Patents by Inventor Yong Shi
Yong Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110209820Abstract: Piezoelectric nanostructures, including nanofibers, nanotubes, nanojunctions and nanotrees, may be made of piezoelectric materials alone, or as composites of piezoelectric materials and electrically-conductive materials. Homogeneous or composite nanofibers and nanotubes may be fabricated by electrospinning. Homogeneous or composite nanotubes, nanojunctions and nanotrees may be fabricated by template-assisted processes in which colloidal suspensions and/or modified sol-gels of the desired materials are deposited sequentially into the pores of a template. The electrospinning or template-assisted fabrication methods may employ a modified sol-gel process for obtaining a perovskite phase in the piezoelectric material at a low annealing temperature.Type: ApplicationFiled: August 25, 2010Publication date: September 1, 2011Inventors: Yong Shi, Shiyou Xu
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Publication number: 20110210650Abstract: Piezoelectric nanostructures, including nanofibers, nanotubes, nanojunctions and nanotrees, may be made of piezoelectric materials alone, or as composites of piezoelectric materials and electrically-conductive materials. Homogeneous or composite nanofibers and nanotubes may be fabricated by electrospinning. Homogeneous or composite nanotubes, nanojunctions and nanotrees may be fabricated by template-assisted processes in which colloidal suspensions and/or modified sol-gels of the desired materials are deposited sequentially into the pores of a template. The electrospinning or template-assisted fabrication methods may employ a modified sol-gel process for obtaining a perovskite phase in the piezoelectric material at a low annealing temperature.Type: ApplicationFiled: August 25, 2010Publication date: September 1, 2011Inventors: Yong Shi, Shiyou Xu
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Publication number: 20110212986Abstract: The present invention relates to anti-flavivirus compounds, including lycorine and derivatives thereof, and their use in treating a subject infected by a flavivirus. The present invention also relates to the use of the anti-flavivirus compounds for the prophylaxis of flavivirus infection. The present invention further relates to a method of suppressing viral RNA synthesis of a flavivirus. Also described is a method of preparing an anti-flavivirus compound for use in the treatment or prophylaxis of flavivirus infection.Type: ApplicationFiled: August 20, 2009Publication date: September 1, 2011Applicants: HEALTH RESEARCH, INC., REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Pei-Yong Shi, Francesc Puig-Basagoiti, Krzysztof W. Pankiewicz, Krzysztof Felczak, Liqiang Chen
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Patent number: 7871570Abstract: The instant application provides a fluidic array device having an elastomeric body that provides easy fluidic control of the device. The elastomeric body may include plurality of intersecting row and column channels. Reactions may occur at the intersection spots formed by the intersecting channels. Pinching applied at suitable locations along the channels enables the channels to be opened or closed, and thus provides control of fluids pumped through the device. The surfaces of the channels and intersection spots may be engineered to have certain properties. In particular, the intersection spots may be nanoengineered to have surface properties differing from those of the channels, and thus reactions may be selectively controlled to occur only, or highly preferentially, in the intersection spots.Type: GrantFiled: February 22, 2008Date of Patent: January 18, 2011Inventors: Joseph Zhili Huang, Yong Shi, Yufeng Ma
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Publication number: 20100279400Abstract: The present invention provides a rapid and sensitive method for the detection of a West Nile virus (WNV), Japanese encephalitis virus (JEV), St. Louis encephalitis virus (SLEV) and Dengue virus (DENV) and antibodies directed against thereof involving contacting a biological specimen suspected of being infected with WNV, JE, SLE or DEN with a substantially purified and isolated WNV E glycoprotein or subfragment thereof having a native conformation wherein the E glycoprotein or subfragment thereof has a reactivity with antibodies against WNV and a cross-reactivity with antibodies against JEV, SLEV and DENV. The instant invention further provides a rapid, sensitive, and consistent method for the specific detection of WNV by employing diagnostic assays having the antigen NS5 which is specifically reactive with anti-WNV antibodies but not cross-reactive with antibodies against other flaviviruses such as JEV, SLEV, or DENV.Type: ApplicationFiled: April 1, 2008Publication date: November 4, 2010Inventors: Susan J. Wong, Pei-Yong Shi
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Publication number: 20100084791Abstract: A method of fabricating micro- and nano-scale fiber comprises: spreading micro- and nano-scale particles into a liquid or fluid-like material prior to forcing portions of the liquid or fluid-like material that surround the particles to depart from the original liquid or fluid-like environment by using a force field; stretching to elongate the portions of the liquid or fluid-like material until the free ends of the stretched portions stop motion to complete fiber or fiber-like structures in micro- and nano-scales.Type: ApplicationFiled: October 8, 2009Publication date: April 8, 2010Inventors: Xingtao Wu, Yong Shi
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Publication number: 20100058315Abstract: A method and a system for process upgrade are disclosed. A source process implements data interaction, via a socket interface, with a far end entity connected with the socket interface. When the source process intends to upgrade itself, the source process copies its process data to a target process and determines if the data from the far end entity received via socket interface is complete. If it is determined that the data is complete, the source process ceases data interaction with the socket interface and copies the received data to the target process. After the data is copied, the source process sends an upgrade and switch indication to the target process and enables the target process to send an upgrade and switch request to the socket interface. The socket interface then switches a socket interface service to the target process. Accordingly, the technical solutions according to the present invention realize a reliable and smooth process upgrade without disconnecting the socket connection.Type: ApplicationFiled: November 12, 2009Publication date: March 4, 2010Applicant: HUAWEI TECHNOLOGIES CO., LTD.Inventors: Hanjun Luo, Boyan Tu, Yong Shi
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Publication number: 20090056094Abstract: Piezoelectric nanostructures, including nanofibers, nanotubes, nanojunctions and nanotrees, may be made of piezoelectric materials alone, or as composites of piezoelectric materials and electrically-conductive materials. Homogeneous or composite nanofibers and nanotubes may be fabricated by electrospinning. Homogeneous or composite nanotubes, nanojunctions and nanotrees may be fabricated by template-assisted processes in which colloidal suspensions and/or modified sol-gels of the desired materials are deposited sequentially into the pores of a template. The electrospinning or template-assisted fabrication methods may employ a modified sol-gel process for obtaining a perovskite phase in the piezoelectric material at a low annealing temperature.Type: ApplicationFiled: August 20, 2008Publication date: March 5, 2009Inventors: Yong Shi, Shiyou Xu
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Publication number: 20080320188Abstract: A method for backing up a TCP connection includes a data transmission process and a data receiving process. The data transmission process includes obtaining, by an AMB of a transmitting end, boundary information of data; and backing up the data and the boundary information of the data to a SMB of the transmitting end. The data receiving process includes backing up, by the SMB, data received from a peer side of the TCP connection and the boundary information of the data received by the peer side to the AMB; and deleting the data received by the peer side from the data backed up by the SMB during the transmission process according to the boundary information of the data received by the peer side. The disclosure also provides an apparatus for backing up a TCP connection.Type: ApplicationFiled: September 4, 2008Publication date: December 25, 2008Applicant: HUAWEI TECHNOLOGIES CO., LTD.Inventors: Hanjun Luo, Boyan Tu, Yu Fu, Yong Shi
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Publication number: 20080206101Abstract: The instant application provides a fluidic array device having an elastomeric body that provides easy fluidic control of the device. The elastomeric body may include plurality of intersecting row and column channels. Reactions may occur at the intersection spots formed by the intersecting channels. Pinching applied at suitable locations along the channels enables the channels to be opened or closed, and thus provides control of fluids pumped through the device. The surfaces of the channels and intersection spots may be engineered to have certain properties. In particular, the intersection spots may be nanoengineered to have surface properties differing from those of the channels, and thus reactions may be selectively controlled to occur only, or highly preferentially, in the intersection spots.Type: ApplicationFiled: February 22, 2008Publication date: August 28, 2008Inventors: Joseph Zhili Huang, Yong Shi, Yufeng Ma
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Patent number: 7384785Abstract: The present invention provides a rapid and sensitive method for the detection of a West Nile virus (WNV), Japanese encephalitis virus (JEV), St. Louis encephalitis virus (SLEV) and Dengue virus (DENV) and antibodies directed against thereof involving contacting a biological specimen suspected of being infected with WNV, JE, SLE or DEN with a substantially purified and isolated WNV E glycoprotein or subfragment thereof having a native conformation wherein the E glycoprotein or subfragment thereof has a reactivity with antibodies against WNV and a cross-reactivity with antibodies against JEV, SLEV and DENV. The instant invention further provides a rapid, sensitive, and consistent method for the specific detection of WNV by employing diagnostic assays having the antigen NS5 which is specifically reactive with anti-WNV antibodies but not cross-reactive with antibodies against other flaviviruses such as JEV, SLEV, or DENV.Type: GrantFiled: May 4, 2004Date of Patent: June 10, 2008Assignee: Health Research, Inc.Inventors: Susan J. Wong, Pei-Yong Shi
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Patent number: 7355033Abstract: The instant invention provides stable and novel lineage I WNV reverse genetics systems, and methods for making the reverse genetics systems, specifically, a fully-infectious lineage I WNV cDNA or replicon system engineered with one or more nucleotide sequences each encoding a reporter gene to be used in high throughput cell-based screening assays for the identification of novel antiflaviviral chemotherapeutics and/or vaccines effective to treat and/or immunize against infections by WNV and other emerging flaviviruses, such as, for example, JEV, SLEV, AV, KV, JV, CV, YV, TBEV, DENV-1, DENV-2, DENV-3, DENV-4, YFV and MVEV. The present invention further provides methods of high throughput screening of antiflaviviral compounds or improved derivatives thereof using novel lineage I WNV reverse genetics systems and/or cell lines stably containing the reverse genetics systems.Type: GrantFiled: November 13, 2003Date of Patent: April 8, 2008Assignee: Health Research, Inc.Inventors: Pei-Yong Shi, Michael Lo, Mark Tilgner
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Patent number: 7351547Abstract: The present invention provides a rapid and sensitive method for the detection of a West Nile virus (WNV), Japanese encephalitis virus (JEV), St. Louis encephalitis virus (SLEV) and Dengue virus (DENV) and antibodies directed against thereof involving contacting a biological specimen suspected of being infected with WNV, JE, SLE or DEN with a substantially purified and isolated WNV E glycoprotein or subfragment thereof having a native conformation wherein the E glycoprotein or subfragment thereof has a reactivity with antibodies against WNV and a cross-reactivity with antibodies against JEV, SLEV and DENV. The instant invention further provides a rapid, sensitive, and consistent method for the specific detection of WNV by employing diagnostic assays having the antigen NS5 which is specifically reactive with anti-WNV antibodies but not cross-reactive with antibodies against other flaviviruses such as JEV, SLEV, or DENV.Type: GrantFiled: October 31, 2003Date of Patent: April 1, 2008Assignee: Health Research, Inc.Inventors: Susan J. Wong, Pei-Yong Shi
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Publication number: 20070104335Abstract: In a method of acoustic feedback suppression, digitized time-domain samples of acoustic signals are obtained, and discrete time-frequency transformation is performed on the digitized time-domain samples to generate a plurality of frequency bins of a frequency resolution. A howling frequency bin is identified, where the howling frequency has the maximum magnitude among the plurality of frequency bins. A peak frequency within the howling frequency bin is detected, and this peak frequency is suppressed.Type: ApplicationFiled: March 27, 2006Publication date: May 10, 2007Applicant: GPE International LimitedInventors: Yong Shi, Jing Sun
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Publication number: 20060115896Abstract: The present invention provides a rapid and sensitive method for the detection of a West Nile virus (WNV), Japanese encephalitis virus (JEV), St. Louis encephalitis virus (SLEV) and Dengue virus (DENV) and antibodies directed against thereof involving contacting a biological specimen suspected of being infected with WNV, JE, SLE or DEN with a substantially purified and isolated WNV E glycoprotein or subfragment thereof having a native conformation wherein the E glycoprotein or subfragment thereof has a reactivity with antibodies against WNV and a cross-reactivity with antibodies against JEV, SLEV and DENV. The instant invention further provides a rapid, sensitive, and consistent method for the specific detection of WNV by employing diagnostic assays having the antigen NS5 which is specifically reactive with anti-WNV antibodies but not cross-reactive with antibodies against other flaviviruses such as JEV, SLEV, or DENV.Type: ApplicationFiled: May 4, 2004Publication date: June 1, 2006Inventors: Susan Wong, Pei-Yong Shi
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Publication number: 20050058987Abstract: The instant invention provides stable and novel lineage I WNV reverse genetics systems, and methods for making the reverse genetics systems, specifically, a fully-infectious lineage I WNV cDNA or replicon system engineered with one or more nucleotide sequences each encoding a reporter gene to be used in high throughput cell-based screening assays for the identification of novel antiflaviviral chemotherapeutics and/or vaccines effective to treat and/or immunize against infections by WNV and other emerging flaviviruses, such as, for example, JEV, SLEV, AV, KV, JV, CV, YV, TBEV, DENV-1, DENV-2, DENV-3, DENV-4, YFV and MVEV. The present invention further provides methods of high throughput screening of antiflaviviral compounds or improved derivatives thereof using novel lineage I WNV reverse genetics systems and/or cell lines stably containing the reverse genetics systems.Type: ApplicationFiled: November 13, 2003Publication date: March 17, 2005Inventors: Pei-Yong Shi, Michael Lo, Mark Tilgner
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Publication number: 20040197769Abstract: The present invention provides a rapid and sensitive method for the detection of a West Nile virus (WNV), Japanese encephalitis virus (JEV), St. Louis encephalitis virus (SLEV) and Dengue virus (DENV) and antibodies directed against thereof involving contacting a biological specimen suspected of being infected with WNV, JE, SLE or DEN with a substantially purified and isolated WNV E glycoprotein or subfragment thereof having a native conformation wherein the E glycoprotein or subfragment thereof has a reactivity with antibodies against WNV and a cross-reactivity with antibodies against JEV, SLEV and DENV. The instant invention further provides a rapid, sensitive, and consistent method for the specific detection of WNV by employing diagnostic assays having the antigen NS5 which is specifically reactive with anti-WNV antibodies but not cross-reactive with antibodies against other flaviviruses such as JEV, SLEV, or DENV.Type: ApplicationFiled: October 31, 2003Publication date: October 7, 2004Inventors: Susan J. Wong, Pei-Yong Shi