Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds.

Abstract: Certain embodiments of the invention include recombinant reverse genetic systems for SARS-COV-2 virus.

Abstract: Provided herein are antibodies binding to Coronavirus S protein and the uses of the antibodies in detecting and treating Coronavirus infection, such as COVID-19.

Abstract: A lithium-ion battery thermal management system and method based on PCM and mutually embedded fins. The thermal management system includes a battery box, a lithium-ion battery pack and a temperature detection unit are arranged in the battery box; the lithium-ion battery pack at least includes two cells, the periphery of each cell is wrapped by a battery inner shell and a battery outer shell, and PCM is filled between the battery inner shell and the battery outer shell; a plurality of fins are arranged on the battery outer shell on the opposite sides of the two adjacent cells, the fins are arranged at intervals, the fins on the opposite sides of the two adjacent cells are arranged in a staggered manner, and heat-conducting plates are connected between each fin and the battery inner shell.

Abstract: Certain embodiments of the invention include recombinant reverse genetic systems for Omicron variant of SARS-CoV-2 virus.

Abstract: The present invention discloses a live attenuated strain of Zika virus (ZIKV) having a deletion in the 3? untranslated region (3?UTR) of the viral genome, which may affect viral RNA synthesis and sensitivity to type I interferon inhibition, but may not affect viral RNA translation. The present invention also discloses the use of these live attenuated ZIKV strains in the preparation of ZIKV vaccines and for providing immunoprotection against ZIKV infection and congenital ZIKV syndrome, particularly in pregnant females.

Abstract: The high-frequency vibration nicking device for microbead surfaces includes a high-frequency vibration assembly and a container. Microbeads or mixed materials of the microbeads and a grinding material are filled in the container, and the vibration output end of the high-frequency vibration assembly is connected with the container to perform high-frequency vibration on the microbeads. The high-frequency vibration nicking method for microbead surfaces includes steps of adding the microbeads into the container, turning on the high-frequency vibration assembly, and performing high-frequency vibration motion on the microbeads in the container under the action of the high-frequency vibration assembly.

Abstract: A lithium-ion battery thermal management system and method based on PCM and mutually embedded fins. The thermal management system includes a battery box, a lithium-ion battery pack and a temperature detection unit are arranged in the battery box; the lithium-ion battery pack at least includes two cells, the periphery of each cell is wrapped by a battery inner shell and a battery outer shell, and PCM is filled between the battery inner shell and the battery outer shell; a plurality of fins are arranged on the battery outer shell on the opposite sides of the two adjacent cells, the fins are arranged at intervals, the fins on the opposite sides of the two adjacent cells are arranged in a staggered manner, and heat-conducting plates are connected between each fin and the battery inner shell.

Abstract: Provided is a method of detecting the presence of an anti-Zika virus (ZIKV) antibody in a sample, including contacting a sample with a suspension having a plurality of microspheres wherein individual microspheres are conjugated to a peptide and the peptide includes a ZIKV peptide selected from the group including ZIKV NS1, ZIKV NS5, and ZIKV envelope protein, forming a first incubated suspension by incubating said sample with said suspension to permit binding of anti-ZIKV antibodies present in the sample to said microspheres, forming a second incubated suspension by contacting said first incubated suspension with an anti-ZIKV antibody detecting-reagent to permit binding of the anti-ZIKV antibody detecting reagent to said microspheres, removing from the second incubated suspension anti-ZIKV antibody detecting-reagent molecules that are not bound to said microspheres, and detecting the presence of anti-ZIKV antibody detecting-reagent molecules in the second incubated suspension.

Abstract: Provided herein is a system for measuring and analyzing skin and hair, which includes a skin and hair measurement and analysis device, a smart terminal of a user in which an application interlinked with the skin and hair measurement and analysis device is installed, and a server interlinked with the skin and hair measurement and analysis device and interlinked with the smart terminal.

Abstract: Embodiments of this application provide an information processing method, a device, a system, a storage medium, and a computer program product, and relate to a web conferencing technology. In the method, when a plurality of users join a web conference by using a plurality of participating terminal devices, at least two users may use their own participating terminal devices. In addition, screen sharing is performed by using a web conferencing system. Therefore, the plurality of participating terminal devices in the conference may display, on screens of the plurality of participating terminal devices, information shared by the at least two sharing terminal devices. In this manner, the web conferencing system supports screen sharing performed by a plurality of sharing terminal devices at a same moment, and each sharing terminal device can control the screen sharing. This facilitates information sharing between the pluralities of users, and improves communication efficiency between the users.

Abstract: Certain embodiments are directed to a stable recombinant flavivirus nucleic acid having a heterologous reporter cassette, the reporter cassette having a 5? end, a nucleotide segment encoding a reporter, and a 3? end; the 5? end of the reporter cassette encoding 25 to 38 amino acids of a flavivirus capsid protein; the 3? end of the reporter cassette encoding 25 to 38 amino acids of a flavivirus capsid protein.

Abstract: A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2',5(3H)-dione analogues, the use thereof and the preparation thereof.

Abstract: This technology comprises a combined accessory of an in-situ concrete 3-D printed horizontal load-bearing member and a preparation method. The combined accessory includes 3-D printed concrete and a bottom mesh, the 3-D printed concrete contains fine aggregates having the particle size of 0.08 mm-4.75 mm, and the fluidity of the 3-D printed concrete is larger than or equal to 110 mm and smaller than or equal to 190 mm; the bottom mesh is a reinforcing mesh or expanded metal, the diameter of the reinforcing bar is larger than or equal to 0.5 mm, and the mesh aperture of the reinforcing mesh is smaller than or equal to 7.5 times of an upper limit of the particle size of the fine aggregate and is larger than or equal to 7.5 times of a lower limit of the particle size of the fine aggregate.

Abstract: This disclosure provides multimeric binding molecules that bind to SARS-CoV-2. This disclosure also provides compositions comprising the multimeric binding molecules, polynucleotides that encode the multimeric binding molecules, and host cells that can produce the binding molecules. Further this disclosure provides methods of using the multimeric binding molecules, including methods for treating and preventing coronavirus disease 2019 (COVID-19).

Abstract: A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3?-indoline]-2?,5(3H)-dione analogues, the use thereof and the preparation thereof.

Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds.

Abstract: The invention discloses a special equipment and a method for surface microcrystallization of cementitious materials. The specialized equipment includes a vibrator, a vibration signal generator, a power amplifier and a vibration transmitting body. A signal output terminal of the vibration signal generator is connected to a signal input terminal of the power amplifier, a signal output terminal of the power amplifier is connected to a signal input terminal of the vibrator, the vibrator is connected to the vibration transmitting body, and the vibration transmitting body is to be in contact with the cement product after initial setting. The surface microcrystallization method for cement product: after the casting and before the final setting of the cement product, vibration is applied to its outer or inner surface, the vibration frequency is greater than or equal to 1 KHz, and the vibration time is greater than or equal to 5 minutes.

Abstract: Provided is a method of detecting the presence of an anti-Zika virus (ZIKV) antibody in a sample, including contacting a sample with a suspension having a plurality of microspheres wherein individual microspheres are conjugated to a peptide and the peptide includes a ZIKV peptide selected from the group including ZIKV NS1, ZIKV NS5, and ZIKV envelope protein, forming a first incubated suspension by incubating said sample with said suspension to permit binding of anti-ZIKV antibodies present in the sample to said microspheres, forming a second incubated suspension by contacting said first incubated suspension with an anti-ZIKV antibody detecting-reagent to permit binding of the anti-ZIKV antibody detecting reagent to said microspheres, removing from the second incubated suspension anti-ZIKV antibody detecting-reagent molecules that are not bound to said microspheres, and detecting the presence of anti-ZIKV antibody detecting-reagent molecules in the second incubated suspension.

Abstract: Provided is a method of detecting the presence of an anti-Zika virus (ZIKV) antibody in a sample, including contacting a sample with a suspension having a plurality of microspheres wherein individual microspheres are conjugated to a peptide and the peptide includes a ZIKV peptide selected from the group including ZIKV NS1, ZIKV NS5, and ZIKV envelope protein, forming a first incubated suspension by incubating said sample with said suspension to permit binding of anti-ZIKV antibodies present in the sample to said microspheres, forming a second incubated suspension by contacting said first incubated suspension with an anti-ZIKV antibody detecting-reagent to permit binding of the anti-ZIKV antibody detecting reagent to said microspheres, removing from the second incubated suspension anti-ZIKV antibody detecting-reagent molecules that are not bound to said microspheres, and detecting the presence of anti-ZIKV antibody detecting-reagent molecules in the second incubated suspension.