Abstract: The present invention provides substituted imidazo[1,2-b]pyridazines that are useful as protein kinase inhibitors and have one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. For example, a compound having the following structure: Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.

Abstract: The disclosure provides a digital video content security authentication method, wherein the method comprises: a secret information embedding step of selectively modifying a pixel grayscale value for each frame image in a digital video so as to complete the embedding of 1-bit secret information; and a secret information extraction and video authentication step of carrying out secret information extraction from the digital video in which the secret information is embedded according to a key so as to realize the security authentication of the digital video content. The disclosure also provides a digital video content security authentication system. According to the technical scheme provided by the disclosure, the authentication security is improved on the basis of not influencing user experience.

Abstract: Cell culture devices and methods of their use are provided according to aspects of the present invention which include a base having a pair of spaced apart wells and at least one fluid port defined from an exterior of the base to each of the wells, each fluid port being spaced above the base sheet by a distance sufficient to introduce a material above a matrix deposited on the base sheet in the wells; and a cover having a pair of spaced apart well covering portions that are each disposed above a respective one of the one spaced apart wells of the base body when the cover is covering the upper surface of the base body and having a gas passage defined between the spaced apart well covering portions and at least one gas port defined from an exterior of the cover to each of the well covering portions.

Abstract: The present invention provides compositions, methods, and kits comprising one or more compounds of Formula I, such as XY018, alone or in combination with one or more anticancer drugs, such as an anti-androgen drug, that are useful for treating cancer, e.g., prostate cancer, such as castration-resistant prostate cancer (CRPC), and numerous other types of cancer including lung cancer, breast cancer, liver cancer, ovarian cancer, endometrial cancer, bladder cancer, colon cancer, gastric cancer, lymphoma, and glioma.

Abstract: The invention provides a method, apparatus, device and storage medium for predicting a protein binding site. The method comprises the steps of: receiving a protein sequence to be predicted, dividing the protein sequence by using a preset sliding window and sliding step to obtain a plurality of amino acid sub-sequences, building word vectors for the protein sequence according to the amino acid sub-sequences, extracting document features from word elements, building document feature vectors for the protein sequence according to the extracted document features, extracting protein chain biological features from the amino acid sub-sequences, building biological feature vectors for the protein sequence according to the extracted biological features, classifying the amino acid sub-sequences expressed with the document feature vectors and the biological feature vectors by using a preset amino acid residue classification model to obtain amino acid residue types for the protein sequence.

Abstract: Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Cell culture devices and methods of their use are provided according to aspects of the present invention which include a base having a pair of spaced apart wells and at least one fluid port defined from an exterior of the base to each of the wells, each fluid port being spaced above the base sheet by a distance sufficient to introduce a material above a matrix deposited on the base sheet in the wells; and a cover having a pair of spaced apart well covering portions that are each disposed above a respective one of the one spaced apart wells of the base body when the cover is covering the upper surface of the base body and having a gas passage defined between the spaced apart well covering portions and at least one gas port defined from an exterior of the cover to each of the well covering portions.

Abstract: The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: The present invention relates to the technical field of medicinal chemistry, and in particular discloses a 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof. The compound and pharmaceutically acceptable salt, isomer, racemate, prodrug, co-crystallized complex, hydrate, and solvate thereof can effectively inhibit the BET bromodomain receptor, and can be used for preparing a medicine for treating cancers, cell proliferative disorders, inflammatory diseases, and autoimmune disorders, sepsis, and viral infections.

Abstract: The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R1, R2, R3, R4 and R5 are, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase.

Abstract: The disclosure provides a digital video content security authentication method, wherein the method comprises: a secret information embedding step of selectively modifying a pixel grayscale value for each frame image in a digital video so as to complete the embedding of 1-bit secret information; and a secret information extraction and video authentication step of carrying out secret information extraction from the digital video in which the secret information is embedded according to a key so as to realize the security authentication of the digital video content. The disclosure also provides a digital video content security authentication system. According to the technical scheme provided by the disclosure, the authentication security is improved on the basis of not influencing user experience.

Abstract: The present invention is intended to provide a LED light that could display brilliant heart shape rainbow-like lighting effects and offer flexible casing structure for easily extending the hardware capability. It has case and circuit board. The circuit board has Micro Control Unit (MCU), LED chips, micro push buttons and power supply module, etc. The LED chips are electrically connected to the MCU via an output power amplifier module. The micro push buttons are electrically connected to the MCU, and the power supply module offers DC power to the circuit board.

Abstract: The present subject matter relates to carbon fiber composites. A method to form a polymer carbon fiber composite includes subjecting two sheets of carbon fibers to an insert molding mold, such that one sheet is secured at a cavity side of the insert molding mold and another sheet is secured at a core side of the insert molding mold. The method further includes insert molding a polymer between the two sheets of carbon fibers to form the polymer carbon fiber composite, wherein the polymer sets between the two sheets of carbon fibers to form a sandwich structure of the polymer carbon fiber composite, and wherein the polymer is in contact with the two sheets of carbon fibers.

Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1, 5-alpha]benzimidazole compound and the preparation method and intermediate thereof.

Abstract: The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.

Abstract: The present invention is intended to provide a LED light that could display brilliant heart shape rainbow-like lighting effects and offer flexible casing structure for easily extending the hardware capability. It has case and circuit board. The circuit board has Micro Control Unit (MCU), LED chips, micro push buttons and power supply module, etc. The LED chips are electrically connected to the MCU via an output power amplifier module. The micro push buttons are electrically connected to the MCU, and the power supply module offers DC power to the circuit board.

Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.

Abstract: This disclosure describes a sensor for detecting vibrations, particularly low-frequency vibrations. The sensor is of a cascaded gapped cantilever construction and may include a single sensing beam extending from a base to a proof mass across the plurality of gaps, a mechanical beam opposite the piezoelectric beam. The sensor may be included in a system including a housing, a support, and electronic components for converting and measuring signal. The sensor may be mounted to an item of furniture, such as a bed or a sofa, and measure physiological data including ballistocardiogram and respiratory data of a subject positioned on the furniture.