Abstract: Chemical entities that are quinoxaline kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Abstract: A system for enabling an unmanned aerial vehicle (UAV) to respond to an alert on a premises, where the UAV may either confront the alert situation or monitor the alert situation from a distance. The UAV may respond to the alert situation after a controller receives alert event data from an alert generator. The controller may further match the data received to a number of event types stored in a database. This information allows a flight plan to be determined which will allow the UAV to navigate to a location associated with the alert situation.

Abstract: A panel structure is removably connected with a main housing of an electronic device. The panel structure comprises a panel body, two movable members and at least two elastic members. The panel body comprises two fixing parts; each movable member is movably connected with the panel body, and each movable member comprises a pivoting part and a corresponding fixing part, wherein the two movable members are movably apart from each other in a first axial direction such that each movable member is fixed with each fixing part with each corresponding fixing part, making each pivoting part which moves along with each movable member pivotally connected to the main housing. Each elastic member has two ends respectively connected to the movable members and the panel body.

Abstract: A two-dimensional photonic crystal surface emitting laser has a laminated structure including: a two-dimensional photonic crystal (2DPC) layer in which refractive index distribution is formed by two-dimensionally arranging air holes in a plate-shaped base member; and an active layer for generating light with wavelength ?L by receiving an injection of electric current. The two-dimensional photonic crystal surface emitting laser emits a laser beam in the direction of an inclination angle ? from normal to the 2DPC layer.

Abstract: A super-resolution method for generating a high-resolution (HR) image from a low-resolution (LR) blurred image is provided. The method is based on a transform-invariant directional total variation (TI-DTV) approach with Schattenp=1/2 (S1/2-norm) and L1/2-norm penalties. The S1/2-norm and the L1/2-norm are used to induce a lower-rank component and a sparse component of the LR blurred image so as to determine an affine transform to be adopted in the TI-DTV approach. In particular, the affine transform is determined such that a weighted sum of the S1/2-norm and the L1/2-norm is substantially minimized. Based on the alternating direction method of multipliers (ADMM), an iterative algorithm is developed to determine the affine transform. The determined affine transform is used to transform a candidate HR image to a transformed image used in computing a directional total variation (DTV), which is involved in determining the HR image.

Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Abstract: A switch device includes a circuit module and a pressing module. The circuit module includes a plurality of pushbuttons and a light-emitting member that emits light having different colors when the pushbuttons are pressed. The pressing module includes an operating unit, a driven member and a pressing member. The driven member is moved alternately to a retracted position and a projecting position as a result of depression of the operating unit. The pressing member is connected to the driven member to press one of the pushbuttons when the driven member is at the projecting position, such that one of the colors of the light corresponding to the one of the pushbuttons is visible through the operating unit.

Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Abstract: Chemical entities that are effective as kinase inhibitors, pharmaceutical compositions and methods of treatment are disclosed. The chemical entities disclosed specifically inhibit signal transduction and cellular proliferation by modulating the activity of protein kinases to regulate and modulate abnormal or inappropriate cell proliferation, differentiation, or metabolism. The compounds include a pyrido[3,2-d]pyrimidine scaffold substituted with aromatic and heteroaromatic moieties.

Abstract: A mobile terminal and a method for communication control are provided. The mobile terminal includes a communication device, a communication interface and a signal detector. The communication interface detects connection to a transmission device. Upon detecting that the communication interface is connected to a transmission device, the transmission power of the transmission device is compared with the communication device. Upon the transmission power of the transmission device being greater than the communication device; a strength of a current signal measured by the signal detector is obtained. The obtained strength of the current signal is compared with a preset value. Upon the obtained strength of the current signal being less than the preset value, a control command is sent to control the transmission device to transmit signals for the mobile terminal. An electronic device with communication function is also provided.

Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.

Abstract: A super-resolution method for generating a high-resolution (HR) image from a low-resolution (LR) blurred image is provided. The method is based on a transform-invariant directional total variation (TI-DTV) approach with Schattenp=1/2 (S1/2-norm) and L1/2-norm penalties. The S1/2-norm and the L1/2-norm are used to induce a lower-rank component and a sparse component of the LR blurred image so as to determine an affine transform to be adopted in the TI-DTV approach. In particular, the affine transform is determined such that a weighted sum of the S1/2-norm and the L1/2-norm is substantially minimized. Based on the alternating direction method of multipliers (ADMM), an iterative algorithm is developed to determine the affine transform. The determined affine transform is used to transform a candidate HR image to a transformed image used in computing a directional total variation (DTV), which is involved in determining the HR image.

Abstract: A semiconductor interconnect structure and a manufacturing method thereof are provided. The semiconductor interconnect structure includes a barrier metal layer, a copper metal layer, and a compound thin film. The barrier metal layer is formed on an interconnect trench, the copper metal layer is formed on the barrier metal layer, and the compound thin film is formed on a surface of the copper metal layer, wherein the compound thin film contains organocopper and amorphous carbon. Therefore, the resulting semiconductor interconnect structure has reduced resistivity.

Abstract: The present invention provides a novel semi-supervised learning method based on the combination of the Cox model and the accelerated failure time (AFT) model, each of which is regularized with L1/2 regularization for high-dimensional and low sample size biological data. In this semi-supervised learning framework, the Cox model can classify the “low-risk” or a “high-risk” subgroup though samples as many as possible to improve its predictive accuracy. Meanwhile, the AFT model can estimate the censored data in the subgroup, in which the samples have the same molecular genotype. Combined with L1/2 regularization, some genes can be selected by the Cox model and the AFT model and they are significantly relevant with the cancer.

Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions containing the same, and methods of use thereof are described. Specifically quinazoline derivatives of Formula Ia: and their uses in modulating kinase activities are disclosed.

Abstract: A two-dimensional photonic crystal surface emitting laser has a laminated structure including: a two-dimensional photonic crystal (2DPC) layer in which refractive index distribution is formed by two-dimensionally arranging air holes in a plate-shaped base member; and an active layer for generating light with wavelength ?L by receiving an injection of electric current. The two-dimensional photonic crystal surface emitting laser emits a laser beam in the direction of an inclination angle ? from normal to the 2DPC layer.

Abstract: Chemical entities based on quinoxaline that are kinase inhibitors are described. Specifically quinoxaline derivatives of Formula I, containing a diarylamide or diarylurea substructure that inhibit Braf mutant kinase activity, pharmaceutical compositions containing the inhibitor compounds and methods of treatment of cancer comprising administering an effective amount of the Braf inhibitor compound are described.

Abstract: The present application discloses recombinant bacteria producing L-amino acid(s) its construction method and the method of producing L-amino acid(s). The recombinant bacteria producing L-amino acid(s) according to the present invention has reduced expression of the glucose-6-phosphate isomerase Pgi and improved expression of the glucose-6-phosphate dehydrogenase Zwf-OpcA than the starting bacteria, wherein: said starting bacterium is a bacterial strain which can accumulate target amino acid(s). During fermenting and culturing the recombinant bacteria according to the present invention, it is observed that the effect of improving yield can be additive and the yield of L-amino acid(s) is improved obviously. The strategy of combinational modification according to the present invention develops a new method of improving the yield of L-amino acid(s) and hence it can be applied to produce L-amino acid(s) through bacterialfermentation.

Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.