Abstract: The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging drugs for cancers.

Abstract: An automatic food feeder for aquatic breeding comprises a bottom plate; the lower side of the bottom plate is provided with a driving mechanism, and the driving mechanism comprises four groups of rotating shafts located on the lower side of the bottom plate; gears are sleeved on the outer sides of the two groups of rotating shafts, and a conveyor belt is connected between the two groups of gears; a plurality of groups of meshing teeth matched with the gears are uniformly provided on the inner side of the conveyor belt, and a plurality of groups of electric telescopic push blocks are uniformly arranged on the outer side of the conveyor belt; a placing rack is connected on the upper side of the bottom plate, and a control box is connected on the front part of the lower side of the placing rack.

Abstract: In one aspect, antibodies that specifically bind to a human BACE1 protein are provided herein. In some embodiments, the antibodies contain modifications that reduce effector function, extend serum stability or serum half-life, or promote heterodimerization. In other aspects, bispecific antibodies and pharmaceutical compositions comprising antibodies that bind to human BACE1 protein are provided herein. Methods for inhibiting amyloid-? formation and/or aggregation, inhibiting amyloid plaque formation, and treating neurodegenerative diseases are also provided herein.

Abstract: The present disclosure discloses a microwave processing method for food made of flour and rice fermented with sourdough and belongs to the technical field of food processing. It comprises: adding a sourdough to the raw material to prepare a steamed cake batter; fermenting the batter under the dielectric constant of 20˜34, the loss factor of 6.3˜9.0, the moisture content of 45˜55% and the water activity of 0.920˜0.980; and using microwave heating to obtain the microwave-steamed cake. Due to the regulating effect of the sourdough fermentation on the dielectric properties of the food material, it solves the problems of hard core, textual firmness and toughness, dryness and weak flavor caused by fast and uneven microwave heating without adding food additives; meanwhile, the sourdough fermentation process is optimized and the DY and additive amount of the sourdough are controlled to obtain the microwave-steamed cake with larger specific volume, lower hardness, more fine and uniform pores and better taste.

Abstract: An automatic food feeder for aquatic breeding comprises a bottom plate; the lower side of the bottom plate is provided with a driving mechanism, and the driving mechanism comprises four groups of rotating shafts located on the lower side of the bottom plate; gears are sleeved on the outer sides of the two groups of rotating shafts, and a conveyor belt is connected between the two groups of gears; a plurality of groups of meshing teeth matched with the gears are uniformly provided on the inner side of the conveyor belt, and a plurality of groups of electric telescopic push blocks are uniformly arranged on the outer side of the conveyor belt; a placing rack is connected on the upper side of the bottom plate, and a control box is connected on the front part of the lower side of the placing rack.

Abstract: The present invention relates to an inbuilt seat leg support and a seat. The seat leg support is mounted in a seat. The seat includes a base frame and a cushion frame located above the base frame. A receiving space is formed between the base frame and the cushion frame. The seat leg support includes a leg support frame configured to be received in the receiving space. The leg support frame is movable and adjustable relative to the cushion frame. Movement and adjustment of the leg support frame cause the leg support frame to extend out of the receiving space to be in an extended state or to retract into the receiving space to be in a received state. According to the present invention, a receiving space for a leg support frame is reserved between a base frame and a cushion frame, and the leg support frame is disposed to be movable so that the leg support frame can be received in the receiving space when not in use. Receiving a leg support in a seat causes the present invention to be space-saving.

Abstract: The present disclosure relates to novel lymphoid-specific tyrosine phosphatase (LYP, encoded by the PTPN22 gene) inhibitors, and to methods of making and using the novel LYP inhibitors. Thus, the compounds according to the disclosure may be used for treating diseases or disorders associated with PTPN22 genetic polymorphism, including type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosis, Graves' disease, Addison's disease, vitiligo, juvenile arthritis, Hashimoto thyroiditis, and other rarer diseases. Furthermore, these LYP inhibitors may be served for a novel class of cancer immunotherapy. The compounds can be injected or orally administered.

Abstract: The invention relates to a button lithium ion battery, a preparation method thereof, and a method of producing a lithium ion cell composite flat sheet, wherein the button lithium ion battery comprises a battery housing, a cell accommodated in the battery housing and an electrolyte filled in the battery housing; the cell is formed by winding a composite flat sheet in which a first separator, a positive piece, a second separator and a negative piece are sequentially stacked and hot-laminated to form an integrated structure. The cell of the button lithium ion battery is formed by winding a composite flat sheet, so that winding efficiency can be improved, and misalignment can be avoided; moreover, chances of hand contact can be reduced, the influence of dust and water vapor can be avoided, and the quality of the lithium battery can be improved to the maximum extent.

Abstract: The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of Aß plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.

Abstract: The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging drugs for cancers.

Abstract: A method for micro-ridge mixed-sowing cultivation of dryland crops includes the following steps: S1: cleaning ditches and draining away water in dryland; S2: harvesting the preceding crop, leaving the stubble, smashing the stalks of the preceding crop, and then spreading the smashed stalks on the stubble; S3: trenching the dryland to form ecological trenches; S4: flattening the standing stubble and the smashed stalks on the seedbed surface to form an underlying surface, molding seed-fertilizer-soil compounds into a ridge shape and falling the seed-fertilizer-soil compounds on the underlying surface to form ecological ridges, wherein a plurality of ecological ridges are formed between adjacent ecological trenches, an ecological depression is formed between adjacent ecological ridges, and after sowing, an irrigation is carried out once in a manner, wherein the manner includes: draining water shortly after the irrigation, without leaving a water layer in the field.

Abstract: A method for micro-ridge mixed-sowing cultivation of rice includes: S1: draining away water at the maturity stage of the preceding crop until reaching a state allowing a harvester to operate; S2: harvesting the preceding crop, leaving the stubble, smashing the stalks of the preceding crop, and then spreading the smashed stalks on the stubble to form a rhizosphere layer for rice growth; S3: trenching the field to form ecological trenches; S4: flattening the standing stubble and the smashed stalks on the seedbed surface to form an underlying surface, molding seed-fertilizer-soil compounds into a ridge shape and fall the seed-fertilizer-soil compounds on the underlying surface to form ecological ridges, wherein a plurality of ecological ridges are formed between adjacent ecological trenches, and the seed-fertilizer-soil compounds are obtained by thoroughly mixing rice seeds, chemical fertilizers and soil at a mass ratio of 6 to 14:50 to 70:6,000 to 10,000.

Abstract: Methods and devices for a spintronic device of spin-orbit torque magnetic random access memory (SOT-MRAM) are provided. A unit cell of a device can comprise a ferromagnetic (or ferrimagnetic or antiferromagnetic) layer on the heavy metal layer, and a current source configured to transmit either non-collinear current pulses in the heavy-metal layer or two perpendicular currents in the heavy metal layer. The current pulses exhibit a phase difference, and the magnitude of a sum of the respective current pulses is constant (in its simplest form) and the flow direction of the pulses is time-dependent.

Abstract: A display panel and a display apparatus. The display panel includes a blue light-emitting device, and the blue light-emitting device includes a first electrode, an electron blocking layer, a light-emitting layer and a second electrode which are stacked. The hole mobility of the electron blocking layer is not greater than 5×10?4 cm2/VS, so that electrons and holes in the light-emitting layer tend to be balanced, and luminous efficiency of the blue light-emitting device under the low luminance is improved.

Abstract: The present invention relates to an inbuilt seat leg support and a seat. The seat leg support is mounted in a seat. The seat includes a base frame and a cushion frame located above the base frame. A receiving space is formed between the base frame and the cushion frame. The seat leg support includes a leg support frame configured to be received in the receiving space. The leg support frame is movable and adjustable relative to the cushion frame. Movement and adjustment of the leg support frame cause the leg support frame to extend out of the receiving space to be in an extended state or to retract into the receiving space to be in a received state. According to the present invention, a receiving space for a leg support frame is reserved between a base frame and a cushion frame, and the leg support frame is disposed to be movable so that the leg support frame can be received in the receiving space when not in use. Receiving a leg support in a seat causes the present invention to be space-saving.

Abstract: The present disclosure relates to novel N-aryl oxamic acid based inhibitors for Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB), and to the method of making and using the novel N-aryl oxamic acid based inhibitors. More specifically, compounds provided in this disclosure can be used to inhibit Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) and to treat a patient having a Tuberculosis disease.

Abstract: The present disclosure relates to novel lymphoid-specific tyrosine phosphatase (LYP, encoded by the PTPN22 gene) inhibitors, and to methods of making and using the novel LYP inhibitors. Thus, the compounds according to the disclosure may be used for treating diseases or disorders associated with PTPN22 genetic polymorphism, including type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosis, Graves' disease, Addison's disease, vitiligo, juvenile arthritis, Hashimoto thyroiditis, and other rarer diseases. Furthermore, these LYP inhibitors may be served for a novel class of cancer immunotherapy. The compounds can be injected or orally administered.

Abstract: A cantilever linear motion reference device employing two-layer air suspension. By means of a two-layer force sealed air suspension structure, the invention realizes two-dimensional air suspension support and motion guiding and improves the rotational stiffness per unit for an air suspension working surface. By combining accurate driving and feedback control, the invention achieves high speed, high acceleration, high frequency motion, and enables construction of a small-volume, long cantilever, high torque load two-dimensional motion reference device.