Abstract: The present disclosure relates to an organic photoelectric functional material, a method for the same, usage of the same, and a light-emitting device. The organic photoelectric functional material has electroluminescence and electron transportation properties. The organic photoelectric functional material is selected from a group consisting of compounds represented by formula I and formula II, and combinations thereof. If the organic photoelectric functional material is used as an electroluminescence material, light emission thereof can be adjusted by modifying a quinoline moiety thereof with a substituent, and a luminous range thereof is about 345 nm to about 700 nm.

Abstract: The present disclosure relates to novel N-aryl oxamic acid based inhibitors for Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB), and to the method of making and using the novel N-aryl oxamic acid based inhibitors. More specifically, compounds provided in this disclosure can be used to inhibit Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) and to treat a patient having a Tuberculosis disease.

Abstract: The present invention relates to antibodies that bind blood brain barrier receptors (BBB-R) and methods of using the same.

Abstract: The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of A plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.

Abstract: The invention relates to a button lithium ion battery, a preparation method thereof, and a method of producing a lithium ion cell composite flat sheet, wherein the button lithium ion battery comprises a battery housing, a cell accommodated in the battery housing and an electrolyte filled in the battery housing; the cell is formed by winding a composite flat sheet in which a first separator, a positive piece, a second separator and a negative piece are sequentially stacked and hot-laminated to form an integrated structure. The cell of the button lithium ion battery is formed by winding a composite flat sheet, so that winding efficiency can be improved, and misalignment can be avoided; moreover, chances of hand contact can be reduced, the influence of dust and water vapor can be avoided, and the quality of the lithium battery can be improved to the maximum extent.

Abstract: The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging thugs for cancers.

Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.

Abstract: Techniques for controlling item frequency using machine learning are provides. In one technique, two prediction models are trained: one based on interaction history of multiple content items by multiple entities and the other based on predicted interaction rates and an impression count for each of multiple content items. In response to a request, a particular entity associated with the request is identified and multiple candidate content items are identified. For each identified candidate content item, the first prediction model is used to determine a predicted interaction rate, an impression count of the candidate content item is determined with respect to the particular entity, the second prediction model is used to generate an adjustment based on the impression count, and an adjusted entity interaction rate is generated based on the predicted interaction rate and the adjustment. A particular candidate content item is selected based on the generated adjusted entity interaction rates.

Abstract: A cantilever linear motion reference device employing two-layer air suspension. By means of a two-layer force sealed air suspension structure, the invention realizes two-dimensional air suspension support and motion guiding and improves the rotational stiffness per unit for an air suspension working surface. By combining accurate driving and feedback control, the invention achieves high speed, high acceleration, high frequency motion, and enables construction of a small-volume, long cantilever, high torque load two-dimensional motion reference device.

Abstract: Techniques for controlling resource usage in a computing environment are provided. In one technique, a target resource usage for a particular point in time is determined for a content delivery campaign. Determining, for the content delivery campaign, a current resource usage for the particular point in time. Also, a bandwidth associated with the target resource usage at the particular point in time is determined. Based on a difference between the current resource usage and one or more boundaries of the bandwidth, a throttling factor is calculated. Based on the throttling factor, a probability of the content delivery campaign participating in a content item selection event is determined.

Abstract: Methods and devices for a spintronic device of spin-orbit torque magnetic random access memory (SOT-MRAM) are provided. A unit cell of a device can comprise a ferromagnetic (or ferrimagnetic or antiferromagnetic) layer on the heavy metal layer, and a current source configured to transmit either non-collinear current pulses in the heavy-metal layer or two perpendicular currents in the heavy metal layer. The current pulses exhibit a phase difference, and the magnitude of a sum of the respective current pulses is constant (in its simplest form) and the flow direction of the pulses is time-dependent.

Abstract: The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.

Abstract: An article is described that includes at least one fibrous support surface coated by at least two successive layers including: an inner layer, in contact with the fibrous support, which is a coating including a silicone elastomer, polyurethane or silicone-polyurethane; and a topcoat outer layer, in contact with the inner layer, which is a coating obtained by crosslinking a composition described herein. The first layer, that is in contact with the fibrous support, is a layer based on a silicone elastomer, polyurethane or silicone-polyurethane composition that was crosslinked. The second layer, that is in contact with the first layer, is a layer obtained by crosslinking as described herein.

Abstract: Some embodiments described herein are directed to memory page or bad block monitoring and retirement algorithms, systems and methods for random access memory (RAM). Reliability issues or errors can be detected for multiple memory pages using one or more retirement criterion. In some embodiments, when reliability errors are detected, it may be desired to remove such pages from operation before they create a more serious problem, such as a computer crash. Thus, bad block retirement and replacement mechanisms are described herein.

Abstract: The disclosed embodiments provide a system for performing dynamic job bidding optimization. During operation, the system obtains historical data containing a time series of interactions with a job. Next, the system uses the historical data to calculate an initial price of a job based on a predicted number of interactions with the job. The system then determines a first dynamic adjustment to the initial price that improves utilization of a budget for the job and a second dynamic adjustment to the initial price that improves a performance of the job. Finally, the system applies the first and second adjustments to the initial price to produce an updated price for the job and delivers the job within an online system based on the updated price.

Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.

Abstract: In one aspect, antibodies that specifically bind to a human BACE1 protein are provided herein. In some embodiments, the antibodies contain modifications that reduce effector function, extend serum stability or serum half-life, or promote heterodimerization. In other aspects, bispecific antibodies and pharmaceutical compositions comprising antibodies that bind to human BACE1 protein are provided herein. Methods for inhibiting amyloid-? formation and/or aggregation, inhibiting amyloid plaque formation, and treating neurodegenerative diseases are also provided herein.

Abstract: The present invention relates to antibodies that bind blood brain barrier receptors (BBB-R) and methods of using the same.

Abstract: In some embodiments, systems, methods, and devices disclosed herein are directed to implementing in-memory computer systems that offer improved performance over conventional computer systems. In some embodiments, the implementations of in-memory computer systems, devices, and methods described herein can function without reliance on conventional storage devices and thus are not subject to the bottleneck in processing speed associated with conventional storage devices. Rather, in some embodiments, the implementations of in-memory computer systems described herein include and/or utilize a processor and memory, wherein the memory is used for mass data storage, without reliance on a conventional hard drive, solid state drive, or any other peripheral storage device. Some embodiments herein relate to non-uniform real-time memory access (NURA) computing, for example on an in-memory computing system.

Abstract: A human-machine interaction method and apparatus based on artificial intelligence. In the method, a user-entered interaction sentence is received, and whether to generate an interaction result corresponding to the interaction sentence is determined; and interaction information to be presented to the user is determined based on a determining result, the interaction information including at least one of following items: the generated interaction result corresponding to the interaction sentence, or a search result corresponding to the interaction sentence in a search engine.