Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of IDH1 and mutant IDH1 gene expression and/or activity, and/or modulate an IDH1 or mutant IDH1 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules, including small nucleic acid molecules such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules, that are capable of mediating or that mediate RNA interference (RNAi) against IDH1 or mutant IDH1 gene expression.

Abstract: A method for preparing a graphene oxide/white carbon black/rubber nanocomposite material is described. The prepared graphene oxide/white carbon black/rubber nanocomposite material contains nanoscale graphene oxide and white carbon black that are highly dispersed. The nanocomposite material has a relatively high modulus, excellent wear resistance and tear resistance, a relatively low rolling resistance, and at the same time has a low air-permeability and excellent self-healing capability.

Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of IDH1 and mutant IDH1 gene expression and/or activity, and/or modulate an IDH1 or mutant IDH1 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules, including small nucleic acid molecules such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules, that are capable of mediating or that mediate RNA interference (RNAi) against IDH1 or mutant IDH1 gene expression.

Abstract: A surgical instrument for treating tissue, the instrument including a housing and a shaft with an articulating portion and an end effector. The surgical instrument including a first casing connected to and rotatable with the proximal end of said shaft with an internal frame housed within the first casing and a plurality of posts supported by the internal frame and connected on their distal ends to at least one drive wire, and connected on their proximal ends to a threaded shaft; and a second casing connected to the first casing and rotatable therewith, said second casing housing the threaded shafts. The surgical instrument includes a first electric motor driving a first gear interfacing with the threaded shafts such that a first pair of the plurality of threaded shafts rotate in the same direction and cause the articulating portion to articulate in a first plane.

Abstract: A surgical instrument includes a handle portion and a body portion extending distally from the handle portion and defining a first longitudinal axis. The surgical instrument includes an articulating tool assembly defining a second longitudinal axis and having a proximal end. The articulating tool assembly is disposed at a distal end of the body portion and is configured to be articulated with respect to the body portion, namely, the articulating tool assembly is movable from a first position in which the second longitudinal axis is substantially aligned with the first longitudinal axis to at least a second position in which the second longitudinal axis is disposed at an angle with respect to the first longitudinal axis. The surgical instrument also includes an articulation mechanism configured to articulate the articulating tool assembly.

Abstract: A driving device in a vending machine includes a pushing member, a securing member, and a driving assembly. The motor of the driving assembly provides a rotating force which acts on the securing member, and the securing member supports and rotates the helical pushing member, to drive goods out of the vending machine. The style of attachment between the pushing member and the securing member is such that the starting angle of the helical pushing member can be adjusted by unclipping the end of the pushing member with fingertip force from the securing member and reclipping it at a different preferred orientation. The driving device is used for adjusting the appropriate rotation angle of the pushing member.

Abstract: A surgical instrument for treating tissue, the instrument including a housing and a shaft with an articulating portion and an end effector. The surgical instrument including a first casing connected to and rotatable with the proximal end of said shaft with an internal frame housed within the first casing and a plurality of posts supported by the internal frame and connected on their distal ends to at least one drive wire, and connected on their proximal ends to a threaded shaft; and a second casing connected to the first casing and rotatable therewith, said second casing housing the threaded shafts. The surgical instrument includes a first electric motor driving a first gear interfacing with the threaded shafts such that a first pair of the plurality of threaded shafts rotate in the same direction and cause the articulating portion to articulate in a first plane.

Abstract: A system and method for transferring power includes a power transmitting unit for transmitting power and a power receiving unit for receiving power from the power transmitting unit. The power transmitting unit may be positioned outside a human body and the power receiving unit is located on an intrabody instrument adapted to be movable from the outside of the human body to inside the human body. The intrabody instrument may be a medical instrument connected to or incorporated within a robotic arm. The power transmitting unit may wirelessly transfer power to the power receiving unit in a continuous, non-interrupted manner.

Abstract: The embodiments of the present invention disclose a rolling type input apparatus, a method for setting sensitivity thereof and electronic equipment. The method comprises: detecting a rolling direction and the rolling distance of a rolling device (1) in the rolling process of the rolling device (1) and generating corresponding interrupts; identifying the number and the direction of the interrupts; responding to the interrupts once by transmitting a moving event signal (10) for controlling a cursor (80) to move on a screen (8) when the number of the interrupts in the same direction reaches a threshold value; detecting parameters reflecting the speed and the amplitude of operations of a user for rolling the rolling device (1); and setting the threshold value according to the detected parameters. The technical solution can improve the automation degree of the rolling type input apparatus.

Abstract: A highly available server system based on cloud computing comprises a central control management server, a cloud host server, a storage server and at least one application server; the central control management server is connected with at least one application server, and configured to respectively monitor at least one application server, if detecting that there exists an application server in the fault state among the at least one applications server, then the central control management server sends a first instruction message; the cloud host server is connected with the central control management server, and configured to receive the first instruction message, and call the target virtual machine image file from the storage server according to instructions of the first instruction message, and run the target virtual machine image file; the storage server is configured to store the corresponding virtual machine image file of at least one application server.

Abstract: A surgical instrument includes a handle portion and a body portion extending distally from the handle portion and defining a first longitudinal axis. The surgical instrument includes an articulating tool assembly defining a second longitudinal axis and having a proximal end. The articulating tool assembly is disposed at a distal end of the body portion and is configured to be articulated with respect to the body portion, namely, the articulating tool assembly is movable from a first position in which the second longitudinal axis is substantially aligned with the first longitudinal axis to at least a second position in which the second longitudinal axis is disposed at an angle with respect to the first longitudinal axis. The surgical instrument also includes an articulation mechanism configured to articulate the articulating tool assembly.

Abstract: A mounting device includes an enclosure, a mounting frame, and a pivoting member. The enclosure includes a mounting wall with a hook extending therefrom. The mounting frame is configured for receiving a plurality of fans. The pivoting member is pivotably mounted to the mounting wall. The pivoting member is pivotable relative to the mounting wall to engage in or disengage from the hook. When the pivoting member is engaged in the hook, the pivoting member secures the mounting frame to the mounting wall. When the pivoting member is disengaged from the hook, the mounting frame is removable from the mounting wall. A fan assembly with the mounting device is further disclosed.