Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.

Abstract: Described are methods of treatment of a small cell lung cancer subject expressing Schlafen-11 (SLFN 11) with a Poly (ADP-ribose) polymerases (PARP) inhibitor or a pharmaceutically acceptable salt thereof. Specifically, the method comprising detecting SLFN 11 in a tumor cell sample from the subject, and administering effective amount of a PARP inhibitor, such as talazoparib or the tosylate salt of talazoparib, to the subject.

Abstract: A multiple lens-based smart mechanical arm, wherein it comprises a multi joint multi-functional mechanical arm, a CCD camera for collecting PCB board images to be assembled, a bio-contact device, and a computer; the CCD camera is mounted on the multi joint multi-functional mechanical arm, the bio-contact device is mounted on the fingertip of the multi joint multi-functional mechanical arm, and the CCD camera, and the bio-contact device and the multi joint multi-functional mechanical arm are connected to the computer. The invention adds a biological tactile device on the basis of the binocular positioning to accurately locate the assembly target area and improve the accuracy of the assembly of the irregular parts. The conversion relationship between the pressure and electric output of the sensitive material in the bio-contact device and the mathematical model of pressure and position is applied.

Abstract: An antenna for use in a communication system with a number of plates connected to a ground plane, where when the number of plates are excited by at least two electrical signals, the number of plates are arranged to radiate at least two electromagnetic signals each having an independent resonant frequency.

Abstract: Generally, this disclosure provides systems, devices, methods and computer readable media for estimation of application execution performance variations on a processor, without a priori knowledge of the application. A system may include network traffic data collection circuitry configured to sample a first network traffic statistic, from a network interface circuit associated with the processor, at a first sampling time interval during the application execution. The network traffic data collection circuitry may also be configured to sample a second network traffic statistic from the network interface circuit at a second sampling time interval during the application execution.

Abstract: Generally, this disclosure provides systems, devices, methods and computer readable media for dynamic tuning of multiprocessor and multicore computing systems to improve application performance and scalability. A system may include a number of processing units (CPUs) and profiling circuitry configured to detect the existence of a scalability problem associated with the execution of an application on CPUs and to determine if the scalability problem is associated with an access contention or a resource constraint. The system may also include scheduling circuitry configured to bind the application to a subset of the total number of CPUs if the scalability problem is associated with access contention.

Abstract: An antenna for use in a communication system with a number of plates connected to a ground plane, where when the number of plates are excited by at least two electrical signals, the number of plates are arranged to radiate at least two electromagnetic signals each having an independent resonant frequency.

Abstract: Generally, this disclosure provides systems, devices, methods and computer readable media for estimation of application execution performance variations on a processor, without a priori knowledge of the application. A system may include network traffic data collection circuitry configured to sample a first network traffic statistic, from a network interface circuit associated with the processor, at a first sampling time interval during the application execution. The network traffic data collection circuitry may also be configured to sample a second network traffic statistic from the network interface circuit at a second sampling time interval during the application execution.

Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.

Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.

Abstract: The present disclosure relates to a method, a device and a storage medium for controlling an electronic map. The method includes: detecting a first user operation, configured for setting a viewing angle of the electronic map; in response to the first user operation, setting the viewing angle of the electronic map; and if no first user operation being detected within a predetermined length of time, setting the viewing angle of the electronic map according a posture of the electronic apparatus detected at current time.

Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.

Abstract: A method for controlling a video camera positioning system includes the steps of controlling a motor for driving a video camera to capture a panoramic frame, dividing the panoramic frame into a plurality of frames, controlling the motor for driving the camera lens to turn to the frame corresponding to an encoded command signal when the microcontroller receiving the encoded command signal, and zooming in the frame by the video camera. Furthermore, a video camera positioning system is also disclosed herein.

Abstract: A detecting device is used for detecting existence of target biomolecules in a specimen with use of antibody complexes labeled with fluorescent molecules. The detecting device includes a capture member coated with capture antibodies for immobilizing the antibody complexes on the capture member when the target biomolecules exist in the specimen, a light emitting unit emitting a beam for exciting the fluorescence molecules to generate a fluorescence signal, and a signal processing unit for receiving the fluorescence signal and determining existence of the target biomolecules in the specimen based upon receipt of the fluorescence signal.

Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.

Abstract: A nail structure has a main body having a long section with a slantedly threaded surface. One end of the main body forms a sharp end, while the other end there of has an enlarging ring end with cone shape. Also, the other end of the main body has a head end, and a neck section is formed between the head end and the ring end. When the main body pokes through a fixed unit to attach the fixed unit to a wall surface or structure, the long section is in an engaging status due to the threads on the long section surface, and when the ring end is inserted into the wall or structure, it generates a stopping effect so that the main body of the nail cannot be easily pulled out. Also, the head end is restricted by the fixed unit towards the wall or structure to secure the fixed unit.

Abstract: A method for controlling layer changes for an optical disk drive is provided, where a focus of a laserbeam emitted by a pickup head of the optical disk drive is moved from a current data layer of a disk to a target data layer of the disk. First, a position of a collimator lens of the pickup head is adjusted for spherical aberration correction. The objective lens is then lowered to a low position to move the focus of the laserbeam off the surface of the disk. The objective lens is then raised towards the disk. A focusing error signal is generated while the objective lens is being raised. Whether a target S-curve corresponding to the target data layer is present in the focusing error signal is then started to be detected. If the target S-curve is detected, the focus on operation on the target data layer of the disk is successful.

Abstract: The invention provides an optical disk drive. In one embodiment, the optical disk drive comprises a feeding device, a power driver, and a controller. The feeding device comprises a spherical aberration (SA) lens and a stepping motor, wherein the SA lens corrects spherical aberration of a light beam emitted by a pickup head, and the stepping motor moves the SA lens according to a plurality of control signals. The power driver generates the control signals to drive the stepping motor to move the SA lens. The controller directs the power driver to drive the stepping motor to move the SA lens with only stable steps when the SA lens is required to move, so that the stepping motor is in a stable state without inducing step errors after the stepping motor rotates with the stable steps.