Patents by Inventor Yong Xu

Yong Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cascaded gapped cantilever for low-frequency vibration sensing
    Patent number: 10724897
    Abstract: This disclosure describes a sensor for detecting vibrations, particularly low-frequency vibrations. The sensor is of a cascaded gapped cantilever construction and may include a single sensing beam extending from a base to a proof mass across the plurality of gaps, a mechanical beam opposite the piezoelectric beam. The sensor may be included in a system including a housing, a support, and electronic components for converting and measuring signal. The sensor may be mounted to an item of furniture, such as a bed or a sofa, and measure physiological data including ballistocardiogram and respiratory data of a subject positioned on the furniture.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: July 28, 2020
    Assignee: National Science Foundation
    Inventors: Yong Xu, Yating Hu, Hongen Tu
  • Lamp Bulb and Dedicated Non-Contact Assembling and Disassembling Tool Thereof
    Publication number: 20200208820
    Abstract: A light bulb, comprising a light bulb body (1); at least one connector protrusion (12) is provided on the outer circumference of the light bulb body (1), the connector protrusions (12) being arranged at intervals on the light bulb body (1) or distributed in a radial shape with respect to the center of the light bulb body (1); the connector protrusions (12) cooperate with a dedicated assembling and disassembling tool during light bulb replacement, realizing non-contact and remote assembling and disassembling of light bulbs, achieving the characteristics of safe assembly and disassembly, a simple and practical structure and low maintenance cost.
    Type: Application
    Filed: March 31, 2018
    Publication date: July 2, 2020
    Inventor: Yong Xu
  • Pyrimidine derivative and use thereof
    Patent number: 10695347
    Abstract: The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R1, R2, R3, R4 and R5 are, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: June 30, 2020
    Assignee: HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC.
    Inventors: Xuehai Wang, Yong Xu, Xijun Sheng, Xiaolin Zhang, Hangui Xia, Zhongwen Yang, Yang Yue, Lu Huang, Qiang Xiao
  • NON-COVALENTLY ASSEMBLED CONDUCTIVE HYDROGEL
    Publication number: 20200188294
    Abstract: The present invention provides a conductive hydrogel comprising a polystyrene sulfonate compound selected from poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), reduced graphene oxide polystyrene sulfonate (rGO:PSS) and rGO:PEDOT:PSS; and a conjugate of polyethylene glycol (PEG) and a linker-(BX)n oligopeptide of formula (I) PEG-linker-(BX)n ??(I) wherein B is lysine or arginine, X is selected from alanine, glycine, serine, threonine, tyrosine, glutamic acid or aspartic acid and n is an integer selected from 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20. The invention further relates to processes for assembling the conductive hydrogel. The conductive hydrogel can be used in various biomedical applications, such as neuroprostheses, biosensors, nerve grafts, cell culture and encapsulation of cells and microorganisms as well as for drug delivery.
    Type: Application
    Filed: April 27, 2018
    Publication date: June 18, 2020
    Applicant: DENOVOMATRIX GMBH
    Inventors: Yixin ZHANG, Yong XU, Alvin THOMAS
  • BTK inhibitor
    Patent number: 10662174
    Abstract: Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: May 26, 2020
    Assignee: HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC.
    Inventors: Xuehai Wang, Chengde Wu, Yong Xu, Chunli Shen, Li'e Li, Guoping Hu, Yang Yue, Jian Li, Diliang Guo, Nengyang Shi, Lu Huang, Shuhui Chen, Ronghua Tu, Zhongwen Yang, Xuwen Zhang, Qiang Xiao, Hua Tian, Yanping Yu, Hailiang Chen, Wenjie Sun, Zhenyu He, Jie Shen, Jing Yang, Jing Tang, Wen Zhou, Jing Yu, Yi Zhang, Quan Liu
  • Automatic gas cylinder filling system and operating instructions
    Patent number: 10648617
    Abstract: The disclosure discloses an automatic gas cylinder filling device and an operating method thereof, includes a stand, an electronic scale, a PLC control unit, and a vacuum pump installed on an inner bottom plate of the stand. One side of the stand is provided with an 8-bottle gas cylinder rotating and weighing mechanism, a gas cylinder fixing mechanism, a gas cylinder filling fixture, a lifting frame and a bottle valve hand wheel switch mechanism that are arranged in sequence from bottom to top. The electronic scale is located below the 8-bottle gas cylinder rotating and weighing mechanism. The disclosure is used for filling gas cylinders, wherein the weighing, the fixing of the bottle valve and the rotation of the hand wheel are all automatically controlled and operated by the PLC control unit, and there is no need for operator to stay with the facility.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: May 12, 2020
    Assignee: Jining Xieli Special Gas Co., ltd
    Inventors: Yong Xu, Yan He
  • LIGHT DIFFUSING COMPONENT, BACKLIGHT COMPONENT AND DISPLAY DEVICE
    Publication number: 20200132911
    Abstract: The present disclosure relates to a field of display technologies and provides a light diffusing component, a backlight component having the same, and a display device. The light diffusing component may include a main body, a protruding portion, and a reflecting portion. The protruding portion is disposed on a side of the main body and protruded from the main body; the reflecting portion is disposed on the protruding portion and an edge region of the main body portion connected to the protruding portion, so as to reflect light incident from a lower portion of the light diffusing component. Light transmittance of the reflecting portion gradually increases in a direction away from a center of the diffusing component.
    Type: Application
    Filed: October 1, 2019
    Publication date: April 30, 2020
    Inventors: Qiping Zhang, Yong Xu, Xing Wang
  • AUTOMATIC GAS CYLINDER FILLING SYSTEM AND OPERATING INSTRUCTIONS
    Publication number: 20200124232
    Abstract: The disclosure discloses an automatic gas cylinder filling device and an operating method thereof, includes a stand, an electronic scale, a PLC control unit, and a vacuum pump installed on an inner bottom plate of the stand. One side of the stand is provided with an 8-bottle gas cylinder rotating and weighing mechanism, a gas cylinder fixing mechanism, a gas cylinder filling fixture, a lifting frame and a bottle valve hand wheel switch mechanism that are arranged in sequence from bottom to top. The electronic scale is located below the 8-bottle gas cylinder rotating and weighing mechanism. The disclosure is used for filling gas cylinders, wherein the weighing, the fixing of the bottle valve and the rotation of the hand wheel are all automatically controlled and operated by the PLC control unit, and there is no need for operator to stay with the facility.
    Type: Application
    Filed: October 22, 2018
    Publication date: April 23, 2020
    Applicant: Jining Xieli Special Gas Co.,ltd
    Inventors: Yong Xu, Yan He
  • PKM2 MODULATORS AND METHODS FOR THEIR USE
    Publication number: 20200109120
    Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: September 26, 2019
    Publication date: April 9, 2020
    Inventors: Koc-Kan HO, Yong XU, Michael David SAUNDERS, Xiaohui LIU, Scott Albert PEARCE, Kevin Bret WRIGHT, Jason Marc FOULKS, Kenneth Mark PARNELL, Steven Brian KANNER, David Lee VOLLMER, Jihua LIU
  • SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES AS PROTEIN KINASE INHIBITORS
    Publication number: 20200102313
    Abstract: The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.
    Type: Application
    Filed: July 2, 2019
    Publication date: April 2, 2020
    Inventors: Yong Xu, Benjamin Gary Brenning, Steven G. Kultgen, Xiaohui Liu, Michael David Saunders, Koc-Kan Ho
  • MULTI-VIEW IMAGE CLUSTERING TECHNIQUES USING BINARY COMPRESSION
    Publication number: 20200074220
    Abstract: This disclosure relates to improved techniques for performing multi-view image clustering. The techniques described herein utilize machine learning functions to optimize the image clustering process. Multi-view features are extracted from a collection of images. A machine learning function is configured to jointly learn a fused binary representation that combines the multi-view features and one or more binary cluster structures that can be used to partition the images. A clustering function utilizes the fused binary representation and the one or more binary cluster structures to generate one or more image clusters based on the collection of images.
    Type: Application
    Filed: September 4, 2018
    Publication date: March 5, 2020
    Inventors: Zheng Zhang, Li Liu, Jie Qin, Fan Zhu, Fumin Shen, Yong Xu, Ling Shao, Heng Tao Shen
  • High Fidelity Restriction Endonucleases
    Publication number: 20200063121
    Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
    Type: Application
    Filed: September 11, 2019
    Publication date: February 27, 2020
    Applicant: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Aine Quimby, Shuang-Yong Xu, Shengxi Guan, Hua Wei, Penghua Zhang, Dapeng Sun, Siu-hong Chan
  • METHOD AND APPARATUS FOR DETERMINING BLOOD PRESSURE ON MEASURED HEART SOUNDS
    Publication number: 20200022659
    Abstract: A system and method of determining blood pressure includes measuring heart sounds, separating the measured heart sounds into a first heart sound (S1) and a second heart sound (S2), mathematically characterizing S1 and S2, and determining a blood pressure based on the characterization.
    Type: Application
    Filed: February 7, 2018
    Publication date: January 23, 2020
    Applicant: Wayne State University
    Inventors: William D. Lyman, Gaurav Kapur, Yong Xu, Sean F. Wu, Lingguang Chen
  • 3D building extraction apparatus, method and system
    Patent number: 10521694
    Abstract: Disclosed is a method for 3D building extraction, comprising: extracting building footprints from one or more stereo images for a building; determining, from rational polynomial coefficient of the stereo images, first height estimation of the extracted building footprints; obtaining, from multi-temporal SAR images for the building, scatters with stable attributes; determining second height estimation for the determined scatters; and combining the first height estimation and the second height estimation to generate a fused height for each of the extracted building footprints.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: December 31, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Yong Xu, Chao Ren, Peifeng Ma, Hui Lin, Yan Yung Ng
  • Salt Type And Crystal Type Of 4h-Pyrazolo [1, 5-Alpha] Benzimidazole Compound And Preparation Method And Intermediate Thereof
    Publication number: 20190375756
    Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1, 5-alpha]benzimidazole compound and the preparation method and intermediate thereof.
    Type: Application
    Filed: August 22, 2019
    Publication date: December 12, 2019
    Inventors: Xuehai WANG, Charles Z. DING, Jie SHEN, Shuhui CHEN, Lie LI, Gang LI, Yong XU, Cailin WANG, Ronghua TU, Jimeng WANG, Yang YUE, Biao DENG, Hailiang CHEN, Hui LIU, Wenjie SUN, Cong WANG, Lu HUANG, Zheng WANG, Weidong LI
  • PKM2 modulators and methods for their use
    Patent number: 10472328
    Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: November 12, 2019
    Assignee: TOLERO PHARMACEUTICALS, INC.
    Inventors: Koc-Kan Ho, Yong Xu, Michael David Saunders, Xiaohui Liu, Scott Albert Pearce, Kevin Bret Wright, Jason Marc Foulks, Kenneth Mark Parnell, Steven Brian Kanner, David Lee Vollmer, Jihua Liu
  • MANUFACTURING METHOD FOR A TFT ARRAY SUBSTRATE AND TFT ARRAY SUBSTRATE
    Publication number: 20190326335
    Abstract: A manufacturing method for TFT array substrate and TFT array substrate are disclosed. After depositing an electrode material layer and a metal material layer on the gate insulation layer and the active layer in sequence after the active layer above the gate electrode is formed. A photoresist pattern is formed on the metal material layer. The photoresist pattern includes a first and second photoresist blocks with different thicknesses. The metal material layer and the electrode material layer are etched using the photoresist pattern to form a contact electrode and pixel electrodes connected with two ends of the active layer and the source/drain electrodes on the contact electrode. The process is simple and can effectively reduce the contact resistance between the source/drain and the active layer and improve the quality of the product.
    Type: Application
    Filed: September 18, 2018
    Publication date: October 24, 2019
    Inventors: Guanghui Liu, Peng He, Yong Xu, Fei Ai
  • High fidelity restriction endonucleases
    Patent number: 10450559
    Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: October 22, 2019
    Assignee: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Aine Quimby, Shuang-Yong Xu, Shengxi Guan, Hua Wei, Penghua Zhang, Dapeng Sun, Siu-hong Chan
  • Salt type and crystal type of 4H-pyrazolo [1, 5-alpha] benzimidazole compound and preparation method and intermediate thereof
    Patent number: 10428073
    Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1,5-alpha]benzimidazole compound and a preparation method and intermediate thereof.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: October 1, 2019
    Assignees: Hubei Bio-Pharmaceutical Industrial Technological Institute Inc., Humanwell Healthcare (Group) Co., Ltd.
    Inventors: Xuehai Wang, Charles Z. Ding, Jie Shen, Shuhui Chen, Lie Li, Gang Li, Yong Xu, Cailin Wang, Ronghua Tu, Jimeng Wang, Yang Yue, Biao Deng, Hailiang Chen, Hui Liu, Wenjie Sun, Cong Wang, Lu Huang, Zheng Wang, Weidong Li
  • Monitoring apparatus
    Patent number: D889524
    Type: Grant
    Filed: September 28, 2019
    Date of Patent: July 7, 2020
    Inventor: Yong Xu