Abstract: The present invention relates to a metallocene complex with a heteroatom-containing ?-ligand, having a chemical structure represented by formula (I) as below: wherein M is a transition metal element from Group 3, Group 4, Group 5 and Group 6 in the periodic table, including lanthanides and actinides; X, being the same as or different from each other, is selected from hydrogen, halogen, an alkyl group R, an alkoxyl group OR, a mercapto group SR, a carboxyl group OCOR, an amino group NR2, a phosphino group PR2, —OR?O— and OSO2CF3; n is an integer from 1 to 4 and is not zero; the charge number resulted from multiplying n by the charge number of X equals to the charge number of the central metal atom M minus 2; Q is a divalent radical; A is a ?-ligand; and Z is a ?-ligand; the process for producing the same; a catalyst system of the same; and use of the catalyst system.

Abstract: The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging drugs for cancers.

Abstract: A system according to at least one embodiment comprises a body comprising a plurality of support surfaces. The system further comprises an apparatus comprising a plurality of connector surfaces, each connector surface of the plurality of connector surfaces being engageable with a respective support surface of the plurality of support surfaces, wherein, when any one connector surface of the plurality of connector surfaces is engaged with its respective support surface of plurality of support surfaces, a multi-axis hinge associated with the one connector surface permits movement of the apparatus relative to the body about a plurality of different axes of rotation for the multi-axis hinge.

Abstract: Small molecule compounds derived from ?-sulfophenylacetic amide (SPAA) are provided as novel sulfonic acid based pTyr mimetics. These compounds effectively inhibit a variety of protein tyrosine phosphatases (PTPs), such as mPTPA, mPTPB, LMWPTP, and Laforin. Use of these compounds as pharmaceutical agents for treating diseases associated with abnormal protein tyrosine phosphatase activity is also provided.

Abstract: The present invention relates to the field of pharmaceutical chemistry, and specifically relates to a fused heterocyclic compound derivative and an application thereof. The fused heterocyclic compound derivative has the structure of general formula (I), and can be used to treat neuropsychiatric diseases.

Abstract: An image sensor pixel array comprises a plurality of image pixel units to gather image information and a plurality of phase detection auto-focus (PDAF) pixel units to gather phase information. Each of the PDAF pixel units includes two of first image sensor pixels covered by a shared micro-lens. Each of the image pixel units includes four of second image sensor pixels adjacent to each other, wherein each of the second image sensor pixels is covered by an individual micro-lens. A coating layer is disposed on the micro-lenses and forms a flattened surface across the whole image sensor pixel array to receive incident light.

Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.

Abstract: Systems, methods, and non-transitory computer readable media may be configured to characterize optical characteristics of optical elements. An optical element mount may be configured to carry an optical element. A calibration display may be configured to display a calibration object. The calibration object may include a known visual pattern. Multiple images of the calibration object may be obtained. The multiple images may be acquired using the optical element carried by the optical element mount. The multiple images may include different perspectives of the calibration object. Optical characteristics of the optical element may be characterized based on the known visual pattern and the different perspectives of the calibration object.

Abstract: The present invention relates to a lactam compound derivative, a medicine composition comprising the lactam compound derivative, and uses of the composition and the lactam compound derivative in preparation of a medicine for preventing or treating schizophrenia, the lactam compound derivative having a structure as shown in Formula I.

Abstract: Small molecule compounds derived from ?-sulfophenylacetic amide (SPAA) are provided as novel sulfonic acid based pTyr mimetics. These compounds effectively inhibit a variety of protein tyrosine phosphatases (PTPs), such as mPTPA, mPTPB, LMWPTP, and Laforin. Use of these compounds as pharmaceutical agents for treating diseases associated with abnormal protein tyrosine phosphatase activity is also provided.

Abstract: A liquid crystal display includes a display area and a border area at least partially surrounding the display area, where the display area displays images for viewing and the border area displays display-protection images, which are used to control ion migration in the liquid crystal layer. In a more particular embodiment, the border area displays a series of checkerboard pattern(s), where the checkerboard patterns can alternate between initial and inverted values. The display-protection images protect the liquid crystal display from migrating ions accumulating in particular regions of the pixel array and causing permanent defects in the display area. A liquid crystal display that includes a liquid crystal alignment layer having a plurality of liquid crystal alignment directions is also disclosed. The customized liquid crystal alignment director(s) over the border area promote ion migration away from the display area.

Abstract: An image sensor includes a multi-pixel detector. The multi-pixel detector includes a first pixel formed in a substrate and having a first photodiode region, a second pixel formed in the substrate adjacent to the first pixel and having a second photodiode region, and a microlens above both the first pixel and the second pixel. The microlens includes (a) in a first cross-sectional plane perpendicular to a top surface of the substrate and including both the first and the second photodiode regions, a first height profile having N1 local maxima, and (b) in a second cross-sectional plane perpendicular to the first cross-sectional plane and the top surface and including only one of the first and the second photodiode regions, a second height profile having N2>N1 local maxima.

Abstract: A contactor and a contactor system are provided. The contactor comprises: a fixed contact; a movable contact capable of moving towards or away from the fixed contact; two arc ignition sheets for the movable contact, being positioned respectively at two sides opposite to each other of the movable contact in a first direction and fixed and electrically connected to the movable contact; two arc ignition sheets for the fixed contact, being positioned respectively at two sides opposite to each other of the fixed contact in the first direction and fixed and electrically connected to the fixed contact; and two arc-extinguishing chambers being arranged respectively on extension lines extending from the movable contact to the two arc ignition sheets for the movable contact in the first direction, wherein the two arc ignition sheets for the movable contact form an incomplete encirclement for the movable contact.

Abstract: Packaged photosensor ICs are made by fabricating an integrated circuit (IC) with multiple bondpads; forming vias from IC backside through semiconductor to expose a first layer metal; depositing conductive metal plugs in the vias; depositing interconnect metal; depositing solder-mask dielectric over the interconnect metal and openings therethrough; forming solder bumps on interconnect metal at the openings in the solder-mask dielectric; and bonding the solder bumps to conductors of a package. The photosensor IC has a substrate; multiple metal layers separated by dielectric layers formed on a first surface of the substrate into which transistors are formed; multiple bondpad structures formed of at least a first metal layer of the metal layers; vias with metal plugs formed through a dielectric over a second surface of the semiconductor substrate, interconnect metal on the dielectric forming connection shapes, and shapes of the interconnect layer coupled to each conductive plug and to solder bumps.

Abstract: A liquid crystal display includes a display area and a border area at least partially surrounding the display area, where the display area displays images for viewing and the border area displays display-protection images, which are used to control ion migration in the liquid crystal layer. In a more particular embodiment, the border area displays a series of checkerboard pattern(s), where the checkerboard patterns can alternate between initial and inverted values. The display-protection images protect the liquid crystal display from migrating ions accumulating in particular regions of the pixel array and causing permanent defects in the display area. A liquid crystal display that includes a liquid crystal alignment layer having a plurality of liquid crystal alignment directions is also disclosed. The customized liquid crystal alignment director(s) over the border area promote ion migration away from the display area.

Abstract: Techniques are provided for controlling resource usage in a computing environment. In response to receiving a content request, a set of candidate content delivery campaigns is identified. For a first candidate content delivery campaign in the set, an anticipated resource usage of a resource that is associated with the first candidate content delivery campaign is determined. The anticipated resource usage is determined based on (1) a resource reduction per event of each event in a set of detected events of a content item of the first candidate content delivery campaign and (2) a decay factor. Based on the anticipated resource usage, it is determined whether the first candidate content delivery campaign is to be removed from the set.

Abstract: An electric coolant pump includes an outer housing, a motor, an impeller, and an electrical control unit. The outer housing includes a first housing portion, a second housing portion, and a partition plate integrally formed. The partition plate is disposed between the first housing portion and the second housing portion. The motor is received in the first housing portion. The motor includes a sealing sleeve, a stator disposed on an inner wall surface of the outer housing, and a rotor rotatably received in the sealing sleeve. The impeller is driven by the rotor of the motor to drive a coolant to flow. The electrical control unit is received in the second housing portion and electrically connected to the motor. The electrical control unit and the impeller are respectively located at two opposite ends of the motor.

Abstract: The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of A plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.

Abstract: This disclosure describes a map-matching module that supports a Global Positioning System (GPS) and provides a user with a best match trajectory corresponding to GPS sampling points taken at a low sampling rate. The best match trajectory is based upon a spatial-temporal analysis.

Abstract: An interleaving and mapping method and a deinterleaving and demapping method for an LDPC codeword are provided. The interleaving and mapping method comprises: performing first bit interleaving on a parity bits part of the LDPC codeword to obtain interleaved parity bits; splicing an information bit part of the codeword and the interleaved parity bits into a codeword after the first bit interleaving; dividing the codeword after the first bit interleaving into multiple consecutive bit subblocks in a predetermined length, and changing the order of the bit subblocks according to a corresponding permutation order (bit-swapping pattern) to form a codeword after second bit interleaving; dividing the codeword after the second bit interleaving into two parts, and writing the two parts into storage space in a column order respectively and reading the two parts from the storage space in a row order respectively to obtain a codeword after third bit interleaving.