Abstract: Chemical entities based on quinoxaline that are kinase inhibitors are described. Specifically quinoxaline derivatives of Formula I, containing a diarylamide or diarylurea substructure that inhibit Braf mutant kinase activity, pharmaceutical compositions containing the inhibitor compounds and methods of treatment of cancer comprising administering an effective amount of the Braf inhibitor compound are described.

Abstract: A method and a system for determining an association of at least one biological feature with a medical condition utilizes the novel L1/2 penalized network-constraint regression model to achieve an improved biological analysis, in particular by solving high-dimensional problems. The method and the system of the present invention attain high accuracy and preciseness.

Abstract: A system and a method for determining an estimated survival time of a subject with a medical condition utilizes the novel RS-AFT model and is especially suitable and highly advantageous for survival analysis based on microarray gene expression data because of its exceptional performance of gene selection, stable noise resistance, and high prediction precision.

Abstract: A system and a method for determining an association of one or more biological features with a medical condition provides empirical results and simulations confirming that the involvement of both L1/2-regularized logistic regression and L2-regularized logistic regression in the regression model is highly competitive against usual approaches like Lasso, L1/2, SCAD-L2, and Elastic net in analyzing high dimensional and low sample sizes data.

Abstract: A system and a method for determining an association of at least one biological feature with a medical condition, in particularly, but not exclusively, a system and a method of determining an association of at least one biological feature in form of a gene expression with cancer or a subtype of cancer that can include the generation of a simplified protein-protein interaction network based on processed biological data. The system and respective method is especially suitable for analysis of high dimensional and low sample size biological datasets such as in cancer research.

Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Abstract: The present invention relates to recombinant bacteria producing L-amino acid, in which the recombinant bacteria has reduced expression of the glucose-6-phosphate isomerase gene pgi and improved expression of the glucose-6-phosphate dehydrogenase gene -opcA than the starting bacteria, where the starting bacterium is a bacterial strain that can accumulate target amino acid(s) and preferably, the amino acid is L-histidine.

Abstract: Chemical entities that are quinoxaline kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Abstract: An embodiment of a flame detector coverage verification system includes an optical source for generating a light beam, and a control unit configured to point the beam in a direction generally co-aligned with an optical center line of the flame detector and through a range of movement about the direction to visually demarcate an area that falls within the flame detector's field of view. In one embodiment, the control unit includes a movable mirror to deflect the laser beam. The system may include an indicator device configured to determine and visually indicate a pan direction of the detector optical center line with respect to a defined direction, and a declination indicator configured to determine and visually display the tilt angle (angle of declination) of the detector optical center line with respect to a ground plane.

Abstract: A two-dimensional photonic crystal surface emitting laser capable of improving characteristics of light to be emitted, particularly optical output , which includes: a two-dimensional photonic crystal including a plate-shaped base member and modified refractive index regions where the modified refractive index regions have a refractive index different from that of the plate-shaped base member and are two-dimensionally and periodically arranged in the base member; an active layer provided on one side of the two-dimensional photonic crystal; and a first electrode and a second electrode provided sandwiching the two-dimensional photonic crystal and the active layer for supplying current to the active layer, where the second electrode covers a region equal to or wider than the first electrode, wherein the first electrode is formed so as to supply the current to the active layer with a different density depending on the in-plane position on the first electrode.

Abstract: A photovoltaic device is presented. The photovoltaic device includes a buffer layer disposed on a transparent conductive oxide layer; a window layer disposed on the buffer layer; and an interlayer interposed between the transparent conductive oxide layer and the window layer. The interlayer includes a metal species, wherein the metal species includes gadolinium, beryllium, calcium, barium, strontium, scandium, yttrium, hafnium, cerium, lutetium, lanthanum, or combinations thereof.

Abstract: A sound receiving system is disclosed, each of the plurality of basic array devices has an output terminal connected with one filter, each of the plurality of filters has an output terminal connected with an input terminal of the second sound-mixing output device; the basic array device includes a microphone array, the microphone array includes a plurality of microphones longitudinally arranged along a straight line in order, and two adjacent microphones in the microphone array are separated with a distance of 1 n ? ? ; each microphone has an output terminal connected with one of the time delay circuits, each time delay circuit has an output terminal connected with an input terminal of the first sound-mixing output device; and the i-th time delay circuit has a delay time defined by adding (n-i) times of unit time to a delay time of the last time delay circuit.

Abstract: The present invention discloses an E. coli engineering bacteria producing 1,5-pentanediamine through a whole cell catalysis and its application. The engineering bacteria according to the present invention, is Escherichia coli (E. coli) strain B or its derivative strains with the overexpression of a lysine decarboxylase gene and a proper expression of a lysine-cadaverine antiporter gene cadB. The engineering bacteria according to the present invention is the engineering bacteria producing 1,5-pentanediamine through the whole cell catalysis constructed from Escherichia coli B derivative strains, which has an overexpression of a lysine decarboxylase gene cadA and a proper expression of the lysine-cadaverine antiporter gene cadB.

Abstract: Described herein are kinase inhibitors represented by Formula I: and pharmaceutical compositions thereof, for use in the treatment of cancer.

Abstract: An embodiment of a flame detector coverage verification system includes an optical source for generating a light beam, and a light-path control unit connected to the optical source and configured to direct the beam through a range of movements about a center line direction of the flame detector to visually demarcate an area that falls within the flame detector's field of view. An indicator device configured to visually indicate a pan direction of the detector optical center line. A tilt indicator is configured to determine and visually display the tilt angle of the detector with respect to a ground plane. A hub structure temporarily attaches the control unit to the flame detector, the control unit pivotally connected to the hub structure so that the optical source light beam is oriented perpendicular to a ground plane.

Abstract: An embodiment of a flame detector coverage verification system includes an optical source for generating a light beam, and a control unit configured to point the beam in a direction generally co-aligned with an optical center line of the flame detector and through a range of movement about the direction to visually demarcate an area that falls within the flame detector's field of view. In one embodiment, the control unit includes a movable mirror to deflect the laser beam. The system may include an indicator device configured to determine and visually indicate a pan direction of the detector optical center line with respect to a defined direction, and a declination indicator configured to determine and visually display the tilt angle (angle of declination) of the detector optical center line with respect to a ground plane.

Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Abstract: Chemical entities based on quinoxaline that are kinase inhibitors are described. Specifically quinoxaline derivatives of Formula I, containing a diarylamide or diarylurea substructure that inhibit Braf mutant kinase activity, pharmaceutical compositions containing the inhibitor compounds and methods of treatment of cancer comprising administering an effective amount of the Braf inhibitor compound are described.

Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Abstract: A method for determining a background component and a dynamic component of an image frame from an under-sampled data sequence obtained in a dynamic MRI application is provided. The two components are determined by optimizing a low-rank component and a sparse component of the image frame in a sense of minimizing a weighted sum of terms. The terms include a Schattenp=1/2 (S1/2-norm) of the low-rank component, an L1/2-norm of the sparse component additionally sparsified by a sparsifying transform, and an L2-norm of a difference between the sensed data sequence and a reconstructed data sequence. The reconstructed one is obtained by sub-sampling the image frame according to an encoding or acquiring operation. The background and dynamic components are the low-rank and sparse components, respectively. Experimental results demonstrate that the method outperforms an existing technique that minimizes a nuclear-norm of the low-rank component and an L1-norm of the sparse component.