Abstract: The present disclosure provides resins that can be used as a tie layer in a multilayer structure and to multilayer structures comprising one or more tie layers formed from such resins. In one aspect, a resin for use as a tie layer in a multilayer structure comprises a first composition, wherein the first composition comprises at least one ethylene-based polymer and wherein the first composition comprises a MWCDI value greater than 0.9, and a melt index ratio (I10/I2) that meets the following equation: I10/I2 ? 7.0?1.2×log (I2), wherein the first composition comprises 1 to 99 weight percent of the resin; and a maleic anhydride grafted polyethylene comprising a maleic anhydride grafted high density polyethylene, a maleic anhydride grafted linear low density polyethylene, a maleic anhydride grafted polyethylene elastomer, or a combination thereof, wherein the maleic anhydride grafted polyethylene comprises 1 to 99 weight percent of the resin.

Abstract: The present disclosure provides monoclonal antibodies against protein programmed cell death 1 ligand (PD-L1), which can block the binding of PD-L1 to PD-1, and therefore block the inhibitory function of PD-L1 on PD-1 expressing T cells. The antibodies of disclosure provide very potent agents for the treatment of multiple cancers via modulating human immune function.

Abstract: Provided are novel fully human monoclonal antibodies that bind to human 4-1BB. It also provides the methods of hybridoma generation using humanized rats, the nucleic acid molecules encoding the anti-4-1BB antibodies, vectors and host cells used for the expression of anti-4-1BB antibodies. The invention further provides methods for validating the function of antibodies in vitro and the efficacy of antibodies in vivo. The antibodies of invention provide a very potent agent for the treatment of multiple cancers via modulating human immune function.

Abstract: A key structure includes a keycap and an actuator. The actuator is coupled with the keycap and enables the keycap to move reciprocally along an actuating direction. One of the actuator and the keycap has a base and a slot formed therein, and the other one of the same has a plug. The plug is inserted into the slot in a direction parallel to the actuating direction. The slot has an inner wall pressing the plug and generating friction. The base has a first sidewall thickness perpendicular to the actuating direction and parallel to the inner wall and a second sidewall thickness perpendicular to the actuating direction and perpendicular to the inner wall, wherein the first sidewall thickness is greater than the second sidewall thickness. The disclosure can avoid the horizontal stress generated by the plug when it is inserted into the slot to squeeze against the bas.

Abstract: A Doherty power amplifier having a main power amplification device and an auxiliary power amplification device arranged in parallel with the main power amplification device includes a load modulation circuit having a harmonic injection circuit connected with respective outputs of the main power amplification device and the auxiliary power amplification device. The harmonic injection circuit is arranged to provide a phase shift to simultaneously modulate transfer of second harmonic components generated at the main power amplification device to the auxiliary power amplification device and transfer of second harmonic components generated at the auxiliary power amplification device to the main power amplification device, when the main power amplification device and the auxiliary power amplification device are operated at saturation.

Abstract: The present application provides fully human monoclonal antibodies against tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as OX40 and CD134. It also provides the methods of hybridoma generation using a humanized transgenic rat, the nucleic acid molecules encoding the anti-OX40 antibodies, expression vectors and host cells used for the expression of anti-OX40 antibodies. The invention further provides the methods for validating the function of antibodies in vitro and the efficacy of antibodies in vivo. The antibodies of invention provide a very potent agent for the treatment of multiple cancers via modulating human immune function.

Abstract: The present disclosure provides anti-TIM-3 antibodies or antigen-binding fragments thereof, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the uses thereof.

Abstract: A computer-implemented method comprises initializing a plurality of segment lists. Each segment list of the plurality of segment lists corresponds to a respective one of a plurality of disk drives. Each segment list divides storage space of the respective disk drive into a plurality of segments. The method further comprises, for each of the plurality of disk drives, identifying one or more candidate segments from the plurality of segments; calculating a respective segment distance variance for one or more combinations of identified candidate segments. Each combination of identified candidate segments includes one candidate segment for each of the plurality of disk drives. The method further comprises selecting a combination of the one or more combinations of identified candidate segments having the smallest respective segment distance variance; and storing data on the plurality of disk drives according to the selected combination of identified candidate segments.

Abstract: The present disclosure provides monoclonal antibodies against protein programmed cell death 1 (PD-1), which can block the binding of PD-1 ligands to PD-1, and therefore block the inhibitory function of PD-1 ligands on PD-1 expressing T cells. The antibodies of disclosure provide very potent agents for the treatment of multiple cancers via modulating human immune function.

Abstract: Method and apparatus for reducing resource consumption in container image management. Embodiments include receiving directory information and checksum information corresponding to a plurality of files of a container image. Embodiments include determining, based on the directory information and the checksum information, whether each file of the plurality of files is present in a repository. For each respective file of the plurality of files that is determined to be present in the repository, embodiments include updating a file list for the container image to indicate a respective location in the repository of the respective file. For each given file of the plurality of files that is determined not to be present in the repository, embodiments include storing the given file at a given location in the repository and updating the file list for the container image to indicate the given location in the repository of the given file.

Abstract: A key structure includes a keycap and an actuator. The actuator is coupled with the keycap and enables the keycap to move reciprocally along an actuating direction. One of the actuator and the keycap has a base and a slot formed therein, and the other one of the same has a plug. The plug is inserted into the slot in a direction parallel to the actuating direction. The slot has an inner wall pressing the plug and generating friction. The base has a first sidewall thickness perpendicular to the actuating direction and parallel to the inner wall and a second sidewall thickness perpendicular to the actuating direction and perpendicular to the inner wall, wherein the first sidewall thickness is greater than the second sidewall thickness. The disclosure can avoid the horizontal stress generated by the plug when it is inserted into the slot to squeeze against the bas.

Abstract: A mask has a mask pattern region and a non-mask pattern region located at a peripheral of the mask pattern region. The mask pattern region includes at least one effective mask region. In any effective mask region, the mask includes a plurality of evaporation holes and at least one shielding strip. Each shielding strip is located between two adjacent evaporation holes. The mask has at least one welding region in the non-mask pattern region. A thickness of a portion of the mask in the non-mask pattern region and at least in the welding region is greater than a thickness of the shielding strip of the mask in the effective mask region, and the thickness refers to a dimension of the corresponding portion along a direction perpendicular to a plane where the mask is located.

Abstract: Anti-LAG-3/PD-1 bispecific antibody molecules, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the uses thereof are provided.

Abstract: The disclosure relates to a tie resin formulation for use as a tie layer in a multilayer structure. The resin includes a first polyolefin grafted with an ethylenically unsaturated carboxylic acid, an ethylenically unsaturated acid derivative or a combination thereof, and having a density of 0.857 to 0.885 g/cm3, and 0.001 to 0.20 weight percent (wt. %) of a catalyst comprising at least one Lewis acid, where the resin includes the catalyst and up to 99.999 wt. % of the first polyolefin, where the wt. % is based on a total weight of the resin.

Abstract: The present disclosure provides monoclonal antibodies against protein programmed cell death 1 ligand (PD-L1), which can block the binding of PD-L1 to PD-1, and therefore block the inhibitory function of PD-L1 on PD-1 expressing T cells. The antibodies of disclosure provide very potent agents for the treatment of multiple cancers via modulating human immune function.

Abstract: The present disclosure provides a computer-implemented method, computer system and computer program product for application containerization. According to the computer-implemented method, an application to be containerized can be traced. Information obtained in the tracing can be analyzed to determine one or more features of the application. An image template for the application can be created based on the one or more features. Then, a container image for the application can be built based on the image template.

Abstract: A method of preparing an aqueous dispersion of an ethylene-carboxylic acid copolymer according to exemplary embodiments of the present invention includes: mixing 30% by weight or more of an ethylene-(meth)acrylic acid copolymer, a basic compound, and water to form a mixed solution; and adding an inorganic salt compound to the mixed solution. Therefore, the aqueous dispersion of the ethylene-carboxylic acid copolymer may be effectively dispersed.

Abstract: A mask and a mask assembly with the mask are disclosed. The mask includes: a mask pattern region; a non-mask pattern region around the mask pattern region; and two fixing areas disposed opposite to each other in a first direction in the non-mask pattern region and configured to fix the mask. There is a boundary line between the mask pattern region and the non-mask pattern region in the first direction, and an edge, along the boundary line, of the mask pattern region is concave towards an inner side of the mask pattern region in the first direction.