Abstract: The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: The present invention relates to the technical field of medicinal chemistry, and in particular discloses a 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof. The compound and pharmaceutically acceptable salt, isomer, racemate, prodrug, co-crystallized complex, hydrate, and solvate thereof can effectively inhibit the BET bromodomain receptor, and can be used for preparing a medicine for treating cancers, cell proliferative disorders, inflammatory diseases, and autoimmune disorders, sepsis, and viral infections.

Abstract: The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R1, R2, R3, R4 and R5 are, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase.

Abstract: The disclosure provides a digital video content security authentication method, wherein the method comprises: a secret information embedding step of selectively modifying a pixel grayscale value for each frame image in a digital video so as to complete the embedding of 1-bit secret information; and a secret information extraction and video authentication step of carrying out secret information extraction from the digital video in which the secret information is embedded according to a key so as to realize the security authentication of the digital video content. The disclosure also provides a digital video content security authentication system. According to the technical scheme provided by the disclosure, the authentication security is improved on the basis of not influencing user experience.

Abstract: The present invention is intended to provide a LED light that could display brilliant heart shape rainbow-like lighting effects and offer flexible casing structure for easily extending the hardware capability. It has case and circuit board. The circuit board has Micro Control Unit (MCU), LED chips, micro push buttons and power supply module, etc. The LED chips are electrically connected to the MCU via an output power amplifier module. The micro push buttons are electrically connected to the MCU, and the power supply module offers DC power to the circuit board.

Abstract: The present subject matter relates to carbon fiber composites. A method to form a polymer carbon fiber composite includes subjecting two sheets of carbon fibers to an insert molding mold, such that one sheet is secured at a cavity side of the insert molding mold and another sheet is secured at a core side of the insert molding mold. The method further includes insert molding a polymer between the two sheets of carbon fibers to form the polymer carbon fiber composite, wherein the polymer sets between the two sheets of carbon fibers to form a sandwich structure of the polymer carbon fiber composite, and wherein the polymer is in contact with the two sheets of carbon fibers.

Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1, 5-alpha]benzimidazole compound and the preparation method and intermediate thereof.

Abstract: The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.

Abstract: The present invention is intended to provide a LED light that could display brilliant heart shape rainbow-like lighting effects and offer flexible casing structure for easily extending the hardware capability. It has case and circuit board. The circuit board has Micro Control Unit (MCU), LED chips, micro push buttons and power supply module, etc. The LED chips are electrically connected to the MCU via an output power amplifier module. The micro push buttons are electrically connected to the MCU, and the power supply module offers DC power to the circuit board.

Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.

Abstract: This disclosure describes a sensor for detecting vibrations, particularly low-frequency vibrations. The sensor is of a cascaded gapped cantilever construction and may include a single sensing beam extending from a base to a proof mass across the plurality of gaps, a mechanical beam opposite the piezoelectric beam. The sensor may be included in a system including a housing, a support, and electronic components for converting and measuring signal. The sensor may be mounted to an item of furniture, such as a bed or a sofa, and measure physiological data including ballistocardiogram and respiratory data of a subject positioned on the furniture.

Abstract: Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.

Abstract: A liquid crystal panel includes a first substrate, a TFT layer located on the first substrate, a color resist layer located on the TFT layer, a photospacer layer located on the color resist layer, a protective layer located on the color resist layer and the photospacer layer, a via hole penetrating the color resist layer and the protective layer, a pixel electrode layer formed on the protective layer and electrically connected to the TFT layer with the via hole and a second substrate oppositely located to the first substrate, and one or more color resist material in the photospacer layer and the color resist layer are the same, and the photospacer layer and the color resist layer are formed at the same time during a manufacture process.

Abstract: Disclosed is a method for 3D building extraction, comprising: extracting building footprints from one or more stereo images for a building; determining, from rational polynomial coefficient of the stereo images, first height estimation of the extracted building footprints; obtaining, from multi-temporal SAR images for the building, scatters with stable attributes; determining second height estimation for the determined scatters; and combining the first height estimation and the second height estimation to generate a fused height for each of the extracted building footprints.

Abstract: The present disclosure provides a traffic light for cooperative vehicle-infrastructure and a method for controlling the same. The traffic light for cooperative vehicle-infrastructure includes: a communication module, a central processing module, a Global Positioning System GPS module and a scheduling module. The communication module is configured to receive a set of messages sent by vehicles periodically. The GPS module is configured to locate the position of the traffic light. The central processing module is configured to perform calculations and analyses on the received set of messages and the position of the traffic light, dynamically set lasting times of red and green lamps of the traffic light, and send a control signal carrying the set times to the scheduling module. The scheduling module is configured to control the lasting times of the red and green lamps of traffic light according to the control signal carrying the set times.

Abstract: The present disclosure provides an information processing method and an information processing system. The information processing method is used for controlling a vehicle door, which includes: detecting an action of a vehicle door controlled by an user and feedbacking the action to a processing module through a detecting module; transmitting a control command to a control module according to the detected action through the processing module; and performing the control command to select at least one vehicle door from all vehicle doors and operate the selected vehicle door through the control module. In the technique scheme of the present disclosure, the processing module transmits the control command to the control module according to the detected action; the control module performs the control command to select at least one vehicle door from all vehicle doors and operate the selected vehicle door, thereby increasing the convenience of operating the vehicle door.

Abstract: The present invention provides a LTPS TFT substrate, which includes a black matrix arranged on a first buffer layer of the LTPS TFT substrate to have an area where a TFT device is located is shielded by the black matrix thereby preventing the TFT device from being influenced by light irradiation, maintaining stability of the TFT device; and also saving the manufacturing process of a shielding metal layer, reducing one photo-mask, and lowering down manufacturing cost so as to allow the black matrix, in achieving the functionality of its own (shielding leaking light of the pixel), to also take the place of a shielding metal layer that is commonly adopted in the prior art to shield light for the TFT device and thus providing duality of functionality.

Abstract: The present invention relates to the technical field of medicinal chemistry, and in particular discloses a 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof. The compound and pharmaceutically acceptable salt, isomer, racemate, prodrug, co-crystallized complex, hydrate, and solvate thereof can effectively inhibit the BET bromodomain receptor, and can be used for preparing a medicine for treating cancers, cell proliferative disorders, inflammatory diseases, and autoimmune disorders, sepsis, and viral infections.

Abstract: Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.