Abstract: Chemical entities based on quinoxaline that are kinase inhibitors are described. Specifically, quinoxaline derivatives of Formula I, containing a diarylamide or diarylurea substructure that inhibit Braf mutant kinase activity, pharmaceutical compositions containing the inhibitor compounds and methods of treatment of cancer comprising administering an effective amount of the Braf inhibitor compound are described.

Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.

Abstract: A method for fabricating a semiconductor device includes: forming a plurality of fins from a substrate, the fins including nFET fins and pFET fins; forming a trench between the nFET fins and pFET fins; forming a silicon nitride (SiN) layer over the trench, the nFET fins and the pFET fins to create an intermediate device; and depositing with a high density plasma (HDP) process an HDP layer of silicon dioxide (SiO2) over the trench, the nFET fins and the pFET fins. The HDP process includes loading the intermediate device into a deposition chamber and introducing hydrogen (H2) gas and silane (SiH4) into the deposition chamber, wherein the H2 gas is not introduced into the deposition chamber before the SiH4 is introduced into the deposition chamber.

Abstract: An embodiment of a flame detector coverage verification system includes an optical source for generating a light beam, and a light-path control unit connected to the optical source and configured to direct the beam through a range of movements about a center line direction of the flame detector to visually demarcate an area that falls within the flame detector's field of view. An indicator device configured to visually indicate a pan direction of the detector optical center line. A tilt indicator is configured to determine and visually display the tilt angle of the detector with respect to a ground plane. A hub structure temporarily attaches the control unit to the flame detector, the control unit pivotally connected to the hub structure so that the optical source light beam is oriented perpendicular to a ground plane.

Abstract: In a vehicle-to-vehicle communication system, an intersection-located road side unit (RSU) having two omni-antennas applies spatial filtering to the antennas' RX signals to recover first and second overlapping basic safety messages (BSMs) concurrently transmitted by two intersection-approaching vehicles that have no direct line of sight (NLOS) between them. The RSU retransmits each BSM for receipt by the other vehicle using either an omnidirectional retransmission technique in which the two messages are sequentially transmitted using an omnidirectional beam-pattern, a directional retransmission technique in which the two messages are sequentially transmitted using directional beam-patterns, or an XOR retransmission technique in which the RSU applies an XOR operation to the two BSMs and transmits the resulting XOR message using an omnidirectional beam-pattern. A receiving vehicle can apply an XOR operation to the XOR message and a local copy of the first BSM message to recover the second BSM message.

Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Abstract: Systems, apparatuses, and methods for modifying metadata associated with database objects obtained from providers, such as cloud providers, are disclosed. Modifying metadata associated with database objects obtained from cloud providers may include identifying resources in a computer network that originate from providers, such as cloud providers that do not have associated metadata. A user interface that includes the resources may be generated, and the resource may receive input to select the resources and a descriptor that may be associated with the resources. The selected resources may then be associated, in a configuration management dataset, with metadata derived from the selected descriptor. The metadata may indicate an association of the selected resources to a parameter.

Abstract: To provide a two-dimensional photonic crystal surface emitting laser capable of improving characteristics of light to be emitted, in particular, optical output power. The two-dimensional photonic crystal surface emitting laser includes: a two-dimensional photonic crystal including a plate-shaped base member and modified refractive index regions where the modified refractive index regions have a refractive index different from that of the plate-shaped base member and are two-dimensionally and periodically arranged in the base member; an active layer provided on one side of the two-dimensional photonic crystal; and a first electrode and a second electrode provided sandwiching the two-dimensional photonic crystal and the active layer for supplying current to the active layer, where the second electrode covers a region equal to or wider than the first electrode.

Abstract: Disclosed are embodiments of a multi-layer stack and photolithography methods and systems that employ such a stack. The disclosed multi-layer stacks include a photoresist layer on an underlayer. The photoresist layer and underlayer are made of different materials, which are selected so that valence and conduction band offsets between the underlayer and photoresist layer create an effective electric field (i.e., so that the stack is “self-biased”). When areas of the photoresist layer are exposed to radiation during photolithography and the radiation passes through photoresist layer and excites electrons in the underlayer, this effective electric field facilitates movement of the radiation-excited electrons from the underlayer into the radiation-exposed areas of the photoresist layer in a direction normal to the interface between the underlayer and the photoresist layer.

Abstract: An atomic layer deposition method is provided. The atomic layer deposition method includes the following steps. A substrate is placed in a reaction chamber. At least one deposition cycle is performed to deposit a metal film on the substrate. The at least one deposition cycle includes the following steps. A metal precursor is introduced in the reaction chamber. A hydrogen plasma is introduced to be reacted with the metal precursor adsorbed on the substrate to form the metal film. An annealing process is performed on the metal film. The at least one deposition cycle is performed in a hydrogen atmosphere under UV light irradiation.

Abstract: A method and a system for determining an association of at least one biological feature with a medical condition utilizes the novel L1/2 penalized network-constraint regression model to achieve an improved biological analysis, in particular by solving high-dimensional problems. The method and the system of the present invention attain high accuracy and preciseness.

Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.

Abstract: An atomic layer deposition method is provided. The atomic layer deposition method includes the following steps. A substrate is placed in a reaction chamber. At least one deposition cycle is performed to deposit a metal film on the substrate. The at least one deposition cycle includes the following steps. A metal precursor is introduced in the reaction chamber. A hydrogen plasma is introduced to be reacted with the metal precursor adsorbed on the substrate to form the metal film. An annealing process is performed on the metal film. The at least one deposition cycle is performed in a hydrogen atmosphere under UV light irradiation.

Abstract: The present disclosure relates to the production and use of a multi-layer X-ray source target. In certain implementations, layers of X-ray generating material may be interleaved with thermally conductive layers. To prevent delamination of the layers, various mechanical, chemical, and structural approaches are related, including approaches for reducing the internal stress associated with the deposited layers and for increasing binding strength between layers.

Abstract: A semiconductor structure includes a substrate and a CMOS structure. The CMOS structure includes a PMOS structure and a NMOS structure. The PMOS structure includes two first source/drain regions disposed in the substrate, a first gate dielectric disposed partially in the substrate between the first source/drain regions, and a fully silicided gate electrode disposed on the first gate dielectric. The NMOS structure includes two second source/drain regions disposed in the substrate, a second gate dielectric disposed partially in the substrate between the second source/drain regions, and a non-silicided conductive gate electrode disposed on the second gate dielectric.

Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Abstract: To provide a two-dimensional photonic crystal surface emitting laser capable of improving characteristics of light to be emitted, in particular, optical output power.

Abstract: A method for fermentation-production of a pentanediamine, comprising: culturing a cell expressing a lysine decarboxylase to obtain a whole cell fermentation broth comprising a pentanediamine; and extracting the pentanediamine from the whole cell fermentation broth, and striping the whole cell fermentation broth of carbon dioxide contained therein before adding a strong base. The method greatly increases a production volume of the pentanediamine.

Abstract: An apparatus, method and computer-readable medium provide control of set top box volume based on mobile device events. The apparatus may execute a process that includes controlling a volume setting of an audio amplifier to output audio content to the one or more audio or audio/visual devices. A connection event signal from a mobile device is received via a wireless radio frequency receiver. The connection event signal indicates a call state of the mobile device. In response to receiving the connection event signal, a received signal strength indication associated with the connection event signal obtained. A volume setting that corresponds to the obtained received signal strength indication is determined. The volume setting output to the audio amplifier is adjusted according to the determined volume setting.

Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.