Abstract: Provided is a hydrogel composition, which comprises a modified HA, PEGDA and water; wherein, based on a total weight of the hydrogel composition, a content of the modified HA is 1 wt % to 7 wt % and a content of PEGDA is 43 wt % to 49 wt %; the modified HA is obtained by modifying HA with methacrylic anhydride; an average molecular weight of PEGDA is 1 kDa to 10 kDa. The hydrogel composition of the present invention has good compatibility of raw materials, which does not cause HA precipitation, and a hydrogel material produced therefrom simultaneously has good mechanical properties, good swell capability and good biocompatibility, such that the hydrogel material can be applied in many fields.

Abstract: Disclosed herein are nanoparticles comprising Pazopanib or a derivative thereof encapsulated by the copolymer poly(lactic-co-glycolic acid) (PLGA). Also disclosed herein are methods for treating osteoarthritis, inhibiting or preventing cartilage degeneration, and reducing or inhibiting pain-associated depression in subjects with joint pain with nanoparticles comprising Pazopanib or a derivative thereof.

Abstract: Various systems and methods that enhance an exercise or other physical activity performed by a user are described. In some embodiments, a classification system communicates with a media hub to receive images and perform various methods for classifying or detecting poses, exercises, and/or movements performed by a user during an activity. In some embodiments, the systems and methods include a movements database (dB) that stores information as entries relating individual movements to data associated with the individual movements. Various systems, including class generation systems and body focus/activity systems, can utilize the movements database when presenting class content to users and/or presenting exercise information (e.g., muscle groups worked or targeted) to the users.

Abstract: The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Binding Domains may be selected such that the Tri-Specific Binding Molecules are capable of binding to any three different epitopes. Such epitopes may be epitopes of the same antigen or epitopes of two or three different antigens. In a preferred embodiment, one of such epitopes will be capable of binding to CD3, the second of such epitopes will be capable of binding to CD8, and the third of such epitopes will be capable of binding to an epitope of a Disease-Associated Antigen. The invention also provides a novel ROR1-binding antibody, as well as derivatives thereof and uses for such compositions.

Abstract: An applicator head for applying a product including a cosmetic, care, or pharmaceutical product onto the keratinous substrate. The applicator head includes an applying member elongated along a central longitudinal axis. The applying member includes a front face, a rear face opposing the front face, a left face, and a right face opposing the left face. The applying member has an axial zigzag groove extending along a length of the applying member on at least one of the front face and the rear face of the applying member. The axial zigzag groove has vertices on both side of the central longitudinal axis of the applying member. Further, the applying member includes side grooves disposed on each side of the axial zigzag groove. The axial zigzag groove and the side grooves outline beads on an outer surface of the applying member.

Abstract: The present disclosure relates generally to roofing products, for example, shingles suitable for covering and protecting the roofs of houses, buildings, and other structures. The present disclosure relates more particularly to a roofing shingle including an upper edge, a lower edge, a first end, a second end, a headlap section, and an exposed section. A nail zone extends across the roofing shingle from the first end to the second end within the headlap section. The roofing shingle includes a top shingle layer including a top surface and a bottom surface. A reinforcement strip is secured to the bottom surface of the top shingle layer and overlaps with the nail zone. Further, a self-sealing material is disposed within the nail zone and is configured to form a seal around a mechanical fastener that punctures the roofing shingle in order to secure the roofing shingle to an underlying roof structure.

Abstract: An autonomous vehicle path prediction method includes sensing vehicles driving on a road and generating sensing signals corresponding to the vehicles; surrounding vehicles and a current state of the emergency vehicle and performing an emergency path prediction corresponding to the emergency vehicle when the vehicles further include the emergency vehicle; generating an emergency autonomous driving decision according to the emergency path prediction and providing an autonomous vehicle path planning corresponding to the emergency autonomous driving decision; and controlling the autonomous vehicle to change the driving path and the driving mode on the road according to the autonomous vehicle path planning.

Abstract: The present disclosure relates to the field of microorganisms, and specifically relates to a sulfamethoxazole-degrading Pseudomonas silesiensis strain and an application thereof. The strain is preserved at the China Center for Type Culture Collection, has the preservation number: CCTCC No: M2021338, and was preserved on 6 Apr. 2021. The present strain has a strong ability to degrade sulfamethoxazole, and SMX removal of approximately 75% or more may be achieved in an R2A culture medium; additionally, said strain is also a type of electrochemically active bacterium.

Abstract: Electrodes having associated therewith a protective porous film or coating of boron nitride nanotubes (BNNTs).

Abstract: An example a folding device includes a hinge assembly defining a first axis and a second axis; a first assembly that includes a first shaft rotatably connected to the hinge assembly about the first axis; a second assembly that includes a second shaft rotatably connected to the hinge assembly about the second axis; a first gear mounted on the first shaft; a second gear mounted on the second shaft, wherein the first gear is configured to mesh with the second gear to synchronize movement of the first assembly and the second assembly; a first member on the first shaft; a second member on the second shaft, wherein the first member and the second member are collectively configured to increase an amount of force needed to rotate the first assembly and the second assembly; and a display spanning the first assembly and the second assembly.

Abstract: The present invention relates to innovative protoparvoviruses (PV) expressing RNAi effectors, preferably shRNAs against the PD-L1 gene which display improved anticancer activity. These new viruses are based on the ?H-1PVsilencer platform that consists of a protoparvovirus H-1PV featuring an in-frame deletion within the NS region (?H-1PV) and harbouring a shRNA expression cassette in which the expression of the shRNA is controlled by the H1 Polymerase III promoter. In this invention the inventors aimed to use the ?H-1PVsilencer to silence the PD-L1 gene. PD1/PD-L1 negatively regulates T cell-mediated immune responses and serves as a mechanism for tumors to escape antigen-specific T cell immune responses. The present invention also provides cells or organisms comprising said parvovirus.

Abstract: An apparatus, system and method for providing a consumable level monitor for association with a solid content-filled consumable. The embodiments may include a sensing module embedded in a label associated with the consumable suitable to sense the consumable level; and a visual indicator suitable to receive the consumable level from the sensing module, and for communicating the consumable level to a user.

Abstract: Blood plasma of pregnant women contains fetal and (generally >90%) maternal circulatory extracellular DNA. Most of said fetal DNA contains ?500 base pairs, said maternal DNA having a greater size. Separation of circulatory extracellular DNA of ?500 base pairs results in separation of fetal from maternal DNA. A fraction of a blood plasma or serum sample of a pregnant woman containing, due to size separation (e.g. by chromatography, density gradient centrifugation or nanotechnological methods), extracellular DNA substantially comprising ?500 base pairs is useful for non-invasive detection of fetal genetic traits (including the fetal RhD gene in pregnancies at risk for HDN; fetal Y chromosome-specific sequences in pregnancies at risk for X chromosome-linked disorders; chromosomal aberrations; hereditary Mendelian genetic disorders and corresponding genetic markers; and traits decisive for paternity determination) by e.g. PCR, ligand chain reaction or probe hybridization techniques, or nucleic acid arrays.

Abstract: A system may automatically conduct hygiene cycles for a confined space such an interior space of a box suitable for storing and/or carrying packaged food. The system may include a hygiene device that can be attached to the box to conduct the hygiene cycles and a user interface device that can wirelessly communicate with the hygiene device to control the conduction of the hygiene cycles. The system may also automatically collect information related to the hygiene cycles using the hygiene device and transmit the collected information to a network directly or through the user interface device.

Abstract: A rapid detection tool for a coaxial relationship based on a photosensitive material and a detection method using the same are used to detect coaxiality of two through-holes in the same workpiece to be detected. An image processing unit and a control unit are mounted outside a light-shielding box. Light sources, cameras, sensors, and an air cylinder are mounted in the light-shielding box. A photosensitive plate coated with a photosensitive resin is placed between the two holes, and two sides are irradiated by the light sources. Coordinates of centers of circular patterns formed on the photosensitive plate are calculated so that a coaxial relationship between the two holes can be accurately obtained. An output rod of the air cylinder is controlled to extend outward to reject a workpiece to be detected not meeting requirements.

Abstract: A method and system for locking the resonance frequency of ring resonators by using laser sources to emit a plurality of different wavelengths, applying a tagging signal to each of the wavelengths, multiplexing the tagged wavelengths using a wavelength division multiplexor, coupling the multiplexed tagged wavelengths onto a bus waveguide, detecting the multiplexed tagged wavelengths with a first photodetector disposed before a first ring resonator and a second photodetector disposed after a last ring resonator of a plurality of ring resonators, sending the signals detected by the first and second photodetector to a processor, which identifies and processes the tagging signals, generating a control signal for each ring resonator, by the processor and applying the control signals to phase shifters on each ring resonator of the plurality of ring resonators to tune and align the resonance wavelengths of the ring resonators with the wavelengths of the corresponding laser sources.

Abstract: A building roof photovoltaic power quality evaluation method based on AHP and CRITIC-Entropy is provided. The method includes: obtaining data values of evaluation indicators of a building roof photovoltaic power quality, and constructing a judgment matrix and a probability matrix according to the data values of the evaluation indicators; processing the judgment matrix to obtain a subjective corresponding weight of each of the evaluation indicators by using an improved AHP method, and solving the probability matrix to obtain an objective corresponding weight of each of the evaluation indicators based on the CRITIC-Entropy; and integrating the subjective corresponding weights and the objective corresponding weights to obtain comprehensive weight coefficients, and determining a final evaluation result by the comprehensive weight coefficients and the probability matrix.

Abstract: A sample processing and analyzing device for soil analysis in a karst area comprises a mounting unit, a processing unit arranged on the mounting unit, and an analyzing unit arranged on the mounting unit and connected with the processing unit through a feeding unit. The design of the damping component can control the grinding force to avoid sample crushing. The installation disc can be effectively clamped by the second axial moving component to move the sample position according to the grinding requirements, facilitating step-by-step polishing. The feeding unit sends the sample to the analysis unit through a conveyor belt for effective analysis. The sample processing and analyzing device can effectively process a soil concretion sample into a sample for analysis, has the advantages of easy operation, high degree of automation and high efficiency, and is suitable for mass popularization.

Abstract: An array substrate and a total reflection display panel are provided. The array substrate includes a first substrate, a touch control unit, and a total reflection layer. The touch control unit is disposed on a side of the total reflection layer facing the first substrate. Through arranging the touch unit on a side of the total reflection layer adjacent to the first substrate, a total reflection display is not affected, a close-range interaction function of the total reflection display panel is enhanced through the touch unit, and a versatility of display application scenarios is increased.

Abstract: A display panel has a display region and a peripheral region. The display panel includes a substrate, a first metal layer disposed on the substrate, a planarization layer disposed on a side of the first metal layer away from the substrate, and a retaining wall structure located in the peripheral region and surrounding the display region. The first metal layer includes a signal line pattern located in the peripheral region. The planarization layer includes an opening in the peripheral region. At least a portion of the retaining wall structure is located in the opening. The signal line pattern is provided with at least one through hole, an orthogonal projection of the at least one through hole on the substrate is located within an orthogonal projection of the opening on the substrate, and is at least located on a side of an orthogonal projection of the retaining wall structure on the substrate.