Abstract: A system (10) for expression, purification, and detection and screening of biological drugs comprises: one or more incubators (1), which are used for culturing biological samples to provide basic samples for detection and screening of biological drugs; a liquid operation system (3), which is used for implementing predetermined operations on the biological samples cultured in the incubator(s) (1); a sample detection platform (5), which is used for detecting the biological samples so as to facilitate screening; a transfer platform, which is used for transferring the biological samples between the incubator(s) (1) and the liquid operation system (3) and/or between the liquid operation system (3) and the sample detection platform (5); and an automatic control system (6), which is configured to control the operation of at least one of the incubator(s) (1), the liquid operation system (3), the sample detection platform (5) and the transfer platform.

Abstract: A comfort brake control system and a brake method for a vehicle is disclosed. The comfort brake control system includes: a human-machine interaction interface, configured to provide an interface of multiple optional comfort brake levels of the vehicle, and receive selection of one of the multiple comfort brake levels to switch a current comfort brake level of the vehicle, wherein each comfort brake level comprises a brake parameter corresponding to the comfort brake level, and the brake parameter comprises at least brake pressure and a brake pressure change rate of at least one brake cylinder of the vehicle; and a comfort brake module, configured to determine whether a current state of the vehicle meets a predetermined switching condition; and when it is determined that the switching condition is met, obtain a brake parameter corresponding to a selected comfort brake level, and transmit the obtained brake parameter to a brake system of the vehicle by using a vehicle bus of the vehicle.

Abstract: The present application relates to a compound of formula I as a toll-Like receptor 7 (TLR7) agonist or a pharmaceutically acceptable salt thereof for treating lung cancer, a pharmaceutical combination of the TLR7 agonist and a tyrosine kinase inhibitor for treating lung cancer, and the use of the compound of formula I or the pharmaceutically acceptable salt thereof and the pharmaceutical combination for treating lung cancer.

Abstract: The invention concerns method of treating multiple sclerosis (MS) by administering a therapeutically effective dose of LOU064 or a pharmaceutically acceptable salt thereof.

Abstract: A display module includes a display panel, at least one driving chip, a supporting plate and a strengthening plate. The display panel includes a display portion, a bending portion and a lead-out portion. The display portion has a display surface and a non-display surface. The at least one driving chip is mounted on a side of the lead-out portion away from the display portion. The supporting plate is located on the non-display surface of the display portion. The strengthening plate is located between the supporting plate and the lead-out portion. A depression structure is provided in at least one surface of two opposite surfaces of the strengthening plate and the supporting plate; an orthographic projection of the depression structure in the at least one surface on the lead-out portion at least partially overlaps with an orthographic projection of the at least one driving chip on the lead-out portion.

Abstract: The present disclosure provides, inter alia, methods and compositions for differentiation of pluripotent stem cells and derived hematopoietic lineage cells including hemogenic endothelial cells, hematopoietic progenitor cells and natural killer cells. The differentiation efficiency for the hemogenic endothelial cells, the hematopoietic progenitor cells and the natural killer cells can be improved by using the methods and compositions of this disclosure described herein.

Abstract: Provided are compositions and methods for effective delivery of polynucleotides into the nuclei of cells through electroporation. A new buffer system is provided that facilitates the delivery with greatly reduced cell toxicity. The buffer may include succinate, mannitol, a sugar, glutamine or an analog, and an antioxidant. Also provided are methods that are particularly suitable for delivering an RNA or protein into a cell by electrophoresis in a solution having an osmotic pressure greater than 310 mOsmol/kg.

Abstract: The present disclosure described herein provides, inter alia, an expansion method for expanding mDAPs and a culture medium and a coating matrix combination used in the expansion method, as well as a maturation method for maturing mDAPs and a culture medium used in the maturation method. The present disclosure also provides a substantially homogeneous population of mDAPs and a substantially homogeneous population of mDANs.

Abstract: Systems and methods for accelerated online adaptive radiation therapy (“ART”) are described. The improvements to online ART are generally provided based on the use of textural analysis and machine learning algorithms implemented with a hardware processor and a memory. The described systems and methods enable more efficient and accurate online adaptive replanning (“OLAR”), which can also be implemented in clinically acceptable timeframes. For example, OLAR can be reduced from taking 10-30 minutes down to 5-10 minutes.

Abstract: The present disclosure described herein provides, inter alia, an expansion method for expanding mDAPs and a culture medium and a coating matrix combination used in the expansion method, as well as a maturation method for maturing mDAPs and a culture medium used in the maturation method. The present disclosure also provides a substantially homogeneous population of mDAPs and a substantially homogeneous population of mDANs.

Abstract: The present invention pertains to the technical field of aeromagnetic survey, and specifically pertains to a storage device for a data analyzer for aerospace magnetic field measurement, which comprises a storage box body, a moving structure for facilitating movement is connected to the storage box body, a shielding structure for shielding sunlight is connected to the storage box body, an accommodating structure for accommodating an article is connected to the storage box body, a support structure for supporting is connected to the accommodating structure, and a placing structure for placing is connected to the storage box body.

Abstract: The present disclosure provides, inter alia, methods and compositions for differentiation of pluripotent stem cells and derived hematopoietic lineage cells including hemogenic endothelial cells, hematopoietic progenitor cells and natural killer cells. The differentiation efficiency for the hemogenic endothelial cells, the hematopoietic progenitor cells and the natural killer cells can be improved by using the methods and compositions of this disclosure described herein.

Abstract: A support plate (001) and a display device including the support plate (001) are provided. The support plate (001) is used for supporting a flexible display module (002). The support plate (001) includes a bending area (BA). The bending area (BA) includes a plurality of hollowed-out patterns (101) arranged in an array. A connecting portion (102) is arranged between two adjacent hollowed-out patterns (101) in the same row. The connecting portions (102) in at least three adjacent rows are staggered in a column direction, which is beneficial for uniform distribution of bending stress.

Abstract: Embodiments described herein relate to managing access to 5G cellular baseband resources for 5G-capable wireless devices. A 5G-capable wireless device of an MNO, while connected to or camped on a legacy 4G LTE cell of the MNO and not engaged in a 4G only LTE service, determines whether an NSA 5G cell of another MNO satisfies performance criteria before measuring and/or sending measurement data for an NSA 4G LTE anchor cell associated with the NSA 5G cell to a wireless network. Refraining from measuring and/or sending measurement data under certain conditions causes the 5G-capable wireless device of the MNO to remain connected to or camped on the legacy 4G LTE cell of the MNO rather than reselecting or handing over to the NSA 4G LTE cell of another MNO. The 5G-capable wireless device also maintains a database of information for valid NSA 4G LTE cells to which to reselect/handover.

Abstract: A projection apparatus and a control method thereof are provided. The projection apparatus includes a processor, a sensor, and a projection module. When a command corresponding to a standby mode is received, the processor sets the projection apparatus to a first sub-standby mode. The sensor is enabled to sense whether there is a living object located in a sensing area outside the projection apparatus. The standby mode is maintained as the first sub-standby mode in response to sensing that the living object is not in the sensing area. The standby mode is set to be switched to a second sub-standby mode in response to sensing that the living object is in the sensing area. A maximum power consumption of the first sub-standby mode is less than a maximum power consumption of the second sub-standby mode. In the first and second sub-standby modes, the projection module is not enabled.

Abstract: Disclosed is a design method for a three-dimensional special-shaped jet nozzle used in the field of water-saving irrigation in farmland.

Abstract: Embodiments of the present disclosure relate to a method, system, and computer program product for efficient execution of a decision tree. According to the method, respective target values of a plurality of attributes of a target entity are obtained. Representations of a plurality of leaf nodes of a decision tree are obtained. Each of the representations indicates respective statistic values of a plurality of attributes of historical entities and a statistic prediction result determined from historical prediction results output at a respective one of the plurality of leaf nodes for the historical entities. Distance measures between the target entity and the plurality of leaf nodes are determined based on the target values and the statistic values indicated by the representations of the plurality of leaf nodes. A target prediction result for the target entity is determined based on the distance measures and the statistic prediction results of the historical entities.

Abstract: A method of cleaning controlled and regulated equipment. A tool handle is pivotably connected to a tool head frame that includes a leading edge opposite a trailing edge between parallel first side and second side edges, where the leading edge and the trailing edge are non-parallel. The tool head frame is disposed in proximity to a tray having a compartment with a pad assembly and a cleaning solution disposed therein. The pad assembly is movable within the compartment between first and second positions. The tool head frame is hands-free attached to the pad assembly in the first or second position and hands-free detached from the pad assembly in the second position.

Abstract: A system and method for automatically cleaning air filters of a medical imaging system is provided. The method includes monitoring an air filter operating condition, determining that the air filter operating condition is not within a pre-determined threshold, and providing a control signal to at least one air filter. The at least one air filter comprises a motor, drive shaft, rotatable passive shaft, continuous belt air filter, and a stationary filter brush. The drive shaft is rotatably coupled to the motor. The continuous belt air filter is coupled to the drive shaft and the passive shaft. The stationary filter brush is mounted against the continuous belt air filter. The method includes rotating, by the motor in response to the control signal, the drive shaft to translate the continuous belt air filter around and between the drive shaft and the rotatable passive shaft, and across the stationary filter brush.

Abstract: A method of making a porous three-dimensional graphene mesh includes combining a graphene-containing material and a polymer having a plurality of hydroxyl groups in an alcohol solvent to form a mixture, adding a salt to the mixture, heating the mixture to form a gel, and washing the gel with water to remove the salt from the gel, leaving behind stable pores to form a scaffold. A three-dimensional porous graphene mesh includes a graphene-containing material and a polymer. The polymer is crosslinked with the graphene-containing material such that the Young's Modulus of the mesh is at least about 5 GPa.