable storage medium. In the method described herein, a distribution point unit (DPU) of the optical network receives a message comprising an identification of a target backhaul model from an Optical Line Terminal (OLT) in the optical network. The received message is parsed to obtain the identification of the target backhaul model. The target backhaul model indicated by the identification is used to communicate with the OLT. In this way, the DPU is compatible with many types of backhaul models and is capable of flexibly switching between the many types of backhaul models.

Abstract: The fingerprint recognition panel includes fingerprint recognition circuits arranged in a matrix, reading signal lines, a gate driving circuit and scanning lines connected with the gate driving circuit. The gate driving circuit is for outputting scanning signals to the scanning lines successively; each fingerprint recognition circuit is in connection with two scanning lines, a reading control end is connected with a first scanning line, and a reset control end is connected with a second scanning line; the first scanning line in connection with the fingerprint recognition circuits of the nth row and the second scanning line in connection with the fingerprint recognition circuits of the (n?m)th row are the same; or the second scanning line in connection with the fingerprint recognition circuits of the nth row and the first scanning line in connection with the fingerprint recognition circuits of the (n?m)th row are the same.

Abstract: An aqueous suspension comprising water, a zeolitic material and one or more of copper and iron, and a chelate complex comprising a zirconium ion and a bidentate organic ligand bonded to said zirconium ion via zirconium oxygen bonds from two oxygen atoms comprised in said ligand, said chelate complex being dissolved in the water.

Abstract: A wearable device based on photoplethysmography PPG and a control method thereof are disclosed, where the wearable device includes a PPG module and a processor. The PPG module includes a plurality of light emitting diodes LEDs and a plurality of photodiodes PDs. The plurality of PDs are distributed around the plurality of LEDs in a surrounding structure. Each LED is configured to emit light signals. The LED is a tricolor integrated LED in which red light, green light, and infrared light are combined, and the light signals include a green light signal, a red light signal, and/or an infrared light signal. Each PD is configured to: receive the light signals, and transmit the light signals to the processor. The processor is configured to obtain a heart rate feature, a blood oxygen feature, and/or a respiration rate feature based on the light signals received from the plurality of PDs.

Abstract: Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

Abstract: A cart for wafer transportation includes a cart body, a separator disposed between first and second wafer holders, an airtight lock configured to seal the cart body. A wafer transfer system includes a cart including a space for holding a wafer holder, a first workstation configured to load the wafer holder into the space and pressurize the space, and a second workstation configured to depressurize the space and unload the wafer holder from the space, wherein the cart is transportable between the first workstation and the second workstation. A method for transporting wafers includes docking a cart in a workstation; loading a wafer holder into a space of the cart; pressurizing the space to cause a pressure of the space to be greater than an atmospheric pressure; maintaining the pressure of the space at the pressure; and moving the cart carrying the wafer holder away from the workstation.

Abstract: A paste extruding device for a tubular positive plate includes a plate main body. The plate main body includes a cross beam, ribs and a tab. The ribs are linearly distributed on a bottom surface of the cross beam, and the tab is provide on a top surface of the cross beam. A processing tube is sleeved outside the rib, and the processing tube has a cavity shell structure with an open top. A filling cavity is formed between the rib and the processing tube, and a sliding groove is provided at a vertical central line of an outer wall of the processing tube. A processing sliding base is slidably sleeved on the outer wall of the processing tube. A paste extruding cavity is provided at an inner top of the processing sliding base, and a cooling cavity is provided at an inner bottom of the processing sliding base.

Abstract: Methods, apparatus, computer program products for exchange data among air-gapped devices are provided. The method comprises: identifying, by a device in a cluster of devices, a plurality of accessible devices in the cluster via corresponding respective quick response (QR) codes; generating, by the device, logical routing information based on the identified plurality of accessible devices, the logical routing information comprising at least identifiers of the identified plurality of accessible devices; and transmitting, by the device, data encoded in a plurality of QR codes to a destination device in the cluster based on a shortest routing path identified in the logical routing information.

Abstract: In example implementations, a computing device is provided. The computing device includes an expansion interface, a first device, a second device, and a processor communicatively coupled to the expansion interface. The expansion interface includes a plurality of slots. Two slots of the plurality of slots are controlled by a single reset signal. The first device is connected to a first slot of the two slots and has a feature that is compatible with the single reset signal. The second device is connected to a second slot of the two slots and does not have the feature compatible with the single reset signal. The process is to detect the first device connected to the first slot and the second device connected to the second slot and disable the feature by preventing the first slot and the second slot from receiving the single reset signal.

Abstract: Disclosed are a battery cell case having a dissoluble mechanism and a high-capacity battery. The battery cell case comprises at least one dissoluble mechanism, which comprises an isolating assembly and a dissoluble assembly; the battery cell case is provided with an opening, where the isolating assembly and the dissoluble mechanism are arranged sequentially in a direction away from the battery cell case; when the dissoluble assembly contacts with electrolyte outside the battery cell case, the isolating assembly is opened because the dissoluble mechanism is dissolved, thereby the interior of the battery cell case communicates with the exterior of the battery cell case. The high-capacity battery comprises at least two battery cells and an electrolyte storage pipeline, where the electrolyte storage pipeline comprises a main pipeline and a plurality of branch pipes, the branch pipes are in one-to-one correspondence to the openings of the battery cell cases.

Abstract: A sealing device for a foot therapeutic apparatus includes an airtight sleeve and a sealing member. The airtight sleeve includes a treatment box connecting end and a limb inlet end. The sealing member is fixedly mounted at the limb inlet end. The sealing member includes a tightening band and an annular gas bag located on the outer periphery of the tightening band. The annular gas bag is connected to a gas source. A foot therapeutic apparatus with the sealing device includes a treatment chamber and an electrical chamber. The treatment chamber comprises a treatment box, and the sealing device is arranged on the treatment box. A box opening is arranged at a top of the treatment box, and the treatment box connecting end of the airtight sleeve of the sealing device is hermetically connected to the box opening.

Abstract: Methods for treating melanin-related afflictions of the skin, such as hyperpigmentation, are provided. The methods comprise administering a composition comprising BoNT/DC.

Abstract: Methods, systems, and computer storage media are provided for tracking an advertisement using a single URL without redirection. When an ad event is received on a client-computing device, a single URL is determined to provide content for the item and to track the ad event, the URL identifying a domain server. A parameter related to the ad event is determined and encoded as a part of the URL or as a HTTP header. The URL is called, causing the domain server to extract the parameter from the URL or the HTTP header and asynchronously request tracking of the ad event. Additionally, the content for the item is received from the domain server.

Abstract: A method of 3D motion reconstruction of outdoor, highly flexible moving subjects with multiple cameras on drones is described herein. A multi-drone capturing system is used to remove the restriction of a dedicated virtual reality shooting place, “the hot seat,” so that the actor/target is able to perform agile or long-distance activities outdoor. The subject's 3D pose parameters are estimated by the captured multi-view images by the drones, and the sequence of poses becomes the motion in time to control the animation of a pre-built 3D model. The method is able to be directly integrated into an existing Virtual Reality/Augmented reality (VR/AR) production chain, and the subject is able to be extended to animals that are difficult to be contained in a VR camera mesh space.

Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, prodrug or stereoisomer thereof, wherein R1, R2a, R3a, R3b, R4a, R4b, G1, G2, L1, L2, m1, m2, A, B, W, X, Y, Z and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

Abstract: A liquid outlet device for reagent kit includes a spray pipe and a nozzle that is arranged at one end of the spray pipe, where each blocking strip extends along an axial direction of the spray hole and one end of each blocking strip is provided with a shoulder that extends towards a center of the spray hole. The spray pipe includes a spray pipe body, a plurality of blocking strips and a magnet bar that is movable along the axial direction of the spray hole in a space defined by the shoulders and the blocking strips. The nozzle includes an annular sleeve connected with the spray pipe body through threaded connection or clamped connection, an end plate, a nozzle pipe, a conical nozzle opening and an annular blocking flange.

Abstract: The present disclosure provides compounds and methods for inhibiting the interaction of menin with its upstream or downstream signaling molecules including but not limited to MLL1, MLL2 and MLL-fusion oncoproteins. Compounds of the disclosure may be used in methods for the treatment of a wide variety of cancers and other diseases associated with one or more of MLL1, MLL2, MLL fusion proteins, and menin.