Abstract: The present invention provides materials and methods useful to treat various sGC?1-expressing cancers. Materials include peptides which interfere with sGC?1's pro-survival functions, thereby resulting in apoptosis of sGC?1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.

Abstract: A method is provided for fabricating a PMOS transistor. The method includes providing a semiconductor substrate, and forming a dummy gate structure at least having a dummy gate, a high-K dielectric layer, and a sidewall spacer surrounding the high-K dielectric layer and the dummy gate on the semiconductor substrate. The method also includes forming a source region and a drain region in the semiconductor substrate at both sides of the dummy gate structure by an ion implantation process, and performing a first annealing process to enhance the ion diffusion. Further, the method includes forming an interlayer dielectric layer leveling with the surface of the dummy gate, and forming a trench by removing the dummy gate. Further, the method also includes performing a second annealing process, and forming a metal gate in the trench.

Abstract: Automated valuation model with customizable neighborhood determination. A map image is displayed corresponding to a geographical area, and then user input accommodates definition of a particularly defined geographic area to provide custom identification of a neighborhood to be subject to automated valuation. Once the defined geographic area is established, the automated valuation model is applied to property data corresponding to properties within the defined geographic area. A subject property and corresponding properties within the defined geographic area are then displayed on a map image, preferably with articulation of the defined geographic area as the neighborhood of interest. The neighborhood may be defined by, among other criteria, inclusion within a user-defined shape, as well as exclusion of a user-defined shape from a displayed geographic area.

Abstract: A method is provided for fabricating a High-K layer. The method includes providing a substrate, applying a first precursor gas on the substrate such that the substrate absorbs first precursor gas molecules in a chemical absorption process, and removing the unabsorbed first precursor gas using a first inert gas. The method also includes applying a second precursor gas on the substrate, and forming a first thin film on the substrate as a reaction product of the second precursor gas and the absorbed first precursor gas molecules. Further, the method includes removing unreacted second precursor gas and byproducts using a second inert gas, and forming a high-K layer on the substrate by forming a plurality of the first thin films layer-by-layer.

Abstract: Fluidic sorting systems configured to immobilize, and optionally concentrate and/or analyze, one or more particles within the system are provided. Aspects of the systems include a flow-through chamber and an immobilization component configured to immobilize, preferably reversibly, a particle within the flow-through chamber. Optionally, the systems include an analysis component configured to optically analyze an immobilized particle within the flow-through chamber. In certain aspects, the systems are configured to collect one or more particles from the flow-through chamber for subsequent analysis, experimentation, and/or use. Also provided are methods, components and kits for reversibly immobilizing, and optionally analyzing, one or more particles within a fluidic sorting system.

Abstract: A complete capillary electrophoresis (CE) system that is capable of providing a continuous flow of effluent at the exit of the flow-through outlet vial is provided. A self-contained capillary electrophoresis system with a flow-through outlet vial for interfacing with mass spectrometry includes a capillary having an upstream inlet end and a downstream terminus end; an electrically conductive hollow needle having an inner wall defining an internal tapered chamber, the internal tapered chamber dimensioned and configured to slidably accept the terminus end of the capillary, the capillary longitudinally inserted into and mounted within the internal tapered chamber to a distance whereby the terminus end of the capillary abuts the inner wall of the needle at the taper; and wherein a micro-reservoir is formed between the terminus end of the capillary and the downstream exit orifice.

Abstract: A multilayer biaxially oriented polypropylene film is disclosed which comprises at least three layers. The first layer is an outer layer comprising a first polymer which is a homopolymer polypropylene resin having a melting point of at least 155° C. The second layer is a core layer, having a melting point greater than 150° C. The core layer includes a blend comprising a second polymer which is a polypropylene homopolymer having a melting point of at least 155° C. and a third polymer having a melting point no greater than 145° C. The second polymer comprises from 20% to 80% by weight of the core layer while the third polymer comprises from 80% to 20% by weight of the core layer. The last required layer in the film is a sealant layer. The sealant layer comprises a fourth polymer having a melting point no greater than 145° C.

Abstract: The invention relates to a power grid visualization system and a power grid visualization method based on a three-dimensional geographic information system (GIS) technology. Models to be loaded are divided into different model loading subtasks according to the difference of object types included in a scene to be loaded, and model files are called in parallel from a plurality of subtasks in a multi-thread mode; and meanwhile, on the basis that loading tasks are divided into a plurality of model loading subtasks according to the loaded object types, model files of objects of each type are only read once, moreover, reuse of the model files is not limited to a client loading task, different clients can reuse the read model files, and the characteristics of limited type and relatively consistent specification of power equipment are fully considered, so that rereading of the model files of the same type is avoided.

Abstract: A system may produce a desired three dimensional object that includes a tank that holds a liquid that solidifies upon exposure to light; a controllable stage that controllably moves within the tank; a controllable light source that emits a light image in a controllable pattern; and a controller that controls the controllable stage and the controllable light source so as to cause at least three cascaded layers to be sequentially solidified in the liquid that collectively approximate at least a section of the desired three dimensional object and that collectively form at least one up-facing step at their outer edges; and, following the solidification of the at least three cascaded layers, cause a meniscus of the liquid to form and solidify in the at least one up-facing step. The controller may control the number and/or width of the sequentially solidified cascaded layers.

Abstract: A razor for shaving hairs has an ionizing device that produces ions during a shaving operation of the razor powered by a single battery. The battery can be a 1.5 Volt button battery to provide power to an ion generator that boost the voltage to about 9 Volts.

Abstract: The foaming window for making a foam useful in the manufacture of artificial leather is expanded through the use of a foamable composition comprising (A) a propylene-?-olefin copolymer, (B) a molecular melt (MM) comprising 4,4?-oxydibenzenesulfonylazide (DPO-BSA) and an antioxidant, and (C) a blowing agent. The foaming window can be expanded such that foaming can occur at 220° C. for 20 to 200 or more seconds.

Abstract: A three-dimensional object may be produced in cascaded layers from a liquid resin that solidifies upon exposure to light. A translation stage may be positioned relative to a vat that is suitable for solidifying the highest un-solidified layer of the three-dimensional object directly beneath any existing, solidified layers of the three-dimensional object. A mask image projection system may project a two-dimensional image of the highest un-solidified layer through a transparent bottom of the vat and into the liquid resin. This may cause at least a portion of the liquid resin to solidify in the shape of the two-dimensional image and to adhere to the bottom of a surface beneath the solidified layer. A shearing force may be applied between the bottom surface of the solidified layer and the surface beneath that is great enough to detach the solidified layer from the surface beneath.

Abstract: A mask plate comprises a light transmitting region; a light absorbing region; and a light reflecting region provided in the light absorbing region on one side of the mask plate. An exposing method using the mask plate comprises placing a first substrate coated with a first photosensitive resist layer under and parallel to the mask plate; having first light vertically strike on an upper surface of the mask plate from above, pass through the light transmitting region of the mask plate, and strike on the first photosensitive resist layer; placing a second substrate coated with a second photosensitive resist layer under and parallel to the mask plate; and having second light reflected by the lens device onto the surface of the mask plate where the light reflecting region is provided, then reflected by the light reflecting region and strike on the second photosensitive resist layer.

Abstract: A multiple nozzle differential fluid delivery head is disclosed. The fluid delivery head includes a body that defines a fluid chamber having a longitudinal axis. The body includes an inlet for connection to a fluid source, and the inlet is in fluid communication with the fluid chamber. The fluid delivery head includes a plurality of outlet ports connected to and extending away from the body. Each outlet port has an interior space in fluid communication with the fluid chamber. The fluid delivery head includes a nozzle insert removably secured in an outer end of each outlet port. At least one nozzle insert has a fluid delivery aperture in fluid communication with the interior space of its associated outlet port for delivering fluid out of the interior space of its associated outlet port. One or more of the outlet ports is angled away from a plane normal to the axis of the fluid delivery head.

Abstract: The present invention provides materials and methods useful to treat various sGC?1-expressing cancers. Materials include peptides which interfere with sGC?1's pro-survival functions, thereby resulting in apoptosis of sGC?1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.

Abstract: A nanoscale lithographic method in which a reusable conductive mask, having a pattern of conductive surfaces and insulating surfaces, is positioned upon a substrate whose surface contains an electrically responsive resist layer over a buried conductive layer. When an electric field is applied between the conductive mask and buried conductive layer, the resist layer is altered in portions adjacent the conductive areas of the mask. Selective processing is performed on the surface of the substrate, after mask removal, to remove portions of the resist layer according to the pattern transferred from the mask. The substrate may be a target substrate, or the substrate may be utilized for a lithographic masking step of another substrate. In one aspect of the invention the electrodes to which the charge is applied are divided, such as into a plurality of rows and columns wherein any desired pattern may be created without the need to fabricate specific masks.

Abstract: Provided is a homodimer of insulinotropic peptide analogues and method for preparation thereof and use thereof, wherein the insulinotropic peptide analogue comprises GLP-1 and Exendin-4. The homodimer of insulinotropic peptide analogues of the invention is made by conjugating two identical insulinotropic peptide analogue molecules at the C-terminal Cys residues via disulfide bond or PEG molecule. The homodimer of insulinotropic peptide analogues of the invention has superior stability and biological activity in vivo, and prolonged half-life in the circulation, and can be used for the preparation of hypoglycemic drugs.

Abstract: The present disclosure provides a switch unit and a power generation system thereof. The switch unit includes a contact switch having a main contact and a control terminal, where the control terminal receives a first drive signal to turn on the contact switch; and a bi-directional controllable switch structure, which is connected in parallel to two ends of the main contact of the contact switch and receives one or more second drive signals to turn on the switch structure. When the switch unit performs a turn-off operation, the bi-directional controllable switch structure provides a commutation bypass for the contact switch, so as to protect the contact switch.

Abstract: Compositions comprising (A) propylene-alpha-olefin copolymer, (B) olefin block copolymer, and (C) DPO-BSA molecular melt (MM) are useful in the preparation of the top skin layer of artificial leather multi-layer structures.

Abstract: A memory capacitor based on a field configurable ion-doped polymer is reported. The device can be dynamically and reversibly programmed to analog capacitances with low-voltage (<5 V) pulses. After the device is programmed to a specific value, its capacitance remains nonvolatile. The field configurable capacitance is attributed to the modification of ionic dopant concentrations in the polymer. The ion and dipole concentrations in the ion conductive layer can be modified when the voltage biases applied to the electrodes exceeds a threshold value and can operate as a conventional capacitor when a voltage less than the threshold value is applied. The ion conductive layer will remain at a stable value after the device is modified without applying external voltage. The device has a nonvolatile memory function even when the external voltage is turned off. The memory capacitors may be used for analog memory, nonlinear analog and neuromorphic circuits.