Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: Crystalline Forms of Compound (I); crystalline Forms of Compound (II) and crystalline forms of pharmaceutically acceptable salts of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: The present invention discloses a method for preparing large-area transition metal dichalcogenide (TMDC) single-crystal films and the products obtained therefrom. The method comprises the steps of: (1) providing a single-crystal C-plane sapphire with surface steps along <1010>directions; and (2) taking the sapphire in step (1) as the substrate, generating unidirectionally arranged TMDC domains on the sapphire surface based on a vapor deposition method and keeping the domains continuously grow and merge into a large-area single-crystal film. The lateral size of the TMDC single-crystal films prepared by the method can reach inch level or above, and is limited only by the size of the substrate.

Abstract: The disclosure provides at least one entity chosen from compounds of formula (I), solid state forms of the same, compositions comprising the same, and methods of using the same, including use in treating focal segmental glomeulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).

Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: A resource selection method and terminal device are provided. The method includes: detecting, by a first terminal device, a plurality of resource locations before receiving a higher layer request; obtaining, by the first terminal device based on the plurality of resource locations, a first set in a first time window after the higher layer request is received; determining, by the first terminal device, that a quantity of resources in the first set is less than a preset first threshold; and selecting, by the first terminal device from a resource pool, a resource used to send the to-be-transmitted data. According to the method and the terminal device, impact on sending performance of another terminal device in a system can be reduced and sending performance of the terminal device can be improved.

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.

Abstract: A two-by-two array consists of four pixels. Each pixel comprises one light-sensing transistor and one reading transistor. Both the light sensing transistor and the reading transistor are formed above a same P-type semiconductor substrate, and have a composite dielectric gate structure. The substrates of the four reading transistors are connected to form a regular octagonal ring structure located in the center of the array. On four sides of the regular octagonal ring structure, four heavily-doped N+ regions are formed on the substrates not covered with the composite dielectric gate, of which every two regions are opposite to each other and form right angles, wherein two opposite heavily-doped N+ regions are connected to form a shared N+ source, and the other two are connected to form a shared N+ drain.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: The present invention provides use of berbamine dihydrochloride in preparation of an Ebola virus inhibitor. In the present invention, the primed glycoprotein of the Ebola virus (EBOV-GPcl) is taken as a target site, and an antiviral active compound with the capability of binding to the EBOV-GPcl, i.e., berbamine dihydrochloride, is obtained through structure-based virtual screening. Berbamine dihydrochloride can specifically inhibit the entry of an Ebola recombinant virus by binding to the target protein EBOV-GPcl, thereby achieving the effect of anti-Ebola virus infection. The half-maximum effect concentration (EC50) of berbamine dihydrochloride against EBOV is 0.49 ?M, which indicates that berbamine dihydrochloride has a strong inhibition effect on EBOV.

Abstract: This application provides a communication method and a terminal device. The communication method may include determining, by user equipment (UE), a candidate resource set on a first carrier, where the first carrier is a carrier on which a resource is currently to be selected, and the first carrier is used to transmit first data.

Abstract: An open roof assembly comprises a drive assembly having a slider member. The slider member comprising a coupling member, a first lever member coupled to a sunshade member and a second lever member coupled to a closure member. Each lever member comprises a mating member for coupling with the slider member and a locking lever for releasably engaging a respective locking recess. The slider member is sequentially couplable to one of the lever members. When the slider member is coupled to the first lever member, the sunshade member may be opened or closed by moving the slider member. When the slider member is coupled to the second lever member, the closure member may be opened or closed by moving the slider member.

Abstract: The present disclosure relates to a sprayable gel composition for hair conditioning, comprising (a) from about 0.01% to about 0.35% by weight of an acrylate/alkyl-acrylate cross-polymer, (b) from about 0.1% to about 30% by weight of a silicone oil selected from dimethylpolysiloxane, cyclic polysiloxanes, hydroxyl-terminated polydimethylsiloxanes, polysiloxane-polyalkylene copolymers, alkyl methyl polysiloxanes, phenylmethylpolysiloxane, hydroxyl-terminated polydimethylsiloxanes, divinyldimethicone/dimethicone copolymer, and combination thereof, (c) from about 0.1% to about 30% by weight of a monohydric alcohol containing from about 2 to about 8 carbon atoms, and (d) from about 40% to about 99.

Abstract: A photosensitive detector includes an array of detectin units, each detection unit having a light-sensing transistor (1), a charge storage transistor (2) and a reading transistor (3), or comprising a light-sensing transistor, a charge transfer transistor (4), a charge storage transistor and a reading transistor. The light-sensing transistor is configured to realize the light-sensing function of the photosensitive detector; the charge storage transistor is configured to store photogenerated charges; the reading transistor is configured to read a signal; and, the charge transfer transistor is configured to control the transfer of the photogenerated charges. The photosensitive detector can realize global shutter and fast reading, and is compatible with the existing floating gate CMOS process, and the failure of any pixel will not affect the normal operation of the whole imaging array.

Abstract: The present disclosure relates to a sprayable gel composition, comprising (a) from about 0.08% to about 1.8% by weight of a polysaccharide, (b) from about 0.002% to about 0.08% by weight of a divalent alkaline earth cation, (c) from about 0.1% to about 30% by weight of a humectant, (d) from 0% to about 30% by weight of an emollient, and (e) from about 40% to about 95% by weight of a cosmetically acceptable carrier, wherein the weight percentages are based on the total weight of all components of the sprayable gel composition, and to a method of treating hair in need of a conditioning treatment.

Abstract: System and means generates synthetic forms of social media data such as data from microblogging services (e.g., Twitter) and social networking services (e.g., Facebook). This system and means jointly generate interaction graph structures and text features similar to input social media data. First, an interaction graph is generated by mapping social network interactions in input (real) social media data to graph structures. This interaction graph is fitted to a social network model (or a composite model) by minimizing the distance between the input and the synthetic interaction graphs (of potentially different sizes). The distance is measured statistically or based on the performance of social media analytics. Various patterns (such as anomalies), interaction types and temporal dynamics are generated synthetically. Second, text features are extracted from input social media data with topic modeling and statistical analysis of word tuple distributions.

Abstract: A light emitting device, a method of fabricating a light emitting device and a method of controlling light emission. The light emitting device includes a plasmonic structure. The plasmonic structure is configured to have a plurality of localized surface plasmon resonances. The light emitting device also includes a broadband light emitting layer having an emission spectrum substantially overlapping wavelengths of the localized surface plasmon resonances. A spacer layer is disposed between the plasmonic structure and the broadband light emitting layer. A color of light emitted by the broadband light emitting layer is tunable by the localized surface plasmon resonances of the plasmonic structure.

Abstract: A method for preparing a GaN substrate material includes: performing in-situ epitaxy on a Ga2O3 thin film and a GaN thin film in a multifunctional HVPE growth system. First, the Ga2O3 thin film is grown on a substrate such as sapphire by an HVPE-like method, and the Ga2O3 is nitrided in an ammonia gas atmosphere to form a GaN/Ga2O3 composite thin film. Then, a GaN thick film is grown on the GaN/Ga2O3 composite thin film by HVPE to obtain a high-quality GaN thick film material. The Ga2O3 layer is removed by chemical etching to obtain a self-supporting GaN substrate material. Or, the conventional laser lift-off method is used to separate the GaN thick film from the heterogeneous substrate such as the sapphire to obtain a GaN self-supporting substrate material.

Abstract: The present disclosure provides a data sending method. A first terminal device, determines at least two carriers to transmit at least two pieces of data corresponding to a same transport block, and in a one-to-one correspondence with the at least two pieces of data. The at least two pieces of data can be sent by the first terminal to a second terminal device or a network device by using the at least two carriers. When the first terminal device sends data, the first terminal device may send the at least two pieces of data to the second terminal device or the network device on the at least two carriers to improve reliability of data transmission. The at least two pieces of data may be sent simultaneously, to avoid an increased latency by transmissions of the at least two pieces of data in different time units.

Abstract: A method for resource selection is disclosed. The method includes performing, by a UE, a first sensing operation to determine available resources in a resource pool; transmitting, by the UE, first data using a first set of available resources, the first set of available resources having been selected from the resource pool in accordance with the first sensing operation; performing, by the UE, concurrently with the first sensing operation and resource selection of the first set of available resources and independently from the first sensing operation, a second sensing operation to determine other available resources in the resource pool; and transmitting, by the UE, second data using a second set of available resources, the second set of available resources having been selected from the resource pool in accordance with the second sensing operation, wherein the first set of available resources and the second set of available resources are independently selected.