Abstract: The present disclosure relates to a pyrrolo benzodiazepine derivative and a conjugate, preparation method and use thereof. In particular, the present disclosure relates to a compound of formula (DL) and a antibody-drug conjugate thereof, a pharmaceutical composition containing same, and a use thereof in the preparation of a medicament for the treatment of cancer. The definitions of groups in the general formula (DL) are as defined in the description.

Abstract: A method, computer program product, and computer system for dynamically allocating shared memory among multiple execution threads via use of a dynamically changing memory threshold. A trained machine learning model (MLM) is executed to calculate the memory threshold (MTH) using values of one or more input parameters as input to the MLM. After executing the MLM, a request is received from a requesting execution thread for a requested amount (MR) of the shared memory. In response to the request, the shared memory is distributed among one or more current execution threads currently using the shared memory and the requesting execution thread. The redistributing is performed as a function MTH, MR, MU, and MC, wherein MU is a total amount of the shared memory currently being used by the one or more current execution threads, and wherein MC is a memory capacity of the shared memory.

Abstract: A computer-implemented method, a system and a computer program product for abnormal point simulation are disclosed. A processor analyzes a plurality of data blocks in first time series data to determine traits of respective data blocks. For the respective data blocks, a processor simulates one or more abnormal points based on the traits of the respective data blocks.

Abstract: The present disclosure provides an information searching method and information searching apparatus, a computer device, and a storage medium. The method includes: obtaining and presenting a plurality of question and answer topics in response to a searching operation for historical question and answer information, wherein the question and answer topics are determined based on aggregation results obtained by aggregating a plurality of rounds of historical question and answer information; obtaining, in response to any one of the plurality of question and answer topics represented being triggered, at least one sub-dimension tag under the question and answer topic; and presenting each sub-dimension tag, and presenting a sub-aggregation result under a selected sub-dimension tag according to timing information of historical question and answer information, wherein the sub-aggregation result is obtained by aggregating the aggregation result according to a target dimension indicated by the selected sub-dimension tag.

Abstract: A bending-resistant low-crosstalk photonic orbital angular momentum (OAM) optical fiber waveguide. An optical fiber sequentially comprises, from the center to the outside, a first core layer (1), a second core layer (2), a first cladding layer (3), a second cladding layer (4), and a third cladding layer (5), wherein the third cladding layer (5) is the thickest, the first core layer (1) is the second thickest, and the first cladding layer (3) is the thinnest; the refractive index of the first cladding layer (3) is the lowest, the refractive index of the second cladding layer (4) is the second lowest, and the refractive index of the second core layer (2) is the highest. The waveguide structure can effectively regulate the output of different OAM modes, and an effective refractive index difference between modes is greater than 2×10?4, the modes are easy to separate, and multiplexing and demultiplexing are facilitated.

Abstract: A method (100) of detecting fetal movements includes: deriving a plurality of peaks from the Doppler ultrasound signal acquired from a subject, each peak of the plurality of peaks being associated with an envelope of a signal segment of the Doppler ultrasound signal; calculating a density of the peaks as a function of a plurality of amplitude grids, the density indicating the number of peaks with amplitude in each amplitude grid; selecting a fetal movement threshold based on the calculated density, and determining whether a signal segment of the Doppler ultrasound signal includes a fetal movement by comparing the amplitude of the peak associating with the envelope of the signal segment with the fetal movement threshold.

Abstract: Foam composites and methods of preparation thereof are discussed. For example, the foam composite may include a polymeric material and a particulate filler, wherein the compressive strength of the foam composite is equal to or greater than 20 psi, the density is 4 pcf to 40 pcf, and wherein the thermal conductivity is equal to or less than 0.050 W/n K, the particulate filler may include fly ash. e.g., in an amount of about of 45% to about 75% by weight with respect to the total weight of the foam composite. The foam composite may be prepared from a mixture of a polyol, an isocyanate, the particulate filler, and a liquid blowing agent having a boiling point equal to or greater than 25° C. or 30° C.

Abstract: A bending-resistant low-crosstalk photonic orbital angular momentum (OAM) optical fiber waveguide. An optical fiber sequentially comprises, from the center to the outside, a first core layer (1), a second core layer (2), a first cladding layer (3), a second cladding layer (4), and a third cladding layer (5), wherein the third cladding layer (5) is the thickest, the first core layer (1) is the second thickest, and the first cladding layer (3) is the thinnest; the refractive index of the first cladding layer (3) is the lowest, the refractive index of the second cladding layer (4) is the second lowest, and the refractive index of the second core layer (2) is the highest. The waveguide structure can effectively regulate the output of different OAM modes, and an effective refractive index difference between modes is greater than 2×10?4, the modes are easy to separate, and multiplexing and demultiplexing are facilitated.

Abstract: A computer-implemented method for treating post-modeling data includes computing, sequentially for each category of a feature, a category importance (CI) value. The CI value is based on a model accuracy change when records of a category being examined are reassigned to a remaining set of categories of the feature according to a cumulative distribution of records among the remaining set of categories of the feature, wherein the remaining set of categories include all categories of the feature, except for the category being examined. A post-modeling category is performed to merge of each category having the CI value less than a CI value threshold.

Abstract: Systems and methods are provided to generate a set of vector representations for each word of a plurality of words in a set of social media data by inputting each word into each of a predefined number of machine learning models to output each of the set of vector representations, the set of social media data comprising social media data from a plurality of social network platforms in a predefined window of time. The systems and methods further provide for generating a similarity score for each vector representation in the set of vector representations for each word output from the predefined number of machine learning models with respect to a given brand name, and generating a perception score for each word based on the generated similarity score for each vector representation in the set of vector representations for each word.

Abstract: The present invention discloses a rose petal effect-based biomimetic electrode and a membrane-less water electrolysis reactor utilizing the same, belongs to the technical field of catalytic technology for water electrolysis. The electrode has a surface exhibiting a microscopically alternating hydrophilic-hydrophobic periodic structure. The hydrophilic parts ensure good contact between the catalyst and the electrolyte solution, thereby guaranteeing the electrode's catalytic performance. The hydrophobic parts allow the gas generated at the electrode surface to be discharged through internal porous channels, preventing the formation of visible bubbles on the electrode surface and thereby fundamentally avoiding issues caused by bubble formation. The membrane-less water electrolysis reactor utilizing the electrode can eliminate bubble formation on the electrode surface, thereby avoiding problems related to bubble covering catalytic sites, bubble resistance, and gas mixing.

Abstract: A driving control apparatus, a driving control method and a display apparatus. When a display panel is in a power-on state and it is determined that a user leaves the display panel, a backlight stop signal (VBN) is first output, and a voltage stop signal (VPN) is then output. A backlight control circuit (320) stops operating in response to the backlight stop signal. In response to the voltage stop signal, a power switching circuit (330) stops outputting a driving voltage for driving the display panel to display a picture. When determining that the user returns to the front of the display panel, a voltage start signal (VPQ) can first be output, and a backlight start signal (VBQ) is then output. The backlight control circuit starts to operate in response to the backlight start signal. The power switching circuit outputs the driving voltage in response to the voltage start signal.

Abstract: An electronic device protection structure includes: a substrate, a component group on a side of the substrate, a first protective adhesive tape on a side of the component group away from the substrate, and a second protective adhesive tape on a side of the first protective adhesive tape away from the component group. The first protective adhesive tape includes a covering portion covering the component group, and a lapping portion extending from at least one side of the covering portion until the lapping portion comes into contact with the substrate. The second protective adhesive tape is attached to the periphery of the component group, and is electrically connected to the lapping portion.

Abstract: A display panel has a display area and a peripheral area including: a first fan-out region, a bending region, and a second fan-out region. The display panel includes: a substrate layer, at least one connecting lead and at least one first-type signal line. The substrate layer includes a first substrate and a second substrate. The at least one connecting lead is between the first and second substrates and extends from a side of the bending region to another side of the bending region through the bending region. The at least one first-type signal line is located on a side of the second substrate away from the first substrate. A first-type signal line is in at least one of the first fan-out region or the display area. The first-type signal line is electrically connected to a connecting lead through a via hole in the second substrate.

Abstract: Coated articles can comprise a coating disposed over a first major surface of a substrate. The coating comprises a plurality of functionalized oligomeric silsesquioxanes and a pencil hardness of about 5H or more. In aspects, the coating comprises a linker terminated with a first functional group and a second functional group. In aspects, the coating comprises a silane coupling agent attaching the coating to the first major surface. Methods of making a coated article comprise depositing a layer comprise a plurality of functionalized oligomeric silsesquioxanes over a first major surface of a substrate and curing the layer to form the coating. Methods of forming a composition comprise reacting a plurality of functionalized oligomeric silsesquioxanes with a linker terminated with a first functional group at a first end of the linker and a second functional group at a second end of the linker opposite the first end of the linker.

Abstract: Provided are a method of controllably reducing an oxygen content, a method of preparing titanium metal powder, and a method of preparing Ti6Al4V alloy powder. The method of controllably reducing an oxygen content can accurately control the removal amount of oxygen in titanium oxide or vanadium aluminum alloy by introducing a calcium-containing substance into titanium source and/or vanadium source and using aluminum powder in combination as a reductant, and a simple wet treatment is performed on a reduced material obtained after reduction treatment to achieve separation of a reduction by-product and a first reduction powder to obtain high-purity titanium oxide or high-purity vanadium aluminum alloy, thereby providing theoretical and practical bases for preparing a low-valent titanium oxide having a specific oxygen content, a titanium metal powder having a low oxygen content, a vanadium aluminum alloy having a low oxygen content, and a Ti6Al4V alloy having a low oxygen content.

Abstract: A method for obtaining a natural gas liquid (NGL) product from a liquefied natural gas (LNG) liquefaction facility including receiving a gas feed stream at an LNG facility having an NGL recovery unit integrated therein, cooling the gas feed stream via a demethanizer of the NGL recovery unit to separate a vapor from a liquid, transferring the vapor from the NGL recovery unit to an LNG liquefaction unit and transferring the liquid to a deethanizer within the NGL recovery unit for further cooling, and obtaining an ethane product and an NGL product from the cooled liquid.

Abstract: The present disclosure described herein provides, inter alia, a serum-free and xeno-free culture medium capable of supporting the prolonged expansion of mesenchymal stem cells (MSCs) and a kit comprising the same. The present disclosure also provides a method for expanding mesenchymal stem cells (MSCs) using the culture medium as disclosed as well as a substantially homogeneous population of MSCs produced by said method.

Abstract: This application relates to Pseudomonas fluorescens N1, and usage therefor in solid waste recycling based on full bionic simulation combined with a microorganism. Light, temperature, gas and heat conditions in cyclic transformation of organic carbon in soil are simulated, and solid waste is mixed and stacked in the soil or between hills, wherein the solid waste is basically blended according to the carbon-nitrogen ratio, alkalinity or acidity, and water content of the solid waste, and no turning is performed according to the principle of anaerobic fermentation. By introducing high-carbon, high-salt, alkaline or acidic liquid waste using a bionic head cover during stacking, the anaerobic fermentation process is controlled to stop at an acid production stage so that organic acids produced are fully mixed with the solid waste, and the nutrients in the solid waste are released by using acidic materials and thus become nutritional elements for acidic material chelation.