Abstract: Compositions and methods for editing deleterious mutations associated with Alpha-1 Antitrypsin Deficiency (A1AD). In particular embodiments, the invention provides methods for treating A1AD using a modified adenosine base editor with improved on-target editing and decreased off-target editing to correct mutations associated with A1AD.

Abstract: The present invention features compositions and methods for editing deleterious mutations associated with alpha-1 anti-trypsin (A1AT) deficiency. In particular embodiments, the invention provides methods for correcting mutations in an A1AT polynucleotide using an adenosine deaminase base editor. ABE8, having unprecedented levels of efficiency.

Abstract: The invention features base editors having reduced non-target deamination, methods of using the base editors, and assays for characterizing base editors as having decreased non-target deamination, e.g. compared to programmed, on-target deamination.

Abstract: The present invention features compositions and methods for editing deleterious mutations associated with hemoglobinopathies, such as sickle cell disease (SCD). In particular embodiments, the invention provides methods for correcting mutations in a beta globin polynucleotide using modified adenosine base editors termed “ABE8” having unprecedented levels (e.g., >60-70%) of efficiency.

Abstract: The present invention features genetically modified immune cells comprising novel adenosine base editors (e.g., ABE8) having enhanced anti-neoplasia activity, resistance to immune suppression, and decreased risk of eliciting a graft-versus-host reaction or host-versus-graft reaction, or a combination thereof. The present invention also features methods for producing and using these modified immune effector cells.

Abstract: The present invention features compositions and methods for editing deleterious mutations associated with hemoglobinopathies, such as sickle cell disease (SCD). In particular embodiments, the invention provides methods for correcting mutations in a beta globin polynucleotide using modified adenosine base editors termed “ABE8” having unprecedented levels (e.g., >60-70%) of efficiency.

Abstract: A control method includes performing multi-level classification processing on distributed energy resources to obtain corresponding power supply equipment, power storage equipment, and hybrid equipment, analyzing and processing power distribution data and load data in the smart grid to obtain a power distribution demand of the smart grid, and dividing the smart grid into different division areas, determining corresponding power supply equipment, power storage equipment, or hybrid equipment in accordance with the power distribution demand and the division areas, and performing storage regulation and control on the corresponding power supply equipment, power storage equipment, or hybrid equipment, and if it is determined that the power supply equipment, power storage equipment, or hybrid equipment has a manner of multi-resource participation in the storage regulation and control, adding different multi-resource participation pricing strategies for power supply equipment, power storage equipment, or hybrid equipm

Abstract: The present disclosure discloses a solar cell preparation method, including the following steps: providing a coating carrier plate; and placing, on the coating carrier plate, a wafter to be prepared into the solar cell, and depositing a transparent conductive film on a surface of the wafter, wherein a method for preparing the coating carrier plate include: depositing a metal layer on a carrier plate substrate, and then oxidizing the metal layer to form a metal oxide layer on the metal layer.

Abstract: Systems and methods for synchronizing motion connection communication to time-aware network for industrial systems. One system includes an electronic processor configured to determine a controller Qbv configuration for an industrial controller included in a TSN. The electronic processor is also configured to determine, based at least in part on the controller Qbv configuration, a first start of a Qbv slot for isochronous traffic for an industrial device included in the TSN. The electronic processor is also configured to adjust, based at least in part on the first start of the Qbv slot for isochronous traffic for the industrial device, network scheduling for the industrial device. The electronic processor is also configured to deploy the adjusted network scheduling to the industrial device.

Abstract: The present invention provides novel serine recombinases, recombinase based systems and compositions, and methods for genomic targeting and modification. In some aspects, the large serine recombinases, and systems thereof are used to treat human diseases.

Abstract: A recommendation system leverages multi-target search to provide item listing recommendations and/or query suggestions. For a given input image with multiple objects, multi-target search uses object detection to detect each object, and stores complementary object data associating each object from the image. Additionally, a search of an item listing datastore is performed using each object from the image as a search query. Based on item listings returned as search results, complementary item listings data associating item listings is stored. In some configurations, the complementary item listings data is also used to train a machine learning model to predict complementary item listings for a given item listing. When an input item listing is received, item listing recommendations and/or query suggestions are determined for the input item listing using the complementary object data, the complementary item listing data, and/or the machine learning model.

Abstract: A processing apparatus comprises a transmit path of a first communication system, a transmit path of a satellite communication system, a receive path of the satellite communication system, and a first calibration path. The first communication system and the satellite communication system share the receive path of the satellite communication system. A first end of the first calibration path is connected to the transmit path of the first communication system, or a first end of the first calibration path is connected to the transmit path of the satellite communication system. A second end of the first calibration path is connected to the receive path of the satellite communication system. When the first calibration path is connected to the satellite communication system, the first calibration path may be used to calibrate the satellite communication system.

Abstract: A transmit power adjustment method includes obtaining a first signal sequence, where the first signal sequence includes a valid signal sequence; controlling a first module and a second module to adjust transmit power of the first signal sequence; and sending the first signal sequence. The first module is configured to coarsely adjust the transmit power of the first signal sequence. The second module is configured to finely adjust the transmit power of the first signal sequence. After obtaining the first signal sequence, a transmitter may steadily adjust the transmit power of the first signal sequence by using the first module and the second module, and correspondingly send the valid signal sequence in the first signal sequence when the transmit power reaches the first transmit power threshold and/or the second transmit power threshold.

Abstract: A chip includes a satellite communication system radio frequency (RF) path, a first satellite positioning system RF path, and a first phase-locked loop (PLL). The satellite communication system RF path and the first satellite positioning system RF path share the first PLL.

Abstract: The application relates to a pharmaceutical combination or combinational therapy comprising a therapeutically effective amount of the compound of Formula (I), or a pharmaceutically acceptable salt thereof, and at least one second agent, or a pharmaceutically acceptable salt thereof, for use in the treatment of a BTK-mediated disease or disorder.

Abstract: A method and a system for monitoring wear of a braking frictional pad of a motor vehicle, the motor vehicle including a brake device acting on a vehicle wheel, the brake device including a braking frictional pad that is non-rotatable relative to the vehicle wheel and is linearly movable parallel to a rotational axis of the vehicle wheel; a brake piston configured to drive the braking frictional pad; and an electric parking brake or an electric mechanical brake, the electric parking brake or the electric mechanical brake having a drive motor and a piston driving part driven by the drive motor to be linearly movable, the piston driving part being configured to, when the motor vehicle is braking, drive the brake piston to contact the braking frictional pad and in turn drive the braking frictional pad to move.

Abstract: A recommendation system leverages multi-target search to provide item listing recommendations and/or query suggestions. For a given input image with multiple objects, multi-target search uses object detection to detect each object, and stores complementary object data associating each object from the image. Additionally, a search of an item listing datastore is performed using each object from the image as a search query. Based on item listings returned as search results, complementary item listings data associating item listings is stored. In some configurations, the complementary item listings data is also used to train a machine learning model to predict complementary item listings for a given item listing. When an input item listing is received, item listing recommendations and/or query suggestions are determined for the input item listing using the complementary object data, the complementary item listing data, and/or the machine learning model.