Abstract: The present invention relates to anti-matriptase antibodies and immunoconjugates of anti-matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising an anti-matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase.

Abstract: An impact energy absorbing apparatus includes: a base, an axial crush component, a top plate, and an energy transfer component. The base is fastened to a protected object, and a tapered hole is provided on a top surface of the base. A bottom end face of the metal hollow rod of the axial crush component is joined with the top surface of the base. The energy transfer component includes a force bearing plate and a guiding rod extending outwards, where the force bearing plate is superimposed on a top surface of the metal hollow rod, the guiding rod is inserted to a position corresponding to the tapered hole in the metal hollow rod, an outer diameter of the guiding rod is less than a greatest diameter of the tapered hole, an inner diameter of the guiding rod is greater than a smallest diameter of the tapered hole.

Abstract: The present invention relates to the use of an anti-IL6 receptor antibody in monotherapy for treating rheumatoid arthritis and for improving the physical function and the quality of life of a subject suffering from rheumatoid arthritis.

Abstract: A card use system includes a first client configured to send a card use request including card information of a card, and display a payment code including a first resource account number corresponding to the first client; a second client configured to send a payment request to transfer a first quantity of resources from the first resource account number to a second resource account number corresponding to the second client; a card server configured to validate the card according to the card information; and in response to successfully validating the card, send a confirmation indication to the payment server; and a payment server configured to, in response to receiving the confirmation indication from the card server, transfer a second quantity of resources in the first resource account number corresponding to the first client to the second resource account number corresponding to the second client.

Abstract: A battery connection module comprises a carrying tray, a plurality of busbars and a circuit unit. The carrying tray has a first edge and a second edge positioned at two opposite sides and two end edges. The circuit unit comprises a flexible circuit piece and a connector, the flexible circuit piece has a main body and a mounting bar extending from the main body, the mounting bar has a connecting portion extending from the main body, a bendable portion extending from the connecting portion and a connector mounting portion connected to a distal end of the bendable portion, the connector is provided on the connector mounting portion and has a mating end. The bendable portion is operable to allow the connector to be positioned at positions where the mating end faces different directions.

Abstract: A virtual desktop can be remoted to a client device by transmitting a video stream using a video coding format, such as H.264, where higher resolution video can be streamed than natively supported by the encoder or decoder. The encoder framebuffer is divided into a plurality of equal size child buffers, each child buffer is assigned an identifier for identifying the child buffer. Padding pixels can be added to the child buffers to make the child buffer size acceptable for the video coding format. The child buffers are encoded using the video coding format and the encoded frames are transmitted to a client. On the decoder side, the encoded child frames are decoded, padding pixels are removed, and the data is used to update corresponding child buffers in a framebuffer on the client display system.

Abstract: A packaged semiconductor device with a particle roughened surface on a portion of the lead frame that improves adhesion between the molding compound and the lead frame. A packaged semiconductor device with a particle roughened surface on a portion of the lead frame that improves adhesion between the molding compound and the lead frame and with a reflow wall that surrounds a portion of the solder joint that couples the semiconductor device to the lead frame. A packaged semiconductor device with a reflow wall that surrounds a portion of a solder joint that couples a semiconductor device to a lead frame.

Abstract: The present invention relates to methods of determining the presence or absence of abnormal lymphoid cells or abnormal myeloid cells in a cell sample, with the methods comprising subjecting the cell sample to conditions that will activate any inactive matriptase present in the cell sample and measuring the levels of activated matriptase in the cell sample. Once measured, these levels can then be compared to control levels of active matriptase to determine if the cell sample has elevated levels of activated matriptase over control levels of active matriptase. An elevation in the levels of activated matriptase in the cell sample is indicative that the cell sample contains abnormal lymphoid cells or abnormal myeloid cells.

Abstract: A proximity sensor for a non-aperture mechanism includes a control circuit for generating a control signal; a first light-emitting element for emitting a first light source according to the control signal of the control circuit; a second light-emitting element for emitting a second light source according to the control signal of the control circuit; and a light sensing element coupled to the control circuit, for sensing the first light source and the second light source reflected by an object, and determining a distance between the proximity sensor and the object according to light intensities of the reflected first light source and the reflected sensed second light source; wherein the light sensing element and the first light-emitting element have a first distance therebetween, the light sensing element and the second light-emitting element have a second distance therebetween, and the second distance is greater than the first distance.

Abstract: The disclosure describes multi-junction solar cell structures that include two or more graded interlayers.

Abstract: An integrated circuit (IC) includes a lead frame that has a set of leads coupled to a corresponding set of pins. A semiconductor die with contacts is coupled to the set of leads. Encapsulating material encloses the semiconductor die, such that the set of pins extend beyond the encapsulating material. An additive coating covers one or more of the plurality of pins.

Abstract: A data transmission method is performed by at least one processor of a terminal, and includes displaying one or more messages, each of the one or more messages including a data file, based on a touch and hold input on one of the one or more messages, displaying an option for displaying one or more icons respectively indicating one or more hardware devices capable of executing the data file of the one of the one or more messages, based on a touch input on the option, displaying the one or more icons respectively indicating the one or more hardware devices, and based on a touch input on one of the one or more icons indicating one of the one or more hardware devices, sending, to the one of the one or more hardware devices, the data file of the one of the one or more messages.

Abstract: Described examples include a substrate made of a first material and having a surface. First and second nozzles respectively dispense a first solvent paste including electrically conductive nanoparticles and a second solvent paste including non-conductive nanoparticles, while moving over the surface of the substrate. The first and second nozzles additively deposit a uniform layer including sequential and contiguous zones, alternating between the first solvent paste and the second solvent paste. Energy is applied to sinter together the nanoparticles and diffuse the nanoparticles into the substrate. The sintered nanoparticles form a layer composed of an alternating sequence of electrically conductive zones contiguous with electrically non-conductive zones.

Abstract: A shoe vamp includes a main body, a filler member and an adhesive layer. The main body is formed by enveloping a vamp fabric and has a vamp portion, a lining portion, a beg opening, and an accommodation space between the vamp portion and the lining portion in communication with the beg opening. The filler member is filled into the accommodation space of the main body via the beg opening. The adhesive layer is applied on an outer surface of the filler member and adhesively bonded with an inner wall of the main body.

Abstract: A packaged semiconductor device with a particle roughened surface on a portion of the lead frame that improves adhesion between the molding compound and the lead frame. A packaged semiconductor device with a particle roughened surface on a portion of the lead frame that improves adhesion between the molding compound and the lead frame and with a reflow wall that surrounds a portion of the solder joint that couples the semiconductor device to the lead frame. A packaged semiconductor device with a reflow wall that surrounds a portion of a solder joint that couples a semiconductor device to a lead frame.

Abstract: A packaged semiconductor device includes a lead frame and a semiconductor device. A solder joint is coupled between the lead frame and a terminal on the semiconductor device. A reflow wall is on a portion of the lead frame and is in contact with the solder joint. A molding compound covers portions of the semiconductor device, the lead frame, the solder joint, and the reflow wall.

Abstract: A device comprises a substrate and an adhesive nanoparticle layer patterned into zones of electrical conductance and insulation on top of the substrate surface. A diffusion region adjoining the surface comprises an admixture of the nanoparticles in the substrate material. When the nanoparticle layer is patterned from originally all-conductive nanoparticles, the insulating zones are created by selective oxidation; when the nanoparticle layer is patterned from originally all-non-conductive nanoparticles, the conductive zones are created by depositing selectively a volatile reducing agent. A package of insulating material is in touch with the nanoparticle layer and fills any voids in the nanoparticle layer.

Abstract: The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising a matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase.

Abstract: A battery connection module and a battery device are provided. The battery device comprises a battery box and a battery connection module. The battery connection module comprises a circuit board, a plurality of busbars and a covering mechanism. The plurality of busbars are provided to a bottom surface of the circuit board in two rows spaced apart from each other. Each busbar has a main body portion connecting with the circuit board and at least two electrode connecting portions. The covering mechanism is provided to the bottom surface of the circuit board and comprises a plurality of sealing units. Each sealing unit comprises a cover, two first sealing members and a second sealing member.

Abstract: A battery connection module and a battery device are provided, the battery device comprises a battery box and a battery connection module The battery connection module comprises a covering unit and a circuit unit The covering unit comprises a cover plate and a plurality of sealing members The cover plate has a plate body and a plurality of plugging bodies The sealing members are respectively provided to peripheries of the plugging bodies The circuit unit comprises a circuit board provided to an upper surface of the plate body, a plurality of busbars embedded in the cover plate and a plurality of conductive connecting tabs respectively connecting the busbars to the circuit board.