Abstract: The invention generally relates to the development of immunogenic compositions comprising a DNA copy of at least one live attenuated plus-sense single-stranded RNA virus genome, such as the genome of a live-attenuated Zika vims (ZIKV), Japanese encephalitis virus (JEV) or yellow fever vims (YFV). The immunogenic compositions can be used for treating or conferring protective immunity against diseases related to plus-sense single-stranded RNA viruses, e.g. for affording prolonged immunoprotection against such viruses and protective immunity is conferred at low diseases, e.g., as low as 300 or 500 ng after administration of a single pLAV dosage.

Abstract: The invention discloses a special equipment and a method for surface microcrystallization of cementitious materials. The specialized equipment includes a vibrator, a vibration signal generator, a power amplifier and a vibration transmitting body. A signal output terminal of the vibration signal generator is connected to a signal input terminal of the power amplifier, a signal output terminal of the power amplifier is connected to a signal input terminal of the vibrator, the vibrator is connected to the vibration transmitting body, and the vibration transmitting body is to be in contact with the cement product after initial setting. The surface microcrystallization method for cement product: after the casting and before the final setting of the cement product, vibration is applied to its outer or inner surface, the vibration frequency is greater than or equal to 1 KHz, and the vibration time is greater than or equal to 5 minutes.

Abstract: The present disclosure involves a composition and method of treatment of glioblastoma, using ZIKA virus.

Abstract: A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3?-indoline]-2?,5(3H)-dione analogues, the use thereof and the preparation thereof.

Abstract: The present invention discloses a live attenuated strain of Zika virus (ZIKV) having a deletion in the 3? untranslated region (3?UTR) of the viral genome, which may affect viral RNA synthesis and sensitivity to type I interferon inhibition, but may not affect viral RNA translation. The present invention also discloses the use of these live attenuated ZIKV strains in the preparation of ZIKV vaccines and for providing immunoprotection against ZIKV infection and congenital ZIKV syndrome, particularly in pregnant females.

Abstract: Embodiments of the invention are directed to stable full-length cDNA clones of a clinical, Asian lineage ZIKV strain. Certain embodiments of the invention are directed to high-throughput assays for ZIKV and dengue virus (DENV) diagnosis.

Abstract: Provided is a method of detecting the presence of an anti-Zika virus (ZIKV) antibody in a sample, including contacting a sample with a suspension having a plurality of microspheres wherein individual microspheres are conjugated to a peptide and the peptide includes a ZIKV peptide selected from the group including ZIKV NS1, ZIKV NS5, and ZIKV envelope protein, forming a first incubated suspension by incubating said sample with said suspension to permit binding of anti-ZIKV antibodies present in the sample to said microspheres, forming a second incubated suspension by contacting said first incubated suspension with an anti-ZIKV antibody detecting-reagent to permit binding of the anti-ZIKV antibody detecting reagent to said microspheres, removing from the second incubated suspension anti-ZIKV antibody detecting-reagent molecules that are not bound to said microspheres, and detecting the presence of anti-ZIKV antibody detecting-reagent molecules in the second incubated suspension.

Abstract: Provided is a method of detecting the presence of an anti-Zika virus (ZIKV) antibody in a sample, including contacting a sample with a suspension having a plurality of microspheres wherein individual microspheres are conjugated to a peptide and the peptide includes a ZIKV peptide selected from the group including ZIKV NS1, ZIKV NS5, and ZIKV envelope protein, forming a first incubated suspension by incubating said sample with said suspension to permit binding of anti-ZIKV antibodies present in the sample to said microspheres, forming a second incubated suspension by contacting said first incubated suspension with an anti-ZIKV antibody detecting-reagent to permit binding of the anti-ZIKV antibody detecting reagent to said microspheres, removing from the second incubated suspension anti-ZIKV antibody detecting-reagent molecules that are not bound to said microspheres, and detecting the presence of anti-ZIKV antibody detecting-reagent molecules in the second incubated suspension.

Abstract: Embodiments of the invention are directed to stable full-length cDNA clones of a clinical, Asian lineage ZIKV strain. Certain embodiments of the invention are directed to high-throughput assays for ZIKV and dengue virus (DENV) diagnosis.

Abstract: The invention generally relates to the development of variant Zika strains, cDNA clones and mRNA transcripts that contain specific mutations in the Zika ORF, and methods for producing high yields of Zika viruses (“ZIKVs”) using these variant cDNA clones, transcripts and strains. The produced ZIKVs can be used for the manufacture of purified inactivated vaccines (PIVs), which may be useful for treating ZIKV-related diseases and for providing immunoprotection against ZIKV.

Abstract: The invention generally relates to the development of variant Zika strains, cDNA clones and mRNA transcripts that contain specific mutations in the Zika ORF, and methods for producing high yields of Zika viruses (“ZIKVs”) using these variant cDNA clones, transcripts and strains. The produced ZIKVs can be used for the manufacture of purified inactivated vaccines (PIVs), which may be useful for treating ZIKV-related diseases and for providing immunoprotection against ZIKV.

Abstract: A method for controlling an inverter including, when it is detected that a voltage across a bus capacitor, for example, a bus voltage, is excessively large, controlling a photo-voltaic (PV) battery to short-circuit so that the bus voltage drops. When the bus voltage drops to a particular value, continuing charging, by the PV battery, the bus capacitor to control the bus voltage to rise so that the bus voltage is kept within an operating voltage range of the inverter and the inverter can be equipped with a PV battery having a higher open circuit voltage. Therefore, a charging rate of the bus capacitor can be increased and a startup speed of the inverter can be increased.

Abstract: Provided is a method of detecting the presence of an anti-Zika virus (ZIKV) antibody in a sample, including contacting a sample with a suspension having a plurality of microspheres wherein individual microspheres are conjugated to a peptide and the peptide includes a ZIKV peptide selected from the group including ZIKV NS1, ZIKV NS5, and ZIKV envelope protein, forming a first incubated suspension by incubating said sample with said suspension to permit binding of anti-ZIKV antibodies present in the sample to said microspheres, forming a second incubated suspension by contacting said first incubated suspension with an anti-ZIKV antibody detecting-reagent to permit binding of the anti-ZIKV antibody detecting reagent to said microspheres, removing from the second incubated suspension anti-ZIKV antibody detecting-reagent molecules that are not bound to said microspheres, and detecting the presence of anti-ZIKV antibody detecting-reagent molecules in the second incubated suspension.

Abstract: A method for controlling an inverter including, when it is detected that a voltage across a bus capacitor, for example, a bus voltage, is excessively large, controlling a photo-voltaic (PV) battery to short-circuit so that the bus voltage drops. When the bus voltage drops to a particular value, continuing charging, by the PV battery, the bus capacitor to control the bus voltage to rise so that the bus voltage is kept within an operating voltage range of the inverter and the inverter can be equipped with a PV battery having a higher open circuit voltage. Therefore, a charging rate of the bus capacitor can be increased and a startup speed of the inverter can be increased.

Abstract: The present invention discloses a method of eliciting an immune response and a method of vaccination comprising administration of a mutated flavivirus. The mutated flavivirus comprises at least one mutation in a nucleic acid sequence encoding for the non-structural protein 5 of the flavivirus sequence resulting in inactivation of the 2?O-methyltransferase.

Abstract: A method for backing up a TCP connection includes a data transmission process and a data receiving process. The data transmission process includes obtaining, by an AMB of a transmitting end, boundary information of data; and backing up the data and the boundary information of the data to a SMB of the transmitting end. The data receiving process includes backing up, by the SMB, data received from a peer side of the TCP connection and the boundary information of the data received by the peer side to the AMB; and deleting the data received by the peer side from the data backed up by the SMB during the transmission process according to the boundary information of the data received by the peer side. The disclosure also provides an apparatus for backing up a TCP connection.

Abstract: A method and a system for process upgrade are disclosed. A source process implements data interaction, via a socket interface, with a far end entity connected with the socket interface. When the source process intends to upgrade itself, the source process copies its process data to a target process and determines if the data from the far end entity received via socket interface is complete. If it is determined that the data is complete, the source process ceases data interaction with the socket interface and copies the received data to the target process. After the data is copied, the source process sends an upgrade and switch indication to the target process and enables the target process to send an upgrade and switch request to the socket interface. The socket interface then switches a socket interface service to the target process. Accordingly, the technical solutions according to the present invention realize a reliable and smooth process upgrade without disconnecting the socket connection.

Abstract: Piezoelectric nanostructures, including nanofibers, nanotubes, nanojunctions and nanotrees, may be made of piezoelectric materials alone, or as composites of piezoelectric materials and electrically-conductive materials. Homogeneous or composite nanofibers and nanotubes may be fabricated by electrospinning. Homogeneous or composite nanotubes, nanojunctions and nanotrees may be fabricated by template-assisted processes in which colloidal suspensions and/or modified sol-gels of the desired materials are deposited sequentially into the pores of a template. The electrospinning or template-assisted fabrication methods may employ a modified sol-gel process for obtaining a perovskite phase in the piezoelectric material at a low annealing temperature.