Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: This disclosure relates to improved techniques for performing multi-view image clustering. The techniques described herein utilize machine learning functions to optimize the image clustering process. Multi-view features are extracted from a collection of images. A machine learning function is configured to jointly learn a fused binary representation that combines the multi-view features and one or more binary cluster structures that can be used to partition the images. A clustering function utilizes the fused binary representation and the one or more binary cluster structures to generate one or more image clusters based on the collection of images.

Abstract: The present invention provides a compound having the following structure: Compositions and methods for using the same in the treatment of skin disorders and other Pim kinase-associated conditions are also disclosed.

Abstract: The present disclosure relates to a field of display technologies and provides a light diffusing component, a backlight component having the same, and a display device. The light diffusing component may include a main body, a protruding portion, and a reflecting portion. The protruding portion is disposed on a side of the main body and protruded from the main body; the reflecting portion is disposed on the protruding portion and an edge region of the main body portion connected to the protruding portion, so as to reflect light incident from a lower portion of the light diffusing component. Light transmittance of the reflecting portion gradually increases in a direction away from a center of the diffusing component.

Abstract: The present disclosure relates to systems, methods, and computer readable media for predicting deployment growth on one or more node clusters and selectively permitting deployment requests on a per cluster basis. For example, systems disclosed herein may apply tenant growth prediction system trained to output a deployment growth classification indicative of a predicted growth of deployments on a node cluster. The system disclosed herein may further utilize the deployment growth classification to determine whether a deployment request may be permitted while maintaining a sufficiently sized capacity buffer to avoid deployment failures for existing deployments previously implemented on the node cluster. By selectively permitting or denying deployments based on a variety of factors, the systems described herein can more efficiently utilize cluster resources on a per-cluster basis without causing a significant increase in deployment failures for existing customers.

Abstract: Methods of treating or reducing the risk of obesity and/or obesite-related disorders, e.g., metabolic syndrome, hepatic and non-hepatic steatosis, and diabetes, using C20orf27 proteins or nucleic acids.

Abstract: The present invention discloses a methanol-mediated method for separating an alkaline solution of hemicellulose, and an ethanol-mediated method for separating an alkaline solution of hemicellulose, where methanol/ethanol is added into the alkaline solution in which hemicellulose is dissolved, and stirred thoroughly until the mixture is homogeneous, to destroy the hydrated layer effect formed between the hemicellulose and the alkaline solution through the methanol/ethanol-mediated hydrophobic effect, such that hemicellulose is precipitated from the solution system, and then the mixture is subjected to separation by sedimentation, centrifugation or filtration to obtain a precipitate of hemicellulose and an alkaline solution of methanol/ethanol; and by using the prompting effect of an alkaline condition on evaporation and gasification separation of methanol/ethanol from water, a reduced-pressure distillation (rectification) or gasification membrane is used to separate methanol/ethanol from the alkaline solution,

Abstract: The present invention discloses a CLALS protein, its coding gene and use in predicting the herbicide resistance of a watermelon. The herbicide resistance of a watermelon to be tested in which “the amino acid residue at position 190 from N-terminus of the CLALS protein is only a non-proline residue” or a watermelon to be tested in which “the amino acid residue at position 190 from N-terminus of the CLALS protein is a non-proline residue and a proline residue” is stronger than that of a watermelon to be tested in which “the amino acid residue at position 190 from N-terminus of the CLALS protein is only a proline residue”. Experiments have shown that the type of the amino acid residue at position 190 from the N-terminus of CLALS protein can be used as a detection target to predict the herbicide resistance of a watermelon to be tested. The invention has great application value.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: This disclosure describes a sensor for detecting vibrations, particularly low-frequency vibrations. The sensor is of a cascaded gapped cantilever construction and may include a single sensing beam extending from a base to a proof mass across the plurality of gaps, a mechanical beam opposite the piezoelectric beam. The sensor may be included in a system including a housing, a support, and electronic components for converting and measuring signal. The sensor may be mounted to an item of furniture, such as a bed or a sofa, and measure physiological data including ballistocardiogram and respiratory data of a subject positioned on the furniture.

Abstract: A light bulb, comprising a light bulb body (1); at least one connector protrusion (12) is provided on the outer circumference of the light bulb body (1), the connector protrusions (12) being arranged at intervals on the light bulb body (1) or distributed in a radial shape with respect to the center of the light bulb body (1); the connector protrusions (12) cooperate with a dedicated assembling and disassembling tool during light bulb replacement, realizing non-contact and remote assembling and disassembling of light bulbs, achieving the characteristics of safe assembly and disassembly, a simple and practical structure and low maintenance cost.

Abstract: The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R1, R2, R3, R4 and R5 are, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase.

Abstract: The present invention provides a conductive hydrogel comprising a polystyrene sulfonate compound selected from poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), reduced graphene oxide polystyrene sulfonate (rGO:PSS) and rGO:PEDOT:PSS; and a conjugate of polyethylene glycol (PEG) and a linker-(BX)n oligopeptide of formula (I) PEG-linker-(BX)n ??(I) wherein B is lysine or arginine, X is selected from alanine, glycine, serine, threonine, tyrosine, glutamic acid or aspartic acid and n is an integer selected from 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20. The invention further relates to processes for assembling the conductive hydrogel. The conductive hydrogel can be used in various biomedical applications, such as neuroprostheses, biosensors, nerve grafts, cell culture and encapsulation of cells and microorganisms as well as for drug delivery.

Abstract: Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).

Abstract: The disclosure discloses an automatic gas cylinder filling device and an operating method thereof, includes a stand, an electronic scale, a PLC control unit, and a vacuum pump installed on an inner bottom plate of the stand. One side of the stand is provided with an 8-bottle gas cylinder rotating and weighing mechanism, a gas cylinder fixing mechanism, a gas cylinder filling fixture, a lifting frame and a bottle valve hand wheel switch mechanism that are arranged in sequence from bottom to top. The electronic scale is located below the 8-bottle gas cylinder rotating and weighing mechanism. The disclosure is used for filling gas cylinders, wherein the weighing, the fixing of the bottle valve and the rotation of the hand wheel are all automatically controlled and operated by the PLC control unit, and there is no need for operator to stay with the facility.

Abstract: The present disclosure relates to a field of display technologies and provides a light diffusing component, a backlight component having the same, and a display device. The light diffusing component may include a main body, a protruding portion, and a reflecting portion. The protruding portion is disposed on a side of the main body and protruded from the main body; the reflecting portion is disposed on the protruding portion and an edge region of the main body portion connected to the protruding portion, so as to reflect light incident from a lower portion of the light diffusing component. Light transmittance of the reflecting portion gradually increases in a direction away from a center of the diffusing component.

Abstract: The disclosure discloses an automatic gas cylinder filling device and an operating method thereof, includes a stand, an electronic scale, a PLC control unit, and a vacuum pump installed on an inner bottom plate of the stand. One side of the stand is provided with an 8-bottle gas cylinder rotating and weighing mechanism, a gas cylinder fixing mechanism, a gas cylinder filling fixture, a lifting frame and a bottle valve hand wheel switch mechanism that are arranged in sequence from bottom to top. The electronic scale is located below the 8-bottle gas cylinder rotating and weighing mechanism. The disclosure is used for filling gas cylinders, wherein the weighing, the fixing of the bottle valve and the rotation of the hand wheel are all automatically controlled and operated by the PLC control unit, and there is no need for operator to stay with the facility.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.