Abstract: Small molecule compounds derived from ?-sulfophenylacetic amide (SPAA) are provided as novel sulfonic acid based pTyr mimetics. These compounds effectively inhibit a variety of protein tyrosine phosphatases (PTPs), such as mPTPA, mPTPB, LMWPTP, and Laforin. Use of these compounds as pharmaceutical agents for treating diseases associated with abnormal protein tyrosine phosphatase activity is also provided.

Abstract: Techniques are provided for controlling resource usage in a computing environment. In response to receiving a content request, a set of candidate content delivery campaigns is identified. For a first candidate content delivery campaign in the set, an anticipated resource usage of a resource that is associated with the first candidate content delivery campaign is determined. The anticipated resource usage is determined based on (1) a resource reduction per event of each event in a set of detected events of a content item of the first candidate content delivery campaign and (2) a decay factor. Based on the anticipated resource usage, it is determined whether the first candidate content delivery campaign is to be removed from the set.

Abstract: The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of A plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.

Abstract: The present disclosure relates to an organic photoelectric functional material, a method for the same, usage of the same, and a light-emitting device. The organic photoelectric functional material has electroluminescence and electron transportation properties. The organic photoelectric functional material is selected from a group consisting of compounds represented by formula I and formula II, and combinations thereof. If the organic photoelectric functional material is used as an electroluminescence material, light emission thereof can be adjusted by modifying a quinoline moiety thereof with a substituent, and a luminous range thereof is about 345 nm to about 700 nm.

Abstract: A low-profile dual-band filtering patch antenna and its application to LTE MIMO system are disclosed. By using two embedded U-shaped radiating patches and a multi-stub microstrip feed-line, two operating bands and four radiation nulls can been generated and individually controlled, the design is thus very simple and flexible. Based on the proposed low-profile dual-band filtering patch antenna, a MIMO antenna with a very low profile, low mutual coupling and low ECCs has been presented.

Abstract: The present invention relates to antibodies that bind blood brain barrier receptors (BBB-R) and methods of using the same.

Abstract: A system and method identify a network upgrade from a data set including a plurality of configuration sessions. The system performs the method by receiving a plurality of configuration sessions. Each of the configuration sessions comprises a plurality of configuration commands. The configuration commands are generated by a same user identifier and within a time threshold. The method further includes identifying one of the configuration sessions as a network upgrade session. The identification is based on a rareness of the configuration session or a skewness of the configuration session.

Abstract: Recommendation systems are widely used in Internet applications. In current recommendation systems, users only play a passive role and have limited control over the recommendation generation process. As a result, there is often considerable mismatch between the recommendations made by these systems and the actual user interests, which are fine-grained and constantly evolving. With a user-powered distributed recommendation architecture, individual users can flexibly define fine-grained communities of interest in a declarative fashion and obtain recommendations accurately tailored to their interests by aggregating opinions of users in such communities. By combining a progressive sampling technique with data perturbation methods, the recommendation system is both scalable and privacy-preserving.

Abstract: A filtering switch based on dielectric resonator is disclosed which comprising a rectangular dielectric resonator, a metal cavity in which the dielectric resonator is located, a switch circuitry and a T-shape feeding line structure. The ON- and OFF-states of the filtering switch based on dielectric resonator are realized by controlling a coupling between the dielectric resonator and the feeding line structure. EM fields of the rectangular dielectric resonator and T-shape feeding line structure have been theoretically analyzed and utilized to guide the coupling control. The results have shown low ON-state loss, high power capability and high OFF-state isolation. Transmission zeros are generated at both sides of the passband by cross coupling between dielectric resonators or between feeding line structures and coupling line structures, resulting in high skirt selectivity.

Abstract: Provided are an organic metal complex, its preparation method and light-emitting element containing the complex. The organic metal complex is selected from compounds shown as general formula I and combinations thereof. The ligand containing pyridine unit is introduced into the cyclometalated iridium(III) organic metal complex, and the obtained iridium(III) heterocomplex has a luminous range from near-infrared light to blue light, so that the ppz-Ir structure, which is originally non-luminous, can emit light at room temperature with advantages of wide application scope of spectrum and low cost of massive production.

Abstract: The disclosure discloses a human-machine interaction method and apparatus based on artificial intelligence. A specific embodiment of the method comprises: receiving a user-entered interaction sentence, and determining whether to generate an interaction result corresponding to the interaction sentence; and determining interaction information to be presented to the user based on a determining result, the interaction information comprising at least one of following items: the generated interaction result corresponding to the interaction sentence, or a search result corresponding to the interaction sentence in a search engine.

Abstract: Embodiments of the present disclosure disclose an artificial intelligence based method and apparatus for classifying a voice-recognized text. A specific embodiment of the method includes: acquiring a current interactive text of a voice query from a user; analyzing the current interactive text using a lexical analyzer to obtain a current lexical structure; determining whether the current lexical structure matches a template of a category in a classifier; and classifying, if the current lexical structure matches the template of the category in the classifier, the current interactive text corresponding to the current lexical structure into the category belonging to the matched template. The embodiment can fast classify texts, effectively reduce the magnitude of manually annotated texts, and improve the annotation efficiency in intelligent voice interaction services.

Abstract: Embodiments of the present invention relate to method and device for measuring optical signal-to-noise ratio (OSNR). A method for measuring an OSNR of a signal of interest may comprise: obtaining spectrum of the signal of interest, the spectrum including power spectrum density distribution of the signal of interest in a channel bandwidth B; obtaining spectrum of a comparative signal that has the same spectrum characteristics as but different OSNR than the signal of interest, the spectrum including power spectrum density distribution of the comparative signal in the channel bandwidth B; and calculating the OSNR of the signal of interest by using the spectrum of the signal of interest and the spectrum of a comparative signal.

Abstract: Methods are disclosed herein for administering a oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitor for treating autoimmune and/or glomerulonephritis-associated diseases, and in particular, Systemic Lupus Erythematosus (SLE).

Abstract: The present disclosure provides an artificial intelligence-based searching method and apparatus, a device and a computer-readable storage medium. In embodiments of the present disclosure, the search demand type is obtained according to the search keyword provided by the user, then the demand keyword is obtained according to the search keyword and the search pattern of the search demand type so that the search result can be obtained according to the demand keyword, and be output. Since the search operation is performed not completely depending on the search keyword provided by the user, but performed in conjunction with the demand keyword obtained according to the search demand type to which the search keyword belongs, the search result substantially satisfies the user's real intention.

Abstract: Techniques for controlling resource usage in a computing environment are provided. In one technique, a target resource usage for a particular point in time is determined for a content delivery campaign. Determining, for the content delivery campaign, a current resource usage for the particular point in time. Also, a bandwidth associated with the target resource usage at the particular point in time is determined. Based on a difference between the current resource usage and one or more boundaries of the bandwidth, a throttling factor is calculated. Based on the throttling factor, a probability of the content delivery campaign participating in a content item selection event is determined.

Abstract: Systems and processes for real-time instant funding solutions for miscellaneous income are disclosed. The method of funding miscellaneous income includes securely transmitting a funding information file or a real time funding transaction request with miscellaneous funding information to a funding card processing system using real-time web services APIs which are externally accessible by an external computing system, e.g., point of sale, time and labor or payroll system. The method further includes processing the funding information file with the funding card processing system, which includes at least identifying client information and a user receiving miscellaneous income contained within the miscellaneous funding information. The method further includes funding a payroll card of the identified user with the miscellaneous income received with the miscellaneous funding information of the funding information file.

Abstract: Methods are disclosed herein for administering a oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitor for treating autoimmune and/or glomerulonephritis-associated diseases, and in particular, Systemic Lupus Erythematosus (SLE).

Abstract: Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

Abstract: The present invention discloses a method for preparing optically active carbonyl compound, comprising the following steps: under the catalysis of chiral amine salt and transition metal catalysts, with hydrogen and catalytic amount of dihydropyridine compound as hydrogen source, use ?, ?-unsaturated aldehydes or ?, ?-unsaturated troponoid compounds to conduct asymmetric catalytic reaction to obtain the optically active carbonyl compound. This method comes in moderate reaction condition, simple operation, and catalytic amount of dihydropyridine compounds usage, the target product is easy to be separated and purified from the reaction system, and the metal catalyst can be recycled, it is economical.